The 3,4,5 trimethoxytoluene(TMT) was systhesized using p cresol by three steps including bromination, methoxylation, and methylation with an overall yield of 84%. The structure of TMT was identified by NMR, GC/MS and ...The 3,4,5 trimethoxytoluene(TMT) was systhesized using p cresol by three steps including bromination, methoxylation, and methylation with an overall yield of 84%. The structure of TMT was identified by NMR, GC/MS and IR.“One pot”method was used in methoxylation and methylation for economical and convenient consideration. The mechanism for the methoxylation of 2,6 dibromo 4 methylphenol was discussed.展开更多
This paper is a result of a review through 25 papers on the synthesis of three-, four-, five-, six-, and seven-membered rings on solid support. Solid-phase organic synthesis methods that enable the rapid production of...This paper is a result of a review through 25 papers on the synthesis of three-, four-, five-, six-, and seven-membered rings on solid support. Solid-phase organic synthesis methods that enable the rapid production of arrays of heterocycles are of critical importance to the pharmaceutical industry. The generation of heterocyclic chemistry by solid-phase synthesis will definitely accelerate the development of pharmaceutical research.展开更多
文摘The 3,4,5 trimethoxytoluene(TMT) was systhesized using p cresol by three steps including bromination, methoxylation, and methylation with an overall yield of 84%. The structure of TMT was identified by NMR, GC/MS and IR.“One pot”method was used in methoxylation and methylation for economical and convenient consideration. The mechanism for the methoxylation of 2,6 dibromo 4 methylphenol was discussed.
文摘This paper is a result of a review through 25 papers on the synthesis of three-, four-, five-, six-, and seven-membered rings on solid support. Solid-phase organic synthesis methods that enable the rapid production of arrays of heterocycles are of critical importance to the pharmaceutical industry. The generation of heterocyclic chemistry by solid-phase synthesis will definitely accelerate the development of pharmaceutical research.
