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基于二阶马尔科夫模型预测可趋近性靶基因 被引量:1
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作者 刘文远 刘丽云 +1 位作者 王常武 王宝文 《燕山大学学报》 CAS 2012年第4期334-338,共5页
miRNA是一类重要的基因表达调节因子。准确预测miRNA的靶基因对研究miRNA的功能和作用机制至关重要。文中提出一种考虑靶位点可趋近性(accessibility)的miRNA靶基因预测算法。算法首先选择满足种子互补条件的"部分可趋近性"位... miRNA是一类重要的基因表达调节因子。准确预测miRNA的靶基因对研究miRNA的功能和作用机制至关重要。文中提出一种考虑靶位点可趋近性(accessibility)的miRNA靶基因预测算法。算法首先选择满足种子互补条件的"部分可趋近性"位点;然后用二阶马尔科夫模型计算与miRNA种子区互补的特定核苷酸片段(寡聚体)在3'UTR任意位置上出现的概率并统计"部分可趋近位点"上寡聚体出现的次数;采用过表达水平值评估一个或多个互补位点上至少出现一次寡聚体的概率;最后根据过表达水平值排序miRNA-3'UTR对,并取排序的前个miRNA-3'UTR对作为预测结果。在果蝇和人类数据集上测试的实验结果表明此算法具有较高的灵敏性和精确性。 展开更多
关键词 MIRNA 二阶马尔科夫模型 寡聚体 可趋 过表达水平
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从岙山港口的发展看设置国家储备油库的可趋性
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作者 唐之江 朱根民 庄频 《中国港口》 2000年第8期25-25,共1页
关键词 岙山港口 国家储备油库 可趋性 WTO 石油价格
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An Overview of Bangladeshi Shipbuilding in the Light of Competitive Parameters 被引量:1
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作者 N.M.G. Zakaria M.T. Ali K.A. Hossain 《Journal of Shipping and Ocean Engineering》 2011年第1期8-19,共12页
Shipbuilding in Bangladesh has been considered as the most promising industry in the recent time and the country is dreaming to emerge as a middle income country within a short time by maintaining the upward trend of ... Shipbuilding in Bangladesh has been considered as the most promising industry in the recent time and the country is dreaming to emerge as a middle income country within a short time by maintaining the upward trend of this sector. However, due to global nature and the long term sustainability of this shipbuilding industry, an investigation of competitiveness in terms of global standard is of prime importance. This paper focuses on studying some crucial competitive factors like labor skill, labor availability, labor man-hour, labor cost & productivity for local shipbuilding in Bangladesh. The analysis also focuses on existing access to the resources like materials, knowledge and capital which are equally important factors for the expansion of shipbuilding. Comparison of these parameters with other nations have been made qualitatively and quantitatively to find the level of our shipbuilding. On the basis of existing condition and future vision, some recommendations have been made which might be useful for accelerating the development of this sector. 展开更多
关键词 SHIPBUILDING competitive factor PRODUCTIVITY R&D labor cost.
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Monocyte chemotactic protein-1 and soluble adhesion molecules as possible prognostic markers of the efficacy of antiviral treatment in chronic hepatitis C 被引量:1
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作者 AnatolPanasiuk DanutaProkopowicz BozenaPanasiuk 《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第24期3639-3642,共4页
AIM:To explain the role of Monocyte chemotactic protein-1 (MCP-1) and soluble adhesion molecules in chronic hepatitis C during the treatment of interferon alpha (IFNα) 2 b and ribavirin (RBV). METHODS:Concentrations ... AIM:To explain the role of Monocyte chemotactic protein-1 (MCP-1) and soluble adhesion molecules in chronic hepatitis C during the treatment of interferon alpha (IFNα) 2 b and ribavirin (RBV). METHODS:Concentrations of MCP-1,soluble adhesion molecules intercellular adhesion molecule-1 (sICAM-1),sP- selectin,interleukin (IL) 6,and IL10 in serum were estimated in the group of 40 patients with chronic hepatitis C treated with IFNalpha2 b and RBV in 0,16,32,48 wk of the therapy, RESULTS:In chronic hepatitis C,before and during the treatment,the serum levels of MCP-1 and sP-selectin in responders were similar to those of healthy subjects.In non- responders (NR),MCP-1 increased in the course of IFNc^+RBV treatment,differences were statistically significant as compared to responders.MCP-1 correlated statistically with the activity of periportal inflammation (r=0.35,P<0.05) but not with staging of liver fibrosis,sICAM-1 positively correlated with inflammatory activity and fibrosis in NR.sP-selectin did not correlate with histological findings in the liver.The MCP-1 correlated with the soluble form of sP-selectin concentrations (r= 6,P<0.001) and with IL-10 level in NR (r=0.4,P<0.05).There was no correlation observed between the concentration of MCP-1 and sICAM-1,IL-6 during the treatment. CONCLUSION:MCP-1 concentration may be a prognostic marker of the efficacy of IFN+RBV therapy in patients with chronic hepatitis C. 展开更多
关键词 Adult Antiviral Agents DOSAGE Biological Markers Female Hepatitis C Chronic Humans Intercellular Adhesion Molecule-1 INTERLEUKIN-10 INTERLEUKIN-6 Male Middle Aged Monocyte Chemoattractant Protein-1 P-SELECTIN Prognosis SOLUBILITY
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Soft error reliability in advanced CMOS technologies—trends and challenges 被引量:4
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作者 TANG Du HE ChaoHui +3 位作者 LI YongHong ZANG Hang XIONG Cen ZHANG JinXin 《Science China(Technological Sciences)》 SCIE EI CAS 2014年第9期1846-1857,共12页
With the decrease of the device size,soft error induced by various particles becomes a serious problem for advanced CMOS technologies.In this paper,we review the evolution of two main aspects of soft error-SEU and SET... With the decrease of the device size,soft error induced by various particles becomes a serious problem for advanced CMOS technologies.In this paper,we review the evolution of two main aspects of soft error-SEU and SET,including the new mechanisms to induced SEUs,the advances of the MCUs and some newly observed phenomena of the SETs.The mechanisms and the trends with downscaling of these issues are briefly discussed.We also review the hardening strategies for different types of soft errors from different perspective and present the challenges in testing,modeling and hardening assurance of soft error issues we have to address in the future. 展开更多
关键词 soft error rate direct ionization indirect ionization multiple errors single event transient HARDENING CHALLENGES
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