Inorganic nanoparticles have been introduced into biological systems as useful probes for in vitro diagnosis and in vivo imaging, due to their relatively small size and exceptional physical and chemical properties. A ...Inorganic nanoparticles have been introduced into biological systems as useful probes for in vitro diagnosis and in vivo imaging, due to their relatively small size and exceptional physical and chemical properties. A new kind of color- tunable Gd-Zn-Cu-In-S/ZnS （GZCIS/ZnS） quantum dots （QDs） with stable crystal structure has been successfully synthesized and utilized for magnetic resonance （MR） and fluorescence dual modality imaging. This strategy allows successful fabrication of GZCIS/ZnS QDs by incorporating Gd into ZCIS/ZnS QDs to achieve great MR enhancement without compromising the fluorescence properties of the initial ZCIS/ZnS QDs. The as-prepared GZCIS/ZnS QDs show high T1 MR contrast as well as ＂color-tunable＂ photoluminescence （PL） in the range of 550-725 nm by adjusting the Zn/Cu feeding ratio with high PL quantum yield （QY）. The GZCIS/ZnS QDs were transferred into water via a bovine serum albumin （BSA） coating strategy. The resulting Cd-free GZCIS/ZnS QDs reveal negligible cytotoxicity on both HeLa and A549 cells. Both fluorescence and MR imaging studies were successfully performed in vitro and in vivo. The results demonstrated that GZCIS/ZnS QDs could be a dual-modal contrast agent to simultaneously produce strong MR contrast enhancement as well as fluorescence emission for in vivo imaging.展开更多
A series of Eu^(3+) or Tb^(3+) doped Ba_2Ca(BO_3)_2 phosphors were synthesized by a high temperature solid state method, and the luminescence properties are investigated. Ba_2Ca(BO_3)_2:Tb^(3+) can show an obvious gre...A series of Eu^(3+) or Tb^(3+) doped Ba_2Ca(BO_3)_2 phosphors were synthesized by a high temperature solid state method, and the luminescence properties are investigated. Ba_2Ca(BO_3)_2:Tb^(3+) can show an obvious green emission, and the peak locates at 551 nm, which corresponds to the 5D34→7F5 transition of Tb^(3+). Ba_2Ca(BO_3)_2:Eu+ can present the characteristic emission of Eu^(3+), and the peak locates at 600 nm, which is ascribed to the 5D70→F2 transition of Eu^(3+). In order to achieve the emission-tunable phosphors, the Eu^(3+)/Tb^(3+) co-doped Ba_2Ca(BO_3)_2 are synthesized. When tuning the Eu^(3+) or Tb^(3+) concentration, Ba_2Ca(BO_3)_2:Eu^(3+), Tb^(3+) can both show the tunable emission, which may be induced by the energy transfer from Tb^(3+) to Eu^(3+).展开更多
文摘Inorganic nanoparticles have been introduced into biological systems as useful probes for in vitro diagnosis and in vivo imaging, due to their relatively small size and exceptional physical and chemical properties. A new kind of color- tunable Gd-Zn-Cu-In-S/ZnS （GZCIS/ZnS） quantum dots （QDs） with stable crystal structure has been successfully synthesized and utilized for magnetic resonance （MR） and fluorescence dual modality imaging. This strategy allows successful fabrication of GZCIS/ZnS QDs by incorporating Gd into ZCIS/ZnS QDs to achieve great MR enhancement without compromising the fluorescence properties of the initial ZCIS/ZnS QDs. The as-prepared GZCIS/ZnS QDs show high T1 MR contrast as well as ＂color-tunable＂ photoluminescence （PL） in the range of 550-725 nm by adjusting the Zn/Cu feeding ratio with high PL quantum yield （QY）. The GZCIS/ZnS QDs were transferred into water via a bovine serum albumin （BSA） coating strategy. The resulting Cd-free GZCIS/ZnS QDs reveal negligible cytotoxicity on both HeLa and A549 cells. Both fluorescence and MR imaging studies were successfully performed in vitro and in vivo. The results demonstrated that GZCIS/ZnS QDs could be a dual-modal contrast agent to simultaneously produce strong MR contrast enhancement as well as fluorescence emission for in vivo imaging.
基金supported by the China Postdoctoral Science Foundation(No.2015M581311)the College Students Innovation and Entrepreneurship of Hebei University in China(Nos.2014041 and 2015063)
文摘A series of Eu^(3+) or Tb^(3+) doped Ba_2Ca(BO_3)_2 phosphors were synthesized by a high temperature solid state method, and the luminescence properties are investigated. Ba_2Ca(BO_3)_2:Tb^(3+) can show an obvious green emission, and the peak locates at 551 nm, which corresponds to the 5D34→7F5 transition of Tb^(3+). Ba_2Ca(BO_3)_2:Eu+ can present the characteristic emission of Eu^(3+), and the peak locates at 600 nm, which is ascribed to the 5D70→F2 transition of Eu^(3+). In order to achieve the emission-tunable phosphors, the Eu^(3+)/Tb^(3+) co-doped Ba_2Ca(BO_3)_2 are synthesized. When tuning the Eu^(3+) or Tb^(3+) concentration, Ba_2Ca(BO_3)_2:Eu^(3+), Tb^(3+) can both show the tunable emission, which may be induced by the energy transfer from Tb^(3+) to Eu^(3+).
