Nanoparticles can be enriched at tumor site and improve the therapeutic efficacy of many chemother- apy drugs with the well-known enhanced permeability and retention （EPR） effect. While conventional preparations of ...Nanoparticles can be enriched at tumor site and improve the therapeutic efficacy of many chemother- apy drugs with the well-known enhanced permeability and retention （EPR） effect. While conventional preparations of materials for nanoscale drug delivery system mainly focused on chemical synthesis, recently the combination of synthetic carrier and natural biomimetic carrier has gained more and more attention. As a new generation of biomimetic nanoparticles, cell membrane-coated nanoparticles combine the complex biological functions of natural membranes and the physicochemical properties of synthetic nanomaterials for a more effective drug delivery. Herein, we briefly review the recent advances on cell membrane-coated nanoparticles for tumor-targeted drug delivery via the prolonging systemic circulation lifetime and the active targeting effect. Since the preferential accumulation of cell membrane-coated nanopar- ticles in tumor site, they are able to improve the therapeutic efficacy of conventional chemotherapy drugs in antitumor treatment as well as to reduce the systemic toxicity. We also introduce a systematic targeted strategy for the promising application of this platform on brain tumors.展开更多
Ultrathin zeolite membranes are of paramount importance in accelerating gas transport during membrane separation,and lowering down their membrane thicknesses to submicron scale is deemed to be very challenging.Herein,...Ultrathin zeolite membranes are of paramount importance in accelerating gas transport during membrane separation,and lowering down their membrane thicknesses to submicron scale is deemed to be very challenging.Herein,we develop an advanced approach of surface gel conversion for synthesis of submicron-thick pure silica MFI(silicalite-1)zeolite membranes.Viscous gel is prepared by finely adjusting the precursor composition,enabling its reduced wettability.The unfavorable wetting of the support surface can effectively prevent gel penetration into alumina support voids.Aided by the seeds,the surface gel is directly and fully crystallized into an MFI zeolite membrane with minimal water steam.A membrane with a thickness of 500 nm is successfully acquired and it is free of visible cracks.Additionally,the as-synthesized membranes exhibit rapid and selective separation of hexane isomers by virtue of unprecedentedly high n-hexane permeance of 24.5×10^−7 mol m^−2 s^−1 Pa^−1 and impressive separation factors of 13.3-22.6 for n-hexane over its isomers.This developed approach is of practical interest for sustainable synthesis of high-quality zeolite membranes.展开更多
基金supported by the National Basic Research Program of China (2013CB932500)the National Natural Science Foundation of China (81273458 and 81473149)
文摘Nanoparticles can be enriched at tumor site and improve the therapeutic efficacy of many chemother- apy drugs with the well-known enhanced permeability and retention （EPR） effect. While conventional preparations of materials for nanoscale drug delivery system mainly focused on chemical synthesis, recently the combination of synthetic carrier and natural biomimetic carrier has gained more and more attention. As a new generation of biomimetic nanoparticles, cell membrane-coated nanoparticles combine the complex biological functions of natural membranes and the physicochemical properties of synthetic nanomaterials for a more effective drug delivery. Herein, we briefly review the recent advances on cell membrane-coated nanoparticles for tumor-targeted drug delivery via the prolonging systemic circulation lifetime and the active targeting effect. Since the preferential accumulation of cell membrane-coated nanopar- ticles in tumor site, they are able to improve the therapeutic efficacy of conventional chemotherapy drugs in antitumor treatment as well as to reduce the systemic toxicity. We also introduce a systematic targeted strategy for the promising application of this platform on brain tumors.
基金the National Natural Science Foundation of China(21531003,21501024 and 21971035)Jilin Scientific and Technological Development Program(20170101198JC and 20190103017JH)+2 种基金Jilin Education Office(JJKH20180015KJ)“111”Program(B18012)open projects from the State Key Laboratory of Inorganic Synthesis&Preparative Chemistry and State Key Laboratory of Heavy Oil Processing(2018-8,SKLOP201902003)。
文摘Ultrathin zeolite membranes are of paramount importance in accelerating gas transport during membrane separation,and lowering down their membrane thicknesses to submicron scale is deemed to be very challenging.Herein,we develop an advanced approach of surface gel conversion for synthesis of submicron-thick pure silica MFI(silicalite-1)zeolite membranes.Viscous gel is prepared by finely adjusting the precursor composition,enabling its reduced wettability.The unfavorable wetting of the support surface can effectively prevent gel penetration into alumina support voids.Aided by the seeds,the surface gel is directly and fully crystallized into an MFI zeolite membrane with minimal water steam.A membrane with a thickness of 500 nm is successfully acquired and it is free of visible cracks.Additionally,the as-synthesized membranes exhibit rapid and selective separation of hexane isomers by virtue of unprecedentedly high n-hexane permeance of 24.5×10^−7 mol m^−2 s^−1 Pa^−1 and impressive separation factors of 13.3-22.6 for n-hexane over its isomers.This developed approach is of practical interest for sustainable synthesis of high-quality zeolite membranes.
