蛋白质二级结构预测问题,是生物信息学领域中最为重要的任务之一,历经三十多年的研究,已取得了一些进展,尤其是近来集成预测模型与混合预测模型的引入,为预测精度带来了一定程度的提高,然而其离从二级结构推导三级结构的目标,仍然存在...蛋白质二级结构预测问题,是生物信息学领域中最为重要的任务之一,历经三十多年的研究,已取得了一些进展,尤其是近来集成预测模型与混合预测模型的引入,为预测精度带来了一定程度的提高,然而其离从二级结构推导三级结构的目标,仍然存在很大差距。为了有效提高蛋白质二级结构预测精度,以KDTICM理论的扩展性研究与KDD*模型为基础,使用基于KDD*模型的关联分析蛋白质二级结构预测方法KAAPRO,提出一种基于支持度与可信度的复杂距离度量的CBA(classification based on association)算法,并以该算法为核心构建逐步求精、多层递阶的合成金字塔模型,该模型整体贯穿领域知识,并采用因果细胞自动机选择有效物化属性。在对偏alpha、beta型蛋白质的预测实验中,改进型CBA算法较好地完成了对结构特征不明显氨基酸的预测,获得了较优的预测效果。展开更多
A novel method for multi-image matching by synthesizing image and object-space information is proposed. Firstly, four levels of image pyramids are generated according to the rule that the next pyramid level is generat...A novel method for multi-image matching by synthesizing image and object-space information is proposed. Firstly, four levels of image pyramids are generated according to the rule that the next pyramid level is generated from the previous level using the average gray values of the 3 by 3 pixels, and the first level of pyramid image is generated from the original image. The initial horizontal parallaxes between the reference image and each searching image are calculated at the highest level of the image pyramid. Secondly, corresponding image points are searched in each stereo image pair from the third level of image pyramid, and the matching results in all stereo pairs are integrated in the object space, by which the mismatched image points can be eliminated and more accurate spatial information can be obtained for the subsequent pyramid image matching. The matching method based on correlation coefficient with geometric constraints and global relaxation matching is introduced in the process of image matching. Finally, the feasibility of the method proposed in this paper is verified by the experiments using a set of digital frame aerial images with big overlap. Compared with the traditional image matching method with two images, the accuracy of the digital surface model (DSM) generated using the proposed method shows that the multiimage matching method can eliminate the mismatched points effectively and can improve the matching success rate significantly.展开更多
文摘蛋白质二级结构预测问题,是生物信息学领域中最为重要的任务之一,历经三十多年的研究,已取得了一些进展,尤其是近来集成预测模型与混合预测模型的引入,为预测精度带来了一定程度的提高,然而其离从二级结构推导三级结构的目标,仍然存在很大差距。为了有效提高蛋白质二级结构预测精度,以KDTICM理论的扩展性研究与KDD*模型为基础,使用基于KDD*模型的关联分析蛋白质二级结构预测方法KAAPRO,提出一种基于支持度与可信度的复杂距离度量的CBA(classification based on association)算法,并以该算法为核心构建逐步求精、多层递阶的合成金字塔模型,该模型整体贯穿领域知识,并采用因果细胞自动机选择有效物化属性。在对偏alpha、beta型蛋白质的预测实验中,改进型CBA算法较好地完成了对结构特征不明显氨基酸的预测,获得了较优的预测效果。
基金Supported by the National Natural Science Foundation of China (Nos. 40771176, 40721001)
文摘A novel method for multi-image matching by synthesizing image and object-space information is proposed. Firstly, four levels of image pyramids are generated according to the rule that the next pyramid level is generated from the previous level using the average gray values of the 3 by 3 pixels, and the first level of pyramid image is generated from the original image. The initial horizontal parallaxes between the reference image and each searching image are calculated at the highest level of the image pyramid. Secondly, corresponding image points are searched in each stereo image pair from the third level of image pyramid, and the matching results in all stereo pairs are integrated in the object space, by which the mismatched image points can be eliminated and more accurate spatial information can be obtained for the subsequent pyramid image matching. The matching method based on correlation coefficient with geometric constraints and global relaxation matching is introduced in the process of image matching. Finally, the feasibility of the method proposed in this paper is verified by the experiments using a set of digital frame aerial images with big overlap. Compared with the traditional image matching method with two images, the accuracy of the digital surface model (DSM) generated using the proposed method shows that the multiimage matching method can eliminate the mismatched points effectively and can improve the matching success rate significantly.
