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基于PI3K/Akt信号通路探讨和枢消积方对肝纤维化大鼠的影响
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作者 干佳岑 彭孟云 +2 位作者 蒲清荣 王晓栋 汪静 《中成药》 CAS CSCD 北大核心 2024年第7期2400-2406,共7页
目的探究和枢消积方对肝纤维化大鼠的影响。方法40只大鼠随机分为模型组,和枢消积方低、中、高剂量组(1.625、3.25、6.5g/kg),秋水仙碱组(0.12mg/kg),每组8只,腹腔注射40%四氯化碳6周建立肝纤维化模型,同时给予相应药物干预6周;另取8只... 目的探究和枢消积方对肝纤维化大鼠的影响。方法40只大鼠随机分为模型组,和枢消积方低、中、高剂量组(1.625、3.25、6.5g/kg),秋水仙碱组(0.12mg/kg),每组8只,腹腔注射40%四氯化碳6周建立肝纤维化模型,同时给予相应药物干预6周;另取8只大鼠作为正常组,予以生理盐水(1mL/100g)干预6周。给药结束后,检测肝功能及肝脏组织病理学变化,免疫组化法检测肝组织α-SMA蛋白表达,Westernblot法检测肝组织CollagenⅠ、CollagenⅢ蛋白表达。利用网络药理学预测和枢消积方防治肝纤维化相关靶点及信号通路,并通过ELISA、RT-qPCR、Westernblot法对相关靶点和信号通路进行验证。结果与正常组比较,模型组大鼠肝组织胶原沉积,汇管区炎症细胞浸润,血清ALT、AST、TBIL、ALP水平升高(P<0.01),肝组织α-SMA、CollagenⅠ、CollagenⅢ蛋白水平表达升高(P<0.05);与模型组比较,各给药组肝组织炎症及胶原沉积均改善,血清ALT、AST、TBIL、ALP水平降低(P<0.01),和枢消积方高剂量组和秋水仙碱组肝组织α-SMA、CollagenⅠ、CollagenⅢ蛋白表达降低(P<0.05)。网络药理学显示,和枢消积方防治肝纤维化核心靶点主要为Akt1、TP53、VEGFA、IL-1β,可通过调控PI3K/Akt、TNF-α、IL-17等通路发挥改善肝纤维化作用。与正常组比较,模型组大鼠肝组织PI3K、AktmRNA表达,TNF-α、IL-1β、IL-6水平和p-PI3K/PI3K、p-Akt/Akt1蛋白表达升高(P<0.01);与模型组比较,和枢消积方高剂量组和秋水仙碱组肝组织PI3K、AktmRNA表达降低(P<0.05,P<0.01),各给药组肝组织TNF-α、IL-1β、IL-6水平和p-PI3K/PI3K、p-Akt/Akt1蛋白表达降低(P<0.05,P<0.01)。结论和枢消积方可减轻肝纤维化大鼠肝脏炎症反应,从而发挥改善肝纤维化作用,其机制可能与抑制PI3K/Akt信号通路相关。 展开更多
关键词 和枢消积方 肝纤维化 PI3K/AKT信号通路 炎症 和调理论
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The Degree of Symmetry of Certain Compact Smooth Manifolds II
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作者 Bin XU Department of Mathematics, University of Science and Technology of China, Hefei 230026, China Chern Institute of Mathematics, Nankai University, Tianjin 300071, China Department of Mathematics, Johns Hopkins University, Baltimore, MD 21218, USA. 《Chinese Annals of Mathematics,Series B》 SCIE CSCD 2007年第2期195-204,共10页
We give the sharp estimates for the degree of symmetry and the semi-simple degree of symmetry of certain compact fiber bundles with non-trivial four dimensional fibers in the sense of cobordism, by virtue of the rigid... We give the sharp estimates for the degree of symmetry and the semi-simple degree of symmetry of certain compact fiber bundles with non-trivial four dimensional fibers in the sense of cobordism, by virtue of the rigidity theorem of harmonic maps due to Schoen and Yau (Topology, 18, 1979, 361-380). As a corollary of this estimate, we compute the degree of symmetry and the semi-simple degree of symmetry of CP2×V, where V is a closed smooth manifold admitting a real analytic Riemannian metric of non-positive curvature. In addition, by the Albanese map, we obtain the sharp estimate of the degree of symmetry of a compact smooth manifold with some restrictions on its one dimensional cohomology. 展开更多
关键词 Degree of symmetry Fiber bundle COBORDISM Non-positive Curvature Harmonic map First cohomology
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BOUNDEDNESS OF SOLUTIONS FOR SUPERLINEAR REVERSIBLE SYSTEMS
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作者 LI XIONG 《Chinese Annals of Mathematics,Series B》 SCIE CSCD 2001年第1期31-46,共16页
This paper is concerned with the boundedness of solutions for second order differential equations x + f(x, t)x + g(x, t) = 0, which are neither dissipative nor conservative, and where the functions f and g are odd in ... This paper is concerned with the boundedness of solutions for second order differential equations x + f(x, t)x + g(x, t) = 0, which are neither dissipative nor conservative, and where the functions f and g are odd in x and even in t, which are 1-periodic in t, and the function g satisfies g(x,t/x+, as|x| - +. Using the KAM theory for reversible systems, the author proves the existence of invariant tori and thus the boundedness of all the solutions and the existence of quasiperiodic solutions and subharmonic solutions. 展开更多
关键词 Boundedness of solutions Quasiperiodic solutions Subharmonic solutions KAM theory Reversible systems
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