Chow Sang Sang has a rich heritage in the region. It was first establishedin Guangzhou in 1934 and then relocated to Hong Kong in 1948. “Chow SangSang” in Chinese translates as “endless vitality and rejuvenation”,...Chow Sang Sang has a rich heritage in the region. It was first establishedin Guangzhou in 1934 and then relocated to Hong Kong in 1948. “Chow SangSang” in Chinese translates as “endless vitality and rejuvenation”, andtrue to its name, the company is a tireless innovator that strives to ridethe trend, creating exquisitely designed pieces for its valued customers.With its continuous efforts to upgrade its production technology and servicemanagement, Chow Sang Sang has earned itself the best reputation and leadingmarket position in the industry.展开更多
徜徉百年经典,绽放光芒新姿,周生生在中国香港购物地标K11 MUSEA举办“Art to Life”活动,庆祝全球首家“V&A博物馆×周生生珠宝概念店”开幕一周年。概念店融合古典艺术与数码科技,为顾客带来崭新的“艺术×珠宝”空间体...徜徉百年经典,绽放光芒新姿,周生生在中国香港购物地标K11 MUSEA举办“Art to Life”活动,庆祝全球首家“V&A博物馆×周生生珠宝概念店”开幕一周年。概念店融合古典艺术与数码科技,为顾客带来崭新的“艺术×珠宝”空间体验。众多媒体、明星好友、行业专家等莅临现场,共同见证品牌里程碑的闪耀时刻,书写一站式购物体验新篇。展开更多
瑰丽珠宝生生不息,美好事物代代相传。2022年11月10日,“周生生”香港首家海洋主题珠宝概念店于海港城闪耀揭幕,携本地初创企业共启“Harbour of Love”人工复育珊瑚计划,为璀璨珠宝赋予独特意义,共同见证珠宝美学的全新之旅。。“周生...瑰丽珠宝生生不息,美好事物代代相传。2022年11月10日,“周生生”香港首家海洋主题珠宝概念店于海港城闪耀揭幕,携本地初创企业共启“Harbour of Love”人工复育珊瑚计划,为璀璨珠宝赋予独特意义,共同见证珠宝美学的全新之旅。。“周生生”于11月11日邀请消费者免费搭乘“天星小轮”,饱览碧绿海港景致,从而提倡关注海洋生态。展开更多
Seasonal variation of biochemical components in clam(Saxidomus purpuratus Sowerby 1852) was investigated from March 2012 to February 2013 in relation to environmental condition of Sanggou Bay and the reproductive cycl...Seasonal variation of biochemical components in clam(Saxidomus purpuratus Sowerby 1852) was investigated from March 2012 to February 2013 in relation to environmental condition of Sanggou Bay and the reproductive cycle of clam.According to the histological analysis,the reproductive cycle of S.purpuratus includes two distinctive phases:a total spent and inactive stage from November to January,and a gametogenesis stage,including ripeness and spawning,during the rest of the year.Gametes were generated at a low temperature(2.1℃) in February.Spawning took place once a year from June to October.The massive spawning occurred in August when the highest water temperature and chlorophyll a level could be observed.The key biochemical components(glycogen,protein and lipid) in five tissues(gonad,foot,mantle,siphon and adductor muscle) were analyzed.The glycogen content was high before gametogenesis,and decreased significantly during the gonad development in the gonad,mantle and foot of both females and males,suggesting that glycogen was an important energy source for gonad development.The protein and lipid contents increased in the ovary during the gonad development,demonstrating that they are the major organic components of oocytes.The lipid and protein contents decreased in the testis,implying that they can provide energy and material for spermatogenesis.The results also showed that protein stored in the mantle and foot could support the reproduction after the glycogen was depleted.展开更多
Germinal centers （GC） of secondary lymphoid tissues are critical to mounting a high-affinity humoral immune response. B cells within the GC undergo rapid clonal expansion and selection while diversifying their antib...Germinal centers （GC） of secondary lymphoid tissues are critical to mounting a high-affinity humoral immune response. B cells within the GC undergo rapid clonal expansion and selection while diversifying their antibody genes. Although it is generally believed that GC B cells employ a unique proliferative program to accommodate these processes, little is known about how the GC-associated cell cycle is orchestrated. The D-type cyclins constitute an important component of the cell cycle engine that enables the cells to respond to physiological changes. Cell type- and developmental stage-specific roles of D-type cyclins have been described but the cyclin D requirement during GC reaction has not been addressed. In this study, we report that cyclin D3 is largely dispensable for proliferation and Ig class switching of in vitro activated B cells. In contrast, GC development in Ccnd3^-/- mice is markedly impaired, as is the T cell-dependent antibody response. Within the GC, although both switched and unswitched B cells are affected by cyclin D3 inactivation, the IgM^- pool is more severely reduced. Interestingly, despite a compensatory increase in cyclln D2 expression, a significant number of Ccnd3^-/- GC B cells accumulate in quiescent GO state. Lastly, although cyclin D3 inactivation did not disrupt BCL6 expression in GC B cells, it completely blocked the GC promoting effect of BCL6 overexpression, suggesting that cyclin D3 acts downstream of BCL6 to regulate GC formation. This is the first demonstration that cyclin D3 plays an important and unique role at the GC stage of B cell development.展开更多
Grateloupia turuturu is a commercial red alga with potential value in nutraceuticals and pharmaceuticals. To supplement information on its life history and verify whether carpospores can be used for seedling culture, ...Grateloupia turuturu is a commercial red alga with potential value in nutraceuticals and pharmaceuticals. To supplement information on its life history and verify whether carpospores can be used for seedling culture, early development of G. turuturu was investigated under culture conditions （27~C, 10-13 ~mol/（mZ.s） in irradiance, photoperiod 10：14 h L：D）. Three physiological stages were recognized by continuous microscopic observation： division stage, discoid crust stage, and juvenile seedling stage. At the beginning of the division stage, the carpospores developed germ tubes into which the carpospore protoplasm was evacuated, and then the carpospore protoplasm in the germ tubes began to divide continuously until discoid crusts formed. Finally, upright thalli appeared on the discoid crusts and developed into juvenile seedlings. It took about 60 days for carpospores to develop into juvenile seedlings. The growth parameters, including germination rate for carpospores and discoid crust diameter, were recorded. These results contribute more information on the life cycle, and at the same time are of great significance in the scaling-up of artificial seedling cultures of G. turuturu.展开更多
This article presents the results of hydrochemical and hydrobiological studies of shallow saline lakes of the Borzya group(Zabaikalsky Krai, Russia) at the initial filling phase. The lake-margin ecosystems of the stud...This article presents the results of hydrochemical and hydrobiological studies of shallow saline lakes of the Borzya group(Zabaikalsky Krai, Russia) at the initial filling phase. The lake-margin ecosystems of the studied lakes are characterized by varying degrees of salinity from polyhaline to brine water. Cyclical variations of meteorological conditions and high salinity determined that the compositions of the aquatic organisms are specific, mostly between stenohaline and euryhaline species, the quantities are low, and the community structures are simple.展开更多
文摘Chow Sang Sang has a rich heritage in the region. It was first establishedin Guangzhou in 1934 and then relocated to Hong Kong in 1948. “Chow SangSang” in Chinese translates as “endless vitality and rejuvenation”, andtrue to its name, the company is a tireless innovator that strives to ridethe trend, creating exquisitely designed pieces for its valued customers.With its continuous efforts to upgrade its production technology and servicemanagement, Chow Sang Sang has earned itself the best reputation and leadingmarket position in the industry.
文摘徜徉百年经典,绽放光芒新姿,周生生在中国香港购物地标K11 MUSEA举办“Art to Life”活动,庆祝全球首家“V&A博物馆×周生生珠宝概念店”开幕一周年。概念店融合古典艺术与数码科技,为顾客带来崭新的“艺术×珠宝”空间体验。众多媒体、明星好友、行业专家等莅临现场,共同见证品牌里程碑的闪耀时刻,书写一站式购物体验新篇。
文摘瑰丽珠宝生生不息,美好事物代代相传。2022年11月10日,“周生生”香港首家海洋主题珠宝概念店于海港城闪耀揭幕,携本地初创企业共启“Harbour of Love”人工复育珊瑚计划,为璀璨珠宝赋予独特意义,共同见证珠宝美学的全新之旅。。“周生生”于11月11日邀请消费者免费搭乘“天星小轮”,饱览碧绿海港景致,从而提倡关注海洋生态。
基金supported by the grants from National Marine Public Welfare Research Program (201305005)Scientific and Technical Supporting Program (2011BA D13B01)National Natural Science Foundation of China (41276138)
文摘Seasonal variation of biochemical components in clam(Saxidomus purpuratus Sowerby 1852) was investigated from March 2012 to February 2013 in relation to environmental condition of Sanggou Bay and the reproductive cycle of clam.According to the histological analysis,the reproductive cycle of S.purpuratus includes two distinctive phases:a total spent and inactive stage from November to January,and a gametogenesis stage,including ripeness and spawning,during the rest of the year.Gametes were generated at a low temperature(2.1℃) in February.Spawning took place once a year from June to October.The massive spawning occurred in August when the highest water temperature and chlorophyll a level could be observed.The key biochemical components(glycogen,protein and lipid) in five tissues(gonad,foot,mantle,siphon and adductor muscle) were analyzed.The glycogen content was high before gametogenesis,and decreased significantly during the gonad development in the gonad,mantle and foot of both females and males,suggesting that glycogen was an important energy source for gonad development.The protein and lipid contents increased in the ovary during the gonad development,demonstrating that they are the major organic components of oocytes.The lipid and protein contents decreased in the testis,implying that they can provide energy and material for spermatogenesis.The results also showed that protein stored in the mantle and foot could support the reproduction after the glycogen was depleted.
文摘Germinal centers （GC） of secondary lymphoid tissues are critical to mounting a high-affinity humoral immune response. B cells within the GC undergo rapid clonal expansion and selection while diversifying their antibody genes. Although it is generally believed that GC B cells employ a unique proliferative program to accommodate these processes, little is known about how the GC-associated cell cycle is orchestrated. The D-type cyclins constitute an important component of the cell cycle engine that enables the cells to respond to physiological changes. Cell type- and developmental stage-specific roles of D-type cyclins have been described but the cyclin D requirement during GC reaction has not been addressed. In this study, we report that cyclin D3 is largely dispensable for proliferation and Ig class switching of in vitro activated B cells. In contrast, GC development in Ccnd3^-/- mice is markedly impaired, as is the T cell-dependent antibody response. Within the GC, although both switched and unswitched B cells are affected by cyclin D3 inactivation, the IgM^- pool is more severely reduced. Interestingly, despite a compensatory increase in cyclln D2 expression, a significant number of Ccnd3^-/- GC B cells accumulate in quiescent GO state. Lastly, although cyclin D3 inactivation did not disrupt BCL6 expression in GC B cells, it completely blocked the GC promoting effect of BCL6 overexpression, suggesting that cyclin D3 acts downstream of BCL6 to regulate GC formation. This is the first demonstration that cyclin D3 plays an important and unique role at the GC stage of B cell development.
基金Supported by the Natural Science Foundation of Shandong Province,China(No.Y2007D42)
文摘Grateloupia turuturu is a commercial red alga with potential value in nutraceuticals and pharmaceuticals. To supplement information on its life history and verify whether carpospores can be used for seedling culture, early development of G. turuturu was investigated under culture conditions （27~C, 10-13 ~mol/（mZ.s） in irradiance, photoperiod 10：14 h L：D）. Three physiological stages were recognized by continuous microscopic observation： division stage, discoid crust stage, and juvenile seedling stage. At the beginning of the division stage, the carpospores developed germ tubes into which the carpospore protoplasm was evacuated, and then the carpospore protoplasm in the germ tubes began to divide continuously until discoid crusts formed. Finally, upright thalli appeared on the discoid crusts and developed into juvenile seedlings. It took about 60 days for carpospores to develop into juvenile seedlings. The growth parameters, including germination rate for carpospores and discoid crust diameter, were recorded. These results contribute more information on the life cycle, and at the same time are of great significance in the scaling-up of artificial seedling cultures of G. turuturu.
基金Supported by the Projects from the Ministry of Natural Resources of the Zabaikalsky Krai(Nos.7 and VII.79.1)the Siberian Branch of the Russian Academy of Sciences
文摘This article presents the results of hydrochemical and hydrobiological studies of shallow saline lakes of the Borzya group(Zabaikalsky Krai, Russia) at the initial filling phase. The lake-margin ecosystems of the studied lakes are characterized by varying degrees of salinity from polyhaline to brine water. Cyclical variations of meteorological conditions and high salinity determined that the compositions of the aquatic organisms are specific, mostly between stenohaline and euryhaline species, the quantities are low, and the community structures are simple.
