Whether the benefits that glycoprotein IIb/IIIa inhibitors confer in patients who undergo baremetal stent implantation extend to drug-eluting stents is unknown. We performed a prespecified subgroup analysis of the TAX...Whether the benefits that glycoprotein IIb/IIIa inhibitors confer in patients who undergo baremetal stent implantation extend to drug-eluting stents is unknown. We performed a prespecified subgroup analysis of the TAXUS IV study population to examine the effect of procedural glycoprotein IIb/IIIa inhibition during paclitaxel-eluting stent implantation on periprocedural creatine kinase-MB(CK-MB) levels. Glycoprotein(GP)IIb/IIIa inhibitors were administered to 57.7%of patients who had been randomized to receive the TAXUS stent and to 56.7%of those who had been randomized to receive the control stent. Among patients who received the TAXUS stent, the rate of CKMB increases of >3 times the normal level was 2.6-fold higher in those who received a GP IIb/IIIa inhibitor than in those who did not(11.4%vs 4.4%, p=0.0015). Composite rates of major adverse cardiac events and target vessel failure were also higher at 1 month in the GP IIb/IIIa group. By multivariate analysis, use of GP IIb/IIIa inhibitors during stenting with the TAXUS stent was an independent predictor of CK-MB increases >3 times the normal level. Further studies are warranted.展开更多
Germinating wheat （Triticum aestivum L.） seeds were exposed to CdCI2 （50, 100 and 200 μM） for 48 h and some aspects of oxidative metabolism was assessed in the embryonic tissues. The germination percentage and th...Germinating wheat （Triticum aestivum L.） seeds were exposed to CdCI2 （50, 100 and 200 μM） for 48 h and some aspects of oxidative metabolism was assessed in the embryonic tissues. The germination percentage and the soluble protein content of the embryonic tissues were found to decrease with increasing of Cd concentration. There was elevation in superoxide dismutase （SOD） and decline in catalase （CAT） and peroxidase （POX） activities. The increasing of lipid peroxidation levels indicated the prevalence of oxidative stress in the tissues which was probably due to the alteration of antioxidative enzymes activities. The adding of ascorbate, along with CdCl2, has resulted in restoration of the Cd induced decline in CAT activity. Weakening in H2O2 detoxification system seems to be the principal reason behind Cd induced oxidative stress in germinating seeds. Thus, imposition of oxidative stress might be the consequence of cadmium stress and this finding may help in elucidating the mechanisms underlying cadmium mediated toxicity in germinating seeds.展开更多
文摘Whether the benefits that glycoprotein IIb/IIIa inhibitors confer in patients who undergo baremetal stent implantation extend to drug-eluting stents is unknown. We performed a prespecified subgroup analysis of the TAXUS IV study population to examine the effect of procedural glycoprotein IIb/IIIa inhibition during paclitaxel-eluting stent implantation on periprocedural creatine kinase-MB(CK-MB) levels. Glycoprotein(GP)IIb/IIIa inhibitors were administered to 57.7%of patients who had been randomized to receive the TAXUS stent and to 56.7%of those who had been randomized to receive the control stent. Among patients who received the TAXUS stent, the rate of CKMB increases of >3 times the normal level was 2.6-fold higher in those who received a GP IIb/IIIa inhibitor than in those who did not(11.4%vs 4.4%, p=0.0015). Composite rates of major adverse cardiac events and target vessel failure were also higher at 1 month in the GP IIb/IIIa group. By multivariate analysis, use of GP IIb/IIIa inhibitors during stenting with the TAXUS stent was an independent predictor of CK-MB increases >3 times the normal level. Further studies are warranted.
文摘Germinating wheat （Triticum aestivum L.） seeds were exposed to CdCI2 （50, 100 and 200 μM） for 48 h and some aspects of oxidative metabolism was assessed in the embryonic tissues. The germination percentage and the soluble protein content of the embryonic tissues were found to decrease with increasing of Cd concentration. There was elevation in superoxide dismutase （SOD） and decline in catalase （CAT） and peroxidase （POX） activities. The increasing of lipid peroxidation levels indicated the prevalence of oxidative stress in the tissues which was probably due to the alteration of antioxidative enzymes activities. The adding of ascorbate, along with CdCl2, has resulted in restoration of the Cd induced decline in CAT activity. Weakening in H2O2 detoxification system seems to be the principal reason behind Cd induced oxidative stress in germinating seeds. Thus, imposition of oxidative stress might be the consequence of cadmium stress and this finding may help in elucidating the mechanisms underlying cadmium mediated toxicity in germinating seeds.
