列车脱轨苯磷外流 消防官兵奋勇抢救

5月28日下午3时27分,一满载轻质油、柴油和甲类易燃液体——苯磷的1627次列车西行至临泽新华庄火车站区时,突然发生车厢脱轨翻车事故,3节装有苯磷的罐由于相互碰撞出现裂口,罐内液体不停地向外流,5节柴油罐扭曲变形,随时都有可能发生爆炸的危险。

Mechanisms of Cyclovirobuxine D on APD Prolongation in Rat Ventricular Myocytes

Aim To study the effects of cyclovirobuxine D on inward rectifier K^- current(I_(k1) ) > transient outward K^+ current (I_(to)), L-type Ca^(2+) current (I_(Ca-L)), and actionpotential duration (APD) in isolated rat ventricular myocytes. Methods The whole cell patch-clamptechniques were used to study the changes of I_(k1), I_(to), I_(Ca-L) and APD in rat ventricularmyocytes. Results Cyclovirobuxine D (1-10 μmol·L^(-1)) significantly prolonged APD_(50) andAPD_(90) in isolated rat ventricular myocytes. Resting potential (RP) was decreased by 10μmol·L^(-1) of cyclovirobuxine D. Cyclovirobuxine D significantly decreased both inward andoutward components of I_(k1) . At - 100 mV, 1 and 10 μmol·L^(-1) of cyclovirobuxine D decreasedI_(k1), density from (-8.0+- 1.1) pA/pF to ( - 4.1 +- 0.7) pA/pF and ( - 3.4 +- 0.8) pA/pF,respectively, whereas at - 30 mV, I-(k1) density was decreased from (1.10 +-0.24) pA/pF to (0.61+-0.18) pA/pF and (0.36+- 0.11) pA/pF, respectively. 1_(to) was markedly inhibited bycyclovirobuxine D from the test potential of 0 mV to + 60 mV. At + 40 mV, 1 and 10μmol·L^(-1) ofcyclovirobuxine D decreased I_(to) density from (8.9+- 2.0) pA/pF to (5.5 +- 1.2) pA/pF and (4.9+-0.9) pA/pF, respectively. Cyclovirobuxine D inhibited I_(Ca-L) in a concentration-dependentmanner. At 10 mV, 1 and 10μmol·L^(-1) of cyclovirobuxine D decreased I_(Ca-L) density from ( - 9.9+- 1.8) pA/pF to ( - 6.4 +- 1.4) pA/pF and (-4.2+-0.6) pA/pF, respectively. ConclusionCyclovirobuxine D significantly prolonged APD and inhibited I_(k1), I_(to), and I_(Ca-L) in ratventricular myocytes. The inhibitory effects of cyclovirobuxine D on _(k1) and I_(to) are majormolecular mechanisms of APD prolongation in rat.

小村·山路·古井(散文诗)

小村 小村依偶着小溪,在山花泉树的相伴下,沿着遥远的时空蹒跚而来。于是,小村的故事便像一坛陈年的老酒品味无穷,悠然展开…… 小村总想起那个滴水贵如油的日子——一件件手搅着辘轮柄的愁苦无奈的心事。

Electrophysiological study on differentiation of rat bone marrow stromal stem cells into neuron-like cells in vitro by edaravone

Objective： To explore the electrophysiological proper- ties of differentiation of rat bone marrow-derived stromal stem cells （rBMSCs） to neuron-like cells in vitro by edaravone, a new type of free radical scavenger. Methods： Stromal stem cells were separated from rat bone marrow with Ficoll-Paque reagent and expanded in different culture medium in vitro, rBMSCs were induced by edaravone containing serum-free L-DMEM. Morphologic observation and Western blot analysis including the expression of Nav1.6, Kvl.2, Kv1.3, Cav1.2 were performed, and whole patch-clamp technique was used. Results： Cyton contraction and long processes were shown in differentiated stromal stem cells. Navl.6, Kvl.2, Kv 1.3 and Cav 1.2 were expressed in both differentiated and undifferentiated ceils. However, the expression of channel proteins in differentiated cells was up-regulated. Consistently, their resting potential and outward currents were also enhanced in the differentiated cells, which was especially significant in the outward rectifier potassium current. Conclusion： In vitro, neuron-like cells derived from rBMSCs, induced by edaravone, possess electrophysiological properties of neurons.

Flow Structure Around the Intake of a Vertical Pump

The flow structure around the intake of a vertical pump is investigated experimentally and numerically in order to obtain a guideline in designing the optimum shape of the intake of vertical pumps, in which their installation area is demanded to be minimum without losing the high performance. We concentrate our attention on the expansion ratio of the intake as a representative characteristic of the shape of the pumps and investigate the effect of the expansion ratio on pump performance. It is concluded that the optimum expansion ratio ranges in 1.1-1.2 if we take into consideration that the area needed for the installation of the pump should be minimum.

North Indian Ocean tropical cyclone activities influenced by the Indian Ocean Dipole mode

Using Joint Typhoon Warning Center tropical cyclone(TC)track data over the North Indian Ocean(NIO),National Centers for Environmental Prediction monthly reanalysis wind and outgoing long-wave radiation data,and National Oceanic and Atmospheric Administration sea surface temperature data from 1981 to 2010,spatiotemporal distributions of NIO TC activity and relationships with local sea surface temperature(SST)were studied with statistical diagnosis methods.Results of empirical orthogonal function(EOF)analysis of NIO TC occurrence frequency show that the EOF1 mode,which accounts for 16%of total variance,consistently represents variations of TC occurrence frequency over the whole NIO basin.However,spatial dis- tributions of EOF1 mode are not uniform,mainly indicating variations of westward-moving TCs in the Bay of Bengal.The prevailing TC activity variation mode oscillates significantly on a quasi-5 year interannual time scale.NIO TC activity is notably influenced by the Indian Ocean dipole(IOD)mode.When the Indian Ocean is in a positive(negative)phase of the IOD, NIO SST anomalies are warm in the west(east)and cold in the east(west),which can weaken(strengthen)convection over the Bay of Bengal and eastern Arabian Sea,and cause anticyclonic(cyclonic)atmospheric circulation anomalies at low levels. This results in less(more)TC genesis and reduced(increased)opportunities for TC occurrence in the NIO.In addition,positive(negative)IOD events may strengthen(weaken)westerly steering flow over the Bay of Bengal,which further leads to fewer(more)westward-moving TCs which appear in regions west of 90°E in that bay.