Re（I）tricarbonyl rhenium（I）complexes attracted much attention owing to the good cellular uptake ability and rich photophysical properties.However,normally Re（I）complexes show short triplet state lifetime and wea...Re（I）tricarbonyl rhenium（I）complexes attracted much attention owing to the good cellular uptake ability and rich photophysical properties.However,normally Re（I）complexes show short triplet state lifetime and weak absorption in the visible spectra region,and the absorption wavelength usually is shorter than 450 nm.These features are detrimental to the applications of Re（I）complexes in the areas such as photodynamic therapy（PDT）and luminescence bioimaging.Herein,a novel tricarbonyl rhenium（I）complex Re-1 with strong visible light-absorbing ability（624 nm,ε=5.69′10^4 L/（mol cm））,long-lived triplet excited state（νT=448.9ms）and moderate fluorescence quantum yield（ΦF=41.6%）was prepared.The photophysical properties of Re-1 were studied with steady state UV-Vis absorption and luminescence spectroscopies,nanosecond transient absorption spectroscopy,as well as DFT/TDDFT calculations.Re-1 was used for intracellular PDT and luminescence imaging studies.The results indicate that Re-1 shows low dark toxicity,but it is able to kill cancer cells on illumination with 635 nm LED.展开更多
基金the National Natural Science Foundation of China(NSFC:20972024,21273028,21421005,21473020)the Royal Society(UK)and NSFC(China-UK Cost-Share Science Networks,21011130154)+3 种基金Ministry of Education(SRFDP20120041130005)Program for Changjiang Scholars and Innovative Research Team in University[IRT_13R06]the Fundamental Research Funds for the Central Universities(DUT14ZD226)Dalian University of Technology(DUT2013TB07)
文摘Re（I）tricarbonyl rhenium（I）complexes attracted much attention owing to the good cellular uptake ability and rich photophysical properties.However,normally Re（I）complexes show short triplet state lifetime and weak absorption in the visible spectra region,and the absorption wavelength usually is shorter than 450 nm.These features are detrimental to the applications of Re（I）complexes in the areas such as photodynamic therapy（PDT）and luminescence bioimaging.Herein,a novel tricarbonyl rhenium（I）complex Re-1 with strong visible light-absorbing ability（624 nm,ε=5.69′10^4 L/（mol cm））,long-lived triplet excited state（νT=448.9ms）and moderate fluorescence quantum yield（ΦF=41.6%）was prepared.The photophysical properties of Re-1 were studied with steady state UV-Vis absorption and luminescence spectroscopies,nanosecond transient absorption spectroscopy,as well as DFT/TDDFT calculations.Re-1 was used for intracellular PDT and luminescence imaging studies.The results indicate that Re-1 shows low dark toxicity,but it is able to kill cancer cells on illumination with 635 nm LED.
