Poly(N-isopropylacrylamide)(PNIPAAm)-based thermo-responsive surfaces can switch their wettability(from wettable to non-wettable) and adhesion(from sticky to non-sticky) according to external temperature changes. Thes...Poly(N-isopropylacrylamide)(PNIPAAm)-based thermo-responsive surfaces can switch their wettability(from wettable to non-wettable) and adhesion(from sticky to non-sticky) according to external temperature changes. These smart surfaces with switchable interfacial properties are playing increasingly important roles in a diverse range of biomedical applications; these controlling cell-adhesion behavior has shown great potential for tissue engineering and disease diagnostics. Herein we reviewed the recent progress of research on PNIPAAm-based thermo-responsive surfaces that can dynamically control cell adhesion behavior. The underlying response mechanisms and influencing factors for PNIPAAm-based surfaces to control cell adhesion are described first. Then, PNIPAAm-modified two-dimensional flat surfaces for cell-sheet engineering and PNIPAAm-modified three-dimensional nanostructured surfaces for diagnostics are summarized. We also provide a future perspective for the development of stimuli-responsive surfaces.展开更多
基金supported by the National Basic Research Program of China(2012CB933800,2011CB935700,2012CB933200)the National Natural Science Foundation of China(21175140,20974113,21121001)the Key Research Program of the Chinese Academy of Sciences(KJZD-EW-M01)
文摘Poly(N-isopropylacrylamide)(PNIPAAm)-based thermo-responsive surfaces can switch their wettability(from wettable to non-wettable) and adhesion(from sticky to non-sticky) according to external temperature changes. These smart surfaces with switchable interfacial properties are playing increasingly important roles in a diverse range of biomedical applications; these controlling cell-adhesion behavior has shown great potential for tissue engineering and disease diagnostics. Herein we reviewed the recent progress of research on PNIPAAm-based thermo-responsive surfaces that can dynamically control cell adhesion behavior. The underlying response mechanisms and influencing factors for PNIPAAm-based surfaces to control cell adhesion are described first. Then, PNIPAAm-modified two-dimensional flat surfaces for cell-sheet engineering and PNIPAAm-modified three-dimensional nanostructured surfaces for diagnostics are summarized. We also provide a future perspective for the development of stimuli-responsive surfaces.
