Nutrition during perinatal period is more critical for the developme nt of the immune system than during adulthood, and the relationship between earl y nutrition and diseases in later life has been established. In hum...Nutrition during perinatal period is more critical for the developme nt of the immune system than during adulthood, and the relationship between earl y nutrition and diseases in later life has been established. In humans and labor atory animals, the plasticity of metabolic function in foetuses or neonates enab les them to adapt to malnutrition for survival; however, such an adaptation, as usually evidenced by retarded growth, stunted development of lymphoid organs and impaired immunocompetence, can maintain and persist into later life even when n utrition is improved. Early nutrition may thus programme' the immune system of a nimals. Limited experimental studies have also revealed that long-term immunity against nematode parasites in sheep can be enhanced by a short-term protein su pplementation shortly after weaning, a form of 'nutritional programming', but su ch an effect appears to vanish if the nutritional status of young animals alread y meets at least the requirement for maintenance.展开更多
In the present study,the effects of postnatal development on the number and distribution of skeletal muscle fibers of different types in hind leg of rat and rabbit were studied.The soleus muscles of rats aged 2 days,2...In the present study,the effects of postnatal development on the number and distribution of skeletal muscle fibers of different types in hind leg of rat and rabbit were studied.The soleus muscles of rats aged 2 days,2,4,6,8,and 10 weeks (body weight 10,32,95,190,280,and 320 g),and rabbits aged 2 days,2,4,8,12,16,20,and 24 weeks (body weight 100,220,400,750,1 200,1 600,2 100,and 2 500 g) were stained with succinic dehydrogenase.With an image analysis system,the X-Y coordinates of fibers were used to analyze the growth-related changes.The results of present study showed that three types of fibers were found in the soleus muscles of rat and rabbit,i.e.,type Ⅰ (slow oxidative),ⅡX (fast oxidative),and ⅡA (fast oxidative glycolytic).The type Ⅰ fibers were present throughout the muscle that had a uniform distribution and tended to increase in number with aging.Type ⅡX fibers were scattered throughout the muscle and decreased markedly in number with aging.Type ⅡA fibers were located at the central and deep regions,and showed a little or no change in number and distribution with aging.While be of age,type ⅡA and ⅡX fibers became restricted to the superficial region.No type ⅡB fibers were detected.Type ⅡA fibers had the largest diameter,type Ⅰ intermediate and type ⅡX the smallest.Mean cross-sectional area of each type fibers of rabbits was larger than that of rats.The present results indicate that the number and distribution of muscle fibers of different types in hind limb of rat and rabbit change with the process of postnatal growth.展开更多
The theme of the Conception of the Virgin Mary fascinated 16th-century Mannerist painters, as manifested in Giorgio Vasari's many drawings and paintings and also the numerous replicas in drawings, paintings, and engr...The theme of the Conception of the Virgin Mary fascinated 16th-century Mannerist painters, as manifested in Giorgio Vasari's many drawings and paintings and also the numerous replicas in drawings, paintings, and engravings made after his paintings by his contemporary artists. This essay focuses on Vasari's complex iconography of The Conception of Our Lady of 1540 at SS. Apostoli in Florence, Italy. In his documentation of the painting, Vasari never referred to or entitled the painting as an Allegory of the Immaculate Conception or Immaculate Conception but coined it as The Conception of Our Lady (Concezione di Nostra Donna) as it will be referred in this essay. Vasari's complex iconography derived from the writings of the A retine canon Giovanni Pollastra. The Virgin Mary is depicted as a victorious symbol of grace and salvation, triumphing over evil. Rejoicing angels surround her with scrolls containing Latin inscriptions, QUOS EVE CULPA DAAVIT/MARIAE GRATIAE SOLVIT, ECCE AGNIU[S] and UNIUS ONNOSTAA. These joyful words allude to the restoration of the fate of Adam and Eve after eating the forbidden fruit from the Tree of Knowledge in Paradise. A sinuous serpent coils around the fig tree, while tied-up Old Testament and New Testaments wait for forgiveness and salvation. Three considerations are addressed in this essay: (1) discussion of Vasari's recorded commissions; (2) stylistic observations and influences; and (3) interpretation of the imagery, that is, some observations on the symbolism of the painting.展开更多
MicroRNAs (miRNAs) are important post-transcriptional regulators of their target genes in plants and animals, miRNAs are usually 20-24 nucleotides long. Despite their unusually small sizes, the evolutionary history ...MicroRNAs (miRNAs) are important post-transcriptional regulators of their target genes in plants and animals, miRNAs are usually 20-24 nucleotides long. Despite their unusually small sizes, the evolutionary history of miRNA gene families seems to be similar to their protein-codingcounterparts. In contrast to the small but abundant miRNA families in the animal genomes, plants have fewer but larger miRNA gene families. Members of plant miRNA gene families are often highly similar, suggesting recent expansion via tandem gene duplication and segmental duplication events. Although many miRNA genes are conserved across plant species, the same gene family varies significantly in size and genomic organization in different species, which may cause dosage effects and spatial and temporal differences in target gene regulations. In this review, we summarize the current progress in understanding the evolution of plant miRNA gene families.展开更多
In the evolution of economic growth drivers, technology gaps are a key variable that determines the efficiency of resource allocation. Analysis of an optimal resource allocation path based on an extended endogenous gr...In the evolution of economic growth drivers, technology gaps are a key variable that determines the efficiency of resource allocation. Analysis of an optimal resource allocation path based on an extended endogenous growth model reveals that economic growth drivers evolve from productive investment to R&D investment and a shift from imitation to innovation. Empirical analysis based on China's provincial-level panel data suggests that the effect of productive investment and R&D investment, as well as innovation and imitation, on economic growth and technological progress varies greatly among regions of disparate technology levels. As a late-starting country, China should properly allocate resources between productive investment and R&D investment, and between imitational investment and innovative investment while advancing the transformation of economic growth patterns on a differentiated basis in light of regional technology disparities.展开更多
Kinesins are microtubule-based motors involved in various intracellular transports. Neurons, flagellated cells, and pigment cells have been traditionally used as model systems to study the cellular functions of kinesi...Kinesins are microtubule-based motors involved in various intracellular transports. Neurons, flagellated cells, and pigment cells have been traditionally used as model systems to study the cellular functions of kinesins. Here, we report silkworm posterior silkgland (PSG), specialized cells with an extensive endomembrane system for intracellular transport and efficient secretion of fibroin, as a novel model for kinesin study. To investigate kinesindriven intracellular transport in PSG cells, we cloned five silkworm kinesin-like proteins (KLPs), BmKinesin-1, BmKinesin-6, BmKinesin-7, BmKinesin-13, and BmKinesin-14A. We determined their expression patterns by relative real-time PCR and western blotting. Immunofluorescence microscopy verified their colocalization with microtubules. By combining pull-down assays, LC-MS/MS, and western blotting analysis, we identified many potential cargoes of BmKinesin-1 in PSG, including fibroin-containing granules and exuperantia-associated ribonucleoprotein (RNP) complexes. Moreover, BmKinesin-13 overexpression disrupted the microtubule network in BmN cells, which is consistent with a role of Kinesin-13 in regulating microtubule dynamics in other organisms. On the basis of these results, we concluded that PSG might have advantages in elucidating mechanisms of intracellular transport in secretory tissues and could serve as a potential model for kinesin studies.展开更多
In the creation works of European musicians in late nineteenth Century, it has more profound philosophical and ethical foundation, and its production and development has a profound reflection of music art on social li...In the creation works of European musicians in late nineteenth Century, it has more profound philosophical and ethical foundation, and its production and development has a profound reflection of music art on social life, but it is also a response to contemporary European romanticism non-rationalism ethics.展开更多
A common problem in rabbit production is the occurrence of digestive disorders just after weaning, and fiber is well known to be bcncficiai for rabbit gastrointestinal health. In order to test the hypothesis that w...A common problem in rabbit production is the occurrence of digestive disorders just after weaning, and fiber is well known to be bcncficiai for rabbit gastrointestinal health. In order to test the hypothesis that whether the good points of fiber increases with its dietary content, three isoenergetic and isonitrogenous diets and ninety mixed-sex New Zealand rabbits weaned 35-d-old were used. The results can be concluded as following: (1) Average daily feed intake (ADFI) tended to increase (i〉=0.058) while average daily gain (ADG) (p=0.001) and feed conversion ratio (FCR) (p〈0.001) deteriorated with increasing dietary ADF content. The highest morbidity was observed in the rabbits fed the highest dietary ADF concentration. (2)A decreasing coefficient of total tract apparent digestibility (CTTAD) of dry matter (DM) and crude protein (CP) was obtained with the increase of dietary fiber level (p〈0.001 and =0.003). (3) A significant negative effect of treatments on sucrase and maltase activities in the jejunum was observed (p=0.001 and 0.003). (4) The volatile fatty acid (VFA) concentration (p=0.011) and butyric acid (% total VFA) (P=0.001) dropped while the NH3-N concentration (P〈0.001), pH (P=0.004) and acetic acid (% total VFA) (P〈0.001) increased with increasing dietary ADF. It was concluded that high fiber level was unfavorable to the rabbits in the first two weeks after weaning.展开更多
The carried out experimental work aimed at the improvement of the native rabbit zootechnical performances. The goal was to run a genetical progress of an exotic breed "the Californian" through a crossbreeding with a...The carried out experimental work aimed at the improvement of the native rabbit zootechnical performances. The goal was to run a genetical progress of an exotic breed "the Californian" through a crossbreeding with a native rabbit. Ten females have been crossed with two native males (L × C) compared to controls Native × Native (N × N) and Californian × Californian (C × C). The reproduction and growth performances are clearly improved by crossbreeding effect, the recorded heterosis are: 9.43%, 16.34% and 21.93%, respectively for the alive litter size, alive and weaned; 10%, 16.75% and 2.57%, respectively for the alive litter weight, alive and weaned; 2.57% for the individual weight at birth; 10% and 7% for post weaning performances, respectively day mean gains and feed conversion ratio. Weight at slaughter is improved with 167 g, which representing a considerable level for the native population. Genetic crossbreeding between the Algerian native rabbit and the Californian, raised under rearing conditions of the Blida university farm experiment showed its efficiency on the most zootechnical performances. The complementary effect turned up positively on the crossbred rabbits Their post-weaning growth performance is comparable to those of the Californian with a better viability at weaning and slaughtering age.展开更多
Having been named executor of her late boyfriend's estate. Oedipa Maas. the protagonist, a housewife, started her journey and soon found herself enmeshed in a worldwide conspiracy, meeting some extremely interesting ...Having been named executor of her late boyfriend's estate. Oedipa Maas. the protagonist, a housewife, started her journey and soon found herself enmeshed in a worldwide conspiracy, meeting some extremely interesting and absurd characters, quite beyond her imagination and self-knowledge. These characters came from different walks of life and social classes, but all have some defects and deficiencies in one way or another, both physically or mentally. Meanwhile, they seemed to be busy involving themselves in some ridiculous and meaningless tasks or missions of work or life, lingering and struggling, with uncertainty and hopelessness for the future. In this way. Pynchon's The Crying of Lot 49 presents us a chaotic and meaningless postmodern society which gradually turns into decadence and entropy. These absurd and pathetic characters were exactly, without doubt, both products and victims of this materialized, alienated and depressing postmodern society. The fiction is humorous, obscure, and very complicated, involving politics, history., religion, science and art etc.. This paper is to analyse the absurdity of some main characters in this fiction.展开更多
The article deals with investigating and comparing key modern and postmodern interpretations of St. Francis of Assisi from a philosophical-anthropological perspective. We determine these interpretations to be as foll...The article deals with investigating and comparing key modern and postmodern interpretations of St. Francis of Assisi from a philosophical-anthropological perspective. We determine these interpretations to be as follows: a man of wonder and lover of wisdom, in other words, a true philosopher; hero of all times; defender of the poverty and poor; “champion of liberty”; peace-maker and pacifist; God's troubadour; patron of nature and animals. All of these manifestations of St. Francis' personality have been enriched by his Christocentrism and joyful vision. Moreover, this can be traced in primary sources and also echoes in the late modern period. Postmodernity not only incorporated similar motives into the cultural space with new focus and accent, but it also put forward some new visions. St. Francis was postulated as God's Fool, not so much in the medieval as in the postmodern sense of foolishness and madness as a way of interaction with the absurd and puzzle-like world in which we live. It also reconciles traditional opposition between joy and laughter as inner feelings and outward emotions within the frame of the postmodern Divine Comedy.展开更多
In previous studies, N,O-carboxymethyl chitosan has been shown to decrease the incidence and intensity of abdominal adhesions. In the present study, adhesions were induced in 220 rabbits using a double uterine horn mo...In previous studies, N,O-carboxymethyl chitosan has been shown to decrease the incidence and intensity of abdominal adhesions. In the present study, adhesions were induced in 220 rabbits using a double uterine horn model. Rabbits were randomized to receive an operation only or an operation+medical chitosan intraperitoneally. Twenty-two rabbits from each group were euthanized at one of five different times(Day 3, 7, 14, 28, or 42), and adhesion formation was given gross and histopathological scores. Reductions were observed in adhesion extent(P=0.0337) and tenacity(P=0.0271) as well as inflammation(P<0.0001) on Day 3 when medical chitosan was applied. Prior to Day 14, fibrosis was less obvious in the medical chitosan group(P<0.0005). The tenacity scores were significantly lower in the medical chitosan group following Day 14(P<0.05), while the type scores were lower in the medical chitosan group following Day 28(P<0.03). Thus, medical chitosan decreased both the gross and the histopathological scores of the induced adhesions.展开更多
Late-stage is defined here as the period when Neotectonism occurred since 5.1 Ma. Most petroliferous basins in China lie in the areas where Neotectonism occurred intensively. In recent years, Chinese petroleum geologi...Late-stage is defined here as the period when Neotectonism occurred since 5.1 Ma. Most petroliferous basins in China lie in the areas where Neotectonism occurred intensively. In recent years, Chinese petroleum geologists have paid much attention to late-stage petroleum accumulation. The PL19-3 giant oilfield is situated where faulting activities occurred violently during Neotectonism. To understand the mechanism of lat-stage rapid accumulation, we discussed the most important aspects responsible for the formation of the giant oilfield, including oil generation, active oil-source rock occurrence, fault activity and fault conduits, late-stage rapid oil injection as well as the distinguishing indicators. This study shows that: (1) sufficient oil was supplied to the PL19-3 field since 5.1 Ma because the PL19-3 structure was surrounded by four sags in which three intervals of high-quality source rocks remained active during Neotectonism; (2) densely distributed faults and high porosity/permeability sandstone carrier beds comprised the effective conduit system for oil migration and injection; (3) oil migrated along the faults and charged the PL19-3 structure rapidly by means of seismic pumping which was triggered by frequent earthquakes during Neotetonism. It is documented that elevated reservoir temperature, abnormal geothermal gradients and abnormally high homogenization temperatures of the fluid inclusions are the indicators for late-stage rapid oil accumulation.展开更多
Investigation of protein-DNA interactions provides important information for understanding gene function and regulation, but identification and validation of specific interactions remain major challenges in the post-g...Investigation of protein-DNA interactions provides important information for understanding gene function and regulation, but identification and validation of specific interactions remain major challenges in the post-genomics era. Therefore, effective and economical methods to assess protein-DNA interactions are highly sought-after by molec- ular biologists.展开更多
文摘Nutrition during perinatal period is more critical for the developme nt of the immune system than during adulthood, and the relationship between earl y nutrition and diseases in later life has been established. In humans and labor atory animals, the plasticity of metabolic function in foetuses or neonates enab les them to adapt to malnutrition for survival; however, such an adaptation, as usually evidenced by retarded growth, stunted development of lymphoid organs and impaired immunocompetence, can maintain and persist into later life even when n utrition is improved. Early nutrition may thus programme' the immune system of a nimals. Limited experimental studies have also revealed that long-term immunity against nematode parasites in sheep can be enhanced by a short-term protein su pplementation shortly after weaning, a form of 'nutritional programming', but su ch an effect appears to vanish if the nutritional status of young animals alread y meets at least the requirement for maintenance.
文摘In the present study,the effects of postnatal development on the number and distribution of skeletal muscle fibers of different types in hind leg of rat and rabbit were studied.The soleus muscles of rats aged 2 days,2,4,6,8,and 10 weeks (body weight 10,32,95,190,280,and 320 g),and rabbits aged 2 days,2,4,8,12,16,20,and 24 weeks (body weight 100,220,400,750,1 200,1 600,2 100,and 2 500 g) were stained with succinic dehydrogenase.With an image analysis system,the X-Y coordinates of fibers were used to analyze the growth-related changes.The results of present study showed that three types of fibers were found in the soleus muscles of rat and rabbit,i.e.,type Ⅰ (slow oxidative),ⅡX (fast oxidative),and ⅡA (fast oxidative glycolytic).The type Ⅰ fibers were present throughout the muscle that had a uniform distribution and tended to increase in number with aging.Type ⅡX fibers were scattered throughout the muscle and decreased markedly in number with aging.Type ⅡA fibers were located at the central and deep regions,and showed a little or no change in number and distribution with aging.While be of age,type ⅡA and ⅡX fibers became restricted to the superficial region.No type ⅡB fibers were detected.Type ⅡA fibers had the largest diameter,type Ⅰ intermediate and type ⅡX the smallest.Mean cross-sectional area of each type fibers of rabbits was larger than that of rats.The present results indicate that the number and distribution of muscle fibers of different types in hind limb of rat and rabbit change with the process of postnatal growth.
文摘The theme of the Conception of the Virgin Mary fascinated 16th-century Mannerist painters, as manifested in Giorgio Vasari's many drawings and paintings and also the numerous replicas in drawings, paintings, and engravings made after his paintings by his contemporary artists. This essay focuses on Vasari's complex iconography of The Conception of Our Lady of 1540 at SS. Apostoli in Florence, Italy. In his documentation of the painting, Vasari never referred to or entitled the painting as an Allegory of the Immaculate Conception or Immaculate Conception but coined it as The Conception of Our Lady (Concezione di Nostra Donna) as it will be referred in this essay. Vasari's complex iconography derived from the writings of the A retine canon Giovanni Pollastra. The Virgin Mary is depicted as a victorious symbol of grace and salvation, triumphing over evil. Rejoicing angels surround her with scrolls containing Latin inscriptions, QUOS EVE CULPA DAAVIT/MARIAE GRATIAE SOLVIT, ECCE AGNIU[S] and UNIUS ONNOSTAA. These joyful words allude to the restoration of the fate of Adam and Eve after eating the forbidden fruit from the Tree of Knowledge in Paradise. A sinuous serpent coils around the fig tree, while tied-up Old Testament and New Testaments wait for forgiveness and salvation. Three considerations are addressed in this essay: (1) discussion of Vasari's recorded commissions; (2) stylistic observations and influences; and (3) interpretation of the imagery, that is, some observations on the symbolism of the painting.
文摘MicroRNAs (miRNAs) are important post-transcriptional regulators of their target genes in plants and animals, miRNAs are usually 20-24 nucleotides long. Despite their unusually small sizes, the evolutionary history of miRNA gene families seems to be similar to their protein-codingcounterparts. In contrast to the small but abundant miRNA families in the animal genomes, plants have fewer but larger miRNA gene families. Members of plant miRNA gene families are often highly similar, suggesting recent expansion via tandem gene duplication and segmental duplication events. Although many miRNA genes are conserved across plant species, the same gene family varies significantly in size and genomic organization in different species, which may cause dosage effects and spatial and temporal differences in target gene regulations. In this review, we summarize the current progress in understanding the evolution of plant miRNA gene families.
文摘In the evolution of economic growth drivers, technology gaps are a key variable that determines the efficiency of resource allocation. Analysis of an optimal resource allocation path based on an extended endogenous growth model reveals that economic growth drivers evolve from productive investment to R&D investment and a shift from imitation to innovation. Empirical analysis based on China's provincial-level panel data suggests that the effect of productive investment and R&D investment, as well as innovation and imitation, on economic growth and technological progress varies greatly among regions of disparate technology levels. As a late-starting country, China should properly allocate resources between productive investment and R&D investment, and between imitational investment and innovative investment while advancing the transformation of economic growth patterns on a differentiated basis in light of regional technology disparities.
基金Acknowledgments We wish to thank Prof GZ Zhang and Prof ZF Zhang at the Sericultural Research Institute of the Chinese Academy of Agricultural Sciences for B. mori strain and silkworm artificial diet, respectively. This work was supported by the National Natural Science Foundation of China (30670659, 30771086, 30721064), the Major State Basic Research Development Program of China (973 Program) (2006CB500700, 2006CB910700, 2010CB833705), and the National High Technology Research and Development Program of China (863 Program) (2006AA10A119).
文摘Kinesins are microtubule-based motors involved in various intracellular transports. Neurons, flagellated cells, and pigment cells have been traditionally used as model systems to study the cellular functions of kinesins. Here, we report silkworm posterior silkgland (PSG), specialized cells with an extensive endomembrane system for intracellular transport and efficient secretion of fibroin, as a novel model for kinesin study. To investigate kinesindriven intracellular transport in PSG cells, we cloned five silkworm kinesin-like proteins (KLPs), BmKinesin-1, BmKinesin-6, BmKinesin-7, BmKinesin-13, and BmKinesin-14A. We determined their expression patterns by relative real-time PCR and western blotting. Immunofluorescence microscopy verified their colocalization with microtubules. By combining pull-down assays, LC-MS/MS, and western blotting analysis, we identified many potential cargoes of BmKinesin-1 in PSG, including fibroin-containing granules and exuperantia-associated ribonucleoprotein (RNP) complexes. Moreover, BmKinesin-13 overexpression disrupted the microtubule network in BmN cells, which is consistent with a role of Kinesin-13 in regulating microtubule dynamics in other organisms. On the basis of these results, we concluded that PSG might have advantages in elucidating mechanisms of intracellular transport in secretory tissues and could serve as a potential model for kinesin studies.
文摘In the creation works of European musicians in late nineteenth Century, it has more profound philosophical and ethical foundation, and its production and development has a profound reflection of music art on social life, but it is also a response to contemporary European romanticism non-rationalism ethics.
文摘A common problem in rabbit production is the occurrence of digestive disorders just after weaning, and fiber is well known to be bcncficiai for rabbit gastrointestinal health. In order to test the hypothesis that whether the good points of fiber increases with its dietary content, three isoenergetic and isonitrogenous diets and ninety mixed-sex New Zealand rabbits weaned 35-d-old were used. The results can be concluded as following: (1) Average daily feed intake (ADFI) tended to increase (i〉=0.058) while average daily gain (ADG) (p=0.001) and feed conversion ratio (FCR) (p〈0.001) deteriorated with increasing dietary ADF content. The highest morbidity was observed in the rabbits fed the highest dietary ADF concentration. (2)A decreasing coefficient of total tract apparent digestibility (CTTAD) of dry matter (DM) and crude protein (CP) was obtained with the increase of dietary fiber level (p〈0.001 and =0.003). (3) A significant negative effect of treatments on sucrase and maltase activities in the jejunum was observed (p=0.001 and 0.003). (4) The volatile fatty acid (VFA) concentration (p=0.011) and butyric acid (% total VFA) (P=0.001) dropped while the NH3-N concentration (P〈0.001), pH (P=0.004) and acetic acid (% total VFA) (P〈0.001) increased with increasing dietary ADF. It was concluded that high fiber level was unfavorable to the rabbits in the first two weeks after weaning.
文摘The carried out experimental work aimed at the improvement of the native rabbit zootechnical performances. The goal was to run a genetical progress of an exotic breed "the Californian" through a crossbreeding with a native rabbit. Ten females have been crossed with two native males (L × C) compared to controls Native × Native (N × N) and Californian × Californian (C × C). The reproduction and growth performances are clearly improved by crossbreeding effect, the recorded heterosis are: 9.43%, 16.34% and 21.93%, respectively for the alive litter size, alive and weaned; 10%, 16.75% and 2.57%, respectively for the alive litter weight, alive and weaned; 2.57% for the individual weight at birth; 10% and 7% for post weaning performances, respectively day mean gains and feed conversion ratio. Weight at slaughter is improved with 167 g, which representing a considerable level for the native population. Genetic crossbreeding between the Algerian native rabbit and the Californian, raised under rearing conditions of the Blida university farm experiment showed its efficiency on the most zootechnical performances. The complementary effect turned up positively on the crossbred rabbits Their post-weaning growth performance is comparable to those of the Californian with a better viability at weaning and slaughtering age.
文摘Having been named executor of her late boyfriend's estate. Oedipa Maas. the protagonist, a housewife, started her journey and soon found herself enmeshed in a worldwide conspiracy, meeting some extremely interesting and absurd characters, quite beyond her imagination and self-knowledge. These characters came from different walks of life and social classes, but all have some defects and deficiencies in one way or another, both physically or mentally. Meanwhile, they seemed to be busy involving themselves in some ridiculous and meaningless tasks or missions of work or life, lingering and struggling, with uncertainty and hopelessness for the future. In this way. Pynchon's The Crying of Lot 49 presents us a chaotic and meaningless postmodern society which gradually turns into decadence and entropy. These absurd and pathetic characters were exactly, without doubt, both products and victims of this materialized, alienated and depressing postmodern society. The fiction is humorous, obscure, and very complicated, involving politics, history., religion, science and art etc.. This paper is to analyse the absurdity of some main characters in this fiction.
文摘The article deals with investigating and comparing key modern and postmodern interpretations of St. Francis of Assisi from a philosophical-anthropological perspective. We determine these interpretations to be as follows: a man of wonder and lover of wisdom, in other words, a true philosopher; hero of all times; defender of the poverty and poor; “champion of liberty”; peace-maker and pacifist; God's troubadour; patron of nature and animals. All of these manifestations of St. Francis' personality have been enriched by his Christocentrism and joyful vision. Moreover, this can be traced in primary sources and also echoes in the late modern period. Postmodernity not only incorporated similar motives into the cultural space with new focus and accent, but it also put forward some new visions. St. Francis was postulated as God's Fool, not so much in the medieval as in the postmodern sense of foolishness and madness as a way of interaction with the absurd and puzzle-like world in which we live. It also reconciles traditional opposition between joy and laughter as inner feelings and outward emotions within the frame of the postmodern Divine Comedy.
文摘In previous studies, N,O-carboxymethyl chitosan has been shown to decrease the incidence and intensity of abdominal adhesions. In the present study, adhesions were induced in 220 rabbits using a double uterine horn model. Rabbits were randomized to receive an operation only or an operation+medical chitosan intraperitoneally. Twenty-two rabbits from each group were euthanized at one of five different times(Day 3, 7, 14, 28, or 42), and adhesion formation was given gross and histopathological scores. Reductions were observed in adhesion extent(P=0.0337) and tenacity(P=0.0271) as well as inflammation(P<0.0001) on Day 3 when medical chitosan was applied. Prior to Day 14, fibrosis was less obvious in the medical chitosan group(P<0.0005). The tenacity scores were significantly lower in the medical chitosan group following Day 14(P<0.05), while the type scores were lower in the medical chitosan group following Day 28(P<0.03). Thus, medical chitosan decreased both the gross and the histopathological scores of the induced adhesions.
基金supported by Program for Innovative Research Team in the University (Grant No. IRT0658)National Natural Science Foundation of China (Grant No. 90914006)
文摘Late-stage is defined here as the period when Neotectonism occurred since 5.1 Ma. Most petroliferous basins in China lie in the areas where Neotectonism occurred intensively. In recent years, Chinese petroleum geologists have paid much attention to late-stage petroleum accumulation. The PL19-3 giant oilfield is situated where faulting activities occurred violently during Neotectonism. To understand the mechanism of lat-stage rapid accumulation, we discussed the most important aspects responsible for the formation of the giant oilfield, including oil generation, active oil-source rock occurrence, fault activity and fault conduits, late-stage rapid oil injection as well as the distinguishing indicators. This study shows that: (1) sufficient oil was supplied to the PL19-3 field since 5.1 Ma because the PL19-3 structure was surrounded by four sags in which three intervals of high-quality source rocks remained active during Neotectonism; (2) densely distributed faults and high porosity/permeability sandstone carrier beds comprised the effective conduit system for oil migration and injection; (3) oil migrated along the faults and charged the PL19-3 structure rapidly by means of seismic pumping which was triggered by frequent earthquakes during Neotetonism. It is documented that elevated reservoir temperature, abnormal geothermal gradients and abnormally high homogenization temperatures of the fluid inclusions are the indicators for late-stage rapid oil accumulation.
基金supported by the National Natural Science Foundation of China (31471564) to L. C
文摘Investigation of protein-DNA interactions provides important information for understanding gene function and regulation, but identification and validation of specific interactions remain major challenges in the post-genomics era. Therefore, effective and economical methods to assess protein-DNA interactions are highly sought-after by molec- ular biologists.