The adoption by the 18th Congress of the Communist Party of China in November 2012 of a policy on ecological civilization is a landmark event for the nation and the world community. China's vision for building an eco...The adoption by the 18th Congress of the Communist Party of China in November 2012 of a policy on ecological civilization is a landmark event for the nation and the world community. China's vision for building an ecological civilization is comprehensive, multi-sectoral and systemic and is intended to direct and balance progress among ecological, economic, social, cultural and political dimensions of change. Some on-going efforts and potential future activities that meet China's vision of an ecological civilization are described. Establishment of dedicated ecological civilization areas for experimenting with legal, regulatory and administrative incentives that would facilitate the march towards the ideal is encouraged. Chinese biosphere reserves which are designated with the explicit aim of building harmony between humans and nature would be suitable candidates for designing and developing such dedicated ecological civilization areas.展开更多
We describe a patient with a Homo sapiens mutL homolog 1 (MLH1)-associated Lynch syndrome with previous diagnoses of two distinct primary cancers:a sigmoid colon cancer at the age of 39 years, and a right colon cancer...We describe a patient with a Homo sapiens mutL homolog 1 (MLH1)-associated Lynch syndrome with previous diagnoses of two distinct primary cancers:a sigmoid colon cancer at the age of 39 years, and a right colon cancer at the age of 50 years. The mutation identified in his blood and buccal cells, c.1771delG, p.Asp591Ilefs*25, appears to be a de novo event, as it was not transmitted by either of his parents. This type of de novo event is rare in MLH1 as only three cases have been reported in the literature so far. Further-more, the discordant results observed between repli-cation error phenotyping and immunohistochemistry highlight the importance of the systematic use of both pre-screening tests in the molecular diagnosis of Lynch syndrome.展开更多
文摘The adoption by the 18th Congress of the Communist Party of China in November 2012 of a policy on ecological civilization is a landmark event for the nation and the world community. China's vision for building an ecological civilization is comprehensive, multi-sectoral and systemic and is intended to direct and balance progress among ecological, economic, social, cultural and political dimensions of change. Some on-going efforts and potential future activities that meet China's vision of an ecological civilization are described. Establishment of dedicated ecological civilization areas for experimenting with legal, regulatory and administrative incentives that would facilitate the march towards the ideal is encouraged. Chinese biosphere reserves which are designated with the explicit aim of building harmony between humans and nature would be suitable candidates for designing and developing such dedicated ecological civilization areas.
文摘We describe a patient with a Homo sapiens mutL homolog 1 (MLH1)-associated Lynch syndrome with previous diagnoses of two distinct primary cancers:a sigmoid colon cancer at the age of 39 years, and a right colon cancer at the age of 50 years. The mutation identified in his blood and buccal cells, c.1771delG, p.Asp591Ilefs*25, appears to be a de novo event, as it was not transmitted by either of his parents. This type of de novo event is rare in MLH1 as only three cases have been reported in the literature so far. Further-more, the discordant results observed between repli-cation error phenotyping and immunohistochemistry highlight the importance of the systematic use of both pre-screening tests in the molecular diagnosis of Lynch syndrome.