At room temperature,the copper(Ⅰ) complex [(PPh 3) 2Cu(C 7H 4NO 4)](C 7H 4NO 4=2,3 dicarboxylic acid pyridine)was obtained by treating [(PPh 3) 2Cu(BH 4)] with 2,3 dicarboxylic acid pyridine in the mixed solvent of e...At room temperature,the copper(Ⅰ) complex [(PPh 3) 2Cu(C 7H 4NO 4)](C 7H 4NO 4=2,3 dicarboxylic acid pyridine)was obtained by treating [(PPh 3) 2Cu(BH 4)] with 2,3 dicarboxylic acid pyridine in the mixed solvent of ethanol and dichloromethane.This complex was further characterized by physicochemical and spectroscopic methods.The structure of this complex was also determined by X ray structure analysis.The crystal is triclinic,space group P 1 with parameters a=11 130(2)?,b=12 960(3)?,c=13 420(3)?;α=79 38(3)°,β=75 55(3)°,γ=80 36(3)°,V=1827 4(6)? 3,Z=2,F(000)=780,D calc. =1 371g/cm 3,R=0 0371,and R w=0 1204.The results show that PPh 3 coordinates as monodentate ligand to the Cu(Ⅰ) atoms,and 2,3 dicarboxylic acid pyridine behaves as a bidentate ligand in the prepared complex.Hence,each copper atom had a CuP 2NO tetrahedron coordination skeleton.展开更多
设计、合成香豆素-3-羧酸-烟酸前药并研究其抗血小板聚集活性,以发现活性更高的新型抗血小板聚集剂。利用拼合原理,以不同的连接桥将香豆素-3-羧酸和烟酸偶联,合成目标化合物。通过体外抗血小板聚集试验对目标化合物进行抗血小板聚集活...设计、合成香豆素-3-羧酸-烟酸前药并研究其抗血小板聚集活性,以发现活性更高的新型抗血小板聚集剂。利用拼合原理,以不同的连接桥将香豆素-3-羧酸和烟酸偶联,合成目标化合物。通过体外抗血小板聚集试验对目标化合物进行抗血小板聚集活性评价。设计、合成了5个新的目标化合物,其结构经ESI-MS、IR及1 H NMR确证。体外抗血小板聚集活性结果表明,目标化合物的抗血小板聚集活性均强于阳性对照药阿司匹林,其中化合物6a的活性最强,值得进一步研究。展开更多
The hydrothermal reaction of pyridine-3,4-dicarboxylic acid(pydcH2),4,4'-bipyridine and GdCl3.6H2O yield a novel gadolinium coordination polymer {[Gd2(pydc)2(μ3-OH)2(H2O)2].H2O}n(1).The compound was chara-cterize...The hydrothermal reaction of pyridine-3,4-dicarboxylic acid(pydcH2),4,4'-bipyridine and GdCl3.6H2O yield a novel gadolinium coordination polymer {[Gd2(pydc)2(μ3-OH)2(H2O)2].H2O}n(1).The compound was chara-cterized by elemental analysis,thermal analysis,IR spectra and single-crystal X-ray structure analysis.The crystal of the Gd(Ⅲ) complex belongs to triclinic system,space group P1 with:a=0.796 25(16) nm,b=0.944 46(19) nm,c=1.262 1(3) nm,α=76.50(3)°,β=84.95(3)°,γ=83.04(3)°,Z=2,V=0.914 4(3) nm3,Dc=2.669 g.cm-1,μ=7.269 mm-1,F(000)=692,and R1=0.033 3,wR2=0.062 3.The crystal structure revealed that compound 1 has a 2D layer structure incorporating 1D Gd-O-Gd double chain,and hydrogen bonding interactions result in the former of 3D supramolecular network structure.CCDC:669079.展开更多
文摘At room temperature,the copper(Ⅰ) complex [(PPh 3) 2Cu(C 7H 4NO 4)](C 7H 4NO 4=2,3 dicarboxylic acid pyridine)was obtained by treating [(PPh 3) 2Cu(BH 4)] with 2,3 dicarboxylic acid pyridine in the mixed solvent of ethanol and dichloromethane.This complex was further characterized by physicochemical and spectroscopic methods.The structure of this complex was also determined by X ray structure analysis.The crystal is triclinic,space group P 1 with parameters a=11 130(2)?,b=12 960(3)?,c=13 420(3)?;α=79 38(3)°,β=75 55(3)°,γ=80 36(3)°,V=1827 4(6)? 3,Z=2,F(000)=780,D calc. =1 371g/cm 3,R=0 0371,and R w=0 1204.The results show that PPh 3 coordinates as monodentate ligand to the Cu(Ⅰ) atoms,and 2,3 dicarboxylic acid pyridine behaves as a bidentate ligand in the prepared complex.Hence,each copper atom had a CuP 2NO tetrahedron coordination skeleton.
文摘设计、合成香豆素-3-羧酸-烟酸前药并研究其抗血小板聚集活性,以发现活性更高的新型抗血小板聚集剂。利用拼合原理,以不同的连接桥将香豆素-3-羧酸和烟酸偶联,合成目标化合物。通过体外抗血小板聚集试验对目标化合物进行抗血小板聚集活性评价。设计、合成了5个新的目标化合物,其结构经ESI-MS、IR及1 H NMR确证。体外抗血小板聚集活性结果表明,目标化合物的抗血小板聚集活性均强于阳性对照药阿司匹林,其中化合物6a的活性最强,值得进一步研究。
文摘The hydrothermal reaction of pyridine-3,4-dicarboxylic acid(pydcH2),4,4'-bipyridine and GdCl3.6H2O yield a novel gadolinium coordination polymer {[Gd2(pydc)2(μ3-OH)2(H2O)2].H2O}n(1).The compound was chara-cterized by elemental analysis,thermal analysis,IR spectra and single-crystal X-ray structure analysis.The crystal of the Gd(Ⅲ) complex belongs to triclinic system,space group P1 with:a=0.796 25(16) nm,b=0.944 46(19) nm,c=1.262 1(3) nm,α=76.50(3)°,β=84.95(3)°,γ=83.04(3)°,Z=2,V=0.914 4(3) nm3,Dc=2.669 g.cm-1,μ=7.269 mm-1,F(000)=692,and R1=0.033 3,wR2=0.062 3.The crystal structure revealed that compound 1 has a 2D layer structure incorporating 1D Gd-O-Gd double chain,and hydrogen bonding interactions result in the former of 3D supramolecular network structure.CCDC:669079.
