Objective To investigate the causal relationships between plasma metabolites and osteoporosis via Mendelian randomization(MR)analysis.Methods Bidirectional MR was used to analyze pooled data from different genome-wide...Objective To investigate the causal relationships between plasma metabolites and osteoporosis via Mendelian randomization(MR)analysis.Methods Bidirectional MR was used to analyze pooled data from different genome-wide association studies(GWAS)to investigate the causal relationships between plasma metabolites and osteoporosis.The causal effect of plasma metabolites on osteoporosis was estimated using the inverse variance weighted method,intersections of statistically significant metabolites obtained from different sources of osteoporosis-related GWAS aggregated data was determined,and then sensitivity analysis was performed on these metabolites.Heterogeneity between single nucleotide polymorphisms was evaluated by Cochran’s Q test.Horizontal pleiotropy was assessed through the application of the MR-Egger intercept method and the MR-PRESSO method.The causal effect of osteoporosis on plasma metabolites was also evaluated using the inverse variance weighted method.Additionally,pathway analysis was conducted to identify potential metabolic pathways involved in the regulation of osteoporosis.Results After primary analysis and a series of sensitivity analyses,77 and 61 plasma metabolites were identified as having a causal relationship with osteoporosis from the GWAS data in the GCST90038656 and GCST90044600 datasets,respectively.Five common metabolites were identified via intersection.X-13684 levels(GCST90038656:OR=0.999,95%CI,0.998-1.000,P=0.004;GCST90044600(OR=0.834,95%CI,0.700-0.993,P=0.042),and the glucose-to-maltose ratio(GCST90038656:OR=0.998,95%CI,0.997-1.000,P=0.025;GCST90044600:OR=0.752,95%CI,0.576-0.981,P=0.036)were negatively associated with osteoporosis,whereas glycoursodeoxycholate levels(GCST90038656:OR=1.002,95%CI,1.000-1.003,P=0.032;GCST90044600:OR=1.331,95%CI,1.036-1.709,P=0.025)and arachidoylcarnitine(C20)levels(GCST90038656:OR=1.001,95%CI,1.000-1.003,P=0.039;GCST90044600:OR=1.237;95%CI,1.008-1.518,P=0.042)were positively associated with osteoporosis.The relationship between X-11299 levels and osteoporosis showed contradictory results(GCST90038656:OR=0.998,95%CI,0.997-1.000,P=0.026;GCST90044600:OR=1.402,95%CI,1.071-1.834,P=0.014).Pathway analysis indicated that glycine,serine,and threonine metabolism,valine,leucine,and isoleucine biosynthesis,galactose metabolism,arginine biosynthesis,and starch and sucrose metabolism pathways were participated in the development of osteoporosis.Conclusion We found a causal relationship between plasma metabolites and osteoporosis.These results offer novel perspectives that have implications for targeted interventions focused on metabolites in the management of osteoporosis.展开更多
The gait of the biped robot is described using six parameters such as stature,velocity,length of the step,etc.The algorithm of the Newton-Euler is actualized by object-oriented idea,and then the zero moment point (ZMP...The gait of the biped robot is described using six parameters such as stature,velocity,length of the step,etc.The algorithm of the Newton-Euler is actualized by object-oriented idea,and then the zero moment point (ZMP) of the dynamically walking biped is calculated.Finally,the gait of biped is optimized using gene algorithm,and the optimized result prove the correctness of the algorithm.展开更多
Holocaust memorial sites rarely tell the story of individual fates but rather give attention to the main or larger population groups that were the focus of persecution and extermination during the Nazi Germany twelve ...Holocaust memorial sites rarely tell the story of individual fates but rather give attention to the main or larger population groups that were the focus of persecution and extermination during the Nazi Germany twelve years of terror in Europe 1933-45. This essay takes a closer look at one of the most remarkable exemptions of the prevailing memory culture at Holocaust memorials： the sites and events highlighting Anne Frank and her short life in troubled times. Over the past years millions of travelers from all over the world have shown a genuine interest in learning about the life world of their young heroine thus creating what has been termed Anne Frank Tourism. In 2014, 1.2 million people visited the Anne Frank House in Amsterdam： the museum and educational center, the place in hiding where she wrote her now famous and widely read diary. Several other sites connected to the life path of Anne Frank, from her birth place in Frankfurt to the Bergen-Belsen Concentration Camp where her life prematurely ended, have also become part of the mostly young tourists＇ search for Anne Frank＇s life and legacy. With the rising popularity of Anne Frank related sites the management of some of the locales has become more problematic which is discussed in the context of a several museums, centers and historic sites. On a more general note, it is argued here that in recent years the more group oriented commemoration practices at Holocaust sites have given way to a trend of putting individual faces to the victims of the Holocaust. It was, in particular, novels, films and TV productions about the Holocaust that emphasized individual life paths and events and enticed visitation to more personalized sites. Steven Spielberg＇s popular movie Schindler＇s List, for example, contributed to ＂Schindler tourism＂, a form of special interest tourism in Krakow. More and more Holocaust memorial sites have also started to honor outstanding individuals or small groups in resistance and opposition to Nazi Germany. Examples of this are the fighters of the 1943 uprising at the Sobibor death camp and the courageous student members of the ＂White Rose＂ in Munich who stood up to the powers of the time and were executed. In the concluding part the question will be raised of what is the proper approach in the representation of the fate of the victims of Nazi Germany： A personalized approach or a greater focus on an explanation of the ideology and policies behind the rule of terror which may contribute to the visitors＇ better understanding of a complex history？展开更多
In this paper, Killing vectors of spherically spacetimes have been evaluated in the context of teleparallel theory of gravitation. Further, we investigate the Killing vectors of the Friedmann metrics. It is found that...In this paper, Killing vectors of spherically spacetimes have been evaluated in the context of teleparallel theory of gravitation. Further, we investigate the Killing vectors of the Friedmann metrics. It is found that for static spherically spacetimes the number of Killing vectors turns out to be seven while for the Friedmann models, we obtain six teleparallel Killing vectors. The results are then compared with those of General Relativity. We conclude that both of these descriptions of gravity do not provide the consistent results in general. However, these results may coincide under certain conditions for a particular spacetime.展开更多
This is a study of German Labor Sport organizations and unions in Slovakia in the time parameters area 1918-1938 German workers living in Slovakia started to found their own union after 1918. They got a strong support...This is a study of German Labor Sport organizations and unions in Slovakia in the time parameters area 1918-1938 German workers living in Slovakia started to found their own union after 1918. They got a strong support from similar organizations of German workers living in Sudety. The coordinating role was played by the German Socio-Democratic party in Slovakia. The major concentration of these unions was in Bratislava and Eastern Slovakia. Concerning their specialized field, they can be divided into tourism-practising, physical and sport ones However, the union activities were strongly influenced by political parties. Activities of every union were regional and therefore a strong mutual isolation existed展开更多
文摘Objective To investigate the causal relationships between plasma metabolites and osteoporosis via Mendelian randomization(MR)analysis.Methods Bidirectional MR was used to analyze pooled data from different genome-wide association studies(GWAS)to investigate the causal relationships between plasma metabolites and osteoporosis.The causal effect of plasma metabolites on osteoporosis was estimated using the inverse variance weighted method,intersections of statistically significant metabolites obtained from different sources of osteoporosis-related GWAS aggregated data was determined,and then sensitivity analysis was performed on these metabolites.Heterogeneity between single nucleotide polymorphisms was evaluated by Cochran’s Q test.Horizontal pleiotropy was assessed through the application of the MR-Egger intercept method and the MR-PRESSO method.The causal effect of osteoporosis on plasma metabolites was also evaluated using the inverse variance weighted method.Additionally,pathway analysis was conducted to identify potential metabolic pathways involved in the regulation of osteoporosis.Results After primary analysis and a series of sensitivity analyses,77 and 61 plasma metabolites were identified as having a causal relationship with osteoporosis from the GWAS data in the GCST90038656 and GCST90044600 datasets,respectively.Five common metabolites were identified via intersection.X-13684 levels(GCST90038656:OR=0.999,95%CI,0.998-1.000,P=0.004;GCST90044600(OR=0.834,95%CI,0.700-0.993,P=0.042),and the glucose-to-maltose ratio(GCST90038656:OR=0.998,95%CI,0.997-1.000,P=0.025;GCST90044600:OR=0.752,95%CI,0.576-0.981,P=0.036)were negatively associated with osteoporosis,whereas glycoursodeoxycholate levels(GCST90038656:OR=1.002,95%CI,1.000-1.003,P=0.032;GCST90044600:OR=1.331,95%CI,1.036-1.709,P=0.025)and arachidoylcarnitine(C20)levels(GCST90038656:OR=1.001,95%CI,1.000-1.003,P=0.039;GCST90044600:OR=1.237;95%CI,1.008-1.518,P=0.042)were positively associated with osteoporosis.The relationship between X-11299 levels and osteoporosis showed contradictory results(GCST90038656:OR=0.998,95%CI,0.997-1.000,P=0.026;GCST90044600:OR=1.402,95%CI,1.071-1.834,P=0.014).Pathway analysis indicated that glycine,serine,and threonine metabolism,valine,leucine,and isoleucine biosynthesis,galactose metabolism,arginine biosynthesis,and starch and sucrose metabolism pathways were participated in the development of osteoporosis.Conclusion We found a causal relationship between plasma metabolites and osteoporosis.These results offer novel perspectives that have implications for targeted interventions focused on metabolites in the management of osteoporosis.
文摘The gait of the biped robot is described using six parameters such as stature,velocity,length of the step,etc.The algorithm of the Newton-Euler is actualized by object-oriented idea,and then the zero moment point (ZMP) of the dynamically walking biped is calculated.Finally,the gait of biped is optimized using gene algorithm,and the optimized result prove the correctness of the algorithm.
文摘Holocaust memorial sites rarely tell the story of individual fates but rather give attention to the main or larger population groups that were the focus of persecution and extermination during the Nazi Germany twelve years of terror in Europe 1933-45. This essay takes a closer look at one of the most remarkable exemptions of the prevailing memory culture at Holocaust memorials： the sites and events highlighting Anne Frank and her short life in troubled times. Over the past years millions of travelers from all over the world have shown a genuine interest in learning about the life world of their young heroine thus creating what has been termed Anne Frank Tourism. In 2014, 1.2 million people visited the Anne Frank House in Amsterdam： the museum and educational center, the place in hiding where she wrote her now famous and widely read diary. Several other sites connected to the life path of Anne Frank, from her birth place in Frankfurt to the Bergen-Belsen Concentration Camp where her life prematurely ended, have also become part of the mostly young tourists＇ search for Anne Frank＇s life and legacy. With the rising popularity of Anne Frank related sites the management of some of the locales has become more problematic which is discussed in the context of a several museums, centers and historic sites. On a more general note, it is argued here that in recent years the more group oriented commemoration practices at Holocaust sites have given way to a trend of putting individual faces to the victims of the Holocaust. It was, in particular, novels, films and TV productions about the Holocaust that emphasized individual life paths and events and enticed visitation to more personalized sites. Steven Spielberg＇s popular movie Schindler＇s List, for example, contributed to ＂Schindler tourism＂, a form of special interest tourism in Krakow. More and more Holocaust memorial sites have also started to honor outstanding individuals or small groups in resistance and opposition to Nazi Germany. Examples of this are the fighters of the 1943 uprising at the Sobibor death camp and the courageous student members of the ＂White Rose＂ in Munich who stood up to the powers of the time and were executed. In the concluding part the question will be raised of what is the proper approach in the representation of the fate of the victims of Nazi Germany： A personalized approach or a greater focus on an explanation of the ideology and policies behind the rule of terror which may contribute to the visitors＇ better understanding of a complex history？
文摘In this paper, Killing vectors of spherically spacetimes have been evaluated in the context of teleparallel theory of gravitation. Further, we investigate the Killing vectors of the Friedmann metrics. It is found that for static spherically spacetimes the number of Killing vectors turns out to be seven while for the Friedmann models, we obtain six teleparallel Killing vectors. The results are then compared with those of General Relativity. We conclude that both of these descriptions of gravity do not provide the consistent results in general. However, these results may coincide under certain conditions for a particular spacetime.
文摘This is a study of German Labor Sport organizations and unions in Slovakia in the time parameters area 1918-1938 German workers living in Slovakia started to found their own union after 1918. They got a strong support from similar organizations of German workers living in Sudety. The coordinating role was played by the German Socio-Democratic party in Slovakia. The major concentration of these unions was in Bratislava and Eastern Slovakia. Concerning their specialized field, they can be divided into tourism-practising, physical and sport ones However, the union activities were strongly influenced by political parties. Activities of every union were regional and therefore a strong mutual isolation existed
