影响体外循环血气结果的原因及采集血气标本时应注意的问题

在体外循环转流中以及停机前,常需要从动脉微拴过滤器中或氧合器中采集血气送检。其目的:一为了解病人在手术中全身水盐代谢及酸碱平衡的情况,以便及时增减给药速度和给药量。二为停止转流,结束手术提供可靠的依据。因此,如何使所采集的血气标本能更真实的反映机体代谢情况,是减少体外循环中机体所产生的不良后果的重要手段之一,也是确保灌注质量。

硅橡胶基磁流变弹性体制备及动态剪切性能研究

磁流变弹性体是一种新型的智能复合材料,其动态力学性能受磁场控制,可以应用于变刚度或避免共振的智能器件。在原有制备磁流变弹性体的基础上尝试采用不同的组份配比制备了以双组份室温硫化硅橡胶为基体的高性能磁流变弹性体。在0～700mT磁感应强度范围内,使用动态信号测试分析仪来测试分析所制样品的磁致动态频响函数。结果表明,在700mT磁感应强度下及羰基铁粉质量分数为75%时,所制备的磁流变弹性体的共振频率相对变化率可达到30%,具有较好的频率可控特性,同时,其动态剪切模量最大相对变化率可以达到67%,达到了磁场控制剪切模量的目的。

燕山东部柳江地区构造属性新解与郯庐断裂系活动

传统意义上的柳江盆地位于燕山东段,完整地出露了从前寒武纪到中生界的华北地台盖层沉积地层,地层序列总体上呈中间新,两侧老的特点。前人认为柳江盆地为一轴向N10°E的不对称向斜。新的野外调查显示,柳江地区西侧陡立的产状是断裂作用形成的构造面理产状,为北北东向断裂构造的一部分,可以清楚识别的原始层面产状实际上与东部地层相似,为250°西倾25°～30°倾角。因此,将柳江地区东侧的原始层面产状与西侧的构造面理产状分别对应同一向斜两翼的传统观点是不恰当的。所谓柳江盆地实际上为单斜构造,是地壳断块在北北东向断裂的作用下西侧上升东侧下降的掀斜作用结果,过去对这一地区关于盆地和向斜构造属性的界定应该予以纠正。柳江地区在古生代和中生代时期是华北盆地的一部分,在新生代以来又同时接受剥蚀,一直不曾是独立的盆地单元。由于柳江断陷的沉降与西侧响山隆起相耦合,在两者边界起调节作用的北北东向断裂系具有左旋走滑兼具垂直运动分量的运动性质,是郯庐断裂系的组成部分,北北东向断裂系活动的时限与响山隆起的时限相对应,根据裂变径迹年龄分析结果,活动时代为白垩世末—古新世。

Study on Sporulation Conditions of Trichoderma reesei by Solid Fermentation

[Objective] This study aimed to investigate the sporulation conditions of Tri- choderma reesei by solid fermentation. [Method] With sporulation yield as the response value, single-factor test, Plackett-Burmam design, steepest ascent test, BoxBehnken design and response surface analysis were employed to optimize the con- ditions for sporulation of Trichoderma reesei by solid fermentation. [Result] Based on single-factor test, the most appropriate carbon source for Trichoderma reesei was straw stalk powder and wheat bran with the ratio of 3：2 and optimal amount of 15 g/L; the most appropriate inorganic nitrogen was （NH4）2O4 with the optimal amount of 3 g/L. According to Plackett-Burmam design, moisture content, initial pH and incubation temperature were identified as significant factors affecting the sporulation yield of Trichoderma reeseL The maximum sporulation yield area was approached by steepest ascent test. Based on Box-Behnken design and response surface analysis, the optimal fermentation conditions for the maximum sporulation yield were determined as： straw stalk powder of 6 g/L, wheat bran of 9 g/L, （NH4）2SO4 of 3 g/L, moisture content of 65%, incubation temperature of 29 ℃, fermentation period of 72 h and initial pH of 5.5, under these conditions, the sporulation yield reached 2×10^10 spores/g, which was improved by 1.4 times compared with that before optimization. [Conclusion] In this study, the conditions for sporulation of Trichoderma reesei by solid fermentation were optimized with low-cost straw stalk powder and wheat bran as carbon sources, which was conducive to reducing the production cost of Trichoderma reesei and increasing the sporulation yield, showing certain social and economic significance.

The analysis of frequency-dependent characteristics for fluid detection: a physical model experiment

According to the Chapman multi-scale rock physical model, the seismic response characteristics vary for different fluid-saturated reservoirs. For class I AVO reservoirs and gas-saturation, the seismic response is a high-frequency bright spot as the amplitude energy shifts. However, it is a low-frequency shadow for the Class III AVO reservoirs saturated with hydrocarbons. In this paper, we verified the high-frequency bright spot results of Chapman for the Class I AVO response using the frequency-dependent analysis of a physical model dataset. The physical model is designed as inter-bedded thin sand and shale based on real field geology parameters. We observed two datasets using fixed offset and 2D geometry with different fluid- saturated conditions. Spectral and time-frequency analyses methods are applied to the seismic datasets to describe the response characteristics for gas-, water-, and oil-saturation. The results of physical model dataset processing and analysis indicate that reflection wave tuning and fluid-related dispersion are the main seismic response characteristic mechanisms. Additionally, the gas saturation model can be distinguished from water and oil saturation for Class I AVO utilizing the frequency-dependent abnormal characteristic. The frequency-dependent characteristic analysis of the physical model dataset verified the different spectral response characteristics corresponding to the different fluid-saturated models. Therefore, by careful analysis of real field seismic data, we can obtain the abnormal spectral characteristics induced by the fluid variation and implement fluid detection using seismic data directly.

Township Classification and the Sphere of Influence Based on Voronoi Diagram——A Case of Bijie City

Supported by research available of township system and influential sphere, the research is conducted based on towns in Bijie City, as per Voronoi diagram and breaking point theory. In the research, Shixi Office dominated as the highest center and Salaxi Town and Haizijie Town were sub-centers, supplemented by Yachi Town, Zhuchang Town, Yangjiawan Town, Qingchang Town, Heguantun Town, Qingshuipu Town, Yanzikou Town and Longchangying Town. Hence, township system and influ- ential sphere were determined and related methods and technologies were explored.

RITSD Analysis of the Agronomic Traits of Somaclonal in Rice

[Objective]The aim was to study the sensitive response characteristics of the main agronomic traits of somaclonal and the variation of sensitive response of the lines of somaclonal to sowing date. [Method]The RITSD changing of agronomic traits was studied by using 24 rice somaclonal and its donor parent under two sowing dates. [Result]The average values of RITSD were higher （over one） for the traits of pant height （PH）,density of spikelets （DS）,filled spikelets per panicle （FSP）,spikelets per panicle （SP） and grain weight per plant （GWP）,but lower for days of sowing to heading （DSH）,effective panicles （EP）,panicle length （PL）,seed setting rate （SS） and 1 000-grain weight （1 000-GW）. These showed that PH,DS,FSP,SP and GWP were easily affected by sowing date and tended to higher with the later sowing; the RITSD of somaclonal changed with the agronomic traits. The frequency of RITSD＇ variation of DSH and PH was higher than that of PL. The RITSD＇ value of EP,PL,DS,FSP,SP and SS became higher,and higher or lower for DSH and GWP in different somaclonal; compared with the donor,20 of 24 was significantly different,and the frequency of RITSD variation was over 83. 3%,however,RITSD of the most lines （75%） changed only for 1-2 characters; cluster analysis showed that the RITSD of agronomic traits belonged to different combinations of somaclonal in rice. [Conclusion]the study had provided a theoretical basis for the screening and using of the somaclonal.

现代蛐蛐

这是—个很私人的叫法,现在尚未在社会上流通,我的’蛐蛐”,你们大概都叫“BB机”。 BB机的名称来自它的声音,将其全盘汉化亦可称作“哔哔机”或“逼逼机”等。按照功用,称为传呼机最合适。人们之所以习惯叫它BB机,想来是要尽可能保留其舶来品的味儿,深港一带有将婴儿叫作“BB”的,这是英文“Baby”的缩称兼昵称。所以不要误会,BB机不是婴儿的某种玩具。 BB机的体积只有火柴盒大小。

Spatial and Temporal Differences of Urban Land Comprehensive Carrying Capacity in Guangxi

The comprehensive carrying capacity of urban land can reflect the re- source level, economic scale, social development and environmental pressure of ur- ban land carrying. The assessment indicator system of urban land comprehensive carrying capacity was constructed from the 4 aspects of resource, economy, society, environment, and principal component analysis and cluster analysis were used to evaluate the urban land comprehensive carrying capacity of Guangxi and the 14 cities in 2005-2014, and analyzed its spatial and temporal characteristics as well as the driving forces, with the aim to provide references for improving the urban land comprehensive carrying capacity. The results showed that, the overall urban land comprehensive carrying capacity in Guangxi increased in 2005-2014, and there were significant differences in the land comprehensive carrying capacities among the cities in Guangxi in 2005-2014, in which Liuzhou, Guilin, Nanning belonged to the regions with the highest carrying capacity, while Beihai, Yulin, Wutong belonged to the regions with high carrying capacity, and the carrying capacities of the other cities changed with the changes of time. The economic development degree was an important factor influencing urban land comprehensive carrying capacity, but could not directly represent the urban land comprehensive carrying capacity level.

Analysis of response time probability distribution of workflows

An evaluation approach for the response time probability distribution of workflows based on the fluid stochastic Petri net formalism is presented. Firstly, some problems about stochastic workflow net modeling are discussed. Then how to convert a stochastic workflow net model into a fluid stochastic Petri net model is described. The response time distribution can be obtained directly upon the transient state solution of the fluid stochastic Petri net model. In the proposed approach, there are not any restrictions on the structure of workflow models, and the processing times of workflow tasks can be modeled by using arbitrary probability distributions. Large workflow models can be efficiently tackled by recursively using a net reduction technique.

Optimization of process parameters for in situ casting of Al/TiB_2 composites through response surface methodology

The mathematical models were developed to predict the ultimate tensile strength （UTS） and hardness of Al/TiB2 MMCs fabricated by in situ reaction process. The process parameters include temperature, reaction time and mass fraction of TiB2. The in-situ casting was carried out based on three-factor five-level central composite rotatable design using response surface methodology （RSM）. The validation of the model was carried out using ANOVA. The mathematical models developed for the mechanical properties were predicted at 95% confidence limit.

Measurement of 3db Bandwidth of Laser Diode Chips

An accurate technique for measuring the frequency response of semiconductor laser diode chips is proposed and experimentally demonstrated.The effects of test jig parasites can be completely removed in the measurement by a new calibration method.In theory,the measuring range of the measurement system is only determined by the measuring range of the instruments network analyzer and photo detector.Diodes' bandwidth of 7 5GHz and 10GHz is measured.The results reveal that the method is feasible and comparing with other method,it is more precise and easier to use.

Effects of dietary supplementation with Clostridium butyricum on the growth performance and humoral immune response in Miichthys miiuy

The effects of dietary supplementation with Clostridium butyricum on growth performance and humoral immune response in Miichthys miiuy were evaluated. One hundred and fifty Miichthys miiuy weighing approximately 200-260 g were divided into five groups and reared in 15 tanks with closed circuiting culture system. The animals were fed 5 diets： basal diet only （control） or supplemented of the basal diet with C. butyricum at doses of 10^3 （CB1）, 10^5 （CB2）, 10^7 （CB3） or 10^9 （CB4） CFU/g. Compared with the control, the serum phenoloxidase activity was significantly increased by the supplementation （P〈0.05）, acid phosphatases activity was increased significantly （P〈0.05） at the doses of 10^9 CFU/g. Serum lysozyme activity peaked at dose of 10^7 CFU/g and in the skin mucus at dose of 10^9 CFU/g. Immunoglobulin M level in the serum and skin mucus was increased except at dose of 10^3 CFU/g （P〈0.05）. The growth at the dose of 10^9 CFU/g was higher than that of the control （P〈0.05）. It is concluded that supplementation of C. butyricum can mediate the humoral immune responses and improve the growth performance in Miichthys miiuy.

The Non—local Thermodynamical Equilibrium Effects on Opacity

Based on the detailed configuration accounting (DCA) model, a method is developed to include the resonant photoionization and the excitation-autoionization in the non-local thermodynamical equilibrium (NLTE) average atom (AA) model. Using this new model, the mean charge states and the opacity are calculated for NLTE high- plasmas and compared with other results. The agreement with AA model is poor at low electron density. The present results agree well with those of DCA model within 10%. The calculations show that the NLTE effects on opacity are strong.

Optimization on the Conversion of Bamboo Shoot Shell to Levulinic Acid with Environmentally Benign Acidic Ionic Liquid and Response Surface Analysis

Levulinic acid（LA） has been identified as a promising green,biomass derived platform chemical.Response surface analysis（RSA） with a four-factor-five-level central composite design（CCD） was applied to optimize the hydrolysis conditions for the conversion of bamboo（Phyllostachys Praecox f.preveynalis） shoot shell（BSS） to LA catalyzed with ionic liquid [C4mim]HSO4.The effects of four main reaction parameters including temperature,time,C[C4mim]HSO4（initial [C4mim]HSO4 concentration） and XBSS（initial BSS intake） on the hydrolysis reaction for yield of LA were analyzed.A quadratic equation model for yield of LA was established and fitted to the data with an R2 of 0.9868,and effects of main factors and their corresponding relationships were obtained with RSA.Model validation and results of CCD showed good correspondence between actual and predicted values.The analysis of variance（ANOVA） of the results indicated that the yield of LA in the range studied was significantly（P＆lt;0.05） affected by the four factors.The optimized reaction conditions were as follows：temperature of 145 ℃,time of 103.8 min,C[C4mim]HSO4 of 0.9 mol.L-1 and XBSS of 2.04%（by mass）,respectively.A high yield [（71±0.41）%（by mol）,triplicate experiment] was obtained at the optimum conditions of temperature of 145 ℃,time of 104 min,C[C4mim]HSO4 of 0.9 mol.L-1 and XBSS of 2%（by mass）,which obtained from the real experiments,concurred with the model prediction [73.8%（by mol） based on available C6 sugars in BSS or 17.9%（by mass） based on the mass of BSS],indicating that the model was adequate for the hydrolysis process.

Layered double hydroxide-like Mg_3Al_(1–x)Fe_x materials as supports for Ir catalysts: Promotional effects of Fe doping in selective hydrogenation of cinnamaldehyde

Supported Ir catalysts were prepared using layered double hydrotalcite‐like materials,such as Mg3Al1-xFex,containing Fe and Al species in varying amounts as supports.These Ir catalysts were applied for the selective hydrogenation of cinnamaldehyde(CAL).When x was changed from 0(Ir/Mg3Al)to 1(Ir/Mg3Fe),the rate of CAL hydrogenation reached a maximum at approximately x=0.25,while the selectivity to unsaturated alcohol,i.e.,cinnamyl alcohol,monotonously increased from 44.9%to 80.3%.Meanwhile,the size of the supported Ir particles did not change significantly with x,remaining at 1.7-0.2 nm,as determined by transmission electron microscopy.The chemical state of Ir and Fe species in the Ir/Mg3Al1-xFex catalysts was examined by temperature programmed reduction by H2 and X‐ray photoelectron spectroscopy.The surface of the supported Ir particles was also examined through the in‐situ diffuse reflectance infrared Fourier‐transform of a probe molecule of CO.On the basis of these characterization results,the effects of Fe doping to Mg3Al on the structural and catalytic properties of Ir particles in selective CAL hydrogenation were discussed.The significant factors are the electron transfer from Fe2+in the Mg3Al1–xFex support to the dispersed Ir particles and the surface geometry.

A new cable truss support system for coal roadways affected by dynamic pressure

The support of coal roadways is seriously affected by intense dynamic pressures.This can lead to problems with large deformation of the roof and the two side walls of coal roadways.Rapid convergence of the walls and roof,a high damage rate to the bolts and cables,or even abrupt roof collapse or rib spalling can occur during the service period of these coal roadways.Analyzing the main support measures used in China leads to a proposed new cable truss supporting system.Thorough study of the entire structure shows the superiority of this design for roadways suffering under dynamic pressure.A corresponding mechanical model of the rock surrounding the cable truss system is described in this paper and formulas for calculating pre-tightening forces of the truss cable,and the minimum anchoring forces,were deduced.The new support system was applied to a typical roadway affected by intensive dynamic pressure that is located in the Xinyuan Coal Mine.The results show that the largest subsidence of the roof was 97 mm,the convergence of the two sides was less than 248 mm,and the average depth of the loose,fractured layer was only 6.12 mm.This proves that the new support system is feasible and effective.

Fully Nonlinear Simulation for Fluid/Structure Impact：A Review

This paper presents a review of the work on fluid/structure impact based on inviscid and imcompressible liquid and irrotational flow. The focus is on the velocity potential theory together with boundary element method （BEM）. Fully nonlinear boundary conditions are imposed on the unknown free surface and the wetted surface of the moving body. The review includes （1） vertical and oblique water entry of a body at constant or a prescribed varying speed, as well as free fall motion, （2） liquid droplets or column impact as well as wave impact on a body, （3） similarity solution of an expanding body. It covers two dimensional （2D）, axisymmetric and three dimensional （3D） cases. Key techniques used in the numerical simulation are outlined, including mesh generation on the multivalued free surface, the stretched coordinate system for expanding domain, the auxiliary function method for decoupling the mutual dependence of the pressure and the body motion, and treatment for the jet or the thin liquid film developed during impact.

Cetuximab plus irinotecan in pretreated metastatic colorectal cancer patients:The ELSIE study

AIM:To evaluate the efficacy and safety of cetuxim-ab plus irinotecan in irinotecan-refractory metastatic colorectal cancer (mCRC) patients from South-East Asia and Australia. METHODS:In this open-label,phase Ⅱ study,the main eligibility criteria were epidermal growth factor receptor-positive mCRC with progressive disease within 3 mo of an irinotecan-based regimen as the most recent chemotherapy. Patients received cetuximab 400 mg/m2 initially,then 250 mg/m2 every week,with the same regimen of irinotecan on which the patients had progressed (4 pre-defined regim-ens allowed). The prim-ary objective was evaluation of progression-free survival (PFS) at 12 wk. Secondary objectives included a further investigation of PFS,and an assessment of the overall response rate (ORR),duration of response,time to treatment failure (TTF),overall survival and the safety profile. RESULTS:One hundred and twenty nine patients were enrolled from-25 centers in the Asia-Pacific region and of these 123 received cetuximab plus irinotecan. The most common recent irinotecan regimen used was 180 mg/m2 every 2 wk which had been used in 93 patients (75.6%). The PFS rate at 12 wk was 50% (95% confidence interval (CI,41-59) and m-edian PFS tim-e was 12.1 wk (95% CI:9.7-17.7). The ORR was 13.8% (95% CI:8.3-21.2) and disease control rate was 49.6% (95% CI:40.5-58.8). Median duration of response was 31.1 wk (95% CI:18.0-42.6) and median overall survival was 9.5 mo (95% CI,7.5-11.7). The median TTF was 11.7 wk (95% CI:9.1-17.4). Treatment was generally well tolerated. The most common grade 3/4 adverse events were diarrhea (13.8%),neutropenia (8.9%),rash (5.7%) and vomiting (5.7%).CONCLUSION:In patients from Asia and Australia,this study confirm-s the activity and safety of cetuxim-ab plus irinotecan observed in previous studies in Europe and South America.