Objective: To investigate possible correlations between tumor location and gen etic alterations in a series of oligodendrogliomas.Methods: A series of 158 cons ecutive oligodendrogliomas were retrospectively reviewed....Objective: To investigate possible correlations between tumor location and gen etic alterations in a series of oligodendrogliomas.Methods: A series of 158 cons ecutive oligodendrogliomas were retrospectively reviewed. In each case, the radi ologic picture and the chromosome 1p (chr 1p) status of the tumor detected by th e loss of heterozygosity technique were analyzed. Correlation between tumor loca tion and molecular profile was made by χ2 tests. Results: Eighty-eight of the 158 patients had low-grade oligodendrogliomas, and 70 had anaplastic oligodendr ogliomas. Overall, oligodendrogliomas with chr 1p loss were located preferential ly in the anterior part of the brain, whereas tumors with intact chr 1p affected mainly the posterior part of the brain (p = 0.0038). In terms of lobar involvem ent, a preferential location of oligodendrogliomas with chr 1p loss was found in the frontal lobes as compared with the temporal, parietal, and occipital tumors (p < 0.01). Conclusion:There is a significant correlation between loss of heter ozygosityon chromosome lp and tumor location in oligodendrogliomas,suggesting th at subtypes of oligodendrogliomas could derive from site-specific precursors.展开更多
文摘Objective: To investigate possible correlations between tumor location and gen etic alterations in a series of oligodendrogliomas.Methods: A series of 158 cons ecutive oligodendrogliomas were retrospectively reviewed. In each case, the radi ologic picture and the chromosome 1p (chr 1p) status of the tumor detected by th e loss of heterozygosity technique were analyzed. Correlation between tumor loca tion and molecular profile was made by χ2 tests. Results: Eighty-eight of the 158 patients had low-grade oligodendrogliomas, and 70 had anaplastic oligodendr ogliomas. Overall, oligodendrogliomas with chr 1p loss were located preferential ly in the anterior part of the brain, whereas tumors with intact chr 1p affected mainly the posterior part of the brain (p = 0.0038). In terms of lobar involvem ent, a preferential location of oligodendrogliomas with chr 1p loss was found in the frontal lobes as compared with the temporal, parietal, and occipital tumors (p < 0.01). Conclusion:There is a significant correlation between loss of heter ozygosityon chromosome lp and tumor location in oligodendrogliomas,suggesting th at subtypes of oligodendrogliomas could derive from site-specific precursors.
