白虎汤加减治疗周围神经性痛30例疗效观察

周围神经痛是指主要周围神经病变引起的支配范围之放射性疼痛，与神经缺血损伤、代谢紊乱、自由基损伤及基因表达异常等因素有关，多严重影响患者生活。目前国外的研究比较注重发病机理的探讨，国内则主要集中在临床疗效的观察上。自2011年1月以来，笔者有幸师从骨伤科名家郭振江教授，在郭老指导下运用白虎汤加减治疗周围神经性痛（属中医湿热型，以烧灼样疼痛为主症者）30例，疗效显著，现报告如下。

白虎汤加减的临床应用

白虎汤最早见于《伤寒论》,为解热退烧的经典名方,阳明气分热盛所致诸证,皆可应用白虎汤加减治疗。后世医家在白虎汤基础上进行加减化裁,使其临床应用范围更加广泛。临床上白虎汤加减常用于治疗病毒性感冒、糖尿病、急性痛风关节炎、流行性出血热、周围神经性痛、肾移植术后、银屑病、手足口病、病毒性结角膜炎、鼻咽癌等。现代药理研究表明,白虎汤除了具有解热作用外,还有增强机体免疫作用。其主治疾病的根本病机不外乎阳明气分热盛。因此,阳明气分热盛所致诸证,皆可应用白虎汤加减治疗,体现了"异病同治"的治疗原则及中医辨证论治的灵活性。

CB1 receptor localization in rat spinal cord and roots,dorsal root ganglion,and peripheral nerve

AIM:The localization of CB1 receptors in the spinal cord,spinal roots,dorsal root ganglion(DRG),and peripheral nerve of the rat was determined.METHODS:We studied the distribution of CB1 cannabinoid receptors by immunohistochemistry using an antibody raised against the N-terminal of the receptor.RESULTS:The spinal cord showed numerous transverse fibers labelled for CB1 receptors throughout and concentrated in the dorsal horn.Lightly-stained cells were observed throughout the spinal cord gray matter.The DRG also showed cells and fibers labelled for CB1 receptors.Labelled fibers were observed in both dorsal and ventral roots as well as in peripheral nerves.CONCLUSION:The presence of CB1 receptors in the DRG,the dorsal root,and the dorsal horn is in accordance with the analgesic effects of cannabinoids.The presence of labelled cells and fibers in the ventral horn and ventral root provides a substrate for cannabinoid-induced muscle relaxant and antispastic effects.