AIM:To determine the effect of oral sumatriptan on gastric emptying using a continuous 13 C breath test(BreathID system).METHODS:Ten healthy male volunteers participated in this randomized,2-way crossover study.The su...AIM:To determine the effect of oral sumatriptan on gastric emptying using a continuous 13 C breath test(BreathID system).METHODS:Ten healthy male volunteers participated in this randomized,2-way crossover study.The subjects fasted overnight and were randomly assigned to receive a test meal(200 kcal/200 mL) 30 min after pre-medication with sumatriptan 50 mg(sumatriptan condition),or the test meal alone(control condition).Gastric emptying was monitored for 4 h after administration of the test meal by the 13 C-acetic acid breath test performed continually using the BreathID system.Then,using Oridion Research Software(β version),the time taken for emptying of 50% of the labeled meal(T 1/2) similar to the scintigraphy lag time for 10% emptying of the labeled meal(T lag),the gastric emptying coefficient(GEC),and the regression-estimated constants(β and κ) were calculated.The statistical significance of any differences in the parameters were analyzed using Wilcoxon's signed-rank test.RESULTS:In the sumatriptan condition,significant differences compared with the control condition were found in T 1/2 [median 131.84 min(range,103.13-168.70) vs 120.27 min(89.61-138.25);P = 0.0016],T lag [median 80.085 min(59.23-125.89) vs 61.11 min(39.86-87.05);P = 0.0125],and β [median 2.3374(1.6407-3.8209) vs 2.0847(1.4755-2.9269);P = 0.0284].There were no significant differences in the GEC or κ between the 2 conditions.CONCLUSION:This study showed that oral sumatriptan significantly delayed gastric emptying of a liquid meal.展开更多
This work is concerned with time stepping finite element methods for abstract second order evolution problems. We derive optimal order a posteriori error estimates and a posteriori nodal superconvergence error estimat...This work is concerned with time stepping finite element methods for abstract second order evolution problems. We derive optimal order a posteriori error estimates and a posteriori nodal superconvergence error estimates using the energy approach and the duality argument. With the help of the a posteriori error estimator developed in this work, we will further propose an adaptive time stepping strategy. A number of numerical experiments are performed to illustrate the reliability and efficiency of the a posteriori error estimates and to assess the effectiveness of the proposed adaptive time stepping method.展开更多
This paper considers the Legendre Galerkin spectral approximation for the unconstralnea optimal control problems. The authors derive a posteriori error estimate for the spectral approximation scheme of optimal control...This paper considers the Legendre Galerkin spectral approximation for the unconstralnea optimal control problems. The authors derive a posteriori error estimate for the spectral approximation scheme of optimal control problem. By choosing the appropriate basis functions, the stiff matrix of the discretization equations is sparse. And the authors use the Fast Legendre Transform to improve the efficiency of this method. Two numerical experiments demonstrating our theoretical results are presented.展开更多
文摘AIM:To determine the effect of oral sumatriptan on gastric emptying using a continuous 13 C breath test(BreathID system).METHODS:Ten healthy male volunteers participated in this randomized,2-way crossover study.The subjects fasted overnight and were randomly assigned to receive a test meal(200 kcal/200 mL) 30 min after pre-medication with sumatriptan 50 mg(sumatriptan condition),or the test meal alone(control condition).Gastric emptying was monitored for 4 h after administration of the test meal by the 13 C-acetic acid breath test performed continually using the BreathID system.Then,using Oridion Research Software(β version),the time taken for emptying of 50% of the labeled meal(T 1/2) similar to the scintigraphy lag time for 10% emptying of the labeled meal(T lag),the gastric emptying coefficient(GEC),and the regression-estimated constants(β and κ) were calculated.The statistical significance of any differences in the parameters were analyzed using Wilcoxon's signed-rank test.RESULTS:In the sumatriptan condition,significant differences compared with the control condition were found in T 1/2 [median 131.84 min(range,103.13-168.70) vs 120.27 min(89.61-138.25);P = 0.0016],T lag [median 80.085 min(59.23-125.89) vs 61.11 min(39.86-87.05);P = 0.0125],and β [median 2.3374(1.6407-3.8209) vs 2.0847(1.4755-2.9269);P = 0.0284].There were no significant differences in the GEC or κ between the 2 conditions.CONCLUSION:This study showed that oral sumatriptan significantly delayed gastric emptying of a liquid meal.
基金supported by National Natural Science Foundation of China(Grant Nos.1117121911161130004 and 11101199)+1 种基金E-Institutes of Shanghai Municipal Education Commission(Grant No.E03004)Program for New Century Excellent Talents in Fujian Province University(Grant No.JA12260)
文摘This work is concerned with time stepping finite element methods for abstract second order evolution problems. We derive optimal order a posteriori error estimates and a posteriori nodal superconvergence error estimates using the energy approach and the duality argument. With the help of the a posteriori error estimator developed in this work, we will further propose an adaptive time stepping strategy. A number of numerical experiments are performed to illustrate the reliability and efficiency of the a posteriori error estimates and to assess the effectiveness of the proposed adaptive time stepping method.
基金supported by the Foundation for Talent Introduction of Guangdong Provincial University,Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(2008)the National Natural Science Foundation of China under Grant No.10971074
文摘This paper considers the Legendre Galerkin spectral approximation for the unconstralnea optimal control problems. The authors derive a posteriori error estimate for the spectral approximation scheme of optimal control problem. By choosing the appropriate basis functions, the stiff matrix of the discretization equations is sparse. And the authors use the Fast Legendre Transform to improve the efficiency of this method. Two numerical experiments demonstrating our theoretical results are presented.
