期刊文献+
共找到6篇文章
< 1 >
每页显示 20 50 100
《尘埃落定》:“愚”人命运坚韧性书写
1
作者 黄朝进 《牡丹江大学学报》 2021年第4期27-31,共5页
阿来是我国当代少数民族作家,以少数民族作家的独特视角创作出了《尘埃落定》这一部长篇小说。用“愚”人的思维方式为研究点,对“愚”人视野下的三个方面进行具体的人物形象剖析,首先是生活中“智慧的愚者”,探讨的是作者的“智能观”... 阿来是我国当代少数民族作家,以少数民族作家的独特视角创作出了《尘埃落定》这一部长篇小说。用“愚”人的思维方式为研究点,对“愚”人视野下的三个方面进行具体的人物形象剖析,首先是生活中“智慧的愚者”,探讨的是作者的“智能观”;其次是“权力的享有者”,探讨的是作者的“物质观”;最后是“命运的审视者”,探讨的是作者对于时间、历史、哲学的追问。以“愚”的角度,阐述了阿来对人生及命运的看法,借此来探讨当下的生活与命运。 展开更多
关键词 阿来 《尘埃落定》 命运性
下载PDF
Xom interacts with and stimulates transcriptional activity of LEFI/TCFs: implications for ventral cell fate determination during vertebrate embryogenesis 被引量:2
2
作者 Hong Gao Bin Wu +1 位作者 Roger Giese Zhenglun Zhu 《Cell Research》 SCIE CAS CSCD 2007年第4期345-356,共12页
LEF1/TCFs are high mobility group box-containing transcriptional factors mediating canonical Wnt/β-catenin signaling during early embryogenesis and tumorigenesis. β-Catenin forms a complex with LEF 1/TCFs and transa... LEF1/TCFs are high mobility group box-containing transcriptional factors mediating canonical Wnt/β-catenin signaling during early embryogenesis and tumorigenesis. β-Catenin forms a complex with LEF 1/TCFs and transactivates LEF1/TCF-mediated transcriptions during dorsalization. Although LEF-mediated transcription is also implicated in ventralization, the underlying molecular mechanism is not well understood. Using the vertebrate Xenopus laevis model system, we found that Xom, which is a ventralizing homeobox protein with dual roles of transcriptional activation and repression, forms a complex with LEF 1/TCF through its homeodomain and transactivates LEF 1/TCF-mediated transcription through its N-terminal transactivation domain (TAD). Our data show that Xom lacking the N-terminal TAD fails to transactivate ventral genes, such as BMP4 and Xom itself, but retains the ability to suppress transcriptional activation of dorsal gene promoters, such as the Goosecoid promoter, indicating that transactivation and repression are separable functions of Xom. It has been postulated that Xom forms a positive re-enforcement loop with BMP4 to promote ventral- ization and to suppress dorsal gene expression. Consistent with an essential role of Xom transactivation of LEF1/TCFs during early embryogenesis, we found that expression of the dominant-negative Xom mutant that lacks the TAD fails to re-enforce the ventral signaling of BMP4 and causes a catastrophic effect during gastrulation. Our data suggest that the functional interaction of Xom and LEF 1/TCF-factors is essential for ventral cell fate determination and that LEF 1/TCF factors may function as a point of convergence to mediate the combined signaling of Wnt/β-catenin and BMP4/Xom pathways during early embryogenesis. 展开更多
关键词 Xom VENT Wnt BMP4 β-catenin LEF1/TCFs dorsoventral patterning
下载PDF
A Quarter Century of Work to Revolutionize Architecture, Engineering and Construction Enterprise Information Systems
3
作者 Alain Zarli Patrice Poyet 《Journal of Civil Engineering and Architecture》 2017年第8期715-735,共21页
More than two decades ago, object-oriented representation of AEC (architecture engineering and construction) projects started to offer the promise of seamless communication of semantic data models between computer-b... More than two decades ago, object-oriented representation of AEC (architecture engineering and construction) projects started to offer the promise of seamless communication of semantic data models between computer-based systems used from the design stage to the operation of the facilities. BIM (building information modelling) emerged and appeared as a means to store all relevant data generated during the life-cycle of the facilities. But this upstream view of the built environment, arising from the design and construction stages, extended to the downstream operations where building and industrial facilities appeared more and more as huge dynamic data producers and concentrators while being operated. This created new challenges leading to what is referred to as ISCs (intelligent and smart constructions). The current state of the art is that final constructions still contain various and increasingly versatile control and service systems, which are hardly standardised, and not interconnected among themselves. Monitoring, maintenance and services are done by specialised companies, each responsible of different systems, which are relying on customised software and techniques to meet specific user needs and are based on monolithic applications that require manual configuration for specific uses, maintenance and support. We demonstrate in this paper that the early promises of integration across the actors and along the life-time of facilities have gone a long way but will only be delivered through enhanced standardisation of computerized models, representations, services and operations still not yet fully accomplished 25 years after work started. 展开更多
关键词 Architecture engineering and construction building information models semantic interoperability intelligent and smart built environment information systems and sensors for new services.
下载PDF
生命科技与人类命运:基因编辑的法理反思 被引量:30
4
作者 郑玉双 《法制与社会发展》 CSSCI 北大核心 2019年第4期185-201,共17页
基于"CRISPR/Cas9"的基因编辑技术的发明带来了生命科技领域的革命,同时引发了关于基因编辑技术之适用边界的伦理和法律争议。批评者基于反自然论证、风险论证和尊严论证主张人体基因编辑违反伦理,因此应该对其从法律上加以... 基于"CRISPR/Cas9"的基因编辑技术的发明带来了生命科技领域的革命,同时引发了关于基因编辑技术之适用边界的伦理和法律争议。批评者基于反自然论证、风险论证和尊严论证主张人体基因编辑违反伦理,因此应该对其从法律上加以禁止。然而,这三种论证及其依据的传统伦理框架无法回应基因科技的真正伦理挑战,也不足以对人体胚胎的基因编辑构成有效反驳。基因科技并非带来尊严危机,而是带来了重新理解人之生命和主体地位的道德内涵的新契机。基于个体与人类命运在基因事务上的紧密同构性,基因科技能够促进个体与人类整体在共同利益上的同构性。在这个新伦理框架的引导之下,应该建构一种能够与对基因科技之伦理判断深层互嵌的法律规制体系。 展开更多
关键词 基因编辑 自然 风险 人的尊严 个体与人类命运的紧密同构
原文传递
《对手》:超越类型化的市井反谍叙事
5
作者 陈立强 《当代电视》 CSSCI 2022年第3期40-43,67,共5页
市井反谍剧《对手》为传统反谍剧带来一种不曾有过的叙事景观。去特定化场景,对间谍角色进行市井化设计。去类型化事件,呈现出从情节性到命运性的悬疑感。整部剧渗透着诸多的社会话题,让间谍方与反谍方都经历普通人的烦恼。剧情与人物... 市井反谍剧《对手》为传统反谍剧带来一种不曾有过的叙事景观。去特定化场景,对间谍角色进行市井化设计。去类型化事件,呈现出从情节性到命运性的悬疑感。整部剧渗透着诸多的社会话题,让间谍方与反谍方都经历普通人的烦恼。剧情与人物的家庭伦理化,是对此前反谍剧的类型突破。 展开更多
关键词 《对手》 反谍剧 命运性悬疑 泛话题化 家庭伦理化
原文传递
Novel insights into cell cycle regulation of cell fate determination 被引量:9
6
作者 Su-wei GAO Feng LIU 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2019年第6期467-475,共9页
The stem/progenitor cell has long been regarded as a central cell type in development,homeostasis,and regeneration,largely owing to its robust self-renewal and multilineage differentiation abilities.The balance betwee... The stem/progenitor cell has long been regarded as a central cell type in development,homeostasis,and regeneration,largely owing to its robust self-renewal and multilineage differentiation abilities.The balance between self-renewal and stem/progenitor cell differentiation requires the coordinated regulation of cell cycle progression and cell fate determination.Extensive studies have demonstrated that cell cycle states determine cell fates,because cells in different cell cycle states are characterized by distinct molecular features and functional outputs.Recent advances in high-resolution epigenome profiling,single-cell transcriptomics,and cell cycle reporter systems have provided novel insights into the cell cycle regulation of cell fate determination.Here,we review recent advances in cell cycle-dependent cell fate determination and functional heterogeneity,and the application of cell cycle manipulation for cell fate conversion.These findings will provide insight into our understanding of cell cycle regulation of cell fate determination in this field,and may facilitate its potential application in translational medicine. 展开更多
关键词 Cell cycle Cell fate HETEROGENEITY Fate conversion Stem/progenitor cell
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部