徐州方言“验”的含义无法在现代汉语词典中找到,然而其在方言中的含义却较为丰富,语用功能也值得探讨。本研究通过考察徐州方言“验”的句法分布和语义分类。在句法上,“验”可单独做副词、做副词性语素,也可形成独立句型。在语义上主...徐州方言“验”的含义无法在现代汉语词典中找到,然而其在方言中的含义却较为丰富,语用功能也值得探讨。本研究通过考察徐州方言“验”的句法分布和语义分类。在句法上,“验”可单独做副词、做副词性语素,也可形成独立句型。在语义上主要具有两种含义:“果真”和“恰巧”。在语用上,文章根据概念功能、人际功能和语篇功能这一分类考察了语用功能。在与预期之间的联系方面,文章发现徐州方言“验”具有合预期、反预期的功能,同时,具有反预期功能的“验”还具有预期修正功能。The meaning of “Yan” in the Xuzhou dialect cannot be found in modern Chinese dictionaries, but its meaning in the dialect is relatively rich, and its pragmatic function is also worth exploring. This study examines the syntactic distribution and semantic classification of “Yan” in the Xuzhou dialect. In terms of syntax, “Yan” can be used as an adverb, an adverb morpheme alone, or it can form an independent sentence pattern. There are two main meanings in semantics: “true” and “coincidental”. In terms of pragmatics, this paper examines pragmatic functions according to the classification of conceptual function, interpersonal function and discourse function. In terms of the connection with anticipation, this paper finds that the “Yan” of the Xuzhou dialect has the function of conforming to expectations and counter-expectations, and at the same time, the “Yan” with the function of anti-expectation also has the function of expectation corrections.展开更多
Based on the tropical cyclone data from the Central Meteorological Observatory of China, Japan Meteorological Agency, Joint Typhoon Warning Center and European Centre for Medium-Range Weather Forecasts （ECMWF） durin...Based on the tropical cyclone data from the Central Meteorological Observatory of China, Japan Meteorological Agency, Joint Typhoon Warning Center and European Centre for Medium-Range Weather Forecasts （ECMWF） during the period of 2004 to 2009, three consensus methods are used in tropical cyclone （TC） track forecasts. Operational consensus results show that the objective forecasts of ECMWF help to improve consensus skill by 2%, 3%-5% and 3%-5%, decrease track bias by 2.5 kin, 6-9 km and 10-12 km for the 24 h, 48 h and 72 h forecasts respectively over the years of 2007 to 2009. Analysis also indicates that consensus forecasts hold positive skills relative to each member. The multivariate regression composite is a method that shows relatively low skill, while the methods of arithmetic averaging and composite （in which the weighting coefficient is the reciprocal square of mean error of members） have almost comparable skills among members. Consensus forecast for a lead time of 96 h has negative skill relative to the ECMWF objective forecast.展开更多
The‘Two Oceans and One Sea’area(West Pacific,Indian Ocean,and South China Sea;15°S–60°N,39°–178°E)is a core strategic area for the‘21st Century Maritime Silk Road’project,as well as national ...The‘Two Oceans and One Sea’area(West Pacific,Indian Ocean,and South China Sea;15°S–60°N,39°–178°E)is a core strategic area for the‘21st Century Maritime Silk Road’project,as well as national defense.With the increasing demand for disaster prevention and mitigation,the importance of 10–30-day extended range prediction,between the conventional short-term(around seven days)and the climate scale(longer than one month),is apparent.However,marine extended range prediction is still a‘blank point’in China,making the early warning of marine disasters almost impossible.Here,the authors introduce a recently launched Chinese national project on a numerical forecasting system for extended range prediction in the‘Two Oceans and One Sea’area based on a regional ultra-high resolution multi-layer coupled model,including the scientific aims,technical scheme,innovation,and expected achievements.The completion of this prediction system is of considerable significance for the economic development and national security of China.展开更多
AIM:To assess whether gemcitabine-based combination therapy improves the prognosis of unresectable pancreatic cancer compared with gemcitabine treatment alone.METHODS:A quantitative up-to-date meta-analysis was undert...AIM:To assess whether gemcitabine-based combination therapy improves the prognosis of unresectable pancreatic cancer compared with gemcitabine treatment alone.METHODS:A quantitative up-to-date meta-analysis was undertaken to investigate the efficacy of gemcitabine-based combination treatment compared with gemcitabine monotherapy in locally advanced or metastatic pancreatic cancer.Inclusion was limited to highquality randomized clinical trials.RESULTS:Twenty-six studies were included in the present analysis,with a total of 8808 patients recruited.The studies were divided into four subgroups based on the different kinds of cytotoxic agents,including platinum,fluoropyrimidine,camptothecin and targeted agents.Patients treated with gemcitabine monotherapy had significantly lower objective response rate [risk ratio(RR),0.72;95% confidence interval(CI):0.63-0.83;P < 0.001],and lower 1-year overall survival(RR,0.90;95%CI:0.82-0.99;P = 0.04).Gemcitabine monotherapy caused fewer complications,including fewer grade 3-4 toxicities:including vomiting(RR,0.75;95%CI:0.62-0.89;P = 0.001),diarrhea(RR,0.66;95%CI:0.49-0.89;P = 0.006),neutropenia(RR,0.88;95%CI:0.72-1.06;P = 0.18),anemia(RR,0.96;95%CI:0.82-1.12;P = 0.60),and thrombocytopenia(RR,0.76;95%CI:0.60-0.97;P = 0.03) compared with gemcitabine combination therapies.CONCLUSION:Gemcitabine combination therapy provides a modest improvement of survival,but is associated with more toxicity compared with gemcitabine monotherapy.展开更多
Background Frailty is a new prognostic factor in cardiovascular medicine due to the aging and increasingly complex nature of elderly patients. It is useful and meaningful to prospectively analyze the manner in which f...Background Frailty is a new prognostic factor in cardiovascular medicine due to the aging and increasingly complex nature of elderly patients. It is useful and meaningful to prospectively analyze the manner in which frailty predicts short-term outcomes for elderly patients with acute coronary syndrome （ACS）. Methods Patients aged 〉 65 years, with diagnosis of ACS from cardiology department and geriatrics department were included from single-center. Clinical data including geriatrics syndromes were collected using Comprehensive Geriatrics Assessment. Frailty was defined according to the Clinical Frailty Scale and the impact of the co-morbidities on risk was quantified by the coronary artery disease （CAD）--specific index. Patients were followed up by clinical visit or telephone consultation and the median follow-up time is 120 days. Following-up items included all-cause mortality, unscheduled return visit, in-hospital and recurrent major adverse cardiovascular events. Multivariable regression survival analysis was performed using Cox regression. Results Of the 352 patients, 152 （43.18%） were considered frail according to the study instrument （5-7 on the scale）, and 93 （26.42%） were considered moderately or se- verely frail （6-7 on the scale）. Geriatrics syndromes including incontinence, fall history, visual impairment, hearing impairment, constipation, chronic pain, sleeping disorder, dental problems, anxiety or depression, and delirium were more frequently in frail patients than in non-frail patients （P = 0.000, 0.031, 0.009, 0.014, 0.000, 0.003, 0.022, 0.000, 0.074, and 0.432, respectively）. Adjusted for sex, age, severity of coro- nary artery diseases （left main coronary artery lesion or not） and co-morbidities （CAD specific index） by Cox survival analysis, frailty was found to be strongly and independently associated with risk for the primary composite outcomes： all-canse mortality [Hazard Ratio （HR） = 5.393; 95% CI： 1.477-19.692, P = 0.011] and unscheduled return visit （HR - 2.832; 95% CI： 1.140-7.037, P = 0.025）. Conclusions Comprehensive Geriatrics Assessment and Clinical Frail Scale were useful in evaluation of elderly patients with ACS. Frailty was strongly and independently associated with short-term outcomes for elderly patients with ACS.展开更多
Objective The objective of this study was to evaluate the clinical efficacy of a diaphragmatic suture with tubular stomach to prevent delayed gastric emptying(DGE) after esophagectomy through the cervico-thoracoabdomi...Objective The objective of this study was to evaluate the clinical efficacy of a diaphragmatic suture with tubular stomach to prevent delayed gastric emptying(DGE) after esophagectomy through the cervico-thoracoabdominal approach. Methods A total of 980 patients with esophageal cancer undergoing esophagectomy through the cervico-thoracoabdominal approach were retrospectively included in this study and divided into two groups. All patients underwent tubular stomach creation(group A; n = 530) or a diaphragmatic suture and tubular stomach creation(group B; n = 450). The incidence of early DGE was observed. Results The incidence of early DGE in group A was significantly higher than that in group B(P < 0.05). Conclusion This observation study suggests that the use of a diaphragmatic suture with tubular stomach through the cervico-thoracoabdominal approach can decrease the incidence of early DGE after esophagectomy.展开更多
Analyzing time series characteristics of red tide is the basis of disaster prevention and mitigation,which is very important to red tide prediction.There are trend comp onents and periodic components in annual time se...Analyzing time series characteristics of red tide is the basis of disaster prevention and mitigation,which is very important to red tide prediction.There are trend comp onents and periodic components in annual time series of occurrence freque ncy and area of red tides,so Gray-Periodic Extensional Combinatorial Model(GPECM)is used to extract these components.The fitting degree of occurrence frequency and area can reach 95.20% and 95.24%,respectively.The performance of GPECM is better than Gray Model,Fourier Series Extension Model,and Holt-Winter Exponential Smoothing Model in model stability.Consequently,it is used to forecast the occurrence frequency and area in 2020 and 2021,and results show that the annual frequency of red tides in 2020 and 2021 can rise to 39 and 41,respectively,and that the annual occurrence area of red tides can rise to 3168 km^(2),which is about 59% more than last year.In 2021,it can fall to 1901 km^(2).展开更多
A regional coupled prediction system for the Asia-Pacific(AP-RCP)(38°E-180°,20°S-60°N) area has been established.The AP-RCP system consists of WRF-ROMS(Weather Research and Forecast,and Regional Oc...A regional coupled prediction system for the Asia-Pacific(AP-RCP)(38°E-180°,20°S-60°N) area has been established.The AP-RCP system consists of WRF-ROMS(Weather Research and Forecast,and Regional Ocean Model System) coupled models combined with local observational information through dynamically downscaling coupled data assimilation(CDA).The system generates 18-day forecasts for the atmosphere and ocean environment on a daily quasi-operational schedule at Pilot National Laboratory for Marine Science and Technology(Qingdao)(QNLM),consisting of 2 different-resolution coupled models:27 km WRF coupled with 9 km ROMS,9 km WRF coupled with 3 km ROMS,while a version of 3 km WRF coupled with 3 km ROMS is in a test mode.This study is a first step to evaluate the impact of high-resolution coupled model with dynamically downscaling CDA on the extended-range predictions,focusing on forecasts of typhoon onset,improved precipitation and typhoon intensity forecasts as well as simulation of the Kuroshio current variability associated with mesoscale oceanic activities.The results show that for realizing the extended-range predictability of atmospheric and oceanic environment characterized by statistics of mesoscale activities,a fine resolution coupled model resolving local mesoscale phenomena with balanced and coherent coupled initialization is a necessary first step.The next challenges include improving the planetary boundary physics and the representation of air-sea and air-land interactions to enable the model to resolve kilometer or sub-kilometer processes.展开更多
文摘徐州方言“验”的含义无法在现代汉语词典中找到,然而其在方言中的含义却较为丰富,语用功能也值得探讨。本研究通过考察徐州方言“验”的句法分布和语义分类。在句法上,“验”可单独做副词、做副词性语素,也可形成独立句型。在语义上主要具有两种含义:“果真”和“恰巧”。在语用上,文章根据概念功能、人际功能和语篇功能这一分类考察了语用功能。在与预期之间的联系方面,文章发现徐州方言“验”具有合预期、反预期的功能,同时,具有反预期功能的“验”还具有预期修正功能。The meaning of “Yan” in the Xuzhou dialect cannot be found in modern Chinese dictionaries, but its meaning in the dialect is relatively rich, and its pragmatic function is also worth exploring. This study examines the syntactic distribution and semantic classification of “Yan” in the Xuzhou dialect. In terms of syntax, “Yan” can be used as an adverb, an adverb morpheme alone, or it can form an independent sentence pattern. There are two main meanings in semantics: “true” and “coincidental”. In terms of pragmatics, this paper examines pragmatic functions according to the classification of conceptual function, interpersonal function and discourse function. In terms of the connection with anticipation, this paper finds that the “Yan” of the Xuzhou dialect has the function of conforming to expectations and counter-expectations, and at the same time, the “Yan” with the function of anti-expectation also has the function of expectation corrections.
基金National Natural Science Foundation of Ningbo City(2013A610124)Ningbo Planning Project of Science and Technology(2012C50044)Nanhai Disaster Mitigation Fund of Hainan Provincial Meteorological Bureau(NH2008ZY02)
文摘Based on the tropical cyclone data from the Central Meteorological Observatory of China, Japan Meteorological Agency, Joint Typhoon Warning Center and European Centre for Medium-Range Weather Forecasts （ECMWF） during the period of 2004 to 2009, three consensus methods are used in tropical cyclone （TC） track forecasts. Operational consensus results show that the objective forecasts of ECMWF help to improve consensus skill by 2%, 3%-5% and 3%-5%, decrease track bias by 2.5 kin, 6-9 km and 10-12 km for the 24 h, 48 h and 72 h forecasts respectively over the years of 2007 to 2009. Analysis also indicates that consensus forecasts hold positive skills relative to each member. The multivariate regression composite is a method that shows relatively low skill, while the methods of arithmetic averaging and composite （in which the weighting coefficient is the reciprocal square of mean error of members） have almost comparable skills among members. Consensus forecast for a lead time of 96 h has negative skill relative to the ECMWF objective forecast.
基金supported by the National Key Research and Development Program of China(Grant Nos.2017YFC1404105,2017YFC1404100,2017YFC1404101,2017YFC1404102,2017YFC1404103 and 2017YFC1404104)
文摘The‘Two Oceans and One Sea’area(West Pacific,Indian Ocean,and South China Sea;15°S–60°N,39°–178°E)is a core strategic area for the‘21st Century Maritime Silk Road’project,as well as national defense.With the increasing demand for disaster prevention and mitigation,the importance of 10–30-day extended range prediction,between the conventional short-term(around seven days)and the climate scale(longer than one month),is apparent.However,marine extended range prediction is still a‘blank point’in China,making the early warning of marine disasters almost impossible.Here,the authors introduce a recently launched Chinese national project on a numerical forecasting system for extended range prediction in the‘Two Oceans and One Sea’area based on a regional ultra-high resolution multi-layer coupled model,including the scientific aims,technical scheme,innovation,and expected achievements.The completion of this prediction system is of considerable significance for the economic development and national security of China.
文摘AIM:To assess whether gemcitabine-based combination therapy improves the prognosis of unresectable pancreatic cancer compared with gemcitabine treatment alone.METHODS:A quantitative up-to-date meta-analysis was undertaken to investigate the efficacy of gemcitabine-based combination treatment compared with gemcitabine monotherapy in locally advanced or metastatic pancreatic cancer.Inclusion was limited to highquality randomized clinical trials.RESULTS:Twenty-six studies were included in the present analysis,with a total of 8808 patients recruited.The studies were divided into four subgroups based on the different kinds of cytotoxic agents,including platinum,fluoropyrimidine,camptothecin and targeted agents.Patients treated with gemcitabine monotherapy had significantly lower objective response rate [risk ratio(RR),0.72;95% confidence interval(CI):0.63-0.83;P < 0.001],and lower 1-year overall survival(RR,0.90;95%CI:0.82-0.99;P = 0.04).Gemcitabine monotherapy caused fewer complications,including fewer grade 3-4 toxicities:including vomiting(RR,0.75;95%CI:0.62-0.89;P = 0.001),diarrhea(RR,0.66;95%CI:0.49-0.89;P = 0.006),neutropenia(RR,0.88;95%CI:0.72-1.06;P = 0.18),anemia(RR,0.96;95%CI:0.82-1.12;P = 0.60),and thrombocytopenia(RR,0.76;95%CI:0.60-0.97;P = 0.03) compared with gemcitabine combination therapies.CONCLUSION:Gemcitabine combination therapy provides a modest improvement of survival,but is associated with more toxicity compared with gemcitabine monotherapy.
文摘Background Frailty is a new prognostic factor in cardiovascular medicine due to the aging and increasingly complex nature of elderly patients. It is useful and meaningful to prospectively analyze the manner in which frailty predicts short-term outcomes for elderly patients with acute coronary syndrome （ACS）. Methods Patients aged 〉 65 years, with diagnosis of ACS from cardiology department and geriatrics department were included from single-center. Clinical data including geriatrics syndromes were collected using Comprehensive Geriatrics Assessment. Frailty was defined according to the Clinical Frailty Scale and the impact of the co-morbidities on risk was quantified by the coronary artery disease （CAD）--specific index. Patients were followed up by clinical visit or telephone consultation and the median follow-up time is 120 days. Following-up items included all-cause mortality, unscheduled return visit, in-hospital and recurrent major adverse cardiovascular events. Multivariable regression survival analysis was performed using Cox regression. Results Of the 352 patients, 152 （43.18%） were considered frail according to the study instrument （5-7 on the scale）, and 93 （26.42%） were considered moderately or se- verely frail （6-7 on the scale）. Geriatrics syndromes including incontinence, fall history, visual impairment, hearing impairment, constipation, chronic pain, sleeping disorder, dental problems, anxiety or depression, and delirium were more frequently in frail patients than in non-frail patients （P = 0.000, 0.031, 0.009, 0.014, 0.000, 0.003, 0.022, 0.000, 0.074, and 0.432, respectively）. Adjusted for sex, age, severity of coro- nary artery diseases （left main coronary artery lesion or not） and co-morbidities （CAD specific index） by Cox survival analysis, frailty was found to be strongly and independently associated with risk for the primary composite outcomes： all-canse mortality [Hazard Ratio （HR） = 5.393; 95% CI： 1.477-19.692, P = 0.011] and unscheduled return visit （HR - 2.832; 95% CI： 1.140-7.037, P = 0.025）. Conclusions Comprehensive Geriatrics Assessment and Clinical Frail Scale were useful in evaluation of elderly patients with ACS. Frailty was strongly and independently associated with short-term outcomes for elderly patients with ACS.
文摘Objective The objective of this study was to evaluate the clinical efficacy of a diaphragmatic suture with tubular stomach to prevent delayed gastric emptying(DGE) after esophagectomy through the cervico-thoracoabdominal approach. Methods A total of 980 patients with esophageal cancer undergoing esophagectomy through the cervico-thoracoabdominal approach were retrospectively included in this study and divided into two groups. All patients underwent tubular stomach creation(group A; n = 530) or a diaphragmatic suture and tubular stomach creation(group B; n = 450). The incidence of early DGE was observed. Results The incidence of early DGE in group A was significantly higher than that in group B(P < 0.05). Conclusion This observation study suggests that the use of a diaphragmatic suture with tubular stomach through the cervico-thoracoabdominal approach can decrease the incidence of early DGE after esophagectomy.
文摘Analyzing time series characteristics of red tide is the basis of disaster prevention and mitigation,which is very important to red tide prediction.There are trend comp onents and periodic components in annual time series of occurrence freque ncy and area of red tides,so Gray-Periodic Extensional Combinatorial Model(GPECM)is used to extract these components.The fitting degree of occurrence frequency and area can reach 95.20% and 95.24%,respectively.The performance of GPECM is better than Gray Model,Fourier Series Extension Model,and Holt-Winter Exponential Smoothing Model in model stability.Consequently,it is used to forecast the occurrence frequency and area in 2020 and 2021,and results show that the annual frequency of red tides in 2020 and 2021 can rise to 39 and 41,respectively,and that the annual occurrence area of red tides can rise to 3168 km^(2),which is about 59% more than last year.In 2021,it can fall to 1901 km^(2).
基金supported by the National Key Research and Development Program of China(2017YFC1404100,2017YFC1404104)the National Natural Science Foundation of China(41775100,41830964)+1 种基金the Shandong Province’s"Taishan"Scientist Project(2018012919)the collaborative project between the Ocean University of China(OUC),Texas A&M University(TAMU)and the National Center for Atmospheric Research(NCAR)and completed through the International Laboratory for High Resolution Earth System Prediction(iHESP)-a collaboration among QNLM,TAMU and NCAR。
文摘A regional coupled prediction system for the Asia-Pacific(AP-RCP)(38°E-180°,20°S-60°N) area has been established.The AP-RCP system consists of WRF-ROMS(Weather Research and Forecast,and Regional Ocean Model System) coupled models combined with local observational information through dynamically downscaling coupled data assimilation(CDA).The system generates 18-day forecasts for the atmosphere and ocean environment on a daily quasi-operational schedule at Pilot National Laboratory for Marine Science and Technology(Qingdao)(QNLM),consisting of 2 different-resolution coupled models:27 km WRF coupled with 9 km ROMS,9 km WRF coupled with 3 km ROMS,while a version of 3 km WRF coupled with 3 km ROMS is in a test mode.This study is a first step to evaluate the impact of high-resolution coupled model with dynamically downscaling CDA on the extended-range predictions,focusing on forecasts of typhoon onset,improved precipitation and typhoon intensity forecasts as well as simulation of the Kuroshio current variability associated with mesoscale oceanic activities.The results show that for realizing the extended-range predictability of atmospheric and oceanic environment characterized by statistics of mesoscale activities,a fine resolution coupled model resolving local mesoscale phenomena with balanced and coherent coupled initialization is a necessary first step.The next challenges include improving the planetary boundary physics and the representation of air-sea and air-land interactions to enable the model to resolve kilometer or sub-kilometer processes.
