内科学中的基因研究

在过去十余年中,生物医学所发生的革命性变化犹如本世纪初的物理学,是激动人心的。这是因为分子生物学,特别是基因工程技术的广泛深入发展和应用,一下子把过去人们想知道而不可知的基因一个个呈现在面前,并越来越多地知晓其结构和功能。这样,人类才开始真正步入分子层次去认识生物和医学问题。内科疾患涉及面广,故基因研究在内科学中硕果累累。基因的概念最初源自遗传学,表示体现一定遗传特性的功能单元。现已进一步具体化。

浅谈在幼儿园开展“做中学”的点滴体会

“做中学”科学活动是一种良好的教育活动模式，它以科学研究的方法学习知识，强调学习方法、思维方法和学习态度的培养，通过开展研究探讨活动，让孩子成为真正的小探索者，体验科学探究的乐趣，认识到科学与自己生活的密切关系。

影响因子

影响因子（英文：Impactfactor，缩写IF）是美同科学情报研究所（ISI）的期刊引证报告（JCR）中的一项数据，指的是某一期刊的文章在特定年份或时期被引用的频率，是衡量学术期刊影响力的一个重要指标。由美国科学情报研究所创始人尤金·加菲得（英语：Eugene Garfield）在1960年创立，其后为文献计量学的发展带来了一系列重大革新。

Application of Stable Isotope Tracing Technologies in Identification of Transformation among Waters in Sanjiang Plain,Northeast China

In order to investigate the transformation among the precipitation,groundwater,and surface water in the Sanjiang Plain,Northeast China,precipitation and groundwater samples which were collected at the meteorological station of the Sanjiang Mire Wetland Experimental Station,Chinese Academy of Sciences and the surface water which collected from the Wolulan River were used to identify the transformation of three types of water.The isotope composition of different kinds of water sources were analyzed via stable isotope(deuterium and oxygen-18) investigation of natural water.The results show a clear seasonal difference in the stable isotopes in precipitation.During the cold half-year,the mean stable isotope in precipitation in the Sanjiang Plain reaches its minimum with the minimum temperature.The δ18O and δD values are high in the rainy season.In the Wolulan River,the evaporation is the highest in August and September.The volume of evaporation and the replenishment to the river is mostly same.The groundwater is recharged more by the direct infiltration of precipitation than by the river flow.The results of this study indicate that the water bodies in the Sanjiang Plain have close hydrologic relationships,and that the transformation among each water system frequently occurs.

From Compact City to Smart City： A Sustainability Science ＆ Synergy Perspective

This brief conceptual paper contributes a sustainability theoretic perspective of an urbanization paradigm known as Compact City. Compact City is an urban planning and development concept which promotes relatively high population density associated with an integrated and mixed-use land district. It is enabled by transit-oriented development and results in low transport-related energy consumption and reduced the GHG （Greenhouse Gases） pollution. Compact City conserves the natural capital of land mass and subscribes to the strong sustainability ethics. ICT （Information and Communications Technology） could be deployed to optimize the Compact City operations by first tackling some of the development problems associated with Compact City and also unleashing new urban innovations and functionalities to achieve sustainable urbanization. The paper suggests and elucidates several general systemic synergies archetypes such as co-benefits, cascading, ICT infrastructure reuse, etc., which could be leveraged to facilitate the emergence of compact green smart and resilient city. These archetypes are solutions to the Compact City paradigm thus conductive to the development ofa Sustainability Science of Compact City.

Comparison of Different Height Systems

Geopotential, dynamic, orthometric and normal height systems and the corrections related to these systems are evaluated in this paper. Along two different routes, with a length of about 5 kilometers, precise leveling and gravity measurements are done. One of the routes is in an even field while the other is in a rough field. The magnitudes of orthometric, normal and dynamic corrections are calculated for each route. Orthometric, dynamic, and normal height differences are acquired by adding the corrections to the height differences obtained from geometric leveling. The magnitudes of the corrections between the two routes are compared. In addition, by subtracting orthometric, dynamic, and normal heights from geometric leveling, deviations of these heights from geometric leveling are counted.

Impact of homogeneous pathologic response to preoperative chemotherapy in patients with multiple colorectal liver metastases

AIM To analyze the homogeneity of pathologic response to preoperative chemotherapy(PRPC) after chemotherapy in patients with multiple liver metastases(LM).METHODS From September 2011 to August 2014,patients with at least two LM undergoing preoperative chemotherapy prior to resection were included in this retrospective,single-center study. The endpoints were PRPC homogeneity(according to both the Rubbia-Brandt and MD Anderson classifications),the impact of PRPC on the MDT decision,factors associated with homogeneous PRPC and overall survival of patients with vs. without homogeneous PRPC.RESULTS seventy-three patients with a total of 88 liver resections(including 15 two-stage procedures) were included in the study. The homogeneous PRPC rate was 55% according to the Rubbia-Brandt classification and 53% according to the MD Anderson classification. The MDT decision was modified by the PRPC in only 2.7% of patients(n = 2). CONCLUSION The PRPC was homogeneous in only one half of patients and had very little influence on the MDT decision.

Synergetics as a Positivistic ＂Trick＂ for Philosophy

This paper substantiates the idea that particular science reflects only a certain angle of a complex model of the world. Guidance as to ＂adding＂ particular science data in order to achieve a holistic picture of the world is a philosophical outlook. The meaning of each relatively closed system is revealed only in the context of a more capacious system. According to the author, as the material world itself, its epistemic models as well are built according to the principle of ＂matryoshka dolls.＂ The rational and irrational are discussed in the paper as equal moments of scientific knowledge. Contrary to the importance given to randomness in synergy, the author considers if it is possible to find out the causes of all events. In order to do this, other viewpoints and structure levels should be considered. There is a hidden order in every chaos, and that is revealed only in a certain situation. The main issue is taking into account the counter action of the system with the environment.

Syndrome differentiation in traditional Chinese medicine and E-cadherin/ICAM-1 gene protein expression in gastric carcinoma

AIM： To explore the syndrome differentiation in traditional Chinese medicine （TCM） and gene protein expression in gastric carcinoma METHODS： Preoperative data of gastric cancer cases were collected from the General Surgery Department and classified according to the criteria for syndrome differentiation in TCM. E-cadherin （E-cad） and ICAM-1 gene protein expressions were detected in postoperative specimens from these cases by the immunohistochemical EnVision two-step method. RESULTS： The E-cad positive expression rate was 90% in 100 cases of gastric carcinoma. The difference in E-cad expression was significant between the different syndrome differentiation types in TCM （P 〈 0.01）. Further group-group comparison showed that there was a significant difference in E-cad expression between the stagnation of phlegm-damp type and the deficiency in both qi and blood and the deficiency-cold of stomach and spleen types, where E-cad expression was high. There was no significant difference between the internal obstruction of stagnant toxin type and the in-coordination between liver and stomach type, where E-cad expression was relatively low. The ICAM-1 positive expression rate was 58%, and there was no statistically significant difference between the two groups （x^2= 8.999, P 〉 0.05）. CONCLUSION： E-cad expression is relatively low in the internal obstruction of stagnant toxin type and the incoordination between liver and stomach type, where tumor development and metastasis may be associated with low E-cad expression, or with low homogeneous adhesiveness between tumor cells.

Recommendations on Strengthening the Development of Nuclear Medicine in China

This paper outlines briefly the role of nuclear medicine in life sciences and health care. Molecular imaging by using isotopic tracers can noninvasively visualize the chemistry or hidden process in the cells and tissues inside the body, obtaining "functional" images to provide early information of any disease and revealing the secrets of life. The vitality of nuclear medicine is its ability to translate bench into new clinical application that can benefits the patients. Although nuclear medicine community in China has made significant achievement with a great effort since 1950s, there are many obstacles to future development. Recommended measures are proposed here in an attempt to solve our existing problems.

Exploring social movement concepts and actions in a knowledge uptake and sustainability context: A concept analysis

Objectives:To share a concept analysis of social movement aimed at advancing its application to evidence uptake and sustainability in health-care.Methods:We applied Walker and Avant method to clarify the concept of social movement in the context of knowledge uptake and sustainability.Peer-reviewed and grey literature databases were systematically searched for relevant reports that described how social movement action led to evidence-based practice changes in health and community settings.Titles,abstracts and full texts were reviewed independently and in duplicate,resulting in 38 included articles.Results:Social movement action for knowledge uptake and sustainability can be defined as individuals,groups,or organizations that,as voluntary and intrinsically motivated change agents,mobilize around a common cause to improve outcomes through knowledge uptake and sustainability.The 10 defining attributes,three antecedents and three consequences that we identified are dynamic and interrelated,often mutually reinforcing each other to fortify various aspects of the social movement.Examples of defining attributes include an urgent need for action,collective action and collective identity.The concept analysis resulted in the development of the Social Movement Action Framework.Conclusions:Social movement action can provide a lens through which we view implementation science.Collective action and collective identity e concepts less frequently canvassed in implementation science literature e can lend insight into grassroots approaches to uptake and sustainability.Findings can also inform providers and change leaders on the practicalities of harnessing social movement action for realworld change initiatives.By mobilizing individuals,groups,or organizations through social movement approaches,they can engage as powered change agents and teams that impact the individual,organizational and health systems levels to facilitate knowledge uptake and sustainability.

An extended HLA multilayer federation integration architecture for multidisciplinary collaborative simulation

The development of complex products is essentially concerned with multidisciplinary knowledge. Running on Internet, integration based on muhilayer federation architecture and dynamic reuse of simulation resources are the major difficulties for complex product collaborative design and simulation. Since the traditional Run-Time Infrastructure （RTI） is not good at supporting these new requirements, an extended high level architecture （HLA） multilayer federation integration architecture （MLFIA）, based on the resource management federation （RMF） and its supporting environment based Service-oriented architecture （SOA） and HLA （SOHLA） are proposed, The idea and realization of two key technologies, the dynamic creation of simulation federation based on RMF, TH RTI, an extensible HLA runtime infrastructure （RTI）, used at Internet are emphasized. Finally, an industry case about multiple unit （MU） is given.

Study on Landslide Surge in Reservoir Area

Landslide surge is a fluid-solid coupling problem involving multidisciplinary intersections such as landslide dynamics, fluid mechanics and mechanics along the way, which has important research value. The construction of the reservoir will affect the natural geological conditions of the slope of the reservoir area, slope rock under the joint effect of the waves and the reservoir water level changes, which will cause the reservoir bank collapse and even landslides. The occurrence of landslide will cause some loss. In this paper, the types of landslide generation, disaster classification, research methods and existing problems are reviewed. It makes people understand the basic research ideas of landslide surge. Through the analysis and discussion of the different research methods of landslide surges, the shortcomings of these analytical methods are analyzed, which provide important basis for future research and indicate the future research methods and direction.

《中华整形外科杂志》影响因子上升

由中同科学技术信息研究所、万方数据库股份有限公司期刊七网组编制的《中国期刊引证研究报告》（2003-2004）统计分析表明：《中华整形外科杂志》2003年总被引频次为330，影响因子0．794，2004年总被引频次为511，影响因子为1．064。

斯宾诺莎对阿尔都塞理论探索的影响及其当代效应

阿尔都塞通过“后退”和“绕道”至斯宾诺莎进而厘清了黑格尔与马克思的“理论总问题”之本质区别。可以说,斯宾诺莎的“实体学说”对阿尔都塞重塑马克思主义科学形态的理论探索产生了重要影响,具体表现为:“实体一元论”为他提出“马克思主义是理论上的反人道主义”的命题埋下了理论伏笔;“实体自因说”为他提出“矛盾的多元决定论”给予了启示意义;知识分类理论为他阐发科学与意识形态之间“认识论的断裂”提供了理论参照。而其在“实体论”基础上提出的“身心同一论”,因强调身体的感性力量而促使阿尔都塞重新发现了马克思主义哲学的激进潜能,当代西方激进左翼思想家也在对斯宾诺莎的重构中开启了马克思主义哲学的政治转向。因此,阿尔都塞对斯宾诺莎的理论回溯,不仅确立了马克思主义哲学的科学主义阐释路径,而且进一步发掘了当代政治哲学的现实可能性。

Multidiscipline collaborative optimization of differential steering system of electric vehicle with motorized wheels

Based on the multidiscipline design optimization theory, a multidiscipline collaborative optimization model of the differential steering system of electric vehicle with motorized wheels is built, with the steering economy as the main system and the steering road feel, the steering flexibility and the mechanic character of the steering sensors as the subsystems. Considering the coupled relationship of each discipline, the main system is optimized by the multi-island algorithm and the subsystems are optimized by the sequential quadratic programming algorithm. The simulation results show that the steering economy can be optimized by the collaborative optimization, and that the system can get good steering road feel, good steering flexibility and good mechanic character of the steering sensors.

Effects of Isotopic Concentrations on Thermodynamic Parameters of Deuterium-Tritium Mixtures

Thermodynamic estimation is still too much requested for scientific applications in spite of great advances in simulation methods for efficient determination of phase equilibrium of multi-component systems. In this work, thermodynamic properties of deuterium-tritium mixture in a wide range of temperatures and pressures have been predicted. Buckingham exp-6 potential has been utilized in calculations, based on statistical perturbation theory. The effects of various values of density, temperature and isotopic concentrations on pressure have been studied. Eventually, we have found out symmetrical effects of tritium concentration in deuterium-tritium mixtures.

Tectonomicrobiology:A new paradigm for geobiological research

Geomicrobiology is a sub-discipline of geobiology and emphasizes the interaction between microorganisms and their environment on Earth. There is a need to explicitly emphasize the biogeochemical processes performed by microorganisms associated with Earth's tectonic activities, especially under the framework of the modern theory of plate tectonics. Tectonomicrobiology aims to create a better synergy between microbial and active tectonic processes. This explicit synergy should also foster better communications between solid Earth scientists and life scientists in terms of holistic Earth system dynamics at both tectonic and micro-scales.