The complicated, highly dynamic and diverse nature of biosystems brings great challenges to the specific analysis of molecular processes of interest. Nature provides antibodies for the specific recognition of antigens...The complicated, highly dynamic and diverse nature of biosystems brings great challenges to the specific analysis of molecular processes of interest. Nature provides antibodies for the specific recognition of antigens, which is a straight-forward way for targeted analysis. However, there are still limitations during the practical applications due to the big size of the antibodies, which accelerate the discovery of small molecular probes. Peptides built from various optional building blocks and easily achieved by chemical synthetic approaches with predictable conformations, are versatile and can act as tailor-made targeting vehicles.In this mini review, we summarize the recent developments in the discovery of novel peptides for bioanalytical and biomedical applications. Progresses in peptide-library design and selection strategies are presented. Recent achievements in the peptide-guided detection, imaging and disease treatment are also focused.展开更多
Naturally occurring secolignans have drawn the considerable attention because of their novel structures and diverse biological activities.In recent years,various natural secolignans with extensive bioactivities have b...Naturally occurring secolignans have drawn the considerable attention because of their novel structures and diverse biological activities.In recent years,various natural secolignans with extensive bioactivities have been reported in the literatures.In the present review,we summarized all the available information regarding the biosynthesis,distributions,separation methods,chemical structures,spectral characteristics,and biological activities of natural secolignans,and provided some valuable new insights for the further study.展开更多
基金supported by the National Natural Science Foundation of China (21375134, 21475140, 21135006, 21321003)The National Basic Research Program of China (2015CB856300)the Chinese Academy of Sciences
文摘The complicated, highly dynamic and diverse nature of biosystems brings great challenges to the specific analysis of molecular processes of interest. Nature provides antibodies for the specific recognition of antigens, which is a straight-forward way for targeted analysis. However, there are still limitations during the practical applications due to the big size of the antibodies, which accelerate the discovery of small molecular probes. Peptides built from various optional building blocks and easily achieved by chemical synthetic approaches with predictable conformations, are versatile and can act as tailor-made targeting vehicles.In this mini review, we summarize the recent developments in the discovery of novel peptides for bioanalytical and biomedical applications. Progresses in peptide-library design and selection strategies are presented. Recent achievements in the peptide-guided detection, imaging and disease treatment are also focused.
基金National Natural Science Foundation of China(Grant No.81374067)Shanghai Municipal Health Commission(Grant No.2018ZY002)
文摘Naturally occurring secolignans have drawn the considerable attention because of their novel structures and diverse biological activities.In recent years,various natural secolignans with extensive bioactivities have been reported in the literatures.In the present review,we summarized all the available information regarding the biosynthesis,distributions,separation methods,chemical structures,spectral characteristics,and biological activities of natural secolignans,and provided some valuable new insights for the further study.
