AIM： TO investigate the characteristics and diagnostic value of annexin A2 （ANXA2） expression in cancerous tissues and sera of patients with hepatitis B virus （HBV）-related hepatocellular carcinoma （HCC）. METH...AIM： TO investigate the characteristics and diagnostic value of annexin A2 （ANXA2） expression in cancerous tissues and sera of patients with hepatitis B virus （HBV）-related hepatocellular carcinoma （HCC）. METHODS： Levels of liver ANXA2 gene transcription or protein expression were analyzed in HCC-, their self- controlled precancerous-, and distant cancerous- tissues from 30 HCC. Serum levels of ANXA2 expression in 115 patients with HCC, 25 with metastatic liver can cer, 35 with chronic hepatitis, 28 with acute hepatitis, 38 with cirrhosis, and 30 healthy controls were deter- mined. Clinicopathological characteristics of circulating ANXA2 expression were analyzed, and its diagnostic efficiency and clinical values in HCC were evaluated. RESULTS： ANXA2 expression was localized in both cell membrane and cytoplasm in HCC tissue, mainly in the cytoplasm of matched adjacent cancerous tissue, and there was almost no positive staining in matched distant cancerous tissue. Abnormal expression of liver ANXA2 was present in HCC tissues compared with self-con- trolled adjacent- and distant-cancerous tissues at pro- tein or mRNA level. Circulating ANXA2 in HCC patients was significantly higher than that of other liver diseases （P 〈 0.01） except metastatic liver cancer. If the diag- nostic cutoff value of ANXA2 level was more than 18 ng/ mL, the incidence of serum ANXA2 was 86.96% in the HCC group, 80% in the metastatic liver cancer group, 31.58% in the liver cirrhosis group, none in the chronic hepatitis or acute hepatitis or normal control group, respectively. Serum ANXA2 expression in HCC patients was correlated with HBV infection （27.38 ± 5.67 ng/mL vs 18.58 ± 7.83 ng/mL, P 〈 0.01）, extrahepatic metas- tasis （26.11±5.43 ng/mL ys 22.79 ± 5.64 ng/mL, P 〈 0.01）, and portal vein thrombus （26.03 ± 5.99 ng/mL vs 23.06 ± 5.03 ng/mL, P 〈 0.01）, and was significantly higher （P 〈 0.01） in the moderately- （26.19±5.34 ng/ mL） or the poorly- differentiated group （27.05 ± 5.13 ng/mL） than in the well differentiated group （20.43 ± 4.97 ng/mL）, and in the tumor node metastasis stages Ⅲ-Ⅳ（P 〈 0.01） than in stages Ⅰ-Ⅱ. ANXA2 was not correlated with patient sex, age, size or α-fetoprotein （AFP） level. Area under the receiver operating charac- teristic curve for the whole range of sensitivities and specificities was 0.796 for ANXA2 and 0.782 for AFP. Combining detection of serum ANXA2 and AFP substan- tially improved the diagnostic efficiency （96.52%） and the neclative predictive value （＇96.61%） for HCC.of ANXA2 expression has good diagnostic potential for HCC diagnosis.展开更多
The Nd^(3+) doped fluorochlorozirconate(FCZ) glass was prepared by melt-quenching method. The 3.9 μm emission from Nd^(3+) ions is attributed to the two-photon absorption process. The strong emission transition at 3...The Nd^(3+) doped fluorochlorozirconate(FCZ) glass was prepared by melt-quenching method. The 3.9 μm emission from Nd^(3+) ions is attributed to the two-photon absorption process. The strong emission transition at 3.9 μm fluorescence peak intensity, corresponding to the ~4G_(11/2)→~2K_(13/2) transition, is directly proportional to the NaCl concentration. With the increase of the Cl-ions amount, the mid-infrared(MIR) luminescent intensity is significantly enhanced. Additionally, the Judd-Ofelt(J-O) parameter ?_2 is larger than that of the fluorozirconate(FZ) glass, which indicates the covalency of the bond between RE ions and ligand is stronger as Cl-ions substitution of F-ions in chloride FZ glass. The X-ray diffraction(XRD) patterns show that the amorphous glassy state keeps the FZ glass network structure. In brief, the advantageous spectroscopic characteristics make the Nd^(3+)-doped FCZ glass be a promising candidate for application of 3.9 μm emission.展开更多
Based on Biot's model for fluid-saturated media,which takes the inertial,fluid viscous,mechanical couplings,compressibility of grains and fluid into account,the dispersion equations of plane waves in non-homogeneo...Based on Biot's model for fluid-saturated media,which takes the inertial,fluid viscous,mechanical couplings,compressibility of grains and fluid into account,the dispersion equations of plane waves in non-homogeneously saturated soil are established by using reverberation ray matrix method(RRMM) with the aid of Helmholtz theorem.The non-homogeneity considered is a gradient variation in material properties with depth.The propagation characteristic of elastic waves in non-homogeneously saturated soil is analyzed by numerical example in this paper.The results show that the wave number and dissipation change little for two kinds of compression along the variation direction of the material properties,however,the non-homogeneity has significant effect on the wave number and dissipation of shear wave.展开更多
基金Supported by Priority Academic Program Development of Jiangsu Higher Education Institution (PAPD)the Project of Jiangsu Clinical Medicine (BL2012053)+1 种基金the Programs of Nantong Society Undertaking and Technological Innovation,No.HS2012034 and HS2011012the International S and T Cooperation Program of China
文摘AIM： TO investigate the characteristics and diagnostic value of annexin A2 （ANXA2） expression in cancerous tissues and sera of patients with hepatitis B virus （HBV）-related hepatocellular carcinoma （HCC）. METHODS： Levels of liver ANXA2 gene transcription or protein expression were analyzed in HCC-, their self- controlled precancerous-, and distant cancerous- tissues from 30 HCC. Serum levels of ANXA2 expression in 115 patients with HCC, 25 with metastatic liver can cer, 35 with chronic hepatitis, 28 with acute hepatitis, 38 with cirrhosis, and 30 healthy controls were deter- mined. Clinicopathological characteristics of circulating ANXA2 expression were analyzed, and its diagnostic efficiency and clinical values in HCC were evaluated. RESULTS： ANXA2 expression was localized in both cell membrane and cytoplasm in HCC tissue, mainly in the cytoplasm of matched adjacent cancerous tissue, and there was almost no positive staining in matched distant cancerous tissue. Abnormal expression of liver ANXA2 was present in HCC tissues compared with self-con- trolled adjacent- and distant-cancerous tissues at pro- tein or mRNA level. Circulating ANXA2 in HCC patients was significantly higher than that of other liver diseases （P 〈 0.01） except metastatic liver cancer. If the diag- nostic cutoff value of ANXA2 level was more than 18 ng/ mL, the incidence of serum ANXA2 was 86.96% in the HCC group, 80% in the metastatic liver cancer group, 31.58% in the liver cirrhosis group, none in the chronic hepatitis or acute hepatitis or normal control group, respectively. Serum ANXA2 expression in HCC patients was correlated with HBV infection （27.38 ± 5.67 ng/mL vs 18.58 ± 7.83 ng/mL, P 〈 0.01）, extrahepatic metas- tasis （26.11±5.43 ng/mL ys 22.79 ± 5.64 ng/mL, P 〈 0.01）, and portal vein thrombus （26.03 ± 5.99 ng/mL vs 23.06 ± 5.03 ng/mL, P 〈 0.01）, and was significantly higher （P 〈 0.01） in the moderately- （26.19±5.34 ng/ mL） or the poorly- differentiated group （27.05 ± 5.13 ng/mL） than in the well differentiated group （20.43 ± 4.97 ng/mL）, and in the tumor node metastasis stages Ⅲ-Ⅳ（P 〈 0.01） than in stages Ⅰ-Ⅱ. ANXA2 was not correlated with patient sex, age, size or α-fetoprotein （AFP） level. Area under the receiver operating charac- teristic curve for the whole range of sensitivities and specificities was 0.796 for ANXA2 and 0.782 for AFP. Combining detection of serum ANXA2 and AFP substan- tially improved the diagnostic efficiency （96.52%） and the neclative predictive value （＇96.61%） for HCC.of ANXA2 expression has good diagnostic potential for HCC diagnosis.
基金supported by the National High Technology Research and Development Program of China(No.2013AA014201)the Natural Science Foundation of Tianjin(Nos.11JCYBJC00300,14JCZDJC31200,15JCYBJC16700 and 15JCYBJC16800)+1 种基金the National Key Foundation for Exploring Scientific Instrument of China(No.2014YQ120351)International Cooperation Program from Science and Technology of Tianjin(No.14RCGHGX00872)
文摘The Nd^(3+) doped fluorochlorozirconate(FCZ) glass was prepared by melt-quenching method. The 3.9 μm emission from Nd^(3+) ions is attributed to the two-photon absorption process. The strong emission transition at 3.9 μm fluorescence peak intensity, corresponding to the ~4G_(11/2)→~2K_(13/2) transition, is directly proportional to the NaCl concentration. With the increase of the Cl-ions amount, the mid-infrared(MIR) luminescent intensity is significantly enhanced. Additionally, the Judd-Ofelt(J-O) parameter ?_2 is larger than that of the fluorozirconate(FZ) glass, which indicates the covalency of the bond between RE ions and ligand is stronger as Cl-ions substitution of F-ions in chloride FZ glass. The X-ray diffraction(XRD) patterns show that the amorphous glassy state keeps the FZ glass network structure. In brief, the advantageous spectroscopic characteristics make the Nd^(3+)-doped FCZ glass be a promising candidate for application of 3.9 μm emission.
基金supported by the National Natural Science Foundation of China (Grant No. 11162008)the Fund of Education Department of Gansu Province of China for Master's Tutor (1103-07)the Fundamental Research Funds for the Gansu Universities (Grant No. 1104ZTC140)
文摘Based on Biot's model for fluid-saturated media,which takes the inertial,fluid viscous,mechanical couplings,compressibility of grains and fluid into account,the dispersion equations of plane waves in non-homogeneously saturated soil are established by using reverberation ray matrix method(RRMM) with the aid of Helmholtz theorem.The non-homogeneity considered is a gradient variation in material properties with depth.The propagation characteristic of elastic waves in non-homogeneously saturated soil is analyzed by numerical example in this paper.The results show that the wave number and dissipation change little for two kinds of compression along the variation direction of the material properties,however,the non-homogeneity has significant effect on the wave number and dissipation of shear wave.
