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论“研究生教育学”学科建构的合用性、合法性与合理性 被引量:10
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作者 李金龙 李璐 +1 位作者 裴旭 张淑林 《学位与研究生教育》 CSSCI 北大核心 2015年第2期14-18,共5页
认为在30年的学科体系建构历程中,研究生教育学已具备了社会层面的合用性、制度层面的合法性和学术层面的合理性,应该成为一门以指导研究生教育事业科学发展为使命、完全独立于高等教育学的交叉、应用学科。
关键词 研究生教育学 合用性 合法 合理
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基于用户特征分类的产品设计优先级配置研究 被引量:2
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作者 杨梅 王怡妍 +1 位作者 李雪瑞 侯幸刚 《包装工程》 CAS 北大核心 2022年第12期157-164,173,共9页
目的为合理界定产品合用性需求偏好及其优先程度以针对性提高用户产品合用性体验,提出一种基于用户特征分类的产品设计优先级配置方法。方法将Pearson相关系数融入有限理性假说模型中对用户群体进行特征分类,根据Pearson相关系数筛选用... 目的为合理界定产品合用性需求偏好及其优先程度以针对性提高用户产品合用性体验,提出一种基于用户特征分类的产品设计优先级配置方法。方法将Pearson相关系数融入有限理性假说模型中对用户群体进行特征分类,根据Pearson相关系数筛选用户需求与行为背离现象影响因素,并作为特征用户的划分依据。以层次分析法(AHP)为主,从产品属性、符号要素和人机因素3个维度构建产品合用性评估分析系统,对产品特征要素进行量化分析,探求不同特征用户对于产品设计要素的优先级,把控特征用户在产品选择及使用过程中表现出的需求走向,以此为据提升产品合用性体验。结论以疫情期间女性防护用品为例,验证了该方法的有效性,为女用防护服与其他产品的设计开发提供了产品设计优先级配置方法。 展开更多
关键词 产品合用性 用户特征 需求分析 层次分析法 优先级配置
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Transition metal coordination polymers with flexible dicarboxylate ligand:Synthesis,characterization,and photoluminescence property
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作者 CUI Peipei LI Xin +5 位作者 CHEN Yilin CHENG Zhilin GAO Feiyan GUO Xu YAN Wenning DENG Yuchen 《无机化学学报》 SCIE CAS CSCD 北大核心 2024年第11期2221-2231,共11页
Under solvothermal conditions,six new coordination polymers(CPs)[Mn(L)(phen)(H_(2)O)]_(n)(1),[Co(L)(phen)(H_(2)O)]_(n)(2),[Cu(L)(phen)(H_(2)O)]_(n)(3),[Zn_(2)(L)_(2)(phen)2(H_(2)O)]_(n)(4),[Zn(L)(phen)]_(n)(5),and[Cd(... Under solvothermal conditions,six new coordination polymers(CPs)[Mn(L)(phen)(H_(2)O)]_(n)(1),[Co(L)(phen)(H_(2)O)]_(n)(2),[Cu(L)(phen)(H_(2)O)]_(n)(3),[Zn_(2)(L)_(2)(phen)2(H_(2)O)]_(n)(4),[Zn(L)(phen)]_(n)(5),and[Cd(L)(phen)2]_(n)(6)were synthesized by reactions of dicarboxylate ligand 2,2'-(1,2-phenylenebis(methylene))bis(sulfanediyl)dinobutyric acid(H_(2)L)and 1,10-phenanthroline(phen)with the corresponding metal salts.Complexes 1-6 have been structurally characterized by single-crystal X-ray diffraction analyses,elemental analysis,IR,thermogravimetric analysis,and powder X-ray diffraction.The structures of 1-6 are 1D chains,which are further connected by hydrogen bonding interac-tions to form 3D supramolecular structures.Among them,1 and 2 are isomorphic with L2-of syn-conformation,while L2-shows anti-conformation in 3-6.In addition,the solid-state photoluminescence property of 4-6 was investigated. 展开更多
关键词 flexible dicarboxylate ligand coordination polymers hydrogen bonding interaction CONFORMATION photoluminescence property
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Remote electron effects andπ-πinteractions ofα-diimine nickel complexes
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作者 Yizhan Wang Hailong He Dan Peng 《中国科学技术大学学报》 CAS CSCD 北大核心 2024年第9期17-22,68,共7页
The seminal report ofα-diimine palladium and nickel catalysts in 1995 represented a major breakthrough in the preparation of functionalized polyolefin materials.Owing to the high abundance and low cost of nickel,nick... The seminal report ofα-diimine palladium and nickel catalysts in 1995 represented a major breakthrough in the preparation of functionalized polyolefin materials.Owing to the high abundance and low cost of nickel,nickel-based catalysts have great application prospects in the industrialization process of olefin coordination polymerization.In this work,various N-aryl substituents with different electronic effects were synthesized and introduced intoα-diimine ligands.The aspreparedα-diimine nickel catalysts showed high polymerization activity(0.9×10^(7)–3.0×10^(7)g·mol^(−1)·h^(−1))in ethylene polymerization,generating polyethylene products with adjustable molecular weights(Mn values:7.4×10^(4)–146.9×10^(4)g·mol^(−1))and branching densities(31/1000 C–68/1000 C).The resulting polyethylene products showed excellent mechanical properties,with high tensile strength(up to 25.0 MPa)and high strain at break values(up to 3890%).The copolymerization of ethylene and polar monomers can also be achieved by these nicekel complexes,ultimately preparing functionalized polyolefins. 展开更多
关键词 α-diimine nickel catalyst ethylene polymerization π-πinteraction effect electronic effect polar monomer
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Effect of modified aramid nanofiber on compatibilization of natural rubber/epoxidized natural rubber composites
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作者 ZHANG Ke-yu ZHENG Xiao-tong XU Ming-han 《合成橡胶工业》 CAS 2024年第6期508-508,共1页
The combination of natural rubber(NR)with epoxidized natural rubber(ENR)could improve the wet slid resistance,mechanical properties,abrasion resistance and thermo-oxidative aging resistance of NR,which showed importan... The combination of natural rubber(NR)with epoxidized natural rubber(ENR)could improve the wet slid resistance,mechanical properties,abrasion resistance and thermo-oxidative aging resistance of NR,which showed important research significance.Aramid nanofiber,as a new nano filler for polymer developed in recent years,had the advantages of both macroscopic fibers and polymer nanomaterials.The NR/ENR composites were prepared by dry mixing with NR and the pre-composite prepared from ENR latex and the modified aramid nanofibers(t-ANF). 展开更多
关键词 COMPOSITES RUBBER COMPOSITE
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基于有限元分析法对压力容器制造缺欠的强度校核 被引量:1
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作者 王绍青 《广州化工》 CAS 2012年第13期151-154,共4页
针对一台三类压力容器在制造过程中出现的错边缺欠,根据GB150-1998规范、ASMEⅧ规范、AWS规范的相关内容,对错边缺欠潜在的危害进行了评估,最终运用有限元分析的方法对容器错边部位结构强度进行了计算与分析,对危险截面进行了强度评定,... 针对一台三类压力容器在制造过程中出现的错边缺欠,根据GB150-1998规范、ASMEⅧ规范、AWS规范的相关内容,对错边缺欠潜在的危害进行了评估,最终运用有限元分析的方法对容器错边部位结构强度进行了计算与分析,对危险截面进行了强度评定,从而保证了乙烯和氧气发生氧化产生环氧乙烷和副产品中压蒸汽的安全。 展开更多
关键词 有限元分析 焊接缺欠 错边 合用性评定
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Comparative Study of Photosynthetic and Fluorescence Characters of the Grape under High Temperature and High Light in Turpan 被引量:4
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作者 贾杨 廖康 +4 位作者 马微 江振斌 骆强伟 孙锋 伍国红 《Agricultural Science & Technology》 CAS 2015年第5期868-872,共5页
[Objective] The aim was to explore the photosynthetic characteristics of Turpan grapes under high temperature and strong light conditions. [Method] Using six grape varieties as experimental materials, the photosynthes... [Objective] The aim was to explore the photosynthetic characteristics of Turpan grapes under high temperature and strong light conditions. [Method] Using six grape varieties as experimental materials, the photosynthesis and fluorescence parameters of the grape varieties under high temperature and high light were determined. [Result] The results showed that Thompson Seedless showed strong selfprotection ability on the photosynthetic mechanism in the adversity, and lower photo inhibition on photosynthesis under high temperature and high light than other varieties in which Crimson Seedless was second place. Otherwise the damage on photosynthetic mechanism of Kyoho and Red Globe under the adversity environment is more dipper than the other varieties, and poor self-protection ability. [Conclusion]Thompson Seedless and Crimson Seedless had a strong adaptability for high temperature and strong light. But the adaptability of Kyoho and Red Globe were relatively poor. 展开更多
关键词 Turpan High temperature and high light GRAPE PHOTOSYNTHETIC FLUORESCENCE
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Effects of Water Stress on Photosynthesis and Fluorescence Characteristics in Peony 被引量:18
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作者 张锋 孔祥生 +2 位作者 张妙霞 刘兢文 王海华 《Agricultural Science & Technology》 CAS 2008年第2期101-105,共5页
[ Objective] Study on the photosynthesis and fluorescence characteristics in peony under water stress. [ Method ] The two peony varieties Huhong and Luoyanghong were treated by different water stress for determining t... [ Objective] Study on the photosynthesis and fluorescence characteristics in peony under water stress. [ Method ] The two peony varieties Huhong and Luoyanghong were treated by different water stress for determining the photosynthesis and fluorescence characteristics. [ Result ] With the aggravation of water stress, the net photosynthetic rate (Pn) and stomatal conductance (Gs) decreased, while the intercellular CO2 concentration (Ci) increased. Drought could decrease Pn, constrain gas exchange and change the daily photosynthesis. Fo of peony leaf increased and Fv/Fm decreased under water stress especially water logging, causing the inactivation of the PS II reaction center, and the chlorophyll fluorescence characters gradually recovered until afternoon. [ Conclusion] The 75% soil relative water content (SRWC) is the best condition for growth of peony. Compared with drought, water logging is more unfit for the growth of peony. For the two varieties, Huhong assumed more tolerance to drought, accordingly more adaptability. 展开更多
关键词 PEONY Water stress Photosvthetic characteristics Chlorophyll fluorescence
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Photosynthesis of Resurrection Angiosperms 被引量:3
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作者 阳文龙 胡志昂 +1 位作者 王洪新 匡廷云 《Acta Botanica Sinica》 CSCD 2003年第5期505-508,共4页
Resurrection plants which are able to quickly reactivate after falling into a period of anabiosis caused by dehydration have been very rare among angiosperms, especially among dicotyledons whose chlorophyll content an... Resurrection plants which are able to quickly reactivate after falling into a period of anabiosis caused by dehydration have been very rare among angiosperms, especially among dicotyledons whose chlorophyll content and chloroplast structure little changed in the course of desiccation, therefore has been called homoiochlorophyllous desiccation-tolerant plants (HDTs). Another type of resurrection angiosperms that lost its chlorophyll dining desiccation is called poikilochlorophyllous desiccation-tolerant plants (PDTs). HDTs have been received more attention because of simplicity of protection mechanism which is much easy to the study and utilization of the desiccation tolerance of resurrection angiosperms. Recent advances in studies of photosynthesis of resurrection angiosperms indicate that photochemical activities are sensitive indicators for the study of physiological state of resurrection angiosperms during desiccation and rehydration. Photochemical activities of resurrection angiosperms are inhibited with loss of water similar to those of general plants, however, the magic thing is that they could reactivate rapidly during rehydration even losing more than 95% water. Up-regulations in xanthophyll cycle and antioxidative systems as well as preservation in integrity and stability of photosynthetic membranes during desiccation may be very important to desiccation tolerance of resurrection angiosperms. The fact that phosphate treatment in rehydration stage also strongly influences resurrection indicated importance of studies on rehydration stages of resurrection angiosperms. 展开更多
关键词 resurrection angiosperm PHOTOSYNTHESIS desiccation tolerance xanthophyll cycle ANTIOXIDANT stability of membranes
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Interspecific Transition Among Caragana microphylla, C. davazamcii and C. korshinskii Along Geographic Gradient. Ⅱ. Characteristics of Photosynthesis and Water Metabolism 被引量:13
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作者 马成仓 高玉葆 +1 位作者 郭宏宇 王金龙 《Acta Botanica Sinica》 CSCD 2003年第10期1228-1237,共10页
The characteristics of photosynthesis and water metabolism of Caragana microphylla Lam.,C. davazamcii Sancz. and C. korshinskii Kom. populations in different sites (117.6o-105.7o E, 44.6o-38.8o N)were studied. (1) Fro... The characteristics of photosynthesis and water metabolism of Caragana microphylla Lam.,C. davazamcii Sancz. and C. korshinskii Kom. populations in different sites (117.6o-105.7o E, 44.6o-38.8o N)were studied. (1) From the east to the west, the responses of the three species to photosyntheticallyavailable radiation (PAR) in net photosynthesis rate increased, the relative humidity of the air whichcorresponded to the occurrence of maximum photosynthesis rate decreased, and the corresponding airtemperature increased. Along the same gradient, the before-noon superiority of the photosynthesis be-came evident, and the photosynthesis rate and the light use efficiency (LUE ) increased, while the transp-iration rate decreased, thus the water use efficiency (WUE ) increased notably, and the leaf water contentdecreased gradually. From the east to the west, the plants took a water-saving strategy step by step withhigher photosynthesis rate and lower transpiration rate. These physiological changes in the plants wereadaptable to the conditions of light, temperature and humidity in the habitat of the plants, and might be thebiological foundation for the geographical transition among C. microphylla , C. davazamcii and C. korshinskii.(2) The adaptation of photosynthetic system of C. microphylla , C. davazamcii and C. korshinskii to PAR, airhumidity and temperature exhibited the interspecific continuity, which was consistent with theenvironmental gradient. In different species and different sites, the diurnal changes of net photosynthesisrate, the daily cumulative value of net photosynthesis, the diurnal changes of transpiration rate, the dailycumulative value of transpiration, the water use efficiency and the diurnal changes of leaf water contentvaried with longitudinal descent (from the east to the west). The characteristics of photosynthesis andwater metabolism indicated that the geographical transition among C. microphylla , C. davazamcii and C.korshinskii was in gradual change, and these three species formed a geographical cline. 展开更多
关键词 Caragana microphylla C. davazamcii C. korshinskii geographical transition PHOTOSYNTHESIS water metabolism
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Comparison among Growth, Photosynthesis and Yield in Nanjing 9108 and Its Parents during the Late Development Stage
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作者 李霞 柯希欢 +2 位作者 陈涛 张亚东 朱镇 《Agricultural Science & Technology》 CAS 2015年第9期1933-1938,共6页
A good quality, high yield, slow mature and middle season Japonica rice variety, Nanjing 9108 and its parents Guandong 194 and Wuxiangjing 14,were taken as the materials for the study. The growth and photosynthetic ch... A good quality, high yield, slow mature and middle season Japonica rice variety, Nanjing 9108 and its parents Guandong 194 and Wuxiangjing 14,were taken as the materials for the study. The growth and photosynthetic characteristics of the rice plants at the post-flowering stage were compared and the rice yield components were examined at harvest. The results showed that as compared with Wuxiangjing 14, the per plant yield of Nanjing 9108 was 7.70% higher, and much higher than that of Guandong194. The large total grain per plant and heavy grain weigh of Nanjing 9108 were the important structure basis for its yield. Further analysis o the growth indicators showed that Nanjing 9108 had a large leaf area of upper three green leaves area and a smaller leaf base angle in the third leaf from the bottom blades, which helped get a higher photosynthetic capacity in groups. On the14 thday after flowering, Nanjing 9108 had similar value of net photosynthetic rate(Pn) to that of Wuxianjing 14, but lower than that of Guandong 194. Viewing from the parameters obtained from light response of photosynthesis on the modified model of rectangular hyperbola, Pn of Nanjing 9108 was more aptated to be saturated by light intensity and sensitive to photoinhibition. On the whole, Nanjing 9108 with high yield mainly resulted from its good plant type, grain structure and higher photosynthetic capacity in groups. Further improving its photosynthetic capacity o single leaf in Nanjing 9108 would be an important way for its super high yield po tential in the future. 展开更多
关键词 Japonica rice(Oryza sativa L.) Plant type Photosynthetic characteristics Photosynthetic light response curve YIELD
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王船山“尽器贯道”的实践哲学取向
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作者 田丰 《船山学刊》 2019年第5期45-50,共6页
王船山认为并不存在一个绝对客观化且没有人的理解与实践参与的物性,物性一定是在人的合用性指引中向人显现。'道'乃人应事接物之道,不能等同为'理'或自然物性。'器'是在人的世界中向人显现的物,随着人生存方... 王船山认为并不存在一个绝对客观化且没有人的理解与实践参与的物性,物性一定是在人的合用性指引中向人显现。'道'乃人应事接物之道,不能等同为'理'或自然物性。'器'是在人的世界中向人显现的物,随着人生存方式的变化,才有相应之器被纳入人的视域,由此而有当然之则与器之道。天之道必待人而成之,此之谓'尽器',人接事应物合宜,道器方能会通于至诚而极尽其变化。 展开更多
关键词 王船山 实践哲学 合用性
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Study on Urban Construction Land Suitability Evaluation in Southwestern Mountainous Areas of Yunnan Province Based on the Strategy of "Protecting Farmland in Flatland Areas and Constructing Mountainous Cities" : A Case in Lianghe County 被引量:4
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作者 贺一梅 杨子生 +2 位作者 张博胜 邓有旺 张德省 《Agricultural Science & Technology》 CAS 2014年第10期1774-1777,1780,共5页
According to the particularity of towns' construction in the southwestern mountainous areas of Yunnan Province, this study has built constructive land suit- ability evaluation index system which is different to flat ... According to the particularity of towns' construction in the southwestern mountainous areas of Yunnan Province, this study has built constructive land suit- ability evaluation index system which is different to flat area. Then this study deter- mined single evaluation factors index and comprehensive suitability index using "ex- treme conditions method" and "suitability index method", and analyzed and assessed the constructive land suitability on each evaluation unit polygons and its suitability level by using GIS software. Taking Lianghe County of Dehong Dai-Jingpo Au- tonomous Prefecture as an example to evaluate land suitability in Lianghe County's main towns around the gentle slope, the results show, in the evaluation area, the area of land suitable for construction and unsuitable for construction respectively ac- count 73.58% and 26.42%. And first-class, second and third-class of land suitable for construction should be composited at the ratio of about 11:49:40. The suitability evaluation index system and method developed in this paper is applicable for evalu- ating the construction land suitability in mountainous areas of southwest Yunnan Province, and will provide theoretical and technical support for land policy measures which strengthen the protection of farmland and promote the scientific development of urbanization in Yunnan Province and even similar mountainous areas of the whole China. 展开更多
关键词 Mountainous area Constructive land Suitability evaluation Comprehensive suitability index Southwestern Yunnan Province
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Susceptibilities of Mycoplasma Hominis and Ureaplasma Urealyticum to Fluoroquinolones
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作者 吴移谋 曾焱华 +1 位作者 姚艳冰 张文波 《Chinese Journal of Sexually Transmitted Infections》 2004年第1期28-31,63,64,共6页
Objectives: To determine the susceptibilities of M.hominis and U. urealyticum to fluoroquinolones forthe instruction of reasonable clinical application ofantibiotics.Method: The susceptibilities of M. hominis and U.ur... Objectives: To determine the susceptibilities of M.hominis and U. urealyticum to fluoroquinolones forthe instruction of reasonable clinical application ofantibiotics.Method: The susceptibilities of M. hominis and U.urealyticum to six fluoroquinolones were determinedby the broth dilution method.Results: Sparfloxacin and gatifloxacin were veryactive with MIC50S of 0.03125 and 0.25 μg/ml againstM. hominis, 0.25 and 0.5 μg/ml against U. urealyticum,respectively. Levofloxacin and ofloxacin had MIC50S of1 μg/ml and 2 μg/ml, respectively against both species.Norfloxacin was less effective against both species at16 and 32 μg/ml. Ciprofloxacin was unusual in thatthe MIC50S varied fourfold between species, with 2 μg/ml against M. hominis and 8 μg/ml against U.urealyticum.Conclusions: The results can provide useful infor-mation for selecting fluoroquinolones for treatmentof urogenital mycoplasma infections. 展开更多
关键词 mycoplasma hominis ureaplasmaurealyticum SUSCEPTIBILITY FLUOROQUINOLONES
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Application of seismic multi-attribute fusion method based on D-S evidence theory in prediction of CBM-enriched area 被引量:1
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作者 祁雪梅 张绍聪 《Applied Geophysics》 SCIE CSCD 2012年第1期80-86,116,117,共9页
D-S evidence theory provides a good approach to fuse uncertain inlbrmation. In this article, we introduce seismic multi-attribute fusion based on D-S evidence theory to predict the coalbed methane (CBM) concentrated... D-S evidence theory provides a good approach to fuse uncertain inlbrmation. In this article, we introduce seismic multi-attribute fusion based on D-S evidence theory to predict the coalbed methane (CBM) concentrated areas. First, we choose seismic attributes that are most sensitive to CBM content changes with the guidance of CBM content measured at well sites. Then the selected seismic attributes are fused using D-S evidence theory and the fusion results are used to predict CBM-enriched area. The application shows that the predicted CBM content and the measured values are basically consistent. The results indicate that using D-S evidence theory in seismic multi-attribute fusion to predict CBM-enriched areas is feasible. 展开更多
关键词 D-S evidence theory CBM seismic attributes thsion
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Purification and Spectral Characteristics of Cytochrome b-559 from Oxygen-evolving Photosystem Ⅱ Core Complexes of Spinach and Rice
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作者 辛越勇 郁飞 +2 位作者 唐崇钦 李良璧 匡廷云 《Acta Botanica Sinica》 CSCD 2000年第12期1225-1230,共6页
Cytochrome b_559 in photosystem Ⅱ reaction center was purified from spinach ( Spinacia oleracea L.) and rice ( Oryza sativa L.) by a rapid and simple procedure. Their low temperature fluorescence emission and e... Cytochrome b_559 in photosystem Ⅱ reaction center was purified from spinach ( Spinacia oleracea L.) and rice ( Oryza sativa L.) by a rapid and simple procedure. Their low temperature fluorescence emission and excitation spectra, ultraviolet fluorescence spectra and absolute absorption spectra were presented. The author's purification methods, which enhanced the yield of pure protein and shorted the time for isolation, have several advantages: 1. use of oxygen_evolving PSⅡ core complexes as the starting material in order to avoid disturbing from other cytochromes; 2. isocratic elution of cytochrome b_559 from a DEAE_Sephacel column for eliminating the impurity and yielding the protein in pure state; 3. a simple column procedure for removal of excess Triton X_100. Purified cytochromes b_559 from these species have similar optical spectra and mobility during gel electrophoresis under native conditions. From the results of novel electrophoresis (Tricine_SDS_PAGE), cytochrome b_559 from both spinach and rice reveal two polypeptide bands (apparent molecular weight 9 kD and 4 kD, respectively). By measuring of 77 K fluorescence spectra, it was shown that for the purified cytochrome b_559 there were two excitation peaks at 439 nm and 413 nm, and two emission peaks at 563 nm and 668 nm. This is the first indication that Cyt b_559 is able to emit fluorescence and also transfer excited electrons to chlorophyll. By the use of ultraviolet fluorescence spectra, it was demonstrated for the first time that the location of Trp residue could be in the hydrophobic transmembrane region of cytochrome b_559. 展开更多
关键词 cytochrome b_559 oxygen evolution PSⅡ core complexes Tricine_SDS_PAGE optical spectra
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Long-term alpha interferon and lamivudine combination therapy in non-responder patients with anti-HBe-positive chronic hepatitis B:Results of an open,controlled trial 被引量:10
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作者 M. Francesca Jaboli Carlo Fabbri +12 位作者 Stefania Liva Francesco Azzaroli Giovanni Nigro Silvia Giovanelli Francesco Ferrara Anna Miracolo Sabrina Marchetto Marco Montagnani Antonio Colecchia Davide Festi Letizia Bacchi Reggiani Enrico Roda Giuseppe Mazzella 《World Journal of Gastroenterology》 SCIE CAS CSCD 2003年第7期1491-1495,共5页
AIM: To investigate the safety and efficacy of long-term combination therapy with alpha interferon and lamivudine in non-responsive patients with anti-HBe-positive chronic hepatitis B.METHODS: 34 patients received com... AIM: To investigate the safety and efficacy of long-term combination therapy with alpha interferon and lamivudine in non-responsive patients with anti-HBe-positive chronic hepatitis B.METHODS: 34 patients received combination treatment (1 month lamivudine, 12 month lamivudine+interferon, 6month lamivudine), 24 received lamivudine (12 months),24 received interferon (12 months). Interferon was administered at 6 MU tiw and lamivudine at 100 mg orally once daily. Patients were followed up for 6 months after treatment.RESULTS: At the end of treatment, HBV DNA negativity rates were 88 % with lamivudine+interferon, 99 % with lamivudine and 55 % with interferon, (P=0.004, combination therapy vs. interferon, and P=0.001 lamivudine vs.interferon), and serum transaminase normalization rates were 84 %, 91% and 53 % (P=0.01 combination therapy vs. interferon, and P=0.012 lamivudine vs. interferon). Six months later, HBV DNA negativity rates were 44 % with lamivudine+interferon, 33 % with lamivudine and 25 % with interferon, and serum transaminase normalization rates were 61%, 42 % and 45 %, respectively, without statistical significance. No YMDD variants were observed with lamivudine+interferon (vs. 12 % with lamivudine). The combination therapy appeared to be safe. CONCLUSION: Although viral clearance and transaminase normalization are slower with long-term lamivudine+interferon than that with lamivudine alone, the combination regimen seems to provide more lasting benefits and to protect against the appearance of YMDD variants. Studies with other regimens regarding sequence and duration are needed. 展开更多
关键词 ADULT Antiviral Agents DOSAGE Drug Therapy Combination FEMALE Hepatitis B Chronic Humans INTERFERON-ALPHA LAMIVUDINE Male Middle Aged Reverse Transcriptase Inhibitors Treatment Outcome
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Extensive Computational Study on Conformations of Microsolvated Leucine Complexes
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作者 刘莎 胡安东 林子敬 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2012年第4期409-418,I0003,共11页
The conformations for leucine (Leu) hydrated with one to three water molecules, Leu-(H2O)n (n=1-3), were carefully searched by considering the trial structures generated by all possible combinations of rotamers ... The conformations for leucine (Leu) hydrated with one to three water molecules, Leu-(H2O)n (n=1-3), were carefully searched by considering the trial structures generated by all possible combinations of rotamers of Leu combined with all likely hydration modes. The structures were optimized at the BHandHLYP/6-31+G^* level and the single point energies were calculated at the BHandHLYP/6-311++G^** level. Good correspondence between the conformations of Leu-(H2O)n and bare Leu is found, showing that the conformations of Leu-(H2O)n may be efficiently and reliably determined by the hydration of Leu conformers. The simulated IR spectra of canonical and zwitterionic conformers of Leu-(H2O)n are compared with the experimental result of Leu in aqueous solution. The IR spectrum of zwitterionic Leu- (H2O)3 provides the best description of the experiment. The result demonstrates that the IR spectrum of solute in solution may be simulated by the solute hydrated with an adequate number of water molecules in the gas phase. 展开更多
关键词 Amino acid Hydration effect First principle calculation Potential energy surface IR spectrum
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Research Progress of Quality Characteristics and Comprehensive Utilization of Mung Beans 被引量:5
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作者 Qian TIAN Wenlan ZHANG +5 位作者 Qun LI Tingjin YAN Nana LI Shuang DAI Yanyan PU Hanfeng DING 《Agricultural Science & Technology》 CAS 2017年第1期127-133,136,共8页
Mung bean is one of the major legume crops in China, and its nutritional quality and processing quality directly affect the development of mung bean processing industry. In order to promote the development of mung bea... Mung bean is one of the major legume crops in China, and its nutritional quality and processing quality directly affect the development of mung bean processing industry. In order to promote the development of mung bean processing industry, the research progress of mung bean quality characteristics, including physical quality, nutritional quality, medicinal value and the processing quality, were summarized based on literatures both at home and abroad, and the current exploitation status of starch, protein, dietary fiber, resistant starch, flavonoids and superoxide dismutase of mung bean was also reviewed. In order to promote the development of mung bean processing industry, it should strengthen the research on quality characteristics and functional ingredients of mung bean, pay attention to the development of healthy products, improve the processing technology, and cultivate a group of leading mung bean processing companies with strong competence in the market. 展开更多
关键词 Mung bean Quality characteristics Comprehensive utilization
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Mechanisms of Difference in Mn Efficiency Between Wheat and Oilseed Rape 被引量:7
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作者 FANGZHENG ZHANGFUSUO 《Pedosphere》 SCIE CAS CSCD 2000年第3期213-220,共8页
By solution culture experiment, three wheat genotypes (Ttiticum aestivum L.) and two oilseed rape genotypes (Brassica napus L.) differing in Mn efficiency under Mn-deficient conditions were used to study mechanisms of... By solution culture experiment, three wheat genotypes (Ttiticum aestivum L.) and two oilseed rape genotypes (Brassica napus L.) differing in Mn efficiency under Mn-deficient conditions were used to study mechanisms of the difference in Mn efficiency between wheat and oilseed rape. The results showed that there were significant differences in the abilities of MnIV reduction and acidification in root rhizosphere between the two species. Compared with wheat, oilseed rape had much higher reducing capacity and intensity of rhizosphere acidification under Mn-deficient conditions. Moreover, the higher ratio of functional leaves Mn/old leaves Mn in oilseed rape than in wheat was also an important factor for the different Mn efficiencies between the two species. 展开更多
关键词 genotypic difference MECHANISM Mn efficiency oilseed rape whL
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