目的探讨供精人工授精(artificial insemination by donor,AID)影响妊娠率的临床因素和AID夫妇的心理特征。方法回顾性分析2015年1月至2018年12月在福建省妇幼保健院生殖中心门诊接受AID治疗的夫妇660对临床资料,共1305个AID周期。对女...目的探讨供精人工授精(artificial insemination by donor,AID)影响妊娠率的临床因素和AID夫妇的心理特征。方法回顾性分析2015年1月至2018年12月在福建省妇幼保健院生殖中心门诊接受AID治疗的夫妇660对临床资料,共1305个AID周期。对女方年龄、不孕年限、体重指数(body mass index,BMI)、不孕类型、治疗方案、子宫内膜厚度、授精方式、同一周期AID次数、治疗周期数与AID妊娠率进行χ2检验和二分类Logistic回归分析,探索各临床因素与AID妊娠率的关系。采用生育压力量表(fertility problem inventory,FPI)和生活质量量表(FertiQoL量表)对2018年1月至2018年12月在福建省妇幼保健院生殖中心门诊接受AID治疗的130对夫妇进行心理创伤调查,比较夫妇双方生育压力和生活压力的差异。结果<25岁[31.7%(51/161)]、25~35岁女性[22.8%(244/1072)]和>35岁[19.4(14/72)]女性周期妊娠率差异有统计学意义(χ2=6.913,P=0.032);不孕年限≤5年和>5年的女性之间妊娠率差异有统计学意义(24.8%比18.6%,χ2=4.248,P=0.039);宫腔内人工授精(intrauterine insemination,IUI)的妊娠率(26.2%)明显高于颈管内人工授精(intracervical insemination,ICI)女性(15.6%),差异有统计学意义(χ2=14.912,P<0.010)。二分类Logistic回归分析显示授精方式是影响AID周期妊娠率的主要因素,IUI周期妊娠率较ICI高(OR=2.028,95%CI 1.458~2.822,P<0.010)。AID女性FPI总分高于配偶[(175.00±8.11)分比(168.68±6.86)分,t=6.295,P<0.010],女性在夫妻关系[(36.08±4.77)分比(34.67±4.74分),t=2.502,P=0.014]、无子女压力[(28.91±3.38)分比(26.91±3.18)分,t=6.530,P<0.010]维度的得分亦高于配偶;AID女性FertiQoL总分低于配偶[(55.96±6.57)分比(62.30±6.84)分,t=-8.582,P<0.010],女性在环境[(50.46±9.51)分比(55.01±9.01),t=-4.149,P<0.010]、耐受性[(51.55±6.17)分比(56.29±6.48)分,t=-5.657,P<0.010]、情感反应[(54.92±5.92)分比(59.85±6.79)分,t=-5.736,P<0.010]、婚姻关系[(58.15±6.71)分比(61.80±7.91)分,t=-4.057,P<0.010]、社会关系[(60.08±8.27)分比(62.79±6.47)分,t=-2.886,P=0.005]、身心关系[(60.93±6.09)分比(64.28±5.68)分,t=-4.595,P<0.010]6个维度得分均低于配偶。结论授精方式是影响AID临床妊娠率的重要因素,采用IUI可提高AID的周期妊娠率。AID女性生育压力高于配偶,生活质量低于配偶,临床诊疗中应注重AID夫妇的心理健康,并给予心理指导。展开更多
Objective: To investigate the possible negative effects of a strong ovarian response on oocyte quality.Design: Retrospective study.Setting: Tertiary academic center.Patient(s): A total of 1, 894 women (IVF, n = 1, 544...Objective: To investigate the possible negative effects of a strong ovarian response on oocyte quality.Design: Retrospective study.Setting: Tertiary academic center.Patient(s): A total of 1, 894 women (IVF, n = 1, 544; ICSI, n = 350) who underwent their first ovarian stimulation cycle during the period 1995- 2002.Intervention(s): Standardized controlled ovarian stimulation with urinary FSH or recombinant FSH after pituitary down- regulation, followed by IVF/intracytoplasmic sperm injection (ICSI) and ET.Main Outcome Measure(s): Fertilization rate, fraction of high- quality embryos, and implantation rate.Result(s): Using multivariate logistic regression, we analyzed the effect, expressed as an odds ratio (OR), of the number of oocytes obtained (i.e., ovarian response) on the outcome measures.No effect of the response on the ongoing implantation rate or fraction of high- quality embryos was observed.Both in IVF (OR = 0.81, 95% confidence interval [CI] 0.75- 0.87) and in ICSI (OR = 0.88, 95% CI 0.76- 1.00), a negative effect of increasing ovarian response was seen on the fertilization rate per oocyte obtained.However, no negative effect was observed on the fertilization rate per oocyte injected in ICSI (OR = 1.00, 95% CI 0.87- 1.14).The fraction of immature oocytes rises from 3.9% , in women with ≤ 3 oocytes, to 26% in women with > 20 oocytes.Conclusion(s): Oocytes from high responders contain a greater fraction of immature oocytes, but pregnancy outcome is not impaired.展开更多
文摘目的探讨供精人工授精(artificial insemination by donor,AID)影响妊娠率的临床因素和AID夫妇的心理特征。方法回顾性分析2015年1月至2018年12月在福建省妇幼保健院生殖中心门诊接受AID治疗的夫妇660对临床资料,共1305个AID周期。对女方年龄、不孕年限、体重指数(body mass index,BMI)、不孕类型、治疗方案、子宫内膜厚度、授精方式、同一周期AID次数、治疗周期数与AID妊娠率进行χ2检验和二分类Logistic回归分析,探索各临床因素与AID妊娠率的关系。采用生育压力量表(fertility problem inventory,FPI)和生活质量量表(FertiQoL量表)对2018年1月至2018年12月在福建省妇幼保健院生殖中心门诊接受AID治疗的130对夫妇进行心理创伤调查,比较夫妇双方生育压力和生活压力的差异。结果<25岁[31.7%(51/161)]、25~35岁女性[22.8%(244/1072)]和>35岁[19.4(14/72)]女性周期妊娠率差异有统计学意义(χ2=6.913,P=0.032);不孕年限≤5年和>5年的女性之间妊娠率差异有统计学意义(24.8%比18.6%,χ2=4.248,P=0.039);宫腔内人工授精(intrauterine insemination,IUI)的妊娠率(26.2%)明显高于颈管内人工授精(intracervical insemination,ICI)女性(15.6%),差异有统计学意义(χ2=14.912,P<0.010)。二分类Logistic回归分析显示授精方式是影响AID周期妊娠率的主要因素,IUI周期妊娠率较ICI高(OR=2.028,95%CI 1.458~2.822,P<0.010)。AID女性FPI总分高于配偶[(175.00±8.11)分比(168.68±6.86)分,t=6.295,P<0.010],女性在夫妻关系[(36.08±4.77)分比(34.67±4.74分),t=2.502,P=0.014]、无子女压力[(28.91±3.38)分比(26.91±3.18)分,t=6.530,P<0.010]维度的得分亦高于配偶;AID女性FertiQoL总分低于配偶[(55.96±6.57)分比(62.30±6.84)分,t=-8.582,P<0.010],女性在环境[(50.46±9.51)分比(55.01±9.01),t=-4.149,P<0.010]、耐受性[(51.55±6.17)分比(56.29±6.48)分,t=-5.657,P<0.010]、情感反应[(54.92±5.92)分比(59.85±6.79)分,t=-5.736,P<0.010]、婚姻关系[(58.15±6.71)分比(61.80±7.91)分,t=-4.057,P<0.010]、社会关系[(60.08±8.27)分比(62.79±6.47)分,t=-2.886,P=0.005]、身心关系[(60.93±6.09)分比(64.28±5.68)分,t=-4.595,P<0.010]6个维度得分均低于配偶。结论授精方式是影响AID临床妊娠率的重要因素,采用IUI可提高AID的周期妊娠率。AID女性生育压力高于配偶,生活质量低于配偶,临床诊疗中应注重AID夫妇的心理健康,并给予心理指导。
文摘Objective: To investigate the possible negative effects of a strong ovarian response on oocyte quality.Design: Retrospective study.Setting: Tertiary academic center.Patient(s): A total of 1, 894 women (IVF, n = 1, 544; ICSI, n = 350) who underwent their first ovarian stimulation cycle during the period 1995- 2002.Intervention(s): Standardized controlled ovarian stimulation with urinary FSH or recombinant FSH after pituitary down- regulation, followed by IVF/intracytoplasmic sperm injection (ICSI) and ET.Main Outcome Measure(s): Fertilization rate, fraction of high- quality embryos, and implantation rate.Result(s): Using multivariate logistic regression, we analyzed the effect, expressed as an odds ratio (OR), of the number of oocytes obtained (i.e., ovarian response) on the outcome measures.No effect of the response on the ongoing implantation rate or fraction of high- quality embryos was observed.Both in IVF (OR = 0.81, 95% confidence interval [CI] 0.75- 0.87) and in ICSI (OR = 0.88, 95% CI 0.76- 1.00), a negative effect of increasing ovarian response was seen on the fertilization rate per oocyte obtained.However, no negative effect was observed on the fertilization rate per oocyte injected in ICSI (OR = 1.00, 95% CI 0.87- 1.14).The fraction of immature oocytes rises from 3.9% , in women with ≤ 3 oocytes, to 26% in women with > 20 oocytes.Conclusion(s): Oocytes from high responders contain a greater fraction of immature oocytes, but pregnancy outcome is not impaired.
