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清肺止咳片联合孟鲁司特钠治疗小儿咳嗽变异性哮喘对呼气峰流速及诱导痰炎性因子的影响 被引量:22
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作者 范爱红 代育中 +1 位作者 陈翔 米艳茹 《世界中西医结合杂志》 2021年第8期1500-1505,1510,共7页
目的探讨清肺止咳片患儿联合孟鲁司特钠治疗小儿咳嗽后变异性哮喘(cough variant asthma,CVA)对呼气峰流速(peak expiratory flow,PEF)及诱导痰炎性因子的影响。方法选取2017年9月—2019年10月期间河北省唐山市第三医院收治的130例CVA患... 目的探讨清肺止咳片患儿联合孟鲁司特钠治疗小儿咳嗽后变异性哮喘(cough variant asthma,CVA)对呼气峰流速(peak expiratory flow,PEF)及诱导痰炎性因子的影响。方法选取2017年9月—2019年10月期间河北省唐山市第三医院收治的130例CVA患儿,按随机数字表法分为对照组63例和观察组67例,两组患儿均给予吸氧平喘、止咳化痰、解痉抗感染等常规治疗,对照组在此基础上给予孟鲁司特钠咀嚼片;观察组在对照组基础上给予清肺止咳片,两组患儿均持续治疗4个疗程,随访6个月。观察比较两组患儿治疗前后日间、夜间咳嗽症状评分、CT气道重塑、诱导痰炎性因子、血清因子及肺功能指标1 s用力呼气容积(Forced expiratory volume in one second,FEV1)、PEF变化,并记录两组患儿复发及不良反应发生情况。结果治疗4个疗程后两组患儿日间、夜间咳嗽症状评分均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组治疗4个疗程后日间、夜间咳嗽症状评分均明显低于对照组,两组比较,差异有统计学意义(P<0.05)。治疗4个疗程后两组患儿CT气道重塑项目指标气道腔面积(airway cavity area,AI)、气道横截面积(airway cross-sectional area,AO)、气道壁面积(area of airway wall,WA)、气道壁厚度(airway wall thickness,T),诱导痰相关炎性指标白介素-5(Interleukin-5,IL-5)、白介素-13(interleukin-13,IL-13)、神经生长因子(nerve growth factor,NGF)、P物质(substance P,SP),血清学指标巨噬细胞炎性蛋白-1α(macrophage inflammatory protein-1α,MIP-1α)、嗜酸性粒细胞趋化因子[recombinant human eotaxin(CCL11),Eotaxin]、淀粉样蛋白A(Serum Amyloid A,SAA)水平均优于治疗前,差异有统计学意义(P<0.05)。且观察组治疗4个疗程后CT气道重塑项目指标AI、AO、WA、T水平,诱导痰相关炎性指标IL-5、IL-13、NGF、SP水平,血清学指标MIP-1α、SAA、Eotaxin水平均明显低于对照组,两组比较,差异有统计学意义(P<0.05)。观察组治疗1、2、3、4个疗程后FEV1、PEF变化量明显高于对照组治疗同期,差异均有统计学意义(P<0.05)。治疗期间,观察组不良反应发生率为4.48%(3/67),对照组不良反应发生率为11.11%(7/63),两组患儿不良反应均经对症治疗后得到缓解,不影响疗程用药,两组不良反应发生率比较,差异无统计学意义(P>0.05)。随访期间,对照组复发率为15.87%(10/63),观察组复发率为4.48%(3/67),两组比较,差异有统计学意义(P<0.05)。结论对于咳嗽变异性哮喘患儿,清肺止咳片联合孟鲁司特钠治疗可明显缓解患儿咳嗽症状,降低炎症反应水平,改善肺功能状况。 展开更多
关键词 小儿咳嗽 变异性哮喘 清肺止咳片 呼气流速峰 诱导痰炎性因子
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参附注射液治疗急性心力衰竭疗效观察 被引量:18
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作者 叶淑萍 《现代中西医结合杂志》 CAS 2016年第13期1449-1451,1465,共4页
目的观察参附注射液治疗急性心力衰竭的临床疗效及对呼气流速峰(PEFR)的影响。方法将87例急性心力衰竭患者随机分为2组,对照组43例给予常规内科治疗,观察组44例在常规内科治疗基础上加用参附注射液治疗;比较2组治疗7 d后的临床疗效以及... 目的观察参附注射液治疗急性心力衰竭的临床疗效及对呼气流速峰(PEFR)的影响。方法将87例急性心力衰竭患者随机分为2组,对照组43例给予常规内科治疗,观察组44例在常规内科治疗基础上加用参附注射液治疗;比较2组治疗7 d后的临床疗效以及治疗前与治疗后3 d的血清B型尿钠肽(BNP)、左室射血分数(LVEF)、呼吸困难程度评分、心功能分级以及PEFR。结果观察组的临床总有效率高于对照组(P<0.05);2组治疗后3 d的血清BNP、LVEF、呼吸困难程度评分、心功能分级以及PEFR均较治疗前明显改善(P均<0.05),且观察组各指标改善幅度均显著优于对照组(P均<0.05)。结论参附注射液治疗急性心力衰竭疗效确切,可明显改善患者的心功能及PEFR。 展开更多
关键词 急性心力衰竭 参附注射液 呼气流速峰
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Effect of breathing and Daoyin exercises on the quality of life in patients with chronic obstructive pulmonary disease 被引量:8
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作者 陈麒 史苗颜 +2 位作者 张炜 田君 韩丑萍 《Journal of Acupuncture and Tuina Science》 CSCD 2015年第6期353-360,共8页
Objective: To observe the effect of breathing and Daoyin exercises on the quality of life in patients with stable chronic obstructive pulmonary disease(COPD) due to deficiency of the lung and kidney(grade II-III)... Objective: To observe the effect of breathing and Daoyin exercises on the quality of life in patients with stable chronic obstructive pulmonary disease(COPD) due to deficiency of the lung and kidney(grade II-III).Methods: A total of 60 eligible cases were randomly allocated into a treatment group(n=30) and a control group(n=30) by random number table. Cases in the control group received routine Western medical treatment, whereas cases in the treatment group conducted breathing and Daoyin exercises in addition to routine Western medical treatment. Patients in both groups were treated for a total of 3 months. Then the observation was made on changes in pulmonary ventilation function, major clinical symptoms, modified Medical Research Council scale(m MRC), distance in 6-minute walk test(6-MWT), COPD assessment test(CAT) and efficacy satisfaction questionnaire for COPD(ESQ-COPD) before and after treatment. Results: After treatment, the total effective rate was 80.0% in the treatment group, versus 66.7% in the control group, showing a statistical difference(P〈0.05). Patients in the treatment group obtained more significant improvement in coughing, sputum production, dyspnea and shortness of breath than those in the control group(P〈0.05). Patients in the treatment group obtained more significant elevation in the forced expiratory volume in 1 second percentage of predicted value(FEV1%) and peak expiratory flow rate(PEF%) than those in the control group(P〈0.05). Patients in the treatment group obtained lower m MRC score than those in the control group(P〈0.05). Patients in the treatment group obtained longer 6-MWT distance than those in the control group(P〈0.05). Patients in the treatment group obtained lower CAT score(P〈0.01) and higher ESQ-COPD score(P〈0.05) than those in the control group. Conclusion: Breathing and Daoyin exercises combined with routine Western medical treatment are effective for stable COPD(grade II-III) due to deficiency of the lung and kidney and can improve the patients' quality of life. 展开更多
关键词 Physical and Breathing Exercises Research on Qigong Pulmonary Disease Chronic Obstructive Respiratory Function Tests Peak Expiratory Flow Rate
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Clinical study of optimizing acupoint combining in treatment of bronchial asthma with acupoint application 被引量:2
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作者 Zhang Kai-yong Xu Si-wei +3 位作者 Yang Yang Shou Yin Jiang Hui-ru Zhang Bi-meng 《Journal of Acupuncture and Tuina Science》 CSCD 2019年第5期344-349,共6页
Objective:To observe the therapeutic efficacy of acupoint application at different groups of acupoints in treating bronchial asthma in remission stage.Methods:A total of 120 patients with bronchial asthma in remission... Objective:To observe the therapeutic efficacy of acupoint application at different groups of acupoints in treating bronchial asthma in remission stage.Methods:A total of 120 patients with bronchial asthma in remission stage were recruited and divided by the random number table method into acupoint application group 1,acupoint application group 2 and acupoint application group 3,with 40 cases in each group.In all the three groups,Tiantu(CV 22),Dazhui(GV 14)and Feishu(BL 13)were selected,with Dingchuan(EX-B 1)added in acupoint application group 1,Shenshu(BL 23)added in acupoint application group 2,and Gaohuang(BL 43)added in acupoint application group 3.Before intervention,one month and 3 months after intervention,clinical symptoms,peak expiratory flow(PEF)and forced expiratory volume in 1 second percentage of predicted value(FEV1%)of the three groups were observed,and their clinical efficacies were evaluated.Results:Comparing the therapeutic efficacy regarding traditional Chinese medicine symptoms and signs,after 1-month treatment,the total effective rate was 87.5%in acupoint application group 1,versus 62.5%in acupoint application group 2 and 55.0%in acupoint application group 3,and the between-group differences were statistically significant.After 3-month treatment,the total effective rate was 95.0%in acupoint application group 1,versus 70.0%in acupoint application group 2 and 65.0%in acupoint application group 3,and the between-group differences were statistically significant.After intervention,the three groups all showed significant improvements in pulmonary function with statistical significance;among the three groups,the improvement in acupoint application group 1 was more significant than that in the other two groups.Conclusion:Tiantu(CV 22),Dazhui(GV 14)and Feishu(BL 13)as basic prescription plus Dingchuan(EX-B 1)can improve symptoms of bronchial asthma in remission stage,and it works better in improving pulmonary function than the basic prescription plus Shenshu(BL 23)or Gaohuang(BL 43). 展开更多
关键词 Acupoint Sticking Therapy Application Therapy ASTHMA Respiratory Function Tests Forced Expiratory Volume Peak Expiratory Flow Rate Point Selection
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Influence of acupuncture on pulmonary function of patients with asthma: a review 被引量:1
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作者 Wei Yu-ting Yan Xing-ke 《Journal of Acupuncture and Tuina Science》 CSCD 2018年第3期195-200,共6页
Asthma is a common disease with recurrent onset which severely affects patients' quality of life. Acupuncture can improve pulmonary functions in asthma patients and thus treat this disorder. To summarize the status o... Asthma is a common disease with recurrent onset which severely affects patients' quality of life. Acupuncture can improve pulmonary functions in asthma patients and thus treat this disorder. To summarize the status of acupuncture treatment for asthma, we have collected clinical literatures published in the recent 20 years and analyzed the influence of acupuncture on pulmonary functions in asthma patients from the aspects of frequently used points, needling techniques, manipulation and mechanisms to provide references for treating asthma with acupuncture. 展开更多
关键词 Acupuncture Therapy Acupuncture Points ASTHMA Respiratory Function Tests Forced Expiratory Volume Peak Expiratory Flow Rate Forced Vital Capacity Point Selection
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