[目的]了解宫颈癌化疗病人的味嗅觉改变现状,探讨味嗅觉改变与生活质量的相关性。[方法]采用横断面调查,于2018年3月,采用味嗅觉调查表(TSS)对宫颈癌住院化疗病人104例进行调查。[结果]宫颈癌化疗病人TSS得分为(5.84±4.04)分,中重...[目的]了解宫颈癌化疗病人的味嗅觉改变现状,探讨味嗅觉改变与生活质量的相关性。[方法]采用横断面调查,于2018年3月,采用味嗅觉调查表(TSS)对宫颈癌住院化疗病人104例进行调查。[结果]宫颈癌化疗病人TSS得分为(5.84±4.04)分,中重度改变者63例(60.6%)。不同体质指数(BMI)研究对象的TSS得分比较差异有统计学意义( P <0.05)。分别有42.3%、23.1%、31.7%、 20.2%研究对象出现了咸、甜、酸、苦等基本味觉的敏感度改变,43.3%研究对象诉对气味的敏感度改变。[结论]宫颈癌化疗病人中普遍存在味嗅觉改变,多为中重度,且具有个体特点,需进一步探讨味嗅觉改变与营养状态和生活质量的相关性。展开更多
[目的]了解我国宫颈癌化疗病人的味嗅觉改变(taste and smell alterations,TSAs)发生情况,探讨TSAs与病人自我报告症状及困扰程度的相关性。[方法]以2017年9月在四川省某三级甲等肿瘤医院妇科肿瘤中心住院,行紫杉醇类+铂类化疗,符合纳...[目的]了解我国宫颈癌化疗病人的味嗅觉改变(taste and smell alterations,TSAs)发生情况,探讨TSAs与病人自我报告症状及困扰程度的相关性。[方法]以2017年9月在四川省某三级甲等肿瘤医院妇科肿瘤中心住院,行紫杉醇类+铂类化疗,符合纳入、排除标准的宫颈癌病人160例为研究对象,采用味嗅觉调查表(the Taste and Smell Survey,TSS)和中文版M.D.安德森症状量表进行横断面调查。[结果]共发放和收回问卷160份,有效问卷150份(93.75%)。108例(72.0%)报告TSAs,化疗1个或2个疗程的87例病人中有51例(58.6%)报告TSAs,化疗5个或6个疗程的12例病人(100.0%)报告TSAs。病人自我报告的13个核心症状中发生率前3位的是口干(94%)、胃口差(88%)、疲劳(88%),TSAS程度对核心症状数有影响(F=11.143,P<0.01),核心症状得分与TSS得分有相关性(P<0.05),仅有疼痛得分与TSS得分无相关性(r=0.237,P=0.097)。TSAS程度对生活的干扰数有影响(F=4.128,P=0.011),对日常生活干扰情况得分与TSS得分有相关性(P<0.05)。[结论]宫颈癌化疗病人TSAs出现早、发生率高,且随着TSAs程度加重,病人自我报告症状及其对生活的干扰也越多、越重,尤其是胃肠道症状。展开更多
This paper presents a novel strategy for the response enhancement of olfactory sensory neurons (OSNs)-based biosensors by monitoring the enhancive responses of OSNs to odorants. An OSNs-based biosensor was developed o...This paper presents a novel strategy for the response enhancement of olfactory sensory neurons (OSNs)-based biosensors by monitoring the enhancive responses of OSNs to odorants. An OSNs-based biosensor was developed on the basis of the light addressable potentiometric sensor (LAPS), in which rat OSNs were cultured on the surface of LAPS chip and served as sensing elements. LY294002, the specific inhibitor of phosphatidylinositol 3-kinase (PI3K), was used to enhance the responses of OSNs to odorants. The responses of OSNs to odorants with and without the treatment of LY294002 were recorded by LAPS. The results show that the enhancive effect of LY294002 was recorded efficiently by LAPS and the responses of this OSNs-LAPS hybrid biosensor were enhanced by LY294002 by about 1.5-fold. We conclude that this method can enhance the responses of OSNs-LAPS hybrid biosensors, which may provide a novel strategy for the bioelectrical signal monitor of OSNs in biosensors. It is also suggested that this strategy may be applicable to other kinds of OSNs-based biosensors for cellular activity detection, such as microelectrode array (MEA) and field effect transistor (FET).展开更多
文摘[目的]了解宫颈癌化疗病人的味嗅觉改变现状,探讨味嗅觉改变与生活质量的相关性。[方法]采用横断面调查,于2018年3月,采用味嗅觉调查表(TSS)对宫颈癌住院化疗病人104例进行调查。[结果]宫颈癌化疗病人TSS得分为(5.84±4.04)分,中重度改变者63例(60.6%)。不同体质指数(BMI)研究对象的TSS得分比较差异有统计学意义( P <0.05)。分别有42.3%、23.1%、31.7%、 20.2%研究对象出现了咸、甜、酸、苦等基本味觉的敏感度改变,43.3%研究对象诉对气味的敏感度改变。[结论]宫颈癌化疗病人中普遍存在味嗅觉改变,多为中重度,且具有个体特点,需进一步探讨味嗅觉改变与营养状态和生活质量的相关性。
文摘[目的]了解我国宫颈癌化疗病人的味嗅觉改变(taste and smell alterations,TSAs)发生情况,探讨TSAs与病人自我报告症状及困扰程度的相关性。[方法]以2017年9月在四川省某三级甲等肿瘤医院妇科肿瘤中心住院,行紫杉醇类+铂类化疗,符合纳入、排除标准的宫颈癌病人160例为研究对象,采用味嗅觉调查表(the Taste and Smell Survey,TSS)和中文版M.D.安德森症状量表进行横断面调查。[结果]共发放和收回问卷160份,有效问卷150份(93.75%)。108例(72.0%)报告TSAs,化疗1个或2个疗程的87例病人中有51例(58.6%)报告TSAs,化疗5个或6个疗程的12例病人(100.0%)报告TSAs。病人自我报告的13个核心症状中发生率前3位的是口干(94%)、胃口差(88%)、疲劳(88%),TSAS程度对核心症状数有影响(F=11.143,P<0.01),核心症状得分与TSS得分有相关性(P<0.05),仅有疼痛得分与TSS得分无相关性(r=0.237,P=0.097)。TSAS程度对生活的干扰数有影响(F=4.128,P=0.011),对日常生活干扰情况得分与TSS得分有相关性(P<0.05)。[结论]宫颈癌化疗病人TSAs出现早、发生率高,且随着TSAs程度加重,病人自我报告症状及其对生活的干扰也越多、越重,尤其是胃肠道症状。
基金supported by the National Natural Science Foundation ofChina (No. 60725102)the Natural Science Foundation of Zhejiang Province, China (No. R205505)
文摘This paper presents a novel strategy for the response enhancement of olfactory sensory neurons (OSNs)-based biosensors by monitoring the enhancive responses of OSNs to odorants. An OSNs-based biosensor was developed on the basis of the light addressable potentiometric sensor (LAPS), in which rat OSNs were cultured on the surface of LAPS chip and served as sensing elements. LY294002, the specific inhibitor of phosphatidylinositol 3-kinase (PI3K), was used to enhance the responses of OSNs to odorants. The responses of OSNs to odorants with and without the treatment of LY294002 were recorded by LAPS. The results show that the enhancive effect of LY294002 was recorded efficiently by LAPS and the responses of this OSNs-LAPS hybrid biosensor were enhanced by LY294002 by about 1.5-fold. We conclude that this method can enhance the responses of OSNs-LAPS hybrid biosensors, which may provide a novel strategy for the bioelectrical signal monitor of OSNs in biosensors. It is also suggested that this strategy may be applicable to other kinds of OSNs-based biosensors for cellular activity detection, such as microelectrode array (MEA) and field effect transistor (FET).
