This paper is focus on the brand effect of industrial agglomeration, and undertakes the following conclusions: firstly, regional industrial brand and industry agglomeration will influence each other. Secondly, indust...This paper is focus on the brand effect of industrial agglomeration, and undertakes the following conclusions: firstly, regional industrial brand and industry agglomeration will influence each other. Secondly, industrial agglomeration on regional industry brand has the strengthening mechanism. Thirdly, the more of enterprises in industrial cluster, the more "hitchhike" problems will occur. It shows that enterprises in promoting the regional industry brand will influence exacted input and reward asymmetry, causing the enterprise to promote the maintenance of regional industry brand intrinsic motivation deficiency. However, widespread presence "hitchhike" psychologicalexpectations. This led to the regional industrial brand are often not appropriate and reasonable maintenance and promotion.展开更多
This paper generally analyzes the current international and domestic brand evaluation theory on brand value. Starting from the most basic assessment of object analysis, it analyzes the current methods of brand evaluat...This paper generally analyzes the current international and domestic brand evaluation theory on brand value. Starting from the most basic assessment of object analysis, it analyzes the current methods of brand evaluation and its focus, and then analyzes the actual operation of the most authoritative international brand evaluation agencies - Interbrand, to conduct a detailed research and analysis. Based on this, combining with the current situation of China fashion brand market, it re-summaries the evaluation parameter respectively, from the short-term brand strength factors, to the long-term brand benefit and consumer factors, in order to establish a new evaluation frame fit for China fashion industry.展开更多
Firstly, this article carry on the theory research combined with the related theories of cluster brand and the relevant theories of performance evaluation, and distill four main indicators factors of performance evalu...Firstly, this article carry on the theory research combined with the related theories of cluster brand and the relevant theories of performance evaluation, and distill four main indicators factors of performance evaluation of the cluster brand. Then proceed analysts survey and questionnaire investigation, and then use SPSS software to process date for statistical analysis; use AMOS software to formulate the second-order model, at last, establish structure relationship model of performance evaluation of the cluster brand. Build the model of the cluster brand performance evaluation with fuzzy-synthetic evaluation model.展开更多
A randomized, two-way, crossover study was conducted in 15 fasting, healthy, Algerian volunteers to compare the bioavailability of two brands of Valsartan 80 mg coated breakable tablets. The present study aimed to eva...A randomized, two-way, crossover study was conducted in 15 fasting, healthy, Algerian volunteers to compare the bioavailability of two brands of Valsartan 80 mg coated breakable tablets. The present study aimed to evaluate the intra-subject variability of this active substance in the Algerian population. The test brand was compared to TAREG (Novartis) as the reference product. The study was performed at the bioequivalence center of the national control laboratory for pharmaceuticals products, in joint venture with University Hospital Center Ibn Badis, Constantine, Algeria. The drug was administered with 200 mL of water after a 10 h overnight fasting on two treatment days separated by one week washout period. After dosing, serial blood samples were collected for a period of 24 h. A reliable, simple, and robust liquid chromatography-tandem mass spectro-metric (LC-MS/MS) method has been developed and validated that employs protein precipitation (or denaturation) for the estimation of valsartan in human plasma using losartan as internal standard. The assay was found to be linear over the range of 50-5,000 ng/mL, with a lower limit of quantitation of 50ng/mL. Various pharnaacokinetic parameters including AUC0-t, AUC∞, Cmax, Tmax, and TI/2 were determined from plasma concentrations of both formulations and found to be in good agreement with reported values. The pharmacokinetical and statistical analysis was conducted with Kinetica 4.4.1. AUC0.t, AUC0-∞ and Cmax were tested for bioequivalence after log-transformation of data. No significant difference was found based on ANOVA; 90% confidence interval ([85.82%, 118.76%] for AUC0.t [86.09%, 118.83%] for AUC0-∞) of test/reference ratio for these parameters were found within bioequivalence acceptance range of 80-125%. But for the Cmax, the 90% confidence interval of test/reference ratio wasn't in this acceptance range [90.18%, 131.07%] .The results of PK analysis suggested that the reference and test formulations ofvalsartan 80 mg coated breakable tablets weren't bioequivalent during fasting state in these healthy algerian volunteers.展开更多
A randomized, two-way, crossover study was conducted in 12 fasting, healthy, algerian volunteers to compare the bioavailability of two brands of metformin hydrochloride 850 mg coated tablets. The present study aimed t...A randomized, two-way, crossover study was conducted in 12 fasting, healthy, algerian volunteers to compare the bioavailability of two brands of metformin hydrochloride 850 mg coated tablets. The present study aimed to appreciate the bioequivalence of the generic product and to evaluate the intra-subject variability of this active substance in the Algerian population. The test brand was compared to Glucophage (Merck UK) as the reference product. The study was performed at the bioequivalence center of the national control laboratory for pharmaceuticals products from 03 to 04, 2011, in joint venture with specialized medical hospital center of E1 Hadi Flici, Algiers, Algeria. The drug was administered with 200 mL of water after a 10 h overnight fasting on two treatment days separated by one week washout period. After dosing, serial blood samples were collected for a period of 12 h. A reliable, simple, and robust liquid chromatography-tandem mass spectro-metric (LC-MS/MS) method has been developed and validated for estimation of metformin in human plasma using propranolol as internal standard. The analytes were extracted from plasma by using the protein precipitation extraction technique. The assay was found to be linear over the range of 50-3000 ng/mL with a lower limit of quantitation of 50 ng/mL. Various pharmacokinetic parameters including AUC0-t, AUC0-∞, Cmax, Tmax, and T1/2 were determined from plasma concentrations of both formulations and found to be in good agreement with reported values. The pharmacokinetical and statistical analysis was conducted with Kinetica 4.4.1. AUC0-t, AUC0-∞ and Cmax were tested for bioequivalence after log-transformation of data. No significant difference was found based on ANOVA; 90% confidence interval ([91.62 %, 115.66%] for AUC0-t, [92.07 %, 115.53 %] for AUC0-∞; [94.58%, 119.58 %] for Cmax) of test/reference ratio for these parameters were found within bioequivalence acceptance range of 80-125%. Based on these statistical inferences, it was concluded that Metformin hydrochloride test is bioequivalent to Glucophage.展开更多
基金ACKNOWLEDGMENT This paper was sponsor by National Natural Science Foundation of China (Youth Project ): "Chinese regional industry brand diffusion path and structural industry policy research", project number (71003029) and Guangdong Provincial Science and Technology Department of science and technology project (social development project ):" Guangdong" double transfer" strategy under the optimization of industrial structure and regional financial support services", project number (2010B080701029)
文摘This paper is focus on the brand effect of industrial agglomeration, and undertakes the following conclusions: firstly, regional industrial brand and industry agglomeration will influence each other. Secondly, industrial agglomeration on regional industry brand has the strengthening mechanism. Thirdly, the more of enterprises in industrial cluster, the more "hitchhike" problems will occur. It shows that enterprises in promoting the regional industry brand will influence exacted input and reward asymmetry, causing the enterprise to promote the maintenance of regional industry brand intrinsic motivation deficiency. However, widespread presence "hitchhike" psychologicalexpectations. This led to the regional industrial brand are often not appropriate and reasonable maintenance and promotion.
文摘This paper generally analyzes the current international and domestic brand evaluation theory on brand value. Starting from the most basic assessment of object analysis, it analyzes the current methods of brand evaluation and its focus, and then analyzes the actual operation of the most authoritative international brand evaluation agencies - Interbrand, to conduct a detailed research and analysis. Based on this, combining with the current situation of China fashion brand market, it re-summaries the evaluation parameter respectively, from the short-term brand strength factors, to the long-term brand benefit and consumer factors, in order to establish a new evaluation frame fit for China fashion industry.
文摘Firstly, this article carry on the theory research combined with the related theories of cluster brand and the relevant theories of performance evaluation, and distill four main indicators factors of performance evaluation of the cluster brand. Then proceed analysts survey and questionnaire investigation, and then use SPSS software to process date for statistical analysis; use AMOS software to formulate the second-order model, at last, establish structure relationship model of performance evaluation of the cluster brand. Build the model of the cluster brand performance evaluation with fuzzy-synthetic evaluation model.
文摘A randomized, two-way, crossover study was conducted in 15 fasting, healthy, Algerian volunteers to compare the bioavailability of two brands of Valsartan 80 mg coated breakable tablets. The present study aimed to evaluate the intra-subject variability of this active substance in the Algerian population. The test brand was compared to TAREG (Novartis) as the reference product. The study was performed at the bioequivalence center of the national control laboratory for pharmaceuticals products, in joint venture with University Hospital Center Ibn Badis, Constantine, Algeria. The drug was administered with 200 mL of water after a 10 h overnight fasting on two treatment days separated by one week washout period. After dosing, serial blood samples were collected for a period of 24 h. A reliable, simple, and robust liquid chromatography-tandem mass spectro-metric (LC-MS/MS) method has been developed and validated that employs protein precipitation (or denaturation) for the estimation of valsartan in human plasma using losartan as internal standard. The assay was found to be linear over the range of 50-5,000 ng/mL, with a lower limit of quantitation of 50ng/mL. Various pharnaacokinetic parameters including AUC0-t, AUC∞, Cmax, Tmax, and TI/2 were determined from plasma concentrations of both formulations and found to be in good agreement with reported values. The pharmacokinetical and statistical analysis was conducted with Kinetica 4.4.1. AUC0.t, AUC0-∞ and Cmax were tested for bioequivalence after log-transformation of data. No significant difference was found based on ANOVA; 90% confidence interval ([85.82%, 118.76%] for AUC0.t [86.09%, 118.83%] for AUC0-∞) of test/reference ratio for these parameters were found within bioequivalence acceptance range of 80-125%. But for the Cmax, the 90% confidence interval of test/reference ratio wasn't in this acceptance range [90.18%, 131.07%] .The results of PK analysis suggested that the reference and test formulations ofvalsartan 80 mg coated breakable tablets weren't bioequivalent during fasting state in these healthy algerian volunteers.
文摘A randomized, two-way, crossover study was conducted in 12 fasting, healthy, algerian volunteers to compare the bioavailability of two brands of metformin hydrochloride 850 mg coated tablets. The present study aimed to appreciate the bioequivalence of the generic product and to evaluate the intra-subject variability of this active substance in the Algerian population. The test brand was compared to Glucophage (Merck UK) as the reference product. The study was performed at the bioequivalence center of the national control laboratory for pharmaceuticals products from 03 to 04, 2011, in joint venture with specialized medical hospital center of E1 Hadi Flici, Algiers, Algeria. The drug was administered with 200 mL of water after a 10 h overnight fasting on two treatment days separated by one week washout period. After dosing, serial blood samples were collected for a period of 12 h. A reliable, simple, and robust liquid chromatography-tandem mass spectro-metric (LC-MS/MS) method has been developed and validated for estimation of metformin in human plasma using propranolol as internal standard. The analytes were extracted from plasma by using the protein precipitation extraction technique. The assay was found to be linear over the range of 50-3000 ng/mL with a lower limit of quantitation of 50 ng/mL. Various pharmacokinetic parameters including AUC0-t, AUC0-∞, Cmax, Tmax, and T1/2 were determined from plasma concentrations of both formulations and found to be in good agreement with reported values. The pharmacokinetical and statistical analysis was conducted with Kinetica 4.4.1. AUC0-t, AUC0-∞ and Cmax were tested for bioequivalence after log-transformation of data. No significant difference was found based on ANOVA; 90% confidence interval ([91.62 %, 115.66%] for AUC0-t, [92.07 %, 115.53 %] for AUC0-∞; [94.58%, 119.58 %] for Cmax) of test/reference ratio for these parameters were found within bioequivalence acceptance range of 80-125%. Based on these statistical inferences, it was concluded that Metformin hydrochloride test is bioequivalent to Glucophage.