目的:观察盐酸戊乙奎醚对小剂量吗啡臂丛神经阻滞用于上肢术后镇痛副反应的影响。方法:64例在臂丛麻醉下行上肢手术的患者,随机均分为A、B两组。A组局麻药内加盐酸戊乙奎醚1 m g及吗啡4 m g,B组局麻药内仅加吗啡4 m g。结果:恶心呕吐及...目的:观察盐酸戊乙奎醚对小剂量吗啡臂丛神经阻滞用于上肢术后镇痛副反应的影响。方法:64例在臂丛麻醉下行上肢手术的患者,随机均分为A、B两组。A组局麻药内加盐酸戊乙奎醚1 m g及吗啡4 m g,B组局麻药内仅加吗啡4 m g。结果:恶心呕吐及皮肤瘙痒的发生率A组低于B组(P<0.01或0.05),口干的发生率A组高于B组(P<0.01)。结论:盐酸戊乙奎醚可较明显地降低小剂量吗啡用于臂丛神经阻滞术后镇痛副反应的发病率。展开更多
Objective: To observe the effects of morphine on the excitatory postsynaptic currents (EPSCs) and miniature EPSCs (mEPSCs) in rat supraoptic nucleus (SON) neurons and to explore its synaptic mechanism. Methods: Using ...Objective: To observe the effects of morphine on the excitatory postsynaptic currents (EPSCs) and miniature EPSCs (mEPSCs) in rat supraoptic nucleus (SON) neurons and to explore its synaptic mechanism. Methods: Using whole-cell voltage-clamp recording technique in the brain slices, the EPSCS and mEPSCs of rat SON neurons were recorded, respectively. Results: Morphine (20μmol/L) decreased the frequency of EPSCs and mEPSCs (by 65% for EPSCS and by 45% for mEPSCs), and reduced the amplitude of EPSCs by 44% in all SON neurons, but the amplitude distribution of mEPSCs was not affected. Conclusion: Morphine inhibits the excitatory transmissions via presynaptic mechanisms in SON neurons from rat brain slices.展开更多
文摘目的:观察盐酸戊乙奎醚对小剂量吗啡臂丛神经阻滞用于上肢术后镇痛副反应的影响。方法:64例在臂丛麻醉下行上肢手术的患者,随机均分为A、B两组。A组局麻药内加盐酸戊乙奎醚1 m g及吗啡4 m g,B组局麻药内仅加吗啡4 m g。结果:恶心呕吐及皮肤瘙痒的发生率A组低于B组(P<0.01或0.05),口干的发生率A组高于B组(P<0.01)。结论:盐酸戊乙奎醚可较明显地降低小剂量吗啡用于臂丛神经阻滞术后镇痛副反应的发病率。
文摘Objective: To observe the effects of morphine on the excitatory postsynaptic currents (EPSCs) and miniature EPSCs (mEPSCs) in rat supraoptic nucleus (SON) neurons and to explore its synaptic mechanism. Methods: Using whole-cell voltage-clamp recording technique in the brain slices, the EPSCS and mEPSCs of rat SON neurons were recorded, respectively. Results: Morphine (20μmol/L) decreased the frequency of EPSCs and mEPSCs (by 65% for EPSCS and by 45% for mEPSCs), and reduced the amplitude of EPSCs by 44% in all SON neurons, but the amplitude distribution of mEPSCs was not affected. Conclusion: Morphine inhibits the excitatory transmissions via presynaptic mechanisms in SON neurons from rat brain slices.
