ESPITE the strong association between gastroesophageal reflux disease （GERD） and asthma has been undisputedly established and widely recognized by experts in advanced countries. Yet few topics in medicine are as con...ESPITE the strong association between gastroesophageal reflux disease （GERD） and asthma has been undisputedly established and widely recognized by experts in advanced countries. Yet few topics in medicine are as controversial as the causal relationship between GERD and asthma： some argue that GERD causes asthma, while others think the other way around is true, still quite a few believe that bronchodilator medications are to blame. This controversy continues to be a conundrum or more piece of the puzzle.1 We would like to share two thoughts which might be a belated revelation with scholars and experts and invite them for further cooperative studies： the GERD-derived respiratory distress is not asthma, but GERD pure and simple; and the pathogenesis of respiratory distress is not asthma, but laryngotracheal irritation/spasm/suffocation.展开更多
Objective：To observe the effect of rapid point pressure on clinical effect and pulmonary function of patients with chronic persistent bronchial asthma. 〈br〉 Methods：A total of 60 confirmed chronic persistent bronc...Objective：To observe the effect of rapid point pressure on clinical effect and pulmonary function of patients with chronic persistent bronchial asthma. 〈br〉 Methods：A total of 60 confirmed chronic persistent bronchial asthma cases were randomly allocated into two groups, 30 in each group. Cases in the treatment group were treated with rapid point pressure, 1 h for the initial treatment, and 40 min for the ensuing treatments. The treatment was done once a day for 40 d. Cases in the control group were treated with Compound Methoxyphenamine Hydrochloride Capsules, 2 capsules for each dose, 3 times a day. The treatment lasted for 7 consecutive days. A 1-year follow-up was made for both groups. 〈br〉 Results：After treatment, the scores of each symptom and total symptom scores for the traditional Chinese medicine （TCM） symptoms in the treatment group were significantly higher than those in the control group （P〈0.05）;the total effective rates in the treatment group were higher than those in the control group in each time frame; and there was a between-group statistical significance in total effective rate after 7 d of treatment （P〈0.01）. After 40-day treatments, there were statistical significances in the forced expiratory volume in 1 s percentage of predicted value （FEV 1%） and inspiratory capacity （IC%） in the treatment group （P〈0.05）; however, there were no statistical significances （P〉0.05） in forced expiratory volume in 1 second to forced vital capacity ratio （FEV1/FVC）, peak expiratory flow rate （PEF%） and maximum midexpiratory flow rate （MMEF%）; and there were no statistical significances in pulmonary function parameters in the control group. In addition, as for pulmonary function parameters, there were no intra-group statistical significances in differences before and after treatment （P〉0.05）. 〈br〉 Conclusion：Rapid point pressure can alleviate patients’ TCM symptoms and improve their FEV%and IC%.展开更多
Objective:To observe the therapeutic efficacy of acupoint application at different groups of acupoints in treating bronchial asthma in remission stage.Methods:A total of 120 patients with bronchial asthma in remission...Objective:To observe the therapeutic efficacy of acupoint application at different groups of acupoints in treating bronchial asthma in remission stage.Methods:A total of 120 patients with bronchial asthma in remission stage were recruited and divided by the random number table method into acupoint application group 1,acupoint application group 2 and acupoint application group 3,with 40 cases in each group.In all the three groups,Tiantu(CV 22),Dazhui(GV 14)and Feishu(BL 13)were selected,with Dingchuan(EX-B 1)added in acupoint application group 1,Shenshu(BL 23)added in acupoint application group 2,and Gaohuang(BL 43)added in acupoint application group 3.Before intervention,one month and 3 months after intervention,clinical symptoms,peak expiratory flow(PEF)and forced expiratory volume in 1 second percentage of predicted value(FEV1%)of the three groups were observed,and their clinical efficacies were evaluated.Results:Comparing the therapeutic efficacy regarding traditional Chinese medicine symptoms and signs,after 1-month treatment,the total effective rate was 87.5%in acupoint application group 1,versus 62.5%in acupoint application group 2 and 55.0%in acupoint application group 3,and the between-group differences were statistically significant.After 3-month treatment,the total effective rate was 95.0%in acupoint application group 1,versus 70.0%in acupoint application group 2 and 65.0%in acupoint application group 3,and the between-group differences were statistically significant.After intervention,the three groups all showed significant improvements in pulmonary function with statistical significance;among the three groups,the improvement in acupoint application group 1 was more significant than that in the other two groups.Conclusion:Tiantu(CV 22),Dazhui(GV 14)and Feishu(BL 13)as basic prescription plus Dingchuan(EX-B 1)can improve symptoms of bronchial asthma in remission stage,and it works better in improving pulmonary function than the basic prescription plus Shenshu(BL 23)or Gaohuang(BL 43).展开更多
Asthma is a common disease with recurrent onset which severely affects patients＇ quality of life. Acupuncture can improve pulmonary functions in asthma patients and thus treat this disorder. To summarize the status o...Asthma is a common disease with recurrent onset which severely affects patients＇ quality of life. Acupuncture can improve pulmonary functions in asthma patients and thus treat this disorder. To summarize the status of acupuncture treatment for asthma, we have collected clinical literatures published in the recent 20 years and analyzed the influence of acupuncture on pulmonary functions in asthma patients from the aspects of frequently used points, needling techniques, manipulation and mechanisms to provide references for treating asthma with acupuncture.展开更多
To investigate whether terbutaline affects alveolar liquid deorance after oleic acid-induced lung injury in rats. Methods ： Forty healthy Wistor rats （ weighing 250- 280 g） were randomly divided into five groups ...To investigate whether terbutaline affects alveolar liquid deorance after oleic acid-induced lung injury in rats. Methods ： Forty healthy Wistor rats （ weighing 250- 280 g） were randomly divided into five groups （ n = 8 in each group ） ： the normal control group （ control group ）, oleic acid injury group （injury group）, group （terbutaline group ）, terbutaline plus amiloridetreated group （ terbutaline ＋ amiloride group ） and terbutaline plus ouabaln-treated group （terbutaline ＋ ouabaln group）. Acute lung injury model was induced by intravenous oleic acid （0. 25 ml/kg body weight）. 24 hours later, 1.5 μCi^125 I-labeled 5% albumin solution （5 ml/kg body weight） was dripped into the lungs through trachea. The alveolar liquid clearance rate, extravascular lung water content, and arterial blood gas were measured 1 hour thereafter. Results： At24 hours after infusion of oleic acid, the rats developed pulmonary edema and severe hypoxemia,with the alveolar liquid clearance rate decreased by 49. 2 % and the extravascnlar lung water content elevated by 47.9%. Compared with the rats in the injury group, terbutaline （ 10^-4 mol/L ） significantly increased the alveolar liquid clearance rate, decreased the extravascular lung water content and improved hypoxemia. The effect of terlmtaUne was partly blocked by amiloride and ouabain, which were inhibitors of sodium transport. Terbutaline increased the alveolar liquid clearance rate by 63.7 %, and amiloride and ouabain reduced the alveolar liquid clearance rate by 54.7 % and 56. 8 %, respectively. Conclusions： Terbutaline can accelerate alveolar liquid clearance through increasing sodim transport to attenuate pulmonary edema, thus improving gas exchange, which may have therapeutical effect on pulmonary edema after acute lung injury.展开更多
Objective: To observe the effect of combining spreading moxibustion and point injection on serum eosinophil cationic protein(ECP), lipid peroxidase(LPO) and cellular immunity in patients with cough-variant asthma. Met...Objective: To observe the effect of combining spreading moxibustion and point injection on serum eosinophil cationic protein(ECP), lipid peroxidase(LPO) and cellular immunity in patients with cough-variant asthma. Methods: A total of 150 cases who met the inclusion criteria were randomized into three groups, 50 in each group. Spreading moxibustion and point injection were employed in the observation group, spreading moxibustion alone in the spreading moxibustion group and point injection alone in the point injection group. Then the therapeutic efficacies were evaluated after one course of treatment. Results: The recovery rate and total effective rate were 50.0% and 98.0% respectively in the observation group, versus 18.0% and 86.0% in the spreading moxibustion group and 14.0% and 82.0% in the point injection group, showing a statistically significant difference(P < 0.01). Before treatment, there were no inter-group statistically significant differences in levels of ECP, LPO, CD3+,CD4+, CD4+/CD8+ and CD8+, forced vital capacity(FCV), forced expiratory volume 1(FEV1), and peak expiratory flow(PEF)(P>0.05). After treatment, the ECP and LPO levels in the observation group were more significantly reduced than those in the other two groups, showing statistically significant difference(P<0.01); the levels of CD3+, CD4+ and CD4+/CD8+ in the observation group were significantly elevated but CD8+ was significantly reduced, showing statistically significant differences compared with those in the other two groups(P<0.01); and the lung function indexes(FVC, FEV1 and PEF) in the observation group were more significantly elevated than those in the other two groups(P<0.05). Conclusion: Combining spreading moxibustion and point injection could remarkably reduce the contents of ECP and LPO in patients with cough-variant asthma, improve cellular immunity, increase the contents of CD3+, CD4+ and CD4+/CD8+, reduce the content of CD8+ and improve the lung function.展开更多
Adenoid cystic carcinoma rarely occurs within the subglottic larynx. In this study, a case of subglottic adenoid cystic carcinoma was reported. A 54 year-old Chinese woman developed a sudden onset of chest distress an...Adenoid cystic carcinoma rarely occurs within the subglottic larynx. In this study, a case of subglottic adenoid cystic carcinoma was reported. A 54 year-old Chinese woman developed a sudden onset of chest distress and cough worsening after physical exertion, and was diagnosed with, and treated as, bronchial asthma. Regular anti-asthmatic therapy did not improve the symptoms. Until a sudden dyspnea, a cervicothoracic computerized tomography （CT） revealed that her upper airway was obstructed by a laryngeal tumor. The patient was diagnosed with a subglottic adenoid cystic carcinoma and treated with complete surgical excision and adjuvant radiation therapy. Follow-up endoscopy and laryngeal magnetic resonance imaging （MR1） at six months showed no recurrence of the tumor. The diagnosis of subglottic adenoid cystic carcinoma should be considered in patients who are characterized by dyspnea, cough, and stridor, but do not respond to regular anti-asthmatic therapy.展开更多
文摘ESPITE the strong association between gastroesophageal reflux disease （GERD） and asthma has been undisputedly established and widely recognized by experts in advanced countries. Yet few topics in medicine are as controversial as the causal relationship between GERD and asthma： some argue that GERD causes asthma, while others think the other way around is true, still quite a few believe that bronchodilator medications are to blame. This controversy continues to be a conundrum or more piece of the puzzle.1 We would like to share two thoughts which might be a belated revelation with scholars and experts and invite them for further cooperative studies： the GERD-derived respiratory distress is not asthma, but GERD pure and simple; and the pathogenesis of respiratory distress is not asthma, but laryngotracheal irritation/spasm/suffocation.
基金supported by the 3-year Action Plan for Shanghai Development of Traditional Chinese Medicine(No.ZYSNXD-CC-ZDYJ055)
文摘Objective：To observe the effect of rapid point pressure on clinical effect and pulmonary function of patients with chronic persistent bronchial asthma. 〈br〉 Methods：A total of 60 confirmed chronic persistent bronchial asthma cases were randomly allocated into two groups, 30 in each group. Cases in the treatment group were treated with rapid point pressure, 1 h for the initial treatment, and 40 min for the ensuing treatments. The treatment was done once a day for 40 d. Cases in the control group were treated with Compound Methoxyphenamine Hydrochloride Capsules, 2 capsules for each dose, 3 times a day. The treatment lasted for 7 consecutive days. A 1-year follow-up was made for both groups. 〈br〉 Results：After treatment, the scores of each symptom and total symptom scores for the traditional Chinese medicine （TCM） symptoms in the treatment group were significantly higher than those in the control group （P〈0.05）;the total effective rates in the treatment group were higher than those in the control group in each time frame; and there was a between-group statistical significance in total effective rate after 7 d of treatment （P〈0.01）. After 40-day treatments, there were statistical significances in the forced expiratory volume in 1 s percentage of predicted value （FEV 1%） and inspiratory capacity （IC%） in the treatment group （P〈0.05）; however, there were no statistical significances （P〉0.05） in forced expiratory volume in 1 second to forced vital capacity ratio （FEV1/FVC）, peak expiratory flow rate （PEF%） and maximum midexpiratory flow rate （MMEF%）; and there were no statistical significances in pulmonary function parameters in the control group. In addition, as for pulmonary function parameters, there were no intra-group statistical significances in differences before and after treatment （P〉0.05）. 〈br〉 Conclusion：Rapid point pressure can alleviate patients’ TCM symptoms and improve their FEV%and IC%.
文摘Objective:To observe the therapeutic efficacy of acupoint application at different groups of acupoints in treating bronchial asthma in remission stage.Methods:A total of 120 patients with bronchial asthma in remission stage were recruited and divided by the random number table method into acupoint application group 1,acupoint application group 2 and acupoint application group 3,with 40 cases in each group.In all the three groups,Tiantu(CV 22),Dazhui(GV 14)and Feishu(BL 13)were selected,with Dingchuan(EX-B 1)added in acupoint application group 1,Shenshu(BL 23)added in acupoint application group 2,and Gaohuang(BL 43)added in acupoint application group 3.Before intervention,one month and 3 months after intervention,clinical symptoms,peak expiratory flow(PEF)and forced expiratory volume in 1 second percentage of predicted value(FEV1%)of the three groups were observed,and their clinical efficacies were evaluated.Results:Comparing the therapeutic efficacy regarding traditional Chinese medicine symptoms and signs,after 1-month treatment,the total effective rate was 87.5%in acupoint application group 1,versus 62.5%in acupoint application group 2 and 55.0%in acupoint application group 3,and the between-group differences were statistically significant.After 3-month treatment,the total effective rate was 95.0%in acupoint application group 1,versus 70.0%in acupoint application group 2 and 65.0%in acupoint application group 3,and the between-group differences were statistically significant.After intervention,the three groups all showed significant improvements in pulmonary function with statistical significance;among the three groups,the improvement in acupoint application group 1 was more significant than that in the other two groups.Conclusion:Tiantu(CV 22),Dazhui(GV 14)and Feishu(BL 13)as basic prescription plus Dingchuan(EX-B 1)can improve symptoms of bronchial asthma in remission stage,and it works better in improving pulmonary function than the basic prescription plus Shenshu(BL 23)or Gaohuang(BL 43).
文摘Asthma is a common disease with recurrent onset which severely affects patients＇ quality of life. Acupuncture can improve pulmonary functions in asthma patients and thus treat this disorder. To summarize the status of acupuncture treatment for asthma, we have collected clinical literatures published in the recent 20 years and analyzed the influence of acupuncture on pulmonary functions in asthma patients from the aspects of frequently used points, needling techniques, manipulation and mechanisms to provide references for treating asthma with acupuncture.
基金This study was supported by the Research Project of the "Tenth Five-year Plan" of PLA (No.01Z074)
文摘To investigate whether terbutaline affects alveolar liquid deorance after oleic acid-induced lung injury in rats. Methods ： Forty healthy Wistor rats （ weighing 250- 280 g） were randomly divided into five groups （ n = 8 in each group ） ： the normal control group （ control group ）, oleic acid injury group （injury group）, group （terbutaline group ）, terbutaline plus amiloridetreated group （ terbutaline ＋ amiloride group ） and terbutaline plus ouabaln-treated group （terbutaline ＋ ouabaln group）. Acute lung injury model was induced by intravenous oleic acid （0. 25 ml/kg body weight）. 24 hours later, 1.5 μCi^125 I-labeled 5% albumin solution （5 ml/kg body weight） was dripped into the lungs through trachea. The alveolar liquid clearance rate, extravascular lung water content, and arterial blood gas were measured 1 hour thereafter. Results： At24 hours after infusion of oleic acid, the rats developed pulmonary edema and severe hypoxemia,with the alveolar liquid clearance rate decreased by 49. 2 % and the extravascnlar lung water content elevated by 47.9%. Compared with the rats in the injury group, terbutaline （ 10^-4 mol/L ） significantly increased the alveolar liquid clearance rate, decreased the extravascular lung water content and improved hypoxemia. The effect of terlmtaUne was partly blocked by amiloride and ouabain, which were inhibitors of sodium transport. Terbutaline increased the alveolar liquid clearance rate by 63.7 %, and amiloride and ouabain reduced the alveolar liquid clearance rate by 54.7 % and 56. 8 %, respectively. Conclusions： Terbutaline can accelerate alveolar liquid clearance through increasing sodim transport to attenuate pulmonary edema, thus improving gas exchange, which may have therapeutical effect on pulmonary edema after acute lung injury.
基金supported by Taihe Hospital,Hubei University of Medicine
文摘Objective: To observe the effect of combining spreading moxibustion and point injection on serum eosinophil cationic protein(ECP), lipid peroxidase(LPO) and cellular immunity in patients with cough-variant asthma. Methods: A total of 150 cases who met the inclusion criteria were randomized into three groups, 50 in each group. Spreading moxibustion and point injection were employed in the observation group, spreading moxibustion alone in the spreading moxibustion group and point injection alone in the point injection group. Then the therapeutic efficacies were evaluated after one course of treatment. Results: The recovery rate and total effective rate were 50.0% and 98.0% respectively in the observation group, versus 18.0% and 86.0% in the spreading moxibustion group and 14.0% and 82.0% in the point injection group, showing a statistically significant difference(P < 0.01). Before treatment, there were no inter-group statistically significant differences in levels of ECP, LPO, CD3+,CD4+, CD4+/CD8+ and CD8+, forced vital capacity(FCV), forced expiratory volume 1(FEV1), and peak expiratory flow(PEF)(P>0.05). After treatment, the ECP and LPO levels in the observation group were more significantly reduced than those in the other two groups, showing statistically significant difference(P<0.01); the levels of CD3+, CD4+ and CD4+/CD8+ in the observation group were significantly elevated but CD8+ was significantly reduced, showing statistically significant differences compared with those in the other two groups(P<0.01); and the lung function indexes(FVC, FEV1 and PEF) in the observation group were more significantly elevated than those in the other two groups(P<0.05). Conclusion: Combining spreading moxibustion and point injection could remarkably reduce the contents of ECP and LPO in patients with cough-variant asthma, improve cellular immunity, increase the contents of CD3+, CD4+ and CD4+/CD8+, reduce the content of CD8+ and improve the lung function.
文摘Adenoid cystic carcinoma rarely occurs within the subglottic larynx. In this study, a case of subglottic adenoid cystic carcinoma was reported. A 54 year-old Chinese woman developed a sudden onset of chest distress and cough worsening after physical exertion, and was diagnosed with, and treated as, bronchial asthma. Regular anti-asthmatic therapy did not improve the symptoms. Until a sudden dyspnea, a cervicothoracic computerized tomography （CT） revealed that her upper airway was obstructed by a laryngeal tumor. The patient was diagnosed with a subglottic adenoid cystic carcinoma and treated with complete surgical excision and adjuvant radiation therapy. Follow-up endoscopy and laryngeal magnetic resonance imaging （MR1） at six months showed no recurrence of the tumor. The diagnosis of subglottic adenoid cystic carcinoma should be considered in patients who are characterized by dyspnea, cough, and stridor, but do not respond to regular anti-asthmatic therapy.
