A novel technique combining photoelectronic microscopy and computer imaging tracing was used to investigate the synthesis of thioether(2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-(methylsulfanyl)]-1H-benzoimidaz...A novel technique combining photoelectronic microscopy and computer imaging tracing was used to investigate the synthesis of thioether(2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-(methylsulfanyl)]-1H-benzoimidazole),which is an intermediate for lansoprazole.Visualization in sub-microcosmic surroundings was realized to study interfacial phenomenon.The reaction kinetics study by a visualization technique was carried out in a mini-reactor,and the concentration-gray scale standard curves for thioether were obtained by analyzing the gray scales of digital images.Based on the concentration-gray scale standard curves,the reactant concentrations at different times were calculated,and the reaction kinetics curve and reaction rate equation were obtained.Also the total mass-transfer resistance from bulk phase to interface of sodium imidazole and bromopyridine was obtained.Liquid-liquid interface of synthesizing thioether was observed and its mass transfer mechanism was discussed.展开更多
In situ metal/ligand reactions have been investigated for decades and turn out to be efficient for discovery of new organic reactions and coordination compounds with novel topology and functionalities. 4-[(2-Pyridin-2...In situ metal/ligand reactions have been investigated for decades and turn out to be efficient for discovery of new organic reactions and coordination compounds with novel topology and functionalities. 4-[(2-Pyridin-2-yl)-1-(pyridin-2-yl)vinylthio]benzoic acid(L) was in situ generated in solvethermal condition with CuO and CuBr2. A copper coordination polymer[Cu2(L)Br2]n(1) was obtained synchronously and characterized by X-ray single crystal diffraction,elemental analysis and FTIR spectrum. The Cu+ ions were bridged into a tetranuclear cluster by μ3-Br and μ2-Br ions,and the clusters were further linked into 1D ribbon-like chain. The intermolecular in situ elimination is rare but meaningful in the synthesis of organic compounds.展开更多
文摘A novel technique combining photoelectronic microscopy and computer imaging tracing was used to investigate the synthesis of thioether(2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-(methylsulfanyl)]-1H-benzoimidazole),which is an intermediate for lansoprazole.Visualization in sub-microcosmic surroundings was realized to study interfacial phenomenon.The reaction kinetics study by a visualization technique was carried out in a mini-reactor,and the concentration-gray scale standard curves for thioether were obtained by analyzing the gray scales of digital images.Based on the concentration-gray scale standard curves,the reactant concentrations at different times were calculated,and the reaction kinetics curve and reaction rate equation were obtained.Also the total mass-transfer resistance from bulk phase to interface of sodium imidazole and bromopyridine was obtained.Liquid-liquid interface of synthesizing thioether was observed and its mass transfer mechanism was discussed.
文摘In situ metal/ligand reactions have been investigated for decades and turn out to be efficient for discovery of new organic reactions and coordination compounds with novel topology and functionalities. 4-[(2-Pyridin-2-yl)-1-(pyridin-2-yl)vinylthio]benzoic acid(L) was in situ generated in solvethermal condition with CuO and CuBr2. A copper coordination polymer[Cu2(L)Br2]n(1) was obtained synchronously and characterized by X-ray single crystal diffraction,elemental analysis and FTIR spectrum. The Cu+ ions were bridged into a tetranuclear cluster by μ3-Br and μ2-Br ions,and the clusters were further linked into 1D ribbon-like chain. The intermolecular in situ elimination is rare but meaningful in the synthesis of organic compounds.
