Opisthorchiasis caused by Opisthorchis viverrini （Oviverrini） remains a major public health problem in many parts of Southeast Asia including Thailand, Lao PDR, Vietnam and Cambodia. The infection is associated with...Opisthorchiasis caused by Opisthorchis viverrini （Oviverrini） remains a major public health problem in many parts of Southeast Asia including Thailand, Lao PDR, Vietnam and Cambodia. The infection is associated with a number of hepatobUiary diseases, including cholangitis, obstructive jaundice, hepatomegaly, cholecystitis, cholelithiasis and cholangiocarcinoma. The liver fluke infection was induced by eating raw or uncooked fish products that is the tradition and popular in the northeastern and northern region, particularly in rural areas of Thailand. Health education programs to prevent and control opisthorchiasis are still required in high-risk areas.展开更多
AIM:Biliary stones are frequently encountered in areas endemic for opisthorchiasis in Thailand.The present study was to describe the prevalence and pathogenesis of these stones. METHODS:Gallstones and/or common bile d...AIM:Biliary stones are frequently encountered in areas endemic for opisthorchiasis in Thailand.The present study was to describe the prevalence and pathogenesis of these stones. METHODS:Gallstones and/or common bile duct stones and bile specimens from 113 consecutive cholecystectomies were included.Bile samples,including sludge and/or microcalculi,were examined for Opisthorchis viverrinieggs, calcium and bilirubin.The stones were also processed for scanning electron microscopic(SEM)study. RESULTS:Of the 113 cases,82 had pigment stones,while one had cholesterol stones.The other 30 cases had no stones.Most of the stone cases(76%,63/83)had multiple stones,while the remainder had a single stone.Stones were more frequently observed in females.Bile examination was positive for O.viverrini eggs in 50% of the cases studied.Aggregates of calcium bilirubinate precipitates were observed in all cases with sludge.Deposition of calcium bilirubinate on the eggshell was visualized by special staining.A SEM study demonstrated the presence of the parasite eggs in the stones.Numerous crystals, morphologically consistent with calcium derivatives and cholesterol precipitates,were seen. CONCLUSION:Northeast Thailand has a high prevalence of pigment stones,as observed at the cholecystectomy,and liver fluke infestation seems involved in the pathogenesis of stone formation.展开更多
文摘Opisthorchiasis caused by Opisthorchis viverrini （Oviverrini） remains a major public health problem in many parts of Southeast Asia including Thailand, Lao PDR, Vietnam and Cambodia. The infection is associated with a number of hepatobUiary diseases, including cholangitis, obstructive jaundice, hepatomegaly, cholecystitis, cholelithiasis and cholangiocarcinoma. The liver fluke infection was induced by eating raw or uncooked fish products that is the tradition and popular in the northeastern and northern region, particularly in rural areas of Thailand. Health education programs to prevent and control opisthorchiasis are still required in high-risk areas.
基金Supported by in part by the Tropical Health Program and NHMRC.Commonwealth Government,Australia
文摘AIM:Biliary stones are frequently encountered in areas endemic for opisthorchiasis in Thailand.The present study was to describe the prevalence and pathogenesis of these stones. METHODS:Gallstones and/or common bile duct stones and bile specimens from 113 consecutive cholecystectomies were included.Bile samples,including sludge and/or microcalculi,were examined for Opisthorchis viverrinieggs, calcium and bilirubin.The stones were also processed for scanning electron microscopic(SEM)study. RESULTS:Of the 113 cases,82 had pigment stones,while one had cholesterol stones.The other 30 cases had no stones.Most of the stone cases(76%,63/83)had multiple stones,while the remainder had a single stone.Stones were more frequently observed in females.Bile examination was positive for O.viverrini eggs in 50% of the cases studied.Aggregates of calcium bilirubinate precipitates were observed in all cases with sludge.Deposition of calcium bilirubinate on the eggshell was visualized by special staining.A SEM study demonstrated the presence of the parasite eggs in the stones.Numerous crystals, morphologically consistent with calcium derivatives and cholesterol precipitates,were seen. CONCLUSION:Northeast Thailand has a high prevalence of pigment stones,as observed at the cholecystectomy,and liver fluke infestation seems involved in the pathogenesis of stone formation.
