Based on experimental data,machine learning(ML) models for Young's modulus,hardness,and hot-working ability of Ti-based alloys were constructed.In the models,the interdiffusion and mechanical property data were hi...Based on experimental data,machine learning(ML) models for Young's modulus,hardness,and hot-working ability of Ti-based alloys were constructed.In the models,the interdiffusion and mechanical property data were high-throughput re-evaluated from composition variations and nanoindentation data of diffusion couples.Then,the Ti-(22±0.5)at.%Nb-(30±0.5)at.%Zr-(4±0.5)at.%Cr(TNZC) alloy with a single body-centered cubic(BCC) phase was screened in an interactive loop.The experimental results exhibited a relatively low Young's modulus of(58±4) GPa,high nanohardness of(3.4±0.2) GPa,high microhardness of HV(520±5),high compressive yield strength of(1220±18) MPa,large plastic strain greater than 30%,and superior dry-and wet-wear resistance.This work demonstrates that ML combined with high-throughput analytic approaches can offer a powerful tool to accelerate the design of multicomponent Ti alloys with desired properties.Moreover,it is indicated that TNZC alloy is an attractive candidate for biomedical applications.展开更多
To take into account the couple stress effects, a modified Reynolds equation is derived for dynamically loaded journal beatings with the consideration of the elasticity of the liner. The numerical results show that th...To take into account the couple stress effects, a modified Reynolds equation is derived for dynamically loaded journal beatings with the consideration of the elasticity of the liner. The numerical results show that the influence of couple stresses on the bearing characteristics is significant. Compared with Newtonian lubricants, lubricants with couple stresses increase the fluid film pressure, as a result enhance the load-carrying capacity and reduce the friction coefficient. However, since the elasticity of the liner weakens the couple stress effect, elastic liners yield a reduction in the load-carrying capacity and an increase in the friction coefficient. The elastic deformation of the bearing liner should be considered in an accurate performance evaluation of the journal bearing.展开更多
In order to increase the efficiency and reliability of the dynamic analysis for flexible planar linkage containing the coupling of multi-energy domains, a method based on bond graph is introduced. From the viewpoint o...In order to increase the efficiency and reliability of the dynamic analysis for flexible planar linkage containing the coupling of multi-energy domains, a method based on bond graph is introduced. From the viewpoint of power conservation, the peculiar property of bond graph multiport element MTF is discussed. The procedure of modeling planar flexible muhibody mechanical systems by bond graphs and its dynamic principle are deseribed. To overcome the algebraic difficulty brought by differential causality anti nonlinear junction structure, the constraint forces at joints can be considered as unknown effort sources and added to the corresponding O-junctions of system bond graph model. As a result, the automatic modeling on a computer is realized. The validity of the procedure is illustrated by a practical example.展开更多
The quantum behavior ofa precooled cantilever can be probed highly efficiently by electrostatically coupling to a trapped ultracold ion, in which a fast cooling of the cantilever down to the ground vibrational state ...The quantum behavior ofa precooled cantilever can be probed highly efficiently by electrostatically coupling to a trapped ultracold ion, in which a fast cooling of the cantilever down to the ground vibrational state is possible. Within a simple model with an ultracold ion coupled to a cantilever with only few vibrational quanta, we solve the dynamics of the coupling system by a squeezed-state expansion technique, and can in principle obtain the exact solution of the time-evolution of the coupling system in the absence of the rotating-wave approximation. Comparing to the treatment under the rotating-wave approximation, we present a more accurate description of the quantum behavior of the cantilever.展开更多
Based on a dynamical Langevin equation coupled with a statistical decay model, we calculate the variation of the post-saddle giant dipole resonance （GDR） q-ray multiplicity of the heavy nuclei 24^240Cf, ^246Cf, ^252...Based on a dynamical Langevin equation coupled with a statistical decay model, we calculate the variation of the post-saddle giant dipole resonance （GDR） q-ray multiplicity of the heavy nuclei 24^240Cf, ^246Cf, ^252Cf and ^240U with the post-saddle friction strength （13）. We find that the sensitivity of the post-saddle γ emission to β decreases considerably with increasing the neutron-to-proton ratio （N/Z） of the system. Moreover, for 240 U, the γ emission is no longer sensitive to 13. We suggest that to accurately obtain information of the post-saddle friction strength by measuring pre-scission GDR γ-ray multiplicities, it is optimal to choose among the various compound systems those with low N/Z.展开更多
The preparation of polymer-anticancer drug conjugates is an effective way to improve the efficacy and decrease the toxicity of anticancer drugs. Polymer-drug conjugates, which were made by combining a suitable polymer...The preparation of polymer-anticancer drug conjugates is an effective way to improve the efficacy and decrease the toxicity of anticancer drugs. Polymer-drug conjugates, which were made by combining a suitable polymeric carrier, a biodegradable linker and a bioactive anticancer agent, could form the basis of a new generation of anticancer agents. Poly （L-glutamic acid）- paclitaxel conjugate is a polymer-drug conjugate that links anticancer agent paclitaxel （PTX） to poly （L-glutamic acid） （PG）. PG-PTX conjugate can improve the anticancer activity, enhance the safety and efficacy, and improve the pharmacokinetic properties of PTX. Therefore, the application of PG-PTX facilitates the clinical therapy of a variety of human cancers.展开更多
Two dinucleotide PNA-cyclen copper(II) complexes with α-PNA (P1) and classical PNA (P2) backbones were synthesized and characterized.The interactions between title complexes and DNA were investigated under physiologi...Two dinucleotide PNA-cyclen copper(II) complexes with α-PNA (P1) and classical PNA (P2) backbones were synthesized and characterized.The interactions between title complexes and DNA were investigated under physiological conditions.Fluorescence studies indicate that the binding ability of complex P1 to CT-DNA is as twice as that of P2.DNA melting experiments were also carried out and the results show that ΔTm caused by P1 is higher than that caused by P2.Agarose gel electrophoresis experiments demonstrate that P1 is an excellent chemical nuclease,which can cleavage plasmid DNA completely in 12 h.展开更多
基金the financial supports from the National Key Research and Development Program of China (No. 2022YFB3707501)the National Natural Science Foundation of China (No. 51701083)+1 种基金the GDAS Project of Science and Technology Development, China (No. 2022GDASZH2022010107)the Guangzhou Basic and Applied Basic Research Foundation, China (No. 202201010686)。
文摘Based on experimental data,machine learning(ML) models for Young's modulus,hardness,and hot-working ability of Ti-based alloys were constructed.In the models,the interdiffusion and mechanical property data were high-throughput re-evaluated from composition variations and nanoindentation data of diffusion couples.Then,the Ti-(22±0.5)at.%Nb-(30±0.5)at.%Zr-(4±0.5)at.%Cr(TNZC) alloy with a single body-centered cubic(BCC) phase was screened in an interactive loop.The experimental results exhibited a relatively low Young's modulus of(58±4) GPa,high nanohardness of(3.4±0.2) GPa,high microhardness of HV(520±5),high compressive yield strength of(1220±18) MPa,large plastic strain greater than 30%,and superior dry-and wet-wear resistance.This work demonstrates that ML combined with high-throughput analytic approaches can offer a powerful tool to accelerate the design of multicomponent Ti alloys with desired properties.Moreover,it is indicated that TNZC alloy is an attractive candidate for biomedical applications.
基金Project (No. 571123) supported by the Scientific Research SpecialFoundation for the Excellent Youth Teacher of Shanghai University byEducation Committee of Shanghai, China
文摘To take into account the couple stress effects, a modified Reynolds equation is derived for dynamically loaded journal beatings with the consideration of the elasticity of the liner. The numerical results show that the influence of couple stresses on the bearing characteristics is significant. Compared with Newtonian lubricants, lubricants with couple stresses increase the fluid film pressure, as a result enhance the load-carrying capacity and reduce the friction coefficient. However, since the elasticity of the liner weakens the couple stress effect, elastic liners yield a reduction in the load-carrying capacity and an increase in the friction coefficient. The elastic deformation of the bearing liner should be considered in an accurate performance evaluation of the journal bearing.
文摘In order to increase the efficiency and reliability of the dynamic analysis for flexible planar linkage containing the coupling of multi-energy domains, a method based on bond graph is introduced. From the viewpoint of power conservation, the peculiar property of bond graph multiport element MTF is discussed. The procedure of modeling planar flexible muhibody mechanical systems by bond graphs and its dynamic principle are deseribed. To overcome the algebraic difficulty brought by differential causality anti nonlinear junction structure, the constraint forces at joints can be considered as unknown effort sources and added to the corresponding O-junctions of system bond graph model. As a result, the automatic modeling on a computer is realized. The validity of the procedure is illustrated by a practical example.
基金The project supported by National Natural Science Foundation of China under Grant Nos. 10474118 and 10274093 and the National Fundamental Research Program of China under Grant No. 2005CB724502
文摘The quantum behavior ofa precooled cantilever can be probed highly efficiently by electrostatically coupling to a trapped ultracold ion, in which a fast cooling of the cantilever down to the ground vibrational state is possible. Within a simple model with an ultracold ion coupled to a cantilever with only few vibrational quanta, we solve the dynamics of the coupling system by a squeezed-state expansion technique, and can in principle obtain the exact solution of the time-evolution of the coupling system in the absence of the rotating-wave approximation. Comparing to the treatment under the rotating-wave approximation, we present a more accurate description of the quantum behavior of the cantilever.
基金Supported by the Foundation of Nanjing University of Finance & Economics under Grant No. JGY1030
文摘Based on a dynamical Langevin equation coupled with a statistical decay model, we calculate the variation of the post-saddle giant dipole resonance （GDR） q-ray multiplicity of the heavy nuclei 24^240Cf, ^246Cf, ^252Cf and ^240U with the post-saddle friction strength （13）. We find that the sensitivity of the post-saddle γ emission to β decreases considerably with increasing the neutron-to-proton ratio （N/Z） of the system. Moreover, for 240 U, the γ emission is no longer sensitive to 13. We suggest that to accurately obtain information of the post-saddle friction strength by measuring pre-scission GDR γ-ray multiplicities, it is optimal to choose among the various compound systems those with low N/Z.
基金National Key Technologies R&D Program for New Drugs(Grant No.2009ZX09301-002,2009ZX09304-004).
文摘The preparation of polymer-anticancer drug conjugates is an effective way to improve the efficacy and decrease the toxicity of anticancer drugs. Polymer-drug conjugates, which were made by combining a suitable polymeric carrier, a biodegradable linker and a bioactive anticancer agent, could form the basis of a new generation of anticancer agents. Poly （L-glutamic acid）- paclitaxel conjugate is a polymer-drug conjugate that links anticancer agent paclitaxel （PTX） to poly （L-glutamic acid） （PG）. PG-PTX conjugate can improve the anticancer activity, enhance the safety and efficacy, and improve the pharmacokinetic properties of PTX. Therefore, the application of PG-PTX facilitates the clinical therapy of a variety of human cancers.
基金financially supported by the National Natural Science Foundation of China (20725206, 20732004 & 20902062)Program for Changjiang Scholars and Innovative Research Team in University, the Key Project of Chinese Ministry of Education in China and Scientific Fund of Sichuan Province for Outstanding Young Scientists
文摘Two dinucleotide PNA-cyclen copper(II) complexes with α-PNA (P1) and classical PNA (P2) backbones were synthesized and characterized.The interactions between title complexes and DNA were investigated under physiological conditions.Fluorescence studies indicate that the binding ability of complex P1 to CT-DNA is as twice as that of P2.DNA melting experiments were also carried out and the results show that ΔTm caused by P1 is higher than that caused by P2.Agarose gel electrophoresis experiments demonstrate that P1 is an excellent chemical nuclease,which can cleavage plasmid DNA completely in 12 h.
