Objective: To establish a model for pregnancy-induced hypertension syndrome in rats. Methods: Adult female Wistar rats were randomized into non-pregnant control (NN), non-pregnant cold-stress control (NC), pregnant co...Objective: To establish a model for pregnancy-induced hypertension syndrome in rats. Methods: Adult female Wistar rats were randomized into non-pregnant control (NN), non-pregnant cold-stress control (NC), pregnant control (PN) and pregnant cold-stress (PC) groups. The rats of NN and PN groups were put under 25 ℃ and those of NC and PC groups under (4±2)℃ for 4 h every morning respectively in the whole experimental period. The blood pressure, urine protein, body weight, haematocrit, weight of the placenta and weight and length of the fetus were recorded and the histological changes of the placenta and the kidneys were also studied. Results: The blood pressure and urine protein of the rats of the NC and PC groups after 2 weeks of cold-stress were more significantly increased than the rats of the NN and PN groups. In addition, the weight of the placenta and the weight and length of the fetus were more significantly lower in the former than the latter. Obvious changes of anoxia and ischemia were observed in the tissues of the kidneys and every layer of the placenta. Conclusion: Our findings of hypertension syndrome induced with repeated cold-stress in pregnant rats can be applied to illustrate the pathogenesis of pregnancy-induced hypertension syndrome in human beings.展开更多
The present research work emphasized on identifying and optimizing various significant process parameters of high pressure die casting by using QFD-Taguchi based hybrid approach in order to yield the optimum casting d...The present research work emphasized on identifying and optimizing various significant process parameters of high pressure die casting by using QFD-Taguchi based hybrid approach in order to yield the optimum casting density of the A380alloy.Identification of critical process parameters,selection of appropriate orthogonal array,analysis of means and analysis of variance are employed to study the performance characteristic of the die casting process.The most critical process parameters identified and optimized by QFD-Taguchi based hybrid approach,such as the injection pressure,the molten metal temperature,the plunger velocity(first and second stage)and the die temperature were explored in the experimental work.The results show that injection pressure is the most significant factor among the selected parameters.The contribution of the injection pressure to the variation of mean casting density is around61.483%.Confidence interval(CI)has also been estimated as0.000718for95%consistency level to validate the predicted range of optimum casting density of aforesaid alloy.展开更多
Nanoindentation experiments were conducted under loading rates of 500–6000μN/s and applied peak loads of 4000-12000μN to measure the creep behavior of DD407 Ni-base single crystal superalloy at room temperature.Exp...Nanoindentation experiments were conducted under loading rates of 500–6000μN/s and applied peak loads of 4000-12000μN to measure the creep behavior of DD407 Ni-base single crystal superalloy at room temperature.Experimental results demonstrated that DD407 Ni-base single crystal superalloy had a good creep resistance,but its creep properties were sensitive to the loading rate and peak load.The fitting creep parameters significantly increased with increasing loading rate and peak load based on the Findley’s model,and the corresponding creep mechanism was governed by dislocation based on the calculation of creep stress exponent.During nanoindentation creep tests,it was found that the hardness and reduced modulus decreased with increasing the loading rate and peak load,and through a dimensionless analysis,it was also noted that the effect of the dimensionless loading rate was stronger than that of dimensionless peak load on the creep properties.展开更多
Deformation twins and stacking faults were observed in nanostructure A1-Mg alloys subjected to high pressure torsion. These observations are surprising because deformation twinnings have never been observed in their c...Deformation twins and stacking faults were observed in nanostructure A1-Mg alloys subjected to high pressure torsion. These observations are surprising because deformation twinnings have never been observed in their coarse-grained counterparts under normal conditions. Experimental evidences are introduced on non-equilibrium grain boundaries, deformation twinnings and partial dislocation emissions from grain boundaries. Some of these features can be explained by the results reported from molecular-dynamics simulations of pure FCC metals. Special emphasis is laid on the recent observations of high density hexagonal and rhombic shaped nanostructures with an average size of 3 nm in the A1-Mg alloys processed by high pressure torsion. A possible formation process of these nanostructures is proposed based on molecular-dynamics simulations.展开更多
文摘Objective: To establish a model for pregnancy-induced hypertension syndrome in rats. Methods: Adult female Wistar rats were randomized into non-pregnant control (NN), non-pregnant cold-stress control (NC), pregnant control (PN) and pregnant cold-stress (PC) groups. The rats of NN and PN groups were put under 25 ℃ and those of NC and PC groups under (4±2)℃ for 4 h every morning respectively in the whole experimental period. The blood pressure, urine protein, body weight, haematocrit, weight of the placenta and weight and length of the fetus were recorded and the histological changes of the placenta and the kidneys were also studied. Results: The blood pressure and urine protein of the rats of the NC and PC groups after 2 weeks of cold-stress were more significantly increased than the rats of the NN and PN groups. In addition, the weight of the placenta and the weight and length of the fetus were more significantly lower in the former than the latter. Obvious changes of anoxia and ischemia were observed in the tissues of the kidneys and every layer of the placenta. Conclusion: Our findings of hypertension syndrome induced with repeated cold-stress in pregnant rats can be applied to illustrate the pathogenesis of pregnancy-induced hypertension syndrome in human beings.
基金the National Institute of Technology,Manipur,Imphal for Financial Support to carry out the experimental work of Mr.K.Ch.Apparao
文摘The present research work emphasized on identifying and optimizing various significant process parameters of high pressure die casting by using QFD-Taguchi based hybrid approach in order to yield the optimum casting density of the A380alloy.Identification of critical process parameters,selection of appropriate orthogonal array,analysis of means and analysis of variance are employed to study the performance characteristic of the die casting process.The most critical process parameters identified and optimized by QFD-Taguchi based hybrid approach,such as the injection pressure,the molten metal temperature,the plunger velocity(first and second stage)and the die temperature were explored in the experimental work.The results show that injection pressure is the most significant factor among the selected parameters.The contribution of the injection pressure to the variation of mean casting density is around61.483%.Confidence interval(CI)has also been estimated as0.000718for95%consistency level to validate the predicted range of optimum casting density of aforesaid alloy.
基金financial supports from the National Natural Science Foundation of China(Nos.11772236,11472195)。
文摘Nanoindentation experiments were conducted under loading rates of 500–6000μN/s and applied peak loads of 4000-12000μN to measure the creep behavior of DD407 Ni-base single crystal superalloy at room temperature.Experimental results demonstrated that DD407 Ni-base single crystal superalloy had a good creep resistance,but its creep properties were sensitive to the loading rate and peak load.The fitting creep parameters significantly increased with increasing loading rate and peak load based on the Findley’s model,and the corresponding creep mechanism was governed by dislocation based on the calculation of creep stress exponent.During nanoindentation creep tests,it was found that the hardness and reduced modulus decreased with increasing the loading rate and peak load,and through a dimensionless analysis,it was also noted that the effect of the dimensionless loading rate was stronger than that of dimensionless peak load on the creep properties.
基金Project(50971087) supported by the National Natural Science Foundation of ChinaProject supported by the Research Council of Norway under the Strategic University Program on Light Metals Technology Projects(67692, 71594) supported by the Hungarian National Science Foundation
文摘Deformation twins and stacking faults were observed in nanostructure A1-Mg alloys subjected to high pressure torsion. These observations are surprising because deformation twinnings have never been observed in their coarse-grained counterparts under normal conditions. Experimental evidences are introduced on non-equilibrium grain boundaries, deformation twinnings and partial dislocation emissions from grain boundaries. Some of these features can be explained by the results reported from molecular-dynamics simulations of pure FCC metals. Special emphasis is laid on the recent observations of high density hexagonal and rhombic shaped nanostructures with an average size of 3 nm in the A1-Mg alloys processed by high pressure torsion. A possible formation process of these nanostructures is proposed based on molecular-dynamics simulations.
