By analyzing the key steps that restricted the industrial synthesis of salidroside, selective protection of tyrosol with different acylation reagents was adopted. The strategy facilitated the crystallization of interm...By analyzing the key steps that restricted the industrial synthesis of salidroside, selective protection of tyrosol with different acylation reagents was adopted. The strategy facilitated the crystallization of intermediates, which allowed the scalable synthesis of salidroside. It included a reaction of penta-O-acetyl-β-D-glucose with acyl protected tyrosol in the presence of Lewis acid catalyst（ZnCl2）, followed by deacylation under basic condition（NaOMe/MeOH） to give the salidroside. The total yield of this three-step reaction was 47%. Final product and intermediates were purified by recrystallization, which significantly reduced the cost and made the large scale synthesis feasible.展开更多
Studied in this paper is a(2+1)-dimensional coupled nonlinear Schr?dinger system with variable coefficients,which describes the propagation of an optical beam inside the two-dimensional graded-index waveguide amplifie...Studied in this paper is a(2+1)-dimensional coupled nonlinear Schr?dinger system with variable coefficients,which describes the propagation of an optical beam inside the two-dimensional graded-index waveguide amplifier with the polarization effects. According to the similarity transformation, we derive the type-Ⅰ and type-Ⅱ rogue-wave solutions. We graphically present two types of the rouge wave and discuss the influence of the diffraction parameter on the rogue waves.When the diffraction parameters are exponentially-growing-periodic, exponential, linear and quadratic parameters, we obtain the periodic rogue wave and composite rogue waves respectively.展开更多
基金the National Basic Research Program of China(973 Program,Grant No.2012CB822100)the National Key Technology R&D Program"New Drug Innovation"of China(Grant No.2012ZX09502001-001)the National Natural Science Foundation of China(Grant No.21232002,21072016 and 21072017)
文摘By analyzing the key steps that restricted the industrial synthesis of salidroside, selective protection of tyrosol with different acylation reagents was adopted. The strategy facilitated the crystallization of intermediates, which allowed the scalable synthesis of salidroside. It included a reaction of penta-O-acetyl-β-D-glucose with acyl protected tyrosol in the presence of Lewis acid catalyst（ZnCl2）, followed by deacylation under basic condition（NaOMe/MeOH） to give the salidroside. The total yield of this three-step reaction was 47%. Final product and intermediates were purified by recrystallization, which significantly reduced the cost and made the large scale synthesis feasible.
基金Supported by the National Natural Science Foundation of China under Grant Nos.11772017,11272023,and 11471050the Fund of State Key Laboratory of Information Photonics and Optical Communications(Beijing University of Posts and Telecommunications),China(IPOC:2017ZZ05)the Fundamental Research Funds for the Central Universities of China under Grant No.2011BUPTYB02
文摘Studied in this paper is a(2+1)-dimensional coupled nonlinear Schr?dinger system with variable coefficients,which describes the propagation of an optical beam inside the two-dimensional graded-index waveguide amplifier with the polarization effects. According to the similarity transformation, we derive the type-Ⅰ and type-Ⅱ rogue-wave solutions. We graphically present two types of the rouge wave and discuss the influence of the diffraction parameter on the rogue waves.When the diffraction parameters are exponentially-growing-periodic, exponential, linear and quadratic parameters, we obtain the periodic rogue wave and composite rogue waves respectively.
