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脑科ICU院内感染鲍曼不动杆菌的分子分型和耐药机制研究
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作者 张琼丽 张荣 《中国社区医师(医学专业)》 2008年第22期11-11,共1页
目的:分析脑科监护室院内感染的鲍曼不动杆菌的同源性,并研究其主要耐药机制。主要是A型克隆株,对头孢菌素和碳青烯类抗生素的耐药性主要是由于产OXA-23型碳青霉烯酶。
关键词 院内感染 鲍曼不动杆菌 同源性耐药机制
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基于三层分治结构的领域类库模型设计 被引量:2
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作者 杨鹤标 丁勇 杜江 《江苏大学学报(自然科学版)》 EI CAS 北大核心 2005年第6期521-524,共4页
针对中轻量级领域类库构造中,缺乏构造技术支持及管理维护机制不完善的问题,提出了三层分治结构(Triple-CommuneArchitecture)的领域类库模型,从类部件的功能特征和应用层面,对类库进行横向分类和纵向划分,确定其结构组织形式;采用同源... 针对中轻量级领域类库构造中,缺乏构造技术支持及管理维护机制不完善的问题,提出了三层分治结构(Triple-CommuneArchitecture)的领域类库模型,从类部件的功能特征和应用层面,对类库进行横向分类和纵向划分,确定其结构组织形式;采用同源类链式继承机制,解决类库的扩展及版本升级问题;利用自定义的类部件形式化描述语言,对类库进行形式化描述,对类部件的属性、方法、关系以及其他相关信息进行定义,从而完成类库的维护和管理.在ERP类库原型系统研发中表明该模型提高了软件复用和开发的效率. 展开更多
关键词 领域类库 软件复用 形式化描述 类部件 同源机制
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细菌内构建复制缺陷型人肝细胞生长因子重组腺病毒及其对肝细胞株L02细胞周期的影响
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作者 林勇 张新 《胃肠病学》 2001年第C00期185-185,共1页
关键词 肝细胞株L02 细胞周期 细菌内同源重组机制 缺陷型重组腺病毒 肝细胞增殖
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CRISPR-Cas基因组改造技术研究进展 被引量:10
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作者 颜雯 李海涛 +1 位作者 向华 王晓虎 《广东农业科学》 CAS CSCD 北大核心 2014年第2期149-152,共4页
CRISPRs-Cas系统是一种细菌获得性免疫系统,为一段规律成簇间隔短回文重复,保护细菌和古生菌免遭病毒、质粒等的入侵。这种免疫系统是由一种小RNA和多结构域蛋白质/蛋白复合物构成,其作用机理可能与真核生物的RNA干扰过程类似。这个系... CRISPRs-Cas系统是一种细菌获得性免疫系统,为一段规律成簇间隔短回文重复,保护细菌和古生菌免遭病毒、质粒等的入侵。这种免疫系统是由一种小RNA和多结构域蛋白质/蛋白复合物构成,其作用机理可能与真核生物的RNA干扰过程类似。这个系统已发展为一种高效、特异、操作简单易行的基因修饰工具,与TALEN、ZFN相比,CRISPR-Cas系统的出现使得基因编辑变得更加有效和简易,具有更大的潜力。CRISPR/Cas系统已成功应用到细胞、干细胞、小鼠、斑马鱼及植物等多种生物,显示了其强大的基因编辑优点。综述了CRISPR-Cas系统的技术原理及其在生物学研究中的应用最新研究进展,并探讨了该技术的发展前景。 展开更多
关键词 规律成簇间隔短回文重复(CRISPRs) 内切酶 同源重组机制 同源末端连接机制 脱靶效应
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A homological multi-information fusion method for processing gastric tumor tissue pathological images 被引量:1
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作者 李天钢 王素品 秦辰 《Journal of Medical Colleges of PLA(China)》 CAS 2005年第5期285-293,共9页
A homological multi-information image fusion method was introduced for recognition of the gastric tumor pathological tissue images.The main purpose is that fewer procedures are used to provide more information and the... A homological multi-information image fusion method was introduced for recognition of the gastric tumor pathological tissue images.The main purpose is that fewer procedures are used to provide more information and the result images could be easier to be understood than any other methods.First,multi-scale wavelet transform was used to extract edge feature,and then watershed morphology was used to form multi-threshold grayscale contours.The research laid emphasis upon the homological tissue image fusion based on extended Bayesian algorithm,which fusion result images of linear weighted algorithm was used to compare with the ones of extended Bayesian algorithm.The final fusion images are shown in Fig 5.The final image evaluation was made by information entropy,information correlativity and statistics methods.It is indicated that this method has more advantages for clinical application. 展开更多
关键词 homological multi-information pathological tissue images wavelet transform watershed morphology image fusion
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Focal Fault of the 1999 Datong M_S5.6 Earthquake in Shanxi Province 被引量:1
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作者 WangYan DioGuiling 《Earthquake Research in China》 2002年第4期363-368,共6页
Several earthquakes with M S≥5.0 occurred in the Datong seismic region in 1989, 1991 and 1999. The precise focus location of the earthquake sequence was made by the records of the remote sensing seismic station netwo... Several earthquakes with M S≥5.0 occurred in the Datong seismic region in 1989, 1991 and 1999. The precise focus location of the earthquake sequence was made by the records of the remote sensing seismic station network in Datong. Using that data together with macro-intensity distribution and focal mechanism solutions, we analyze the difference among three subsequences. The results show that the focal fault of the 1999 M S5.6 earthquake was a NWW-trending left-lateral strike-slip fault. It is 16 km long and 12 km wide. It developed at the depth of 5 km and is nearly vertical in dip. The two previous earthquake subsequences, however, were generated by activity along NNE-trending right-lateral strike-slip fault. It can be found that the rupture direction of the 1999 earthquake has changed. It is generally found that a rupture zone has more than two directions and has different strength along these two directions. The complicate degree of focal circumstance is related to the type of earthquake sequences. There is the NE-trending Dawangcun fault and the NW-trending Tuanbu fault in the seismic region, but no proof indicates a connection between focal faults and these two tectonic faults. The feature that focal faults of three subsequences are strike-slip is different from that of the two tectonic faults. It is suggested that the 1999 earthquake subsequence was possibly generated by a new rupture. 展开更多
关键词 Datong earthquake Focal fault Intersecting fault Macro-intensity Focal mechanism
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Passivity-based control of synchronous motors in mine hoist systems
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作者 XUE Hua JIANG Jian-guo +1 位作者 YUAN Ming-han JIANG Hua 《Journal of Coal Science & Engineering(China)》 2009年第3期332-336,共5页
An adaptive PBC strategy for SM with a time-varying load torque to track fluxand speed trajectories was proposed.The key point of this method was the identificationof terms,known as workless forces,which appeared in t... An adaptive PBC strategy for SM with a time-varying load torque to track fluxand speed trajectories was proposed.The key point of this method was the identificationof terms,known as workless forces,which appeared in the dynamic equations of SM buthad no effect on the energy balance equation of the closed loop.PBC,combined withadaptive control schemes,not only preserved the advantages of PBC such as nonexistenceof singularity,but also rejected the flux and speed tracking error caused by statorand rotor resistance variation.The rotor currents of SM were estimated via a state observer.This algorithm simplified the control structure and enhanced the robustness of thecontrol system.The feasibility and effectiveness were confirmed by experimental resultsbased on dSPACE. 展开更多
关键词 passivity-based control(PBC) adaptive scheme synchronous motors(SM) dSPACE
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