A randomized, two-way, crossover study was conducted in 12 fasting, healthy, algerian volunteers to compare the bioavailability of two brands of metformin hydrochloride 850 mg coated tablets. The present study aimed t...A randomized, two-way, crossover study was conducted in 12 fasting, healthy, algerian volunteers to compare the bioavailability of two brands of metformin hydrochloride 850 mg coated tablets. The present study aimed to appreciate the bioequivalence of the generic product and to evaluate the intra-subject variability of this active substance in the Algerian population. The test brand was compared to Glucophage （Merck UK） as the reference product. The study was performed at the bioequivalence center of the national control laboratory for pharmaceuticals products from 03 to 04, 2011, in joint venture with specialized medical hospital center of E1 Hadi Flici, Algiers, Algeria. The drug was administered with 200 mL of water after a 10 h overnight fasting on two treatment days separated by one week washout period. After dosing, serial blood samples were collected for a period of 12 h. A reliable, simple, and robust liquid chromatography-tandem mass spectro-metric （LC-MS/MS） method has been developed and validated for estimation of metformin in human plasma using propranolol as internal standard. The analytes were extracted from plasma by using the protein precipitation extraction technique. The assay was found to be linear over the range of 50-3000 ng/mL with a lower limit of quantitation of 50 ng/mL. Various pharmacokinetic parameters including AUC0-t, AUC0-∞, Cmax, Tmax, and T1/2 were determined from plasma concentrations of both formulations and found to be in good agreement with reported values. The pharmacokinetical and statistical analysis was conducted with Kinetica 4.4.1. AUC0-t, AUC0-∞ and Cmax were tested for bioequivalence after log-transformation of data. No significant difference was found based on ANOVA; 90% confidence interval （[91.62 %, 115.66%] for AUC0-t, [92.07 %, 115.53 %] for AUC0-∞; [94.58%, 119.58 %] for Cmax） of test/reference ratio for these parameters were found within bioequivalence acceptance range of 80-125%. Based on these statistical inferences, it was concluded that Metformin hydrochloride test is bioequivalent to Glucophage.展开更多
Aiming at facilitating the research of urban tourism image positioning,this paper summarizes the domestic and abroad theories on urban tourism image and analyzes its significance for cities.With Dengfeng as an example...Aiming at facilitating the research of urban tourism image positioning,this paper summarizes the domestic and abroad theories on urban tourism image and analyzes its significance for cities.With Dengfeng as an example,its goal is to boost development of Dengfeng tourism,which is an excellent tourism city in China.This paper presents its current urban tourism developing situation,positions its tourism image,concludes the plan of image brand and proposes promotional slogans based on the analysis of Dengfeng tourism local features,its core elements and perceptions of visitors.展开更多
The colour scheme of brand ready-made clothes, as an integral part of brand culture, is playing a more and more omportant role in modem brand ready-made clothes designing. The cultural background of Chinese clothing b...The colour scheme of brand ready-made clothes, as an integral part of brand culture, is playing a more and more omportant role in modem brand ready-made clothes designing. The cultural background of Chinese clothing brands was explored, the features of the interaction of colour, the design concept of colouring of the local Chinese brano clothes were discussed. International fashion trend was analysed, and both the psychological and social infuences on the colours of a certain season were discussed. In addition, we ought to investigate and study the late essential colours and the salable colours of our own brands, and summarize the clout systems that are practicable.展开更多
A randomized, two-way, crossover study was conducted in 15 fasting, healthy, Algerian volunteers to compare the bioavailability of two brands of Valsartan 80 mg coated breakable tablets. The present study aimed to eva...A randomized, two-way, crossover study was conducted in 15 fasting, healthy, Algerian volunteers to compare the bioavailability of two brands of Valsartan 80 mg coated breakable tablets. The present study aimed to evaluate the intra-subject variability of this active substance in the Algerian population. The test brand was compared to TAREG （Novartis） as the reference product. The study was performed at the bioequivalence center of the national control laboratory for pharmaceuticals products, in joint venture with University Hospital Center Ibn Badis, Constantine, Algeria. The drug was administered with 200 mL of water after a 10 h overnight fasting on two treatment days separated by one week washout period. After dosing, serial blood samples were collected for a period of 24 h. A reliable, simple, and robust liquid chromatography-tandem mass spectro-metric （LC-MS/MS） method has been developed and validated that employs protein precipitation （or denaturation） for the estimation of valsartan in human plasma using losartan as internal standard. The assay was found to be linear over the range of 50-5,000 ng/mL, with a lower limit of quantitation of 50ng/mL. Various pharnaacokinetic parameters including AUC0-t, AUC∞, Cmax, Tmax, and TI/2 were determined from plasma concentrations of both formulations and found to be in good agreement with reported values. The pharmacokinetical and statistical analysis was conducted with Kinetica 4.4.1. AUC0.t, AUC0-∞ and Cmax were tested for bioequivalence after log-transformation of data. No significant difference was found based on ANOVA; 90% confidence interval （[85.82%, 118.76%] for AUC0.t [86.09%, 118.83%] for AUC0-∞） of test/reference ratio for these parameters were found within bioequivalence acceptance range of 80-125%. But for the Cmax, the 90% confidence interval of test/reference ratio wasn＇t in this acceptance range [90.18%, 131.07%] .The results of PK analysis suggested that the reference and test formulations ofvalsartan 80 mg coated breakable tablets weren＇t bioequivalent during fasting state in these healthy algerian volunteers.展开更多
Clothing is the human culture and the historical development of the witness, also the combination of human science and new technology and the art of the perfect embodiment. In the modem fashion design, No color depart...Clothing is the human culture and the historical development of the witness, also the combination of human science and new technology and the art of the perfect embodiment. In the modem fashion design, No color department -- has been like a flag stand at the top of the fashion.. No color clothing brand has a good plasticity and explores the market potential. This is no color system as never eliminate color elements and design inspiration in widespread use in the clothing design by designers.展开更多
文摘A randomized, two-way, crossover study was conducted in 12 fasting, healthy, algerian volunteers to compare the bioavailability of two brands of metformin hydrochloride 850 mg coated tablets. The present study aimed to appreciate the bioequivalence of the generic product and to evaluate the intra-subject variability of this active substance in the Algerian population. The test brand was compared to Glucophage （Merck UK） as the reference product. The study was performed at the bioequivalence center of the national control laboratory for pharmaceuticals products from 03 to 04, 2011, in joint venture with specialized medical hospital center of E1 Hadi Flici, Algiers, Algeria. The drug was administered with 200 mL of water after a 10 h overnight fasting on two treatment days separated by one week washout period. After dosing, serial blood samples were collected for a period of 12 h. A reliable, simple, and robust liquid chromatography-tandem mass spectro-metric （LC-MS/MS） method has been developed and validated for estimation of metformin in human plasma using propranolol as internal standard. The analytes were extracted from plasma by using the protein precipitation extraction technique. The assay was found to be linear over the range of 50-3000 ng/mL with a lower limit of quantitation of 50 ng/mL. Various pharmacokinetic parameters including AUC0-t, AUC0-∞, Cmax, Tmax, and T1/2 were determined from plasma concentrations of both formulations and found to be in good agreement with reported values. The pharmacokinetical and statistical analysis was conducted with Kinetica 4.4.1. AUC0-t, AUC0-∞ and Cmax were tested for bioequivalence after log-transformation of data. No significant difference was found based on ANOVA; 90% confidence interval （[91.62 %, 115.66%] for AUC0-t, [92.07 %, 115.53 %] for AUC0-∞; [94.58%, 119.58 %] for Cmax） of test/reference ratio for these parameters were found within bioequivalence acceptance range of 80-125%. Based on these statistical inferences, it was concluded that Metformin hydrochloride test is bioequivalent to Glucophage.
文摘Aiming at facilitating the research of urban tourism image positioning,this paper summarizes the domestic and abroad theories on urban tourism image and analyzes its significance for cities.With Dengfeng as an example,its goal is to boost development of Dengfeng tourism,which is an excellent tourism city in China.This paper presents its current urban tourism developing situation,positions its tourism image,concludes the plan of image brand and proposes promotional slogans based on the analysis of Dengfeng tourism local features,its core elements and perceptions of visitors.
文摘The colour scheme of brand ready-made clothes, as an integral part of brand culture, is playing a more and more omportant role in modem brand ready-made clothes designing. The cultural background of Chinese clothing brands was explored, the features of the interaction of colour, the design concept of colouring of the local Chinese brano clothes were discussed. International fashion trend was analysed, and both the psychological and social infuences on the colours of a certain season were discussed. In addition, we ought to investigate and study the late essential colours and the salable colours of our own brands, and summarize the clout systems that are practicable.
文摘A randomized, two-way, crossover study was conducted in 15 fasting, healthy, Algerian volunteers to compare the bioavailability of two brands of Valsartan 80 mg coated breakable tablets. The present study aimed to evaluate the intra-subject variability of this active substance in the Algerian population. The test brand was compared to TAREG （Novartis） as the reference product. The study was performed at the bioequivalence center of the national control laboratory for pharmaceuticals products, in joint venture with University Hospital Center Ibn Badis, Constantine, Algeria. The drug was administered with 200 mL of water after a 10 h overnight fasting on two treatment days separated by one week washout period. After dosing, serial blood samples were collected for a period of 24 h. A reliable, simple, and robust liquid chromatography-tandem mass spectro-metric （LC-MS/MS） method has been developed and validated that employs protein precipitation （or denaturation） for the estimation of valsartan in human plasma using losartan as internal standard. The assay was found to be linear over the range of 50-5,000 ng/mL, with a lower limit of quantitation of 50ng/mL. Various pharnaacokinetic parameters including AUC0-t, AUC∞, Cmax, Tmax, and TI/2 were determined from plasma concentrations of both formulations and found to be in good agreement with reported values. The pharmacokinetical and statistical analysis was conducted with Kinetica 4.4.1. AUC0.t, AUC0-∞ and Cmax were tested for bioequivalence after log-transformation of data. No significant difference was found based on ANOVA; 90% confidence interval （[85.82%, 118.76%] for AUC0.t [86.09%, 118.83%] for AUC0-∞） of test/reference ratio for these parameters were found within bioequivalence acceptance range of 80-125%. But for the Cmax, the 90% confidence interval of test/reference ratio wasn＇t in this acceptance range [90.18%, 131.07%] .The results of PK analysis suggested that the reference and test formulations ofvalsartan 80 mg coated breakable tablets weren＇t bioequivalent during fasting state in these healthy algerian volunteers.
文摘Clothing is the human culture and the historical development of the witness, also the combination of human science and new technology and the art of the perfect embodiment. In the modem fashion design, No color department -- has been like a flag stand at the top of the fashion.. No color clothing brand has a good plasticity and explores the market potential. This is no color system as never eliminate color elements and design inspiration in widespread use in the clothing design by designers.
