It is well known that Tropical cyclone （TC） activities over the Pacific are affected by E1 Nino events. In most studies El Nifio phenomena have been separated into east Pacific warming （EPW） and central Pacific wa...It is well known that Tropical cyclone （TC） activities over the Pacific are affected by E1 Nino events. In most studies El Nifio phenomena have been separated into east Pacific warming （EPW） and central Pacific wanning （CPW） based on the location of maximum SST anomaly. Since these two kinds of El Nino have different impacts on Pacific tropical cyclone activities, this study investigates different features of TC activities and the genesis potential index （GPI） during EPW years and CPW years. Four eontrib- nting factors, i.e., the low-level absolute vorticity, the relative humidity, the potential intensity and the vertical wind shear, are exam- ined to determine which factors are most important in causing the anomalous TC activities. Our results show that during EPW years in July-August （JA-0）, TC activities are more frequent with stronger intensity over the Western North Pacific （WNP） and Eastern North Pacific （ENP）. The maximum anomaly center of TC activities then drifts eastward siguifieantly in September-October （SO-0）. However, centers of anomalous TC activity barely change from JA-0 to SO-0 during CPW years. In January-February-March （JFM-1） of the decaying years of warming events, TC frequency and intensity both have positive anomaly over the South Pacific, The anoma- lies in EPW years have larger amplitude and wider spatial distribution than those in CPW years. These anomalous activities of TC are associated with GPI anomaly and the key factors affecting GPI anomaly for each ocean basin are quite different.展开更多
AIM: To investigate the relationship between mutations of rearranged during transfection (RET) proto-oncogene and Chinese patients with Hirschsprung's disease (HD), and to elucidate the genetic mechanism of famili...AIM: To investigate the relationship between mutations of rearranged during transfection (RET) proto-oncogene and Chinese patients with Hirschsprung's disease (HD), and to elucidate the genetic mechanism of familial HD patient at the molecular level.METHODS: Genomic DNA was extracted from venous blood of probands and their relatives in two genealogies.Polymerase chain reaction (PCR) products, which were amplified using specific primers (RET, exons 11, 13, 15and 17), were electrophoresed to analyze the single-strand conformational polymorphism (SSCP) patterns. The positive amplified products were sequenced. Forty-eight sporadic HD patients and 30 normal children were screened for mutations of RET proto-oncogene simultaneously.RESULTS: Three cases with HD in one family were found to have a G heterozygous insertion at nucleotide 18 974 in exon 13 of RET cDNA (18 974insG), which resulted in a frameshift mutation. In another family, a heterozygosity for T to G transition at nucleotide 18 888 in the same exon which resulted in a synonymous mutation of Leu at codon 745 was detected in the proband and his father. Eight RET mutations were confirmed in 48 sporadic HD patients.CONCLUSION: Mutations of RET proto-oncogene may play an important role in the pathogenesis of Chinese patients with HD. Detection of mutated RET proto-oncogene carriers may be used for genetic counseling of potential risk for HD in the affected families.展开更多
There are many advantages of bended wood, such as good-looking shape, simple process and low cost. The product, however, is easy to get recovery, which is urgent to be dealt with. This paper concludes the features of ...There are many advantages of bended wood, such as good-looking shape, simple process and low cost. The product, however, is easy to get recovery, which is urgent to be dealt with. This paper concludes the features of deformation and recovery of bended wood and wood-based composites and summarizes four treating methods to keep dimensional stability. Compared to bended solid wood, some elementary perspectives on the research of bended wood-based composites are presented. The purpose of this paper is to suggest： 1） to investigate the optimum heating time and temperature that bended wood and wood-based composites need from the formation of deformation to the recovery and to the permanent fixation, according to its changes of dimensional stability such as curvature radius; 2） to measure the composites comprised of wood and adhesives on the changes of stress relaxation, dynamic viscoelasticity and crystallization field; 3） to quantitatively analyze changes of the major components in wood cell wall polymers as well as the composites under heat/steam treatment and untreated conditions. It will be helpful for subsequent research to clarify on the mechanisms of permanent fixation of bended wood and also contribute to that of wood-based composites.展开更多
基金supported by the National Basic Research Program of China (973 Program: 2012CB955604)NSFC-Shangdong Joint Fund for Marine Science Research Centers (U1406401)the CMA Program (GYHY200906008)
文摘It is well known that Tropical cyclone （TC） activities over the Pacific are affected by E1 Nino events. In most studies El Nifio phenomena have been separated into east Pacific warming （EPW） and central Pacific wanning （CPW） based on the location of maximum SST anomaly. Since these two kinds of El Nino have different impacts on Pacific tropical cyclone activities, this study investigates different features of TC activities and the genesis potential index （GPI） during EPW years and CPW years. Four eontrib- nting factors, i.e., the low-level absolute vorticity, the relative humidity, the potential intensity and the vertical wind shear, are exam- ined to determine which factors are most important in causing the anomalous TC activities. Our results show that during EPW years in July-August （JA-0）, TC activities are more frequent with stronger intensity over the Western North Pacific （WNP） and Eastern North Pacific （ENP）. The maximum anomaly center of TC activities then drifts eastward siguifieantly in September-October （SO-0）. However, centers of anomalous TC activity barely change from JA-0 to SO-0 during CPW years. In January-February-March （JFM-1） of the decaying years of warming events, TC frequency and intensity both have positive anomaly over the South Pacific, The anoma- lies in EPW years have larger amplitude and wider spatial distribution than those in CPW years. These anomalous activities of TC are associated with GPI anomaly and the key factors affecting GPI anomaly for each ocean basin are quite different.
基金Supported by the Fund for Excellent Young Talented Persons by Public Health Ministry of China, and Analysis and Testing Foundation of Zhejiang Province, No. 99075
文摘AIM: To investigate the relationship between mutations of rearranged during transfection (RET) proto-oncogene and Chinese patients with Hirschsprung's disease (HD), and to elucidate the genetic mechanism of familial HD patient at the molecular level.METHODS: Genomic DNA was extracted from venous blood of probands and their relatives in two genealogies.Polymerase chain reaction (PCR) products, which were amplified using specific primers (RET, exons 11, 13, 15and 17), were electrophoresed to analyze the single-strand conformational polymorphism (SSCP) patterns. The positive amplified products were sequenced. Forty-eight sporadic HD patients and 30 normal children were screened for mutations of RET proto-oncogene simultaneously.RESULTS: Three cases with HD in one family were found to have a G heterozygous insertion at nucleotide 18 974 in exon 13 of RET cDNA (18 974insG), which resulted in a frameshift mutation. In another family, a heterozygosity for T to G transition at nucleotide 18 888 in the same exon which resulted in a synonymous mutation of Leu at codon 745 was detected in the proband and his father. Eight RET mutations were confirmed in 48 sporadic HD patients.CONCLUSION: Mutations of RET proto-oncogene may play an important role in the pathogenesis of Chinese patients with HD. Detection of mutated RET proto-oncogene carriers may be used for genetic counseling of potential risk for HD in the affected families.
文摘There are many advantages of bended wood, such as good-looking shape, simple process and low cost. The product, however, is easy to get recovery, which is urgent to be dealt with. This paper concludes the features of deformation and recovery of bended wood and wood-based composites and summarizes four treating methods to keep dimensional stability. Compared to bended solid wood, some elementary perspectives on the research of bended wood-based composites are presented. The purpose of this paper is to suggest： 1） to investigate the optimum heating time and temperature that bended wood and wood-based composites need from the formation of deformation to the recovery and to the permanent fixation, according to its changes of dimensional stability such as curvature radius; 2） to measure the composites comprised of wood and adhesives on the changes of stress relaxation, dynamic viscoelasticity and crystallization field; 3） to quantitatively analyze changes of the major components in wood cell wall polymers as well as the composites under heat/steam treatment and untreated conditions. It will be helpful for subsequent research to clarify on the mechanisms of permanent fixation of bended wood and also contribute to that of wood-based composites.
