目的运用基于Meta分析的熵权TOPSIS法,从多个维度探讨针刺干预卒中后丘脑痛的优势方案。方法检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、Web of Science、Cochrane及Embase等数据库,检索建库至2023年8月...目的运用基于Meta分析的熵权TOPSIS法,从多个维度探讨针刺干预卒中后丘脑痛的优势方案。方法检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、Web of Science、Cochrane及Embase等数据库,检索建库至2023年8月收录的针刺治疗卒中后丘脑痛相关文献,运用改良Jadad量表评估文献质量,并对纳入文献进行Meta分析。根据Meta分析结果,确定将治愈率、有效率、VAS评分及治疗次数作为决策指标,运用多指标决策分析(MCDM)法、熵权法确定其权重,并运用TOPSIS法对卒中后丘脑痛针刺优势方案进行筛选。结果共纳入7篇随机对照研究,7篇文献均报道了VAS评分,结果显示,试验组VAS评分低于对照组,差异有统计学意义(MD=-1.80,95%CI:-2.45~-1.15,P<0.001)。有5篇文献报道了PRI评分,结果显示,试验组PRI评分低于对照组,差异有统计学意义(MD=-3.23,95%CI:-5.13~-1.34,P<0.001)。有5篇文献报道了PPI评分,结果显示,试验组PPI评分低于对照组,差异有统计学意义(MD=-1.22,95%CI:-2.00~-0.45,P=0.002)。有3篇文献报道了不良反应,共涉及154例患者,但患者均未出现明显不良反应。治愈率的熵值最低、效用值最高,权重系数为32.620%。VAS评分熵值最高、效用值最低,权重系数为14.352%;改良Jadad评分的熵值较小,效用值较大,权重系数为17.258%。醒脑开窍针法方案最佳,其平均治疗时间为2周,主要选穴为内关、水沟、三阴交、极泉、委中、风池、完骨、天柱、病灶侧顶颞后斜线,治疗频率为每天1次,每次30 min,疗程为28 d。结论本研究所筛选构建卒中后丘脑痛针刺优势方案可为临床应用提供一定参考,基于Meta分析的熵权TOPSIS法为临床筛选治疗优势方案提供了新思路。展开更多
Objective To determine whether the convergences of tactile information also occur at thalamic ventroposterolateral nucleus in rats, we investigated the properties of tactile responses of the thalamic ventroposterolate...Objective To determine whether the convergences of tactile information also occur at thalamic ventroposterolateral nucleus in rats, we investigated the properties of tactile responses of the thalamic ventroposterolateral nucleus in rats. Methods Unit responses were recorded extracellularly from thalamic ventroposterolateral nucleus in anesthetized rats. Results Among 156 neurons examined, 140 neurons （89.7%） had the single, continual and small receptive fields, and 16 neurons （10.3%） had two discrete receptive fields. Some neurons exhibited different responses to the same intensity stimulation which delivered to different points in their receptive fields. In addition, 4.5% neurons （n -- 7） responded only to locomotive stimulation but not to a punctiform tactile stimulation. Conclusion The majority of neurons in ventroposterolateral nucleus of rats have the spatial, temporal and submodal characteristics of cutaneous receptors, while the minority of neurons exhibit the responses of interaction of different peripheral receptors. Therefore, it is con- cluded that there are convergences of tactile information at the ventroposterolateral nucleus of rats.展开更多
文摘目的运用基于Meta分析的熵权TOPSIS法,从多个维度探讨针刺干预卒中后丘脑痛的优势方案。方法检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、Web of Science、Cochrane及Embase等数据库,检索建库至2023年8月收录的针刺治疗卒中后丘脑痛相关文献,运用改良Jadad量表评估文献质量,并对纳入文献进行Meta分析。根据Meta分析结果,确定将治愈率、有效率、VAS评分及治疗次数作为决策指标,运用多指标决策分析(MCDM)法、熵权法确定其权重,并运用TOPSIS法对卒中后丘脑痛针刺优势方案进行筛选。结果共纳入7篇随机对照研究,7篇文献均报道了VAS评分,结果显示,试验组VAS评分低于对照组,差异有统计学意义(MD=-1.80,95%CI:-2.45~-1.15,P<0.001)。有5篇文献报道了PRI评分,结果显示,试验组PRI评分低于对照组,差异有统计学意义(MD=-3.23,95%CI:-5.13~-1.34,P<0.001)。有5篇文献报道了PPI评分,结果显示,试验组PPI评分低于对照组,差异有统计学意义(MD=-1.22,95%CI:-2.00~-0.45,P=0.002)。有3篇文献报道了不良反应,共涉及154例患者,但患者均未出现明显不良反应。治愈率的熵值最低、效用值最高,权重系数为32.620%。VAS评分熵值最高、效用值最低,权重系数为14.352%;改良Jadad评分的熵值较小,效用值较大,权重系数为17.258%。醒脑开窍针法方案最佳,其平均治疗时间为2周,主要选穴为内关、水沟、三阴交、极泉、委中、风池、完骨、天柱、病灶侧顶颞后斜线,治疗频率为每天1次,每次30 min,疗程为28 d。结论本研究所筛选构建卒中后丘脑痛针刺优势方案可为临床应用提供一定参考,基于Meta分析的熵权TOPSIS法为临床筛选治疗优势方案提供了新思路。
文摘Objective To determine whether the convergences of tactile information also occur at thalamic ventroposterolateral nucleus in rats, we investigated the properties of tactile responses of the thalamic ventroposterolateral nucleus in rats. Methods Unit responses were recorded extracellularly from thalamic ventroposterolateral nucleus in anesthetized rats. Results Among 156 neurons examined, 140 neurons （89.7%） had the single, continual and small receptive fields, and 16 neurons （10.3%） had two discrete receptive fields. Some neurons exhibited different responses to the same intensity stimulation which delivered to different points in their receptive fields. In addition, 4.5% neurons （n -- 7） responded only to locomotive stimulation but not to a punctiform tactile stimulation. Conclusion The majority of neurons in ventroposterolateral nucleus of rats have the spatial, temporal and submodal characteristics of cutaneous receptors, while the minority of neurons exhibit the responses of interaction of different peripheral receptors. Therefore, it is con- cluded that there are convergences of tactile information at the ventroposterolateral nucleus of rats.
