AIM: To clarify the effect of SEN virus (SENV) infection on a combination therapy including interferon alfa (IFN-α) or pegylated-IFN with ribavirin in patients with chronic hepatitis and the effect of a combination t...AIM: To clarify the effect of SEN virus (SENV) infection on a combination therapy including interferon alfa (IFN-α) or pegylated-IFN with ribavirin in patients with chronic hepatitis and the effect of a combination therapy on SENV.METHODS: SENV DNA was determined by polymerase chain reaction in serum samples from 95 patients with chronic hepatitis C. Quantitative analysis was done for SENV H DNA.RESULTS: Twenty-one (22%) of 95 patients were positive for SENV DNA. There was no difference in clinical and biochemical parameters between patients with HCV infection alone and coinfected patients. The sustained response rate for HCV clearance after combination therapy did not differ between patients with SENV (52%) and without SENV(50%, n.s.). SENV DNA was undetectable in 76% of the initially SENV positive patients at the end of follow-up. SENV H response to combination therapy was significantly correlated with SENV DNA level (P=-0.05).CONCLUSION: SENV infection had no influence on the HCV sustained response rate to the combination therapy.Response rate of SENV to the combination therapy depends on SENV DNA level.展开更多
This paper studies and analyzes the response and behavior of regular and irregular building structures in earthquake zones. The non-linear dynamic response of tall buildings structures were obtained using five simulat...This paper studies and analyzes the response and behavior of regular and irregular building structures in earthquake zones. The non-linear dynamic response of tall buildings structures were obtained using five simulated models, which were subjected to UBC code dynamic and static equivalent earthquake loads. The maximum response of the structural models were computed and analyzed in order to verify the effects of building configuration on drift results. Drift results agreed with codes recommendations regarding building configuration and showed that regular buildings performance in resisting earthquake forces is better than that of irregular buildings.展开更多
文摘AIM: To clarify the effect of SEN virus (SENV) infection on a combination therapy including interferon alfa (IFN-α) or pegylated-IFN with ribavirin in patients with chronic hepatitis and the effect of a combination therapy on SENV.METHODS: SENV DNA was determined by polymerase chain reaction in serum samples from 95 patients with chronic hepatitis C. Quantitative analysis was done for SENV H DNA.RESULTS: Twenty-one (22%) of 95 patients were positive for SENV DNA. There was no difference in clinical and biochemical parameters between patients with HCV infection alone and coinfected patients. The sustained response rate for HCV clearance after combination therapy did not differ between patients with SENV (52%) and without SENV(50%, n.s.). SENV DNA was undetectable in 76% of the initially SENV positive patients at the end of follow-up. SENV H response to combination therapy was significantly correlated with SENV DNA level (P=-0.05).CONCLUSION: SENV infection had no influence on the HCV sustained response rate to the combination therapy.Response rate of SENV to the combination therapy depends on SENV DNA level.
文摘This paper studies and analyzes the response and behavior of regular and irregular building structures in earthquake zones. The non-linear dynamic response of tall buildings structures were obtained using five simulated models, which were subjected to UBC code dynamic and static equivalent earthquake loads. The maximum response of the structural models were computed and analyzed in order to verify the effects of building configuration on drift results. Drift results agreed with codes recommendations regarding building configuration and showed that regular buildings performance in resisting earthquake forces is better than that of irregular buildings.
