目的检测煤工尘肺及合并肺癌肺组织Bcl-2基因蛋白表达情况,探讨煤工尘肺与肺癌的关系及其分子学机制。方法收集煤工尘肺及煤工尘肺合并肺癌患者尸解病例为研究对象。依据病理诊断,选择煤工尘肺54例,尘肺合并肺癌10例。选取30例煤工尘肺...目的检测煤工尘肺及合并肺癌肺组织Bcl-2基因蛋白表达情况,探讨煤工尘肺与肺癌的关系及其分子学机制。方法收集煤工尘肺及煤工尘肺合并肺癌患者尸解病例为研究对象。依据病理诊断,选择煤工尘肺54例,尘肺合并肺癌10例。选取30例煤工尘肺病变旁正常肺组织(组织结构正常、肺泡间隔无破坏、肺泡腔内未见渗出)作为对照肺组织。利用免疫组化方法检测Bcl-2基因蛋白在肺组织中的表达情况。结果对照肺组织、煤工尘肺肺组织和煤工尘肺合并肺癌肺组织Bcl-2基因蛋白阳性表达率分别为16.7%、24.1%和90.0%,平均光密度值分别为2.08±0.16、2.51±0.19、3.22±0.41。煤工尘肺合并肺癌组阳性表达率高于对照肺组织,差异有统计学意义(2χ=15.96,P<0.05);合并肺癌组肺组织Bcl-2蛋白阳性表达率高于煤工尘肺组,差异有统计学意义(χ2=13.5,P<0.05)。经图像分析软件Image-pro plus 6.0测定,肺癌组Bcl-2蛋白表达量高于对照组(t=12.69,P<0.05)和煤工尘肺组(t=8.54,P<0.05),差异有统计学意义;煤工尘肺组Bcl-2蛋白表达量高于对照组,差异有统计学意义(t=10.42,P<0.05)。Ⅰ、Ⅱ、Ⅲ期煤工尘肺之间肺组织中Bcl-2基因蛋白阳性表达率比较,差异无统计学意义(P>0.05)。结论煤工尘肺合并肺癌肺组织Bcl-2基因蛋白阳性表达率及表达量均明显增高;煤工尘肺肺组织Bcl-2基因蛋白表达量高于正常肺组织。Bcl-2基因蛋白的高表达在煤工尘肺合并肺癌发生中可能起一定作用。展开更多
A low-power 14-bit 150MS/s an- alog-to-digital converter （ADC） is present- ed for communication applications. Range scaling enables a maximal 2-Vp-p input with a single-stage opamp adopted. Opamp and capacitor shari...A low-power 14-bit 150MS/s an- alog-to-digital converter （ADC） is present- ed for communication applications. Range scaling enables a maximal 2-Vp-p input with a single-stage opamp adopted. Opamp and capacitor sharing between the first multi- plying digital-to-analog converter （MDAC） and the second one reduces the total opamp power further. The dedicated sample-and- hold amplifier （SHA） is removed to lower the power and the noise. The blind calibration of linearity errors is proposed to improve the per- formance. The prototype ADC is fabricated in a 130rim CMOS process with a 1.3-V supply voltage. The SNDR of the ADC is 71.3 dB with a 2.4 MHz input and remains 68.5 dB for a 120 MHz input. It consumes 85 roW, which includes 57 mW for the ADC core, 11 mW for the low jitter clock receiver and 17 mW for the high-speed reference buffer.展开更多
In this paper, combined with the ＂Enterprise Accounting Standards No. eighteenth issued -- income tax＂ and ＂Enterprise Accounting Standards No. twentieth＂ -- the merger of enterprises and the State Administration ...In this paper, combined with the ＂Enterprise Accounting Standards No. eighteenth issued -- income tax＂ and ＂Enterprise Accounting Standards No. twentieth＂ -- the merger of enterprises and the State Administration of Taxation on enterprise merger business related income tax provisions of the problem of enterprise income tax, from the perspective that enterprise merger accounting is divided into the same control and the different control corresponds to the general tax treatment and special tax treatment, I compare the process of enterprises under different circumstances of income tax with an example.展开更多
Farmland merging is a significant tool in comprehensive rural areas development. Although a broad range of research relating to this field already exists, not enough emphasis has yet been placed on this issue in Polan...Farmland merging is a significant tool in comprehensive rural areas development. Although a broad range of research relating to this field already exists, not enough emphasis has yet been placed on this issue in Poland. In all probability it would not be a point for broad discussion if this situation related to a country, where agriculture is negligible. Nonetheless, in Poland agriculture plays a very important role in the economy： it employs 17% of labour force and arable land covers about 60% of the total area. Yet, even where land consolidation work has been carried out for years, the expected effects are still not appreciable, mostly because of the disastrous formal and legal policy. This paper intends to make a contribution to the field of knowledge of farmland merging in Poland. Particular attention was focused on the importance of land management policy in the streamlining of land consolidation activities. The study brings a fresh view on the examination of the effectiveness of farmland merging work, based on two different formal procedures carried out in Poland. During the investigation the main obstacles and weaknesses in legal regulation were revealed while at the same time, producing possible solutions.展开更多
文摘目的检测煤工尘肺及合并肺癌肺组织Bcl-2基因蛋白表达情况,探讨煤工尘肺与肺癌的关系及其分子学机制。方法收集煤工尘肺及煤工尘肺合并肺癌患者尸解病例为研究对象。依据病理诊断,选择煤工尘肺54例,尘肺合并肺癌10例。选取30例煤工尘肺病变旁正常肺组织(组织结构正常、肺泡间隔无破坏、肺泡腔内未见渗出)作为对照肺组织。利用免疫组化方法检测Bcl-2基因蛋白在肺组织中的表达情况。结果对照肺组织、煤工尘肺肺组织和煤工尘肺合并肺癌肺组织Bcl-2基因蛋白阳性表达率分别为16.7%、24.1%和90.0%,平均光密度值分别为2.08±0.16、2.51±0.19、3.22±0.41。煤工尘肺合并肺癌组阳性表达率高于对照肺组织,差异有统计学意义(2χ=15.96,P<0.05);合并肺癌组肺组织Bcl-2蛋白阳性表达率高于煤工尘肺组,差异有统计学意义(χ2=13.5,P<0.05)。经图像分析软件Image-pro plus 6.0测定,肺癌组Bcl-2蛋白表达量高于对照组(t=12.69,P<0.05)和煤工尘肺组(t=8.54,P<0.05),差异有统计学意义;煤工尘肺组Bcl-2蛋白表达量高于对照组,差异有统计学意义(t=10.42,P<0.05)。Ⅰ、Ⅱ、Ⅲ期煤工尘肺之间肺组织中Bcl-2基因蛋白阳性表达率比较,差异无统计学意义(P>0.05)。结论煤工尘肺合并肺癌肺组织Bcl-2基因蛋白阳性表达率及表达量均明显增高;煤工尘肺肺组织Bcl-2基因蛋白表达量高于正常肺组织。Bcl-2基因蛋白的高表达在煤工尘肺合并肺癌发生中可能起一定作用。
基金supported by the Major National Science & Technology Program of China under Grant No.2012ZX03004004-002National High Technology Research and Development Program of China under Grant No. 2013AA014302
文摘A low-power 14-bit 150MS/s an- alog-to-digital converter （ADC） is present- ed for communication applications. Range scaling enables a maximal 2-Vp-p input with a single-stage opamp adopted. Opamp and capacitor sharing between the first multi- plying digital-to-analog converter （MDAC） and the second one reduces the total opamp power further. The dedicated sample-and- hold amplifier （SHA） is removed to lower the power and the noise. The blind calibration of linearity errors is proposed to improve the per- formance. The prototype ADC is fabricated in a 130rim CMOS process with a 1.3-V supply voltage. The SNDR of the ADC is 71.3 dB with a 2.4 MHz input and remains 68.5 dB for a 120 MHz input. It consumes 85 roW, which includes 57 mW for the ADC core, 11 mW for the low jitter clock receiver and 17 mW for the high-speed reference buffer.
文摘In this paper, combined with the ＂Enterprise Accounting Standards No. eighteenth issued -- income tax＂ and ＂Enterprise Accounting Standards No. twentieth＂ -- the merger of enterprises and the State Administration of Taxation on enterprise merger business related income tax provisions of the problem of enterprise income tax, from the perspective that enterprise merger accounting is divided into the same control and the different control corresponds to the general tax treatment and special tax treatment, I compare the process of enterprises under different circumstances of income tax with an example.
文摘Farmland merging is a significant tool in comprehensive rural areas development. Although a broad range of research relating to this field already exists, not enough emphasis has yet been placed on this issue in Poland. In all probability it would not be a point for broad discussion if this situation related to a country, where agriculture is negligible. Nonetheless, in Poland agriculture plays a very important role in the economy： it employs 17% of labour force and arable land covers about 60% of the total area. Yet, even where land consolidation work has been carried out for years, the expected effects are still not appreciable, mostly because of the disastrous formal and legal policy. This paper intends to make a contribution to the field of knowledge of farmland merging in Poland. Particular attention was focused on the importance of land management policy in the streamlining of land consolidation activities. The study brings a fresh view on the examination of the effectiveness of farmland merging work, based on two different formal procedures carried out in Poland. During the investigation the main obstacles and weaknesses in legal regulation were revealed while at the same time, producing possible solutions.
