Objective:The aim of the study was to compare the efficacy,side effect and influence on the survival rate of two chemotherapy regimens,paclitaxel liposome combined with platinum and paclitaxel combined with platinum,i...Objective:The aim of the study was to compare the efficacy,side effect and influence on the survival rate of two chemotherapy regimens,paclitaxel liposome combined with platinum and paclitaxel combined with platinum,in concurrent chemoradiotherapy for cervical carcinoma.Methods:The 162 cases with primary cervical carcinoma diagnosed between January 2008 and November 2009 in Jiangxi Maternal and Child Health Hospital(China) were enrolled in this randomized controlled trial.Seventy-one cases were included in paclitaxel group and 91 in paclitaxel liposome group.And the chemotherapy doses were as follows:paclitaxel liposome and paclitaxel 135 mg/m2;cisplatin 80 mg/m2 or carboplatin AUC 4-6;then repeated every 21 days for two or three times.Radical radiotherapy was given to both groups at the same time.Efficacy was evaluated according to the tumor regression six months later and follow-up was done consistently.Results:The overall response rates of paclitaxel group and paclitaxel liposome group were 90.1% and 89 % respectively(P > 0.05).The one year cumulative survival was 91.4% for paclitaxel group and 89.2% for paclitaxel liposome group(P > 0.05).The incidence rates of adverse effects such as rash,gastrointestinal toxicity,bone marrow suppression and muscle/joint pain in paclitaxel liposome group were much lower than those in paclitaxel group(P < 0.05),while there was no difference regarding hair loss,hepatic function damage,peripheral neuritis and other aspects(P > 0.05).Conclusion:Paclitaxel liposome plus platinum is a safe and effective method for staging IIa-IV cervical carcinomas.While the long-term efficacy should be further observed.展开更多
We read the research article entitled Is cardiac resyn- chronisation therapy feasible, safe and beneficial in the very elderly? with great interest. The authors emphasized that despite the average age of heart failur...We read the research article entitled Is cardiac resyn- chronisation therapy feasible, safe and beneficial in the very elderly? with great interest. The authors emphasized that despite the average age of heart failure was 77 years in the general population of UK,patients receiving cardiac re- synchronisation therapy [with pacemaker alone (CRT-P) or with additional defibrillator capabilities (CRT-D)] were on younger ages at 72 and 67 years respectively. In the lights of this data, we agree with the authors that CRT seems to be undemtilized in the elderly patients with heart failure.展开更多
In this paper,we study the advantages of cooperation in broadcasting systems from a geosynchronous earth orbit(GEO)satellite to mobile terminals(MTs),achieved through a terrestrial complementary ground station(CGS) wi...In this paper,we study the advantages of cooperation in broadcasting systems from a geosynchronous earth orbit(GEO)satellite to mobile terminals(MTs),achieved through a terrestrial complementary ground station(CGS) with fixed installment,which acts as a relay.Moreover and in the context of the digital video broadcasting-satellite-to-handheld(DVB-SH) standard,the performance improvements offered by the rotated constellations method are investigated,where prior transmission,a phase rotation of the transmitted symbols by a fixed angle is applied followed by a random component interleaver.Turbo codes with soft decision decoding and appropriate random channel interleavers are also considered.We present analytical expressions for the bit log-likelihood ratios(LLRs)that are needed for soft decision decoding at the MT turbo decoder,while the code combining technique is adapted to improve the end-to-end(E2E) performance.Then,we obtain through extensive computer simulations the average bit error probability(ABEP) of quadrature phase-shift keying(QPSK) signals received over pure land-mobile satellite(LMS)and pure CGS links for coding rates 1/3 and6/7.Moreover,the optimal rotation angles are obtained for both links.E2 E ABEP results are then presented assuming cooperation between GEO and CGS,while the power allocation issue is investigated under fixed total transmission power.Our performance evaluation results show that by using the constellation rotation technique,a performance gain can be achieved for high coding rates.展开更多
文摘Objective:The aim of the study was to compare the efficacy,side effect and influence on the survival rate of two chemotherapy regimens,paclitaxel liposome combined with platinum and paclitaxel combined with platinum,in concurrent chemoradiotherapy for cervical carcinoma.Methods:The 162 cases with primary cervical carcinoma diagnosed between January 2008 and November 2009 in Jiangxi Maternal and Child Health Hospital(China) were enrolled in this randomized controlled trial.Seventy-one cases were included in paclitaxel group and 91 in paclitaxel liposome group.And the chemotherapy doses were as follows:paclitaxel liposome and paclitaxel 135 mg/m2;cisplatin 80 mg/m2 or carboplatin AUC 4-6;then repeated every 21 days for two or three times.Radical radiotherapy was given to both groups at the same time.Efficacy was evaluated according to the tumor regression six months later and follow-up was done consistently.Results:The overall response rates of paclitaxel group and paclitaxel liposome group were 90.1% and 89 % respectively(P > 0.05).The one year cumulative survival was 91.4% for paclitaxel group and 89.2% for paclitaxel liposome group(P > 0.05).The incidence rates of adverse effects such as rash,gastrointestinal toxicity,bone marrow suppression and muscle/joint pain in paclitaxel liposome group were much lower than those in paclitaxel group(P < 0.05),while there was no difference regarding hair loss,hepatic function damage,peripheral neuritis and other aspects(P > 0.05).Conclusion:Paclitaxel liposome plus platinum is a safe and effective method for staging IIa-IV cervical carcinomas.While the long-term efficacy should be further observed.
文摘We read the research article entitled Is cardiac resyn- chronisation therapy feasible, safe and beneficial in the very elderly? with great interest. The authors emphasized that despite the average age of heart failure was 77 years in the general population of UK,patients receiving cardiac re- synchronisation therapy [with pacemaker alone (CRT-P) or with additional defibrillator capabilities (CRT-D)] were on younger ages at 72 and 67 years respectively. In the lights of this data, we agree with the authors that CRT seems to be undemtilized in the elderly patients with heart failure.
基金Support to the SatNEx-Ⅲ Network of Experts (SatNEx-Ⅲ) CoO2,2011-2012
文摘In this paper,we study the advantages of cooperation in broadcasting systems from a geosynchronous earth orbit(GEO)satellite to mobile terminals(MTs),achieved through a terrestrial complementary ground station(CGS) with fixed installment,which acts as a relay.Moreover and in the context of the digital video broadcasting-satellite-to-handheld(DVB-SH) standard,the performance improvements offered by the rotated constellations method are investigated,where prior transmission,a phase rotation of the transmitted symbols by a fixed angle is applied followed by a random component interleaver.Turbo codes with soft decision decoding and appropriate random channel interleavers are also considered.We present analytical expressions for the bit log-likelihood ratios(LLRs)that are needed for soft decision decoding at the MT turbo decoder,while the code combining technique is adapted to improve the end-to-end(E2E) performance.Then,we obtain through extensive computer simulations the average bit error probability(ABEP) of quadrature phase-shift keying(QPSK) signals received over pure land-mobile satellite(LMS)and pure CGS links for coding rates 1/3 and6/7.Moreover,the optimal rotation angles are obtained for both links.E2 E ABEP results are then presented assuming cooperation between GEO and CGS,while the power allocation issue is investigated under fixed total transmission power.Our performance evaluation results show that by using the constellation rotation technique,a performance gain can be achieved for high coding rates.