A multivariable regression(MVR) approach is proposed to identify the real power transfer between generators and loads.Based on solved load flow results,it first uses modified nodal equation method(MNE) to determine re...A multivariable regression(MVR) approach is proposed to identify the real power transfer between generators and loads.Based on solved load flow results,it first uses modified nodal equation method(MNE) to determine real power contribution from each generator to loads.Then,the results of MNE method and load flow information are utilized to determine suitable regression coefficients using MVR model to estimate the power transfer.The 25-bus equivalent system of south Malaysia is utilized as a test system to illustrate the effectiveness of the MVR output compared to that of the MNE method.The error of the estimate of MVR method ranges from 0.001 4 to 0.007 9.Furthermore,when compared to MNE method,MVR method computes generator contribution to loads within 26.40 ms whereas the MNE method takes 360 ms for the calculation of same real power transfer allocation.Therefore,MVR method is more suitable for real time power transfer allocation.展开更多
RLWI （Riserless Light Well Intervention） technology has the advantage of utilizing a special subsea lubricator to perform intervention activities in water depths of up to 1,200 m without the need for the marine rise...RLWI （Riserless Light Well Intervention） technology has the advantage of utilizing a special subsea lubricator to perform intervention activities in water depths of up to 1,200 m without the need for the marine risers. Utilizing the technology, oil companies have been able to save up to 50% on the intervention costs. However, in the last five years, it has seen up to 25% downtime due to waiting on weather （wow）. Thus, in this manuscript, it is attempted to identify the critical elements of the module deployment system and analyze their significance in the objective of raising the operational weather limit. Critical failure modes were found to be failure of crane wire due to excess loading, failure of the lower cursor system due to the impact loading and clashing of the module with the moonpool walls. Analysis of the module deployment system against these failure modes was ensued by using Orcaflex. The results showed the moonpool sea state to be the defining parameter. Although, changing moonpool dimensions affect hydrodynamics positively, however it＇s significance is small due to dependency on the vessel＇s breadth. Based on these results and the available data for the analysis, a recommended system particular was tested. Significance improvement, in lowering the risk of failure was observed.展开更多
We reported herein the synthesis and antibacterial activity evaluation of two oxazolidinone-deferasirox conjugates with different linkers that were designed based on the“Trojan horse”strategy.The conjugates could co...We reported herein the synthesis and antibacterial activity evaluation of two oxazolidinone-deferasirox conjugates with different linkers that were designed based on the“Trojan horse”strategy.The conjugates could combine with Fe^(3+)ions as the deferasirox.However,both conjugates were inactive against tested bacteria,including S.aureus,E.coli,A.baumannii,and P.aeruginosa.The results suggested that the synthesized iron chelator deferasirox was not suitable as a siderophore of the bacteria to transport the antibiotic,or the coupling linker of the synthesized conjugates could not be hydrolyzed to release the oxazolidinone in the cytoplasm.Therefore,the design and synthesis of oxazolidinone-deferasirox conjugates need further exploration.展开更多
A novel vehicle for the delivery of aspirin （ASA） was prepared from porous nano-hydroxyapafite/poly（styrene-divinylbenzene） [nano-HAP/P（St-DVB）] composite microspheres by grafting nano-HAP [Ca10（PO4）6（OH）2] ...A novel vehicle for the delivery of aspirin （ASA） was prepared from porous nano-hydroxyapafite/poly（styrene-divinylbenzene） [nano-HAP/P（St-DVB）] composite microspheres by grafting nano-HAP [Ca10（PO4）6（OH）2] onto porous P（St-DVB） micro- spheres. Four types of porous composite microspheres were prepared, each with different nano-HAP contents. The ASA-loaded composite microspheres prepared with 10% and 15% nano-HAP （mass ratio） exhibited excellent buoyancy with relatively short instantaneous floating time （within l0 min） and a long sustained floating time （12 h） in simulated gastric juice. They also offered good sustained release of ASA （up to 8 h）. Furthermore, these composite microspheres displayed good buff- ering capacity that prevented the buildup of acidity caused by hydrolysis of ASA, keeping the pH of gastric juice within the normal range （pH 0.9 to 1.5）. The results showed that porous nano-HAP/P（St-DVB） composite microspheres prepared with 10% and 15% nano-HAP could be used as a novel drug carrier for ASA, providing a sustained release dose without leading to stomach irritation, a side effect that is often associated with ASA medication.展开更多
文摘A multivariable regression(MVR) approach is proposed to identify the real power transfer between generators and loads.Based on solved load flow results,it first uses modified nodal equation method(MNE) to determine real power contribution from each generator to loads.Then,the results of MNE method and load flow information are utilized to determine suitable regression coefficients using MVR model to estimate the power transfer.The 25-bus equivalent system of south Malaysia is utilized as a test system to illustrate the effectiveness of the MVR output compared to that of the MNE method.The error of the estimate of MVR method ranges from 0.001 4 to 0.007 9.Furthermore,when compared to MNE method,MVR method computes generator contribution to loads within 26.40 ms whereas the MNE method takes 360 ms for the calculation of same real power transfer allocation.Therefore,MVR method is more suitable for real time power transfer allocation.
文摘RLWI （Riserless Light Well Intervention） technology has the advantage of utilizing a special subsea lubricator to perform intervention activities in water depths of up to 1,200 m without the need for the marine risers. Utilizing the technology, oil companies have been able to save up to 50% on the intervention costs. However, in the last five years, it has seen up to 25% downtime due to waiting on weather （wow）. Thus, in this manuscript, it is attempted to identify the critical elements of the module deployment system and analyze their significance in the objective of raising the operational weather limit. Critical failure modes were found to be failure of crane wire due to excess loading, failure of the lower cursor system due to the impact loading and clashing of the module with the moonpool walls. Analysis of the module deployment system against these failure modes was ensued by using Orcaflex. The results showed the moonpool sea state to be the defining parameter. Although, changing moonpool dimensions affect hydrodynamics positively, however it＇s significance is small due to dependency on the vessel＇s breadth. Based on these results and the available data for the analysis, a recommended system particular was tested. Significance improvement, in lowering the risk of failure was observed.
基金The CAMS Innovation Fund for Medical Sciences(CIFMS 2021-I2M-1-028).
文摘We reported herein the synthesis and antibacterial activity evaluation of two oxazolidinone-deferasirox conjugates with different linkers that were designed based on the“Trojan horse”strategy.The conjugates could combine with Fe^(3+)ions as the deferasirox.However,both conjugates were inactive against tested bacteria,including S.aureus,E.coli,A.baumannii,and P.aeruginosa.The results suggested that the synthesized iron chelator deferasirox was not suitable as a siderophore of the bacteria to transport the antibiotic,or the coupling linker of the synthesized conjugates could not be hydrolyzed to release the oxazolidinone in the cytoplasm.Therefore,the design and synthesis of oxazolidinone-deferasirox conjugates need further exploration.
基金financially supported by the Young Scientists Fund of the Natural Science Foundation of Heilongjiang Province (QC2011C099)Scientific Fund of Heilongjiang Province Department of Health (2009-259)+3 种基金Grant from Educational Office of Heilongjiang Province (11551178 and1154HZ11)Fund of Daqing GaoXin Qu (DQGX09YF016)the National Natural Science Foundation of China (30871007)the Natural Science Foundation of Heilongjiang Province (ZD2008-08 and LC2009C12)
文摘A novel vehicle for the delivery of aspirin （ASA） was prepared from porous nano-hydroxyapafite/poly（styrene-divinylbenzene） [nano-HAP/P（St-DVB）] composite microspheres by grafting nano-HAP [Ca10（PO4）6（OH）2] onto porous P（St-DVB） micro- spheres. Four types of porous composite microspheres were prepared, each with different nano-HAP contents. The ASA-loaded composite microspheres prepared with 10% and 15% nano-HAP （mass ratio） exhibited excellent buoyancy with relatively short instantaneous floating time （within l0 min） and a long sustained floating time （12 h） in simulated gastric juice. They also offered good sustained release of ASA （up to 8 h）. Furthermore, these composite microspheres displayed good buff- ering capacity that prevented the buildup of acidity caused by hydrolysis of ASA, keeping the pH of gastric juice within the normal range （pH 0.9 to 1.5）. The results showed that porous nano-HAP/P（St-DVB） composite microspheres prepared with 10% and 15% nano-HAP could be used as a novel drug carrier for ASA, providing a sustained release dose without leading to stomach irritation, a side effect that is often associated with ASA medication.
