Many reviewers have contributed their expertise and time to the peer review,a critical process to ensure the quality of World Journal of Gastroenterology. The editors and authors of the articles submitted to the journ...Many reviewers have contributed their expertise and time to the peer review,a critical process to ensure the quality of World Journal of Gastroenterology. The editors and authors of the articles submitted to the journal are grateful to the following reviewers for evaluating the articles (including those were published and those were rejected in this issue) during the last editing period of time.展开更多
To provide a high-security guaran- tee to network coding and lower the comput- ing complexity induced by signature scheme, we take full advantage of homomorphic prop- erty to build lattice signature schemes and sec- u...To provide a high-security guaran- tee to network coding and lower the comput- ing complexity induced by signature scheme, we take full advantage of homomorphic prop- erty to build lattice signature schemes and sec- ure network coding algorithms. Firstly, by means of the distance between the message and its sig- nature in a lattice, we propose a Distance-bas- ed Secure Network Coding （DSNC） algorithm and stipulate its security to a new hard problem Fixed Length Vector Problem （FLVP）, which is harder than Shortest Vector Problem （SVP） on lattices. Secondly, considering the bound- ary on the distance between the message and its signature, we further propose an efficient Bo- undary-based Secure Network Coding （BSNC） algorithm to reduce the computing complexity induced by square calculation in DSNC. Sim- ulation results and security analysis show that the proposed signature schemes have stronger unforgeability due to the natural property of lattices than traditional Rivest-Shamir-Adleman （RSA）-based signature scheme. DSNC algo- rithm is more secure and BSNC algorithm greatly reduces the time cost on computation.展开更多
Protein binding is essential to the transport,decay and regulation of almost all RNA molecules.However,the structural preference of protein binding on RNAs and their cellular functions and dynamics upon changing envir...Protein binding is essential to the transport,decay and regulation of almost all RNA molecules.However,the structural preference of protein binding on RNAs and their cellular functions and dynamics upon changing environmental conditions are poorly understood.Here,we integrated various high-throughput data and introduced a computational framework to describe the global interactions between RNA binding proteins(RBPs)and structured RNAs in yeast at single-nucleotide resolution.We found that on average,in terms of percent total lengths,~15%of mRNA untranslated regions(UTRs),~37%of canonical non-coding RNAs(ncRNAs)and^11%of long ncRNAs(lncRNAs)are bound by proteins.The RBP binding sites,in general,tend to occur at single-stranded loops,with evolutionarily conserved signatures,and often facilitate a specific RNA structure conformation in vivo.We found that four nucleotide modifications of tRNA are significantly associated with RBP binding.We also identified various structural motifs bound by RBPs in the UTRs of mRNAs,associated with localization,degradation and stress responses.Moreover,we identified>200 novel lncRNAs bound by RBPs,and about half of them contain conserved secondary structures.We present the first ensemble pattern of RBP binding sites in the structured non-coding regions of a eukaryotic genome,emphasizing their structural context and cellular functions.展开更多
文摘Many reviewers have contributed their expertise and time to the peer review,a critical process to ensure the quality of World Journal of Gastroenterology. The editors and authors of the articles submitted to the journal are grateful to the following reviewers for evaluating the articles (including those were published and those were rejected in this issue) during the last editing period of time.
基金ACKNOWLEDGEMENT This work was partially supported by the National Basic Research Program of China under Grant No. 2012CB315905 the National Natural Sci- ence Foundation of China under Grants No. 61272501, No. 61173154, No. 61370190 and the Beijing Natural Science Foundation under Grant No. 4132056.
文摘To provide a high-security guaran- tee to network coding and lower the comput- ing complexity induced by signature scheme, we take full advantage of homomorphic prop- erty to build lattice signature schemes and sec- ure network coding algorithms. Firstly, by means of the distance between the message and its sig- nature in a lattice, we propose a Distance-bas- ed Secure Network Coding （DSNC） algorithm and stipulate its security to a new hard problem Fixed Length Vector Problem （FLVP）, which is harder than Shortest Vector Problem （SVP） on lattices. Secondly, considering the bound- ary on the distance between the message and its signature, we further propose an efficient Bo- undary-based Secure Network Coding （BSNC） algorithm to reduce the computing complexity induced by square calculation in DSNC. Sim- ulation results and security analysis show that the proposed signature schemes have stronger unforgeability due to the natural property of lattices than traditional Rivest-Shamir-Adleman （RSA）-based signature scheme. DSNC algo- rithm is more secure and BSNC algorithm greatly reduces the time cost on computation.
基金supported by the National Natural Science Foundation of China(31271402 and 31100601)the National Key Basic Research Program(2012CB316503)
文摘Protein binding is essential to the transport,decay and regulation of almost all RNA molecules.However,the structural preference of protein binding on RNAs and their cellular functions and dynamics upon changing environmental conditions are poorly understood.Here,we integrated various high-throughput data and introduced a computational framework to describe the global interactions between RNA binding proteins(RBPs)and structured RNAs in yeast at single-nucleotide resolution.We found that on average,in terms of percent total lengths,~15%of mRNA untranslated regions(UTRs),~37%of canonical non-coding RNAs(ncRNAs)and^11%of long ncRNAs(lncRNAs)are bound by proteins.The RBP binding sites,in general,tend to occur at single-stranded loops,with evolutionarily conserved signatures,and often facilitate a specific RNA structure conformation in vivo.We found that four nucleotide modifications of tRNA are significantly associated with RBP binding.We also identified various structural motifs bound by RBPs in the UTRs of mRNAs,associated with localization,degradation and stress responses.Moreover,we identified>200 novel lncRNAs bound by RBPs,and about half of them contain conserved secondary structures.We present the first ensemble pattern of RBP binding sites in the structured non-coding regions of a eukaryotic genome,emphasizing their structural context and cellular functions.
