To evaluate the disease involvement in a patient with acute zonal occult outer retinopathy (AZOOR). Observational case report. A patient with acute zonal occu lt outer retinopathy was imaged with fundus photography, f...To evaluate the disease involvement in a patient with acute zonal occult outer retinopathy (AZOOR). Observational case report. A patient with acute zonal occu lt outer retinopathy was imaged with fundus photography, fluorescein and indocya nine green angiography, and autofluorescence photography. There was subtle depig mentation in the central portion of the lesion with a drusen like deposit at th e outer border. Fluorescein angiography showed a transmission defect centrally a nd a blocking defect at the border where the drusenoid material accumulated. Aut ofluorescent photography demonstrated that the drusenoid material was intensely autofluorescent, consistent with the presence of lipofuscin, and the central por tion of the lesion showed atrophy of the retinal pigment epithelium. Indocyanine green angiography showed atrophy of the choriocapillaris underlying areas of at rophy of the retinal pigment epithelium. In this case acute zonal occult outer r etinopathy caused an area of retinal pigment epithelium cell death with lipofusc in laden cells at the border of the expanding lesion and associated atrophy of the underlying choriocapillaris.展开更多
To investigate the mechanism of bilateral central vision loss in a patient wit h graft-versus-host disease. Observational case report. A 43-year-old man wi th graft-versus-host disease developed acute painless progres...To investigate the mechanism of bilateral central vision loss in a patient wit h graft-versus-host disease. Observational case report. A 43-year-old man wi th graft-versus-host disease developed acute painless progressive central visi on loss, first in the left eye and then in the right. The patient underwent slit -lamp biomicroscopy, indirect ophthalmoscopy, fluorescein angiography, visual f ield testing, full-field electroretinography, multifocal electroretinography, a nd testing for paraneoplastic antibodies. Fundus examination and fluorescein ang iography were unremarkable. Goldmann perimetry revealed enlarged blind spots wit h central scotomas bilaterally. An electroretinogram testing showed asymmetric r etinal dysfunction, consistent with acute zonal occult outer retinopathy. No par aneoplastic autoantibodies were detected. The patient continued to have asymmetr ic progressive vision loss that stabilized over the next 6 months. Graft-versus -host disease should be included in the autoimmune conditions associated with A ZOOR.展开更多
文摘To evaluate the disease involvement in a patient with acute zonal occult outer retinopathy (AZOOR). Observational case report. A patient with acute zonal occu lt outer retinopathy was imaged with fundus photography, fluorescein and indocya nine green angiography, and autofluorescence photography. There was subtle depig mentation in the central portion of the lesion with a drusen like deposit at th e outer border. Fluorescein angiography showed a transmission defect centrally a nd a blocking defect at the border where the drusenoid material accumulated. Aut ofluorescent photography demonstrated that the drusenoid material was intensely autofluorescent, consistent with the presence of lipofuscin, and the central por tion of the lesion showed atrophy of the retinal pigment epithelium. Indocyanine green angiography showed atrophy of the choriocapillaris underlying areas of at rophy of the retinal pigment epithelium. In this case acute zonal occult outer r etinopathy caused an area of retinal pigment epithelium cell death with lipofusc in laden cells at the border of the expanding lesion and associated atrophy of the underlying choriocapillaris.
文摘To investigate the mechanism of bilateral central vision loss in a patient wit h graft-versus-host disease. Observational case report. A 43-year-old man wi th graft-versus-host disease developed acute painless progressive central visi on loss, first in the left eye and then in the right. The patient underwent slit -lamp biomicroscopy, indirect ophthalmoscopy, fluorescein angiography, visual f ield testing, full-field electroretinography, multifocal electroretinography, a nd testing for paraneoplastic antibodies. Fundus examination and fluorescein ang iography were unremarkable. Goldmann perimetry revealed enlarged blind spots wit h central scotomas bilaterally. An electroretinogram testing showed asymmetric r etinal dysfunction, consistent with acute zonal occult outer retinopathy. No par aneoplastic autoantibodies were detected. The patient continued to have asymmetr ic progressive vision loss that stabilized over the next 6 months. Graft-versus -host disease should be included in the autoimmune conditions associated with A ZOOR.
