High precise, high voltage pulse generator made up of high-power IGBT and pulse transformers controlled by a computer are described. A simple main circuit topology employed in this pulse generator can reduce the cost ...High precise, high voltage pulse generator made up of high-power IGBT and pulse transformers controlled by a computer are described. A simple main circuit topology employed in this pulse generator can reduce the cost meanwhile it still meets special requirements for pulsed electric fields (PEFs) in food process. The pulse generator utilizes a complex programmable logic device (CPLD) to generate trigger signals. Pulse-frequency, pulse-width and pulse-number are controlled via RS232 bus by a computer. The high voltage pulse generator well suits to the application for fluid food non-thermal effect in pulsed electric fields, for it can increase and decrease by the step length 1.展开更多
OBJECTIVE In China, vinorelbine plus an anthracycline is a common neoadjuvant regimen for locally-advanced breast cancer （LABC）. Pegylated liposomal doxorubicin （PLD） is an alternate anthracycline formulation with...OBJECTIVE In China, vinorelbine plus an anthracycline is a common neoadjuvant regimen for locally-advanced breast cancer （LABC）. Pegylated liposomal doxorubicin （PLD） is an alternate anthracycline formulation with a more favorable safety profile compared with conventional anthracyclines. METHODS In this open-label trial, 61 women with LABC received up to 6 cycles of PLD 30 mg/m2 on Day 1 and vinorelbine 25 mg/m2 on Days 1 and 8 every 21 days. Hormone receptor and/or HER2 status was not routinely available. RESULTS The overall clinical response rate （primary efficacy endpoint） was 80% （95% CI： 68%-89%）. Two patients achieved a pathological complete response （3%）, with 75% having their tumor down-staged, and 89% proceeding to tumor resection. The most frequent nonhematologic adverse events were stomatitis, fever, rash, and palmar-plantar erythrodysesthesia, with none considered serious. Grade 3 or 4 neutropenia and thrombocytopenia occurred in 10% and 2% of patients, respectively. CONCLUSION PLD plus vinorelbine demonstrated comparable efficacy to conventional anthracyclines plus vinorelbine in the neoadjuvant treatment of LABC, but may offer safety advantages.展开更多
Interface and surface physics is an important sub-discipline within condensed matter physics in recent decades. Novel concepts like oxide-electronic device are prompted, and their performance and lifetime are highly d...Interface and surface physics is an important sub-discipline within condensed matter physics in recent decades. Novel concepts like oxide-electronic device are prompted, and their performance and lifetime are highly dependent on the flatness and abruptness of the layer surfaces and interfaces. Reflection high-energy electron diffraction （RHEED）, which is extremely sensitive to surface morphology, has proven to be a versatile technique for the growth study of oxide thin films. A differential pumping unit enables an implementation of RHEED to pulsed laser deposition （PLD） systems, ensuring an in situ monitoring of the film growth process in a conventional PLD working oxygen pressure up to 30 Pa. By optimizing the deposition conditions and analyzing the RHEED intensity oscillations, layer-by-layer growth mode can be attained. Thus atomic control of the film surface and unit-cell control of the film thickness become reality. This may lead to an advanced miniaturization in the oxide electronics, and more importantly the discovery of a range of emergent physical properties at the interfaces. Herein we will briefly introduce the principle of high-pressure RHEED and summarize our main results relevant to the effort toward this objective, including the growth and characterization of twinned Laz/3Caj/3MnO3 thin films and ReTiO〉6/2 （Re = La, Nd; ~5 = 0 - 1） AnBnO3n＋2 structures, on YSZ-buffered ＇Silicon on Insulator＇ and LaA103 substrates, respectively, as well as the study of the initial structure and growth dynamics of YBazCu307-6 thin films on SrTiO3 substrate. Presently we have realized in situ monitoring and growth mode control during oxide thin film deposition process.展开更多
Magnetic single-domain islands based on in-plane anisotropy （usually, shape anisotropy） and their dipole-dipole interactions have been investigated extensively in recent years. This has been driven by potential appl...Magnetic single-domain islands based on in-plane anisotropy （usually, shape anisotropy） and their dipole-dipole interactions have been investigated extensively in recent years. This has been driven by potential applications in magnetic recording, spintronics, magneto-biology, etc. Here, we propose a concept of out- of-plane magnetic dusters with configurable domain structures （multi-flux states） via dipole-dipole interactions. Their flux stages can be switched through an external magnetic field. The concept has been successfully demonstrated by patterned [Co/Pd] islands. A [Co/Pd] multilayer exhibits a large perpendicular anisotropy, a strong physical separation, and uniform intrinsic properties after being patterned into individual islands by electron beam lithography. A three- island cluster with six stable flux states has been realized by optimizing island size, thickness, gap, anisotropy, saturation magnetization, etc. Using [Co/Pd] multilayers, we have optimized the island structure by tuning magnetic properties （saturation magnetization and perpendicular anisotropy） using Landau-Liftshitz- Gilbert （LLG） simulation/calculation. Potential applications have been proposed, including a flexi-programmable logic device with AND, OR, NAND, and NOR functionalities and a magnetic domino, which can propagate magnetic current as far as 1 μm down from the surface via vertical dipole-dipole interactions.展开更多
文摘High precise, high voltage pulse generator made up of high-power IGBT and pulse transformers controlled by a computer are described. A simple main circuit topology employed in this pulse generator can reduce the cost meanwhile it still meets special requirements for pulsed electric fields (PEFs) in food process. The pulse generator utilizes a complex programmable logic device (CPLD) to generate trigger signals. Pulse-frequency, pulse-width and pulse-number are controlled via RS232 bus by a computer. The high voltage pulse generator well suits to the application for fluid food non-thermal effect in pulsed electric fields, for it can increase and decrease by the step length 1.
文摘OBJECTIVE In China, vinorelbine plus an anthracycline is a common neoadjuvant regimen for locally-advanced breast cancer （LABC）. Pegylated liposomal doxorubicin （PLD） is an alternate anthracycline formulation with a more favorable safety profile compared with conventional anthracyclines. METHODS In this open-label trial, 61 women with LABC received up to 6 cycles of PLD 30 mg/m2 on Day 1 and vinorelbine 25 mg/m2 on Days 1 and 8 every 21 days. Hormone receptor and/or HER2 status was not routinely available. RESULTS The overall clinical response rate （primary efficacy endpoint） was 80% （95% CI： 68%-89%）. Two patients achieved a pathological complete response （3%）, with 75% having their tumor down-staged, and 89% proceeding to tumor resection. The most frequent nonhematologic adverse events were stomatitis, fever, rash, and palmar-plantar erythrodysesthesia, with none considered serious. Grade 3 or 4 neutropenia and thrombocytopenia occurred in 10% and 2% of patients, respectively. CONCLUSION PLD plus vinorelbine demonstrated comparable efficacy to conventional anthracyclines plus vinorelbine in the neoadjuvant treatment of LABC, but may offer safety advantages.
基金supported by the National Natural Science Foundation of China(Grant Nos.10974229 and 11174342)
文摘Interface and surface physics is an important sub-discipline within condensed matter physics in recent decades. Novel concepts like oxide-electronic device are prompted, and their performance and lifetime are highly dependent on the flatness and abruptness of the layer surfaces and interfaces. Reflection high-energy electron diffraction （RHEED）, which is extremely sensitive to surface morphology, has proven to be a versatile technique for the growth study of oxide thin films. A differential pumping unit enables an implementation of RHEED to pulsed laser deposition （PLD） systems, ensuring an in situ monitoring of the film growth process in a conventional PLD working oxygen pressure up to 30 Pa. By optimizing the deposition conditions and analyzing the RHEED intensity oscillations, layer-by-layer growth mode can be attained. Thus atomic control of the film surface and unit-cell control of the film thickness become reality. This may lead to an advanced miniaturization in the oxide electronics, and more importantly the discovery of a range of emergent physical properties at the interfaces. Herein we will briefly introduce the principle of high-pressure RHEED and summarize our main results relevant to the effort toward this objective, including the growth and characterization of twinned Laz/3Caj/3MnO3 thin films and ReTiO〉6/2 （Re = La, Nd; ~5 = 0 - 1） AnBnO3n＋2 structures, on YSZ-buffered ＇Silicon on Insulator＇ and LaA103 substrates, respectively, as well as the study of the initial structure and growth dynamics of YBazCu307-6 thin films on SrTiO3 substrate. Presently we have realized in situ monitoring and growth mode control during oxide thin film deposition process.
文摘Magnetic single-domain islands based on in-plane anisotropy （usually, shape anisotropy） and their dipole-dipole interactions have been investigated extensively in recent years. This has been driven by potential applications in magnetic recording, spintronics, magneto-biology, etc. Here, we propose a concept of out- of-plane magnetic dusters with configurable domain structures （multi-flux states） via dipole-dipole interactions. Their flux stages can be switched through an external magnetic field. The concept has been successfully demonstrated by patterned [Co/Pd] islands. A [Co/Pd] multilayer exhibits a large perpendicular anisotropy, a strong physical separation, and uniform intrinsic properties after being patterned into individual islands by electron beam lithography. A three- island cluster with six stable flux states has been realized by optimizing island size, thickness, gap, anisotropy, saturation magnetization, etc. Using [Co/Pd] multilayers, we have optimized the island structure by tuning magnetic properties （saturation magnetization and perpendicular anisotropy） using Landau-Liftshitz- Gilbert （LLG） simulation/calculation. Potential applications have been proposed, including a flexi-programmable logic device with AND, OR, NAND, and NOR functionalities and a magnetic domino, which can propagate magnetic current as far as 1 μm down from the surface via vertical dipole-dipole interactions.
