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甲骨文“■”、“■”、“■”字考
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作者 郭靜云 《甲骨文与殷商史》 2013年第1期197-221,共25页
壹、前言'■'、'率'字常見於甲骨用辭中。甲骨用辭在殷商占卜文化中有非常重要的作用,除了卜問、確認占卜結果、祭祀、祈禱過程外,也常帶有福祐辭的作用,或與其他福祐字詞組合成複合詞,如'用祐'、'用若'... 壹、前言'■'、'率'字常見於甲骨用辭中。甲骨用辭在殷商占卜文化中有非常重要的作用,除了卜問、確認占卜結果、祭祀、祈禱過程外,也常帶有福祐辭的作用,或與其他福祐字詞組合成複合詞,如'用祐'、'用若'、'用正'、'吉用'等。筆者通讀甲骨文用辭,而獲得初步理解:這些用辭如同金文,有時兼具雙向的解釋功能,既可作祭祀辭,同時也是福祐辭。此外,甲骨文用辭不僅出現在祭祀卜辭中。 展开更多
关键词 吉用 過程 雙向 結果 功能 甲骨 筆者
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Impact of Land-use Patterns on Distributed Groundwater Recharge and Discharge——A Case Study of Western Jilin,China 被引量:4
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作者 Moiwo Juana PAUL 《Chinese Geographical Science》 SCIE CSCD 2006年第3期229-235,共7页
The impact of land-use on distributed groundwater recharge and discharge in the western Jilin (WJ) was analyzed in this study. WJ is a transitional, semi-arid zone with a fragile, hydrological closed ecosystem in the ... The impact of land-use on distributed groundwater recharge and discharge in the western Jilin (WJ) was analyzed in this study. WJ is a transitional, semi-arid zone with a fragile, hydrological closed ecosystem in the Songhua River Basin (SRB). The research tool includes a seamlessly linked MODFLOW, WetSpass, the Seepage packages, and ArcGIS. The model calibration showed good agreement between simulated water table elevation and measured water table depths, while predicted groundwater discharge zones showed strong correlations with field occurrences of drainage systems and wetlands. Simulated averages for distributed recharge, water table elevation and groundwater drawdown were 377.42mm/yr, 194.43m, and 0.18m respectively. Forest vegetation showed the highest recharge, followed by ag- ricultural farmlands, while open-water and other drainage systems constituted groundwater exit zones. When present land-use conditions were compared with the hypothetical natural pre-development scenario, an overall loss of ground- water recharge (24.09mm/yr) was observed, which for the project area is 18.05×108m3. Groundwater abstraction seemed to be the cause of water table drawdown, especially in the immediate vicinities of the supply wells. An important issue of the findings was the ability of the hypothetical forest vegetation to protect, and hence sustain aquifer reserves and dependent ecosystems. The profound data capture capability of ArcGIS makes it particularly useful in spa- tio-temporal hydroecological modeling. 展开更多
关键词 land-use ECOSYSTEM GROUNDWATER RECHARGE DISCHARGE Western Jilin
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Application of Multivariate Model Based on Three Simulated Sensors for Water Quality Variables Estimation in Shitoukoumen Reservoir,Jilin Province,China 被引量:1
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作者 JIANG Guangjia LIU Dianwei +3 位作者 SONG Kaishan WANG Zongming ZHANG Bai WANG Yuandong 《Chinese Geographical Science》 SCIE CSCD 2010年第4期337-344,共8页
This study applied a multivariate model based on three simulated sensors to estimating water quality variables in Shitoukoumen Reservoir,Changchun City,Jilin Province,China,including concentration of total suspended m... This study applied a multivariate model based on three simulated sensors to estimating water quality variables in Shitoukoumen Reservoir,Changchun City,Jilin Province,China,including concentration of total suspended matter,concentration of chlorophyll-a and non-pigment matter absorption.Two field campaigns for spectra measurements with a total of 40 samples were carried out on June 13 and September 23,2008.The in-situ spectra were recalculated to the spectral bands and sensitivities of the instruments applied in this paper,i.e.Landsat TM,Alos and P6,by using the average method.And the recalculated spectra were used for estimating water quality variables by the single model and multivariate model.The results show that the multivariate model is superior to the single model as the multivariate model takes the combined effects of water components into consideration and can estimate water quality variables simultaneously.According to R2 and RMSE,Alos is superior to other sensors for water quality variables estimation although the precision of non-pigment matter absorption inversion performed the second. 展开更多
关键词 remote sensing inland water quality ALOS water components absorption absorption coefficient
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Application of principal component analysis to evaluation of black soil degradation in Jilin 被引量:1
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作者 NIU Cencen WANG Qing WEN Xiuyu GUO Yuan ZHAGN Penglei ZHU Rongyue HE Xianhui 《Global Geology》 2011年第1期54-58,共5页
Principal Component Analysis(PCA) can simplify the structure of database by replacing multi-dimensional parameters with relatively less comprehensive variables in order to ensure the minimum lost in initial data.In th... Principal Component Analysis(PCA) can simplify the structure of database by replacing multi-dimensional parameters with relatively less comprehensive variables in order to ensure the minimum lost in initial data.In this paper,eighteen black soil samples from different sites were tested and thirteen distinctive indexes were chosen to evaluate the degeneration of black soil.By using principal component analysis,variables of thirteen dimensions can be diminished to six unrelated principal indexes.Analysis shows that the soluble salt content,Fulvic acids(FA) and aggregation degree have a high weighing coefficient,indicating these three indexes are the major parts for the evaluation of black soil degradation.It also provides a new path to the degenerated black soil treatment in Northeast China. 展开更多
关键词 principal component analysis black soil soil degradation
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The Interaction of Population,Industry and Land in Process of Urbanization in China:A Case Study in Jilin Province 被引量:14
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作者 LIU Yanjun ZHOU Guolei +3 位作者 LIU Degang YU Huisheng ZHU Liyuan ZHANG Jing 《Chinese Geographical Science》 SCIE CSCD 2018年第3期529-542,共14页
Urbanization is a complex process that covers a wide range of topics, of which population, industry and land urbanization are three important aspects. Jilin Province is an important agricultural province in China. The... Urbanization is a complex process that covers a wide range of topics, of which population, industry and land urbanization are three important aspects. Jilin Province is an important agricultural province in China. The contradiction between population, industry and land urbanization is especially prominent here, and its coupling development is of great practical significance. In this paper, the coupling degree of population-industry-land urbanization in Jilin Province in 1990, 2000 and 2010 is measured by coupling mode. The spatial pattern of the coupling degree is analyzed by trend surface analysis and global and local spatial autocorrelation. The influence factors and their spatial differentiation are discussed using multiple linear regression(MLR) model and geographic weighted regression(GWR) model. The results show that: 1) the coupling degree of population-industry-land urbanization in Jilin Province is at a low level. Judging from the change of time scale, the urbanization of most research units is becoming more and more coordinated. From the comparison of spatial scales, there is significant spatial difference in the research units of different administrative levels. 2) Judging from the global change trend, the coupling degree of population-industry-land urbanization in the central region is higher than that in western and eastern regions. The coordination of urbanization in the central region is relatively good, and the distribution of the cold and hot spots is basically the same as that overall. 3) The spatial pattern of the coupling degree is related to the cold and hot spot distribution of the influence coefficient of urban population density and per capita urban construction land. The variation of the coupling degree spatial pattern is synchronous with the spatial change of the urban population density influence coefficient. 4) The degree of agglomeration of the urban population is the main factor promoting the coupling pattern of population-industry-land urbanization in Jilin Province, and the extent of its influence is gradually increasing. In addition, the level of city administrative, the efficiency of urban expansion and the capacity of market consumption also have an important influence on the coupling pattern. 展开更多
关键词 population urbanization industry urbanization land urbanization coupling relationship influence mechanism Jilin Province
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Three-Stage Six-Step Flue-Curing Technology for Viginia Tobacco Leaves and Its Application in China 被引量:1
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作者 Hongfeng Wang Houlong Jiang +3 位作者 Chen Xu Daibin Wang Chao Yang Bojun Wang 《Journal of Agricultural Science and Technology(A)》 2016年第4期232-238,共7页
In order to overcome the problem that the leaf yellowing stage in tobacco curing reduces the fragrance of the product, this study introduced the principle and key parameters of a three-stage six-step curing technology... In order to overcome the problem that the leaf yellowing stage in tobacco curing reduces the fragrance of the product, this study introduced the principle and key parameters of a three-stage six-step curing technology. The field trail was conducted in Wulong county of Chongqing city in 2010, and Virginia K326 was the tested cultivar. The middle leaves were harvested and plaited after maturity, and then cured with the three-stage six-step curing technology and traditional three-stage curing technology, respectively. Three replicates were established for each of the two curing technologies. Then, chemical constituents, aromatic substances and smoking quality were analyzed. The results show that compared with the traditional three-stage curing technology, the three-stage six-step curing technology produces more suitable ratios of chemical constituents, higher aromatic component content and higher smoking quality grade of tobacco leaves. Therefore, the continuous improvement of corollary equipment and matching technologies is expected to widen the applications of the three-stage six-step curing technology in tobacco and provide a strong technical support for the development of the tobacco industry. 展开更多
关键词 Flue-cured tobacco curing technology quality index.
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Comparison of pharmacokinetics,efficacy and toxicity profile of gemcitabine using two different administration regimens in Chinese patients with non-small-cell lung cancer 被引量:1
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作者 WANG Lin-run LIU Jian HUANG Ming-zhu XU Nong 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2007年第5期307-313,共7页
Objective: To conduct a randomized comparative trial of pharmacokinetics, efficacy and toxicity profile treatment with 1200 mg/m^2 gemcitabine using standard 30-min infusion or fixed dose rate (FDR) infusion [10 mg... Objective: To conduct a randomized comparative trial of pharmacokinetics, efficacy and toxicity profile treatment with 1200 mg/m^2 gemcitabine using standard 30-min infusion or fixed dose rate (FDR) infusion [10 mg/(m^2-min)] on days 1 and 8 plus carboplatin AUC (area under curve) 5 on day 1 in Chinese non-small-cell cancer patients. Twelve patients were enrolled in this study. Methods: Plasma gemcitabine concentrations were measured by ion-pair reversed phase high performance liquid chromatography. Antitumoral activity and toxicity of gemcitabine was assessed according to World Health Organization criteria. Results: The obtained mean parameters, such as T1/2 (elimination half time), AUC, and CL (clearance), were consistent with those reported in literature. Qualified response rate in our study was 33.3% for standard arm and 50% for FDR ann. Additional 50% and 33.3% patients contracted stable disease (SD) in standard arm and FDR arm, respectively. The predominant toxicity was hematologic, and patients in the standard infusion ann experienced consistently more hematologic toxicity, Conclusion: Pharmacokinetic and clinical data in this trial support the continued evaluation of the FDR infusion strategy with gemcitabine. 展开更多
关键词 GEMCITABINE Non-small-cell lung cancer PHARMACOKINETICS Qualified response Safety
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Level of Independence in Georgia Throughout the 14th Century
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作者 Giuli Alasania 《Journal of Literature and Art Studies》 2016年第8期964-978,共15页
In 1329-1334, George the Brilliant took advantage of the situation created in the llkhanate, eliminated his political opponents and restored the territorial integrity of Georgia. He created a solid legal basis for the... In 1329-1334, George the Brilliant took advantage of the situation created in the llkhanate, eliminated his political opponents and restored the territorial integrity of Georgia. He created a solid legal basis for the country and regulated the ecclesiastic area. He was in West Georgia in 1329-1332/1333. The llkhanid coin was not minted in Georgia during that period; yet, soon the king of Georgia, which had already been united by that time, restored relations with llkhanids and returned to Tbilisi, which implied making the already united Georgia subject to Mongols. Ilkhanid coins and later, coins of Chobanids, the Golden Horde and Jalayirids circulated during the reign of George the Brdhant. In 1338-1339 George the Brilliant conquered Ossetia and Ilkhanid coins were disseminated on the territory of the Golden Horde after that. Formally, Georgia remained under the control of Ilkhanids, which was replaced by Chobanids in 1338 and the governors of the Golden Horde in 757/1356; and in parallel and afterwards by Jalayirids, which is evidenced by written sources as well as numismatic data; Despite formal dependence on the foreign power, which is evidenced by the deployment of 10,000 troops at the border of Georgia as well, the country enjoyed a rather wide internal autonomy. Participation of George the Brilliant in sending envoys for the purpose of the redemption of the Jvari (Cross) Monastery in Palestine in 1316/7, 1320 cannot be assumed. It seems that in those years envoys were sent by Constantine, the king of West Georgia. All the above do not diminish the merits of George V to the Georgian nation and his historic role in terms of the political unification of the country, the creation of a legal basis for it and the regulation of ecclesiastic affairs--the accomplishments of the king, who deservedly bears the name "the Brilliant". 展开更多
关键词 George the Brilliant Mongols the Ilkhanate Georgia
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Re-Os isotopic dating and geological significance of molybdenite from Xintian Cu-Mo polymetallic deposit in Yanbian,Jilin
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作者 YIN Yue CUI Bo +4 位作者 WANG Li WANG Linlin HUO Liang LI Liang DUAN Hongchang 《Global Geology》 2018年第3期177-185,共9页
Xintian polymetallie deposit is a hydrothermal vein type Cu-Mo deposit. Analysis on Re-Os isotopic dating for the molybdenite from this deposit is undertaken to determine metallogenic epoch and dynamics setting of the... Xintian polymetallie deposit is a hydrothermal vein type Cu-Mo deposit. Analysis on Re-Os isotopic dating for the molybdenite from this deposit is undertaken to determine metallogenic epoch and dynamics setting of the deposit. Re-Os isotopic dating for the molybdenite yields model ages ranging from 123.9 ± 1.9 Ma to 124.7 ± 1.8 Ma, with a weighted mean age of 123.4 ±0.81 Ma, and an isochron age of 127 ± 16 Ma, MSWD = 0.25, indicating that the metallization was at late Yanshanian. The content of Re in molybdenite is (330.1 ±4.0-367.9 ± 3.1 ) xl0^-6, which demonstrates mantle derived metallogenic sources. Integrating the region-al tectonic evolution and the metallogenic characteristics of other contemporaneous Cu-Mo deposits in the re-gion, it is suggested that the Cu-Mo mineralization of this deposit occurred in an active epieontinental environ-ment under lithospheric extension resulted from the subduction of the Izanagi plate to the Paleo-Asia continental margin at late Yanshanian. The Mantle wedge was partially melted with large amount of metallogenic elements dissolved in it. Under the favorable conditions of crust-mantle interaction, large-scale magmatic activity turns out to be the important mechanism of the mineralization of many Cu-Mo deposits in the Xiaoxingan Range-Zhangguangcai Mountain metallogenic belt, including the Xintian Cu-Mo polymetallic deposit. 展开更多
关键词 Re-Os isotope MOLYBDENITE Xintian Yanbian Cu-Mo polymetallic deposit
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Non-equilibrium State Salt-forming Phase Diagram:Utilization of Bittern Resource in High Efficiency 被引量:3
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作者 周桓 陈亚东 +4 位作者 康启宇 张建波 张红丽 袁建军 沙作良 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2010年第4期635-641,共7页
Salt-forming regions for a complex salt-water system in non-equilibrium state of evaporation process are usually different from those in solubility diagrams.To understand the solid-forming region of NaCl and improve t... Salt-forming regions for a complex salt-water system in non-equilibrium state of evaporation process are usually different from those in solubility diagrams.To understand the solid-forming region of NaCl and improve the utilization of bittern resources,experiments were carried out to evaporate 20 representative mixture solution samples of Na ^+,Mg ^2+ //Cl^-, SO4^2--H2O system with an average evaporation intensity of(1.4±0.4) g·L^-1 ·min^-1(water) at boiling temperature 348 K,and determine the NaCl solid-forming regions in non-equilibrium state.Because of the complexity of salt-forming region,a maximal region and a minimal region were proposed to express the non-equilibrium state salt-forming region with different crystal seed,and a conditional salt-forming region was proposed to present the characteristic region of non-equilibrium salt-forming phase diagram.The areas of the maximal and minimal regions are 2.00 and 1.56 times those in solubility diagram,so it is possible to utilize bittern resources in high efficiency.The recovery rates of NaCl were 99.65%,93.14%,88.57%,72.76%,and 83.68%for six typical bittern sources from Tulantai Salt Lake(China),Dongtai Salt Lake(China) ,Jilantai Salt Lake(China),Qarun Salt Lake(Egypt) and seawater,respectively.It is testified that the non-equilibrium state salt-forming phase diagram can be used in industrial processes. 展开更多
关键词 phase diagram non-equilibrium state EVAPORATION salt-forming BITTERN
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On resource survey of natural mineral drugs in eastern Jilin and their sustaining application
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作者 LI Xian-zhou LIU Li-hua +2 位作者 YANG He-ting NING Wei-kun FAN Wen 《Journal of Geoscientific Research in Northeast Asia》 2005年第1期142-145,共4页
There are rich natural resources of natural mineral drugs in eastern Jilin Province. Systematic resource investigation can elevate fractional conversion of this area' s mineral drugs resources superiority. Researc... There are rich natural resources of natural mineral drugs in eastern Jilin Province. Systematic resource investigation can elevate fractional conversion of this area' s mineral drugs resources superiority. Research on natural mineral drugs of this area can upgrade the translation rate of resource superiority and accelerate the development of local medical industry, especially, it can provide scientific data for founding the strategic design of Chinese traditional medicine's trademark of Jilin Changbai Mountain. Since the resource of mineral drugs can not be regenerated, it must be exploited scientifically, utilized reasonably and protected effectively its sustaining application. 展开更多
关键词 natural mineral drugs sustaining use eastern Jilin
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Research on compound plugging removal technology and its application in Xinmu oilfield of Jilin
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作者 WANG Xianfeng MO Xiuwen 《Global Geology》 2012年第3期252-256,共5页
Most fault-block reservoirs in Xinmu oilfield belong to heterogeneous sandstone in characters which has low permeability, and reservoir pollution is a common phenomenon in this area. Acidizing deplugging in oil wells ... Most fault-block reservoirs in Xinmu oilfield belong to heterogeneous sandstone in characters which has low permeability, and reservoir pollution is a common phenomenon in this area. Acidizing deplugging in oil wells has become one of the major measures to improve production efficiency in the field. A compound deplug- ging technology in high efficiency low corrosion is developed for this kind of low permeability sandstone reser- voir. On the basis of profoundly understanding of the reservoir's physical properties and sensitivity, along with comprehensive analysis of the cause for jams in oil wells, a series of experiments are carried out in order to in- vestigate the dissolution reaction among samples and deplugging inhibitor, sample dissolving speed, formation fluid compatibility, reduction of secondary pollution, etc. Considered reservoir condition in nearby wells the op- timized compositional deplugging liquid formula is selected for this reservoir. It is featured by reducing the de- plugging reaction speed, extending solution for processing radius, preventing secondary damage in dissolution processing, and removing plug pollution effectively. To implement this high efficiency low corrosion deplugging measure based on reservoir condition in the borehole and nearby wells, a relatively better result of deplugging and production increasing is achieved, which enriches the measures to increase production in Xinmu oilfield, and this method can be applied to other similar oiffields for the purpose of maintaining the crude oil production and providing assistant for increasing the production significantly. 展开更多
关键词 compound plugging removal technology performance evaluation field application Xinmu oilfield
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RESPONSES OF WETLAND ECO SECURITY TO LAND USE CHANGE IN WESTERN JILIN PROVINCE, CHINA
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作者 WANG Zhi-qiang ZHANG Bai +2 位作者 YANG Guang WANG Zong-ming ZHANG Shu-qing 《Chinese Geographical Science》 SCIE CSCD 2005年第4期330-336,共7页
By the use of the software of ARCGIS, dynamic changes of the landscape elements, landscape structure, conversion processes of the landscape gradients and the responses of wetland eco-security to land use/cover changes... By the use of the software of ARCGIS, dynamic changes of the landscape elements, landscape structure, conversion processes of the landscape gradients and the responses of wetland eco-security to land use/cover changes (LUCC) in the western Jilin Province were studied from 1930 to 2000. The results show that the landscape elements of grassland, wetland, forestland and water area shrank rapidly, and wetlands underwent huge losses in the study period due to the conversion from wetland into arable land and grassland in large quantities. The responses of wetland eco-security to LUCC were inverse evolvement of wetland vegetation, loss of biodiversity, water deficiency in wetland ecosystem, the changes of the heterogeneity of wetlands and the fragmentation of the wetland habitats. Suggestions were given for protection of wetlands and the regional sustainable development. 展开更多
关键词 LUCC wetland eco-security RS GIS western Jilin Province
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Spatial and seasonal dynamics of soil loss ratio in mountain rangelands of south-western Kyrgyzstan
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作者 Maksim KULIKOV Udo SCHICKI-IOFF Peter BORCHARDT 《Journal of Mountain Science》 SCIE CSCD 2016年第2期316-329,共14页
Vegetation cover is the main factor of soil loss prevention.The C-factor of the RUSLE(Revised Universal Soil Loss Equation) was predicted with NDVI,ground data and exponential regression equation for mountain rangelan... Vegetation cover is the main factor of soil loss prevention.The C-factor of the RUSLE(Revised Universal Soil Loss Equation) was predicted with NDVI,ground data and exponential regression equation for mountain rangelands of Kyrgyzstan.Time series of C-factor,precipitation and temperature were decomposed into seasonal and trend components with STL(seasonal decomposition by loess) to assess their interrelations.C-factor,precipitation and temperature trend components indicated significant lagged correlation,whereas seasonal components indicated more complex relations with climate factors which can be promoting as well as limiting factors for vegetation development,depending on the season.Rainy springs and hot summers may increase soil loss dramatically,whereas warm and dry springs with rainy summers can decrease it.Steep slopes indicated higher soil loss ratio,whereas flat areas were better protected by vegetation. 展开更多
关键词 Soil loss ratio C-FACTOR RUSLE NDVI Time series Remote sensing
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Heavy Charged Gauge Bosons with General CP Violating Couplings
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作者 Mojtaba Mohammadi Najafabadi 《Communications in Theoretical Physics》 SCIE CAS CSCD 2010年第6期1137-1139,共3页
Heavy gauge bosons such as W' are expected to exist in many extensions of the Standard Model. In this paper, the most general Lagrangian for the interaction of W' with top and bottom quarks is considered. This Lagra... Heavy gauge bosons such as W' are expected to exist in many extensions of the Standard Model. In this paper, the most general Lagrangian for the interaction of W' with top and bottom quarks is considered. This Lagrangian consists of V- A and V + A structure with in general complex couplings. Such interactions produce an Electric Dipole Moment (EDM) for the top quark at one loop level. We predict the allowed ranges for the mass and couplings of W' by using the upper limit on the top quark EDM. 展开更多
关键词 heavy gauge boson electric dipole moment
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Wbselen and gemcitabine synergistically inhibited the viability of JF305 and MiaPaCa-2 human pancreatic cancer cells
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作者 回艺 马微微 +1 位作者 熊堃 曾慧慧 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2013年第2期177-183,共7页
Gemcitabine (GEM) is a cell-cycle specific inhibitor of DNA synthesis and repair, and has been applied as the first-line therapy for patients with locally advanced or metastatic pancreatic cancers. However, the medi... Gemcitabine (GEM) is a cell-cycle specific inhibitor of DNA synthesis and repair, and has been applied as the first-line therapy for patients with locally advanced or metastatic pancreatic cancers. However, the median survival time is only 5.65 mon when GEM was administrated as a monothearpy. Therefore, novel therapeutic agents and/or combinations with GEM are needed for the treatment of pancreatic cancer. In this study, we aim to evaluate the efficacy of treatment with wbselen (WB), GEM, and combination treatment with GEM and WB in two pancreatic cancer cell lines, JF305 and MiaPaCa-2 cells. The combination index (CI) and the dose-reduction index (DRI) of combined treatment with different dose and time regimes were analyzed based on median-effect theory. Compared with single treatment with GEM, combination treatment displayed decreased response time and IC 50 , and increased maximum inhibition. Among the different combination regimes, the most significant synergistic effect was achieved when the dose ratios of WB to GEM was 2:1 in JF305 cells and 1:1 in MiaPaCa-2 cells after 48 h of drug treatment. When combinations of WB and GEM were used in these two cell lines, the dose of GEM was significantly reduced while the total drug concentration increased, especially after 48 h of drug treatments. Our results indicated that the combination treatment with WB and GEM had synergistic effect against pancreatic cancer in vitro. 展开更多
关键词 Wbselen Gemcitabine Synergistic effect
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Concomitant administration of gastric acid suppression might attenuates the clinical efficacy of gefitinib:a single cancer center retrospective study 被引量:3
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作者 Zihan Guo Qiong Du +4 位作者 Xuan Ye Feifei Gao Yufang You Bo Yu Qing Zhai 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2020年第3期192-198,共7页
Recent pharmacokinetic studies have demonstrated that gastric acid suppression(AS)reduces exposure of gefitinib.However,the clinical significance of this drug-drug interaction(DDI)has not been determined.We,therefore,... Recent pharmacokinetic studies have demonstrated that gastric acid suppression(AS)reduces exposure of gefitinib.However,the clinical significance of this drug-drug interaction(DDI)has not been determined.We,therefore,evaluated it in this real-world study.A total of 200 NSCLC patients who received gefitinib from 2016 to 2018 at Fudan University Shanghai Cancer Center(FUSCC)were randomly selected.The patients were divided into two groups according to whether AS was used.The clinical characteristics of the patients were collected,and the efficacy and safety of gefitinib were compared between the two groups.We showed that 188 patients were considered eligible for this retrospective analysis,49 received AS(AS user group),while 139 patients did not(AS non-user group).Objective response rate(ORR)and disease control rate(DCR)in the AS user group versus AS non-user group were 69.4%versus 73.4%(P=0.591)and 89.8%versus 90.6%(P=0.486),respectively,while the progression-free survival(PFS)were 9.7 versus 12.2 months(P=0.0644).No significant difference in ORR,DCR or PFS was observed between the two groups.Further study showed that the PFS was related to the time of co-administration,and the patients receiving over 50%AS prescription overlap with gefitinib was significantly less compared with the other people(8.4 vs 12.6 months,P=0.0004).The frequencies of rash(8.2%vs 15.1%,P=0.281),diarrhea(4.1%vs 6.5%,P=0.539)and elevated ALT or AST level(6.1%vs 10.1%,P=0.407)were similar for both groups.Therefore,concomitant use of AS and gefitinib might affect the efficacy of gefitinib,which should be avoided if possible. 展开更多
关键词 Drug interactions Gastric acid suppression GEFITINIB Clinical impact
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