Objective： The aim of our study was to investigate the early outcome of the taxotere and cisplatin chemora- diotherapy to the advanced cervical cancer. Methods： Fifty-six cases with cervical cancer （FIGO lib to IVa...Objective： The aim of our study was to investigate the early outcome of the taxotere and cisplatin chemora- diotherapy to the advanced cervical cancer. Methods： Fifty-six cases with cervical cancer （FIGO lib to IVa） were divided randomly into two groups in the oncology hospital of Jingzhou from September 2009 to October 2010, radiotherapy alone （28 cases） and radiation plus chemotherapy （TP） group. There was no difference of radiotherapy between the two groups, the RT ＋ C cases who accepted TP regimen during the radiation, and DDP once weekly injection of vain, according to 20 mg/m2 and taxotere once weekly i.v. according to 35 mg/m2. These regimen were given for 4-5 weeks, and some medicine for vomit- ing was given to the RT ＋ C cases. Two groups were received an oral medicine MA 160 mg every day during the treatment. Results： The early outcome： the complete remission rate was 64.3% and partial remission rate was 35.7% in RT ＋ C. The complete remission rate was 32.1% and partial remission rate was 39.3% in RT. The total response rate and complete remis- sion of RT ＋ C group was higher than that of the RT group. There was significant difference between the two groups. In RT ＋ C group, 1-year survive rate was 100.00% （28/28）; in RT group, 1-year survive rate was 85.71% （24/28）. There was significant difference between the two groups （X2 = 4.31 〉 3.84, P 〈 0.05）. Conclusion： The taxotere and cisplatin chemoradiotherapy can improve the early outcome of the advanced cervical cancer, and the adverse effect are raised, but that can be endured.展开更多
Considering the transverse inertia effect of pile, the vertical soil layer is studied. The wave propagations in the outer and inner soil dynamic response of a large diameter pipe pile in viscoelastic are simulated by ...Considering the transverse inertia effect of pile, the vertical soil layer is studied. The wave propagations in the outer and inner soil dynamic response of a large diameter pipe pile in viscoelastic are simulated by three-dimensional elastodynamic theory and those in the pile are simulated by Rayleigh-Love rod theory. The vertical and radial displacements of the outer and inner soil are obtained by utilizing Laplace transform technique and differentiation on the governing equations of soils. Then, based on the continuous conditions between the pile and soils, the displacements of the pile are derived. The frequency domain velocity admittance and time domain velocity response of the pile top are also presented. The solution is compared to a classical rod model solution to verify the validity. The influences of the radii and Poisson ratio of pile on the transverse inertia effect of pile are analyzed. The parametric study shows that Poisson ratio and outer radius of pile have significant influence on the transverse inertia effect of large diameter pipe piles, while the inner radius has little effect.展开更多
文摘Objective： The aim of our study was to investigate the early outcome of the taxotere and cisplatin chemora- diotherapy to the advanced cervical cancer. Methods： Fifty-six cases with cervical cancer （FIGO lib to IVa） were divided randomly into two groups in the oncology hospital of Jingzhou from September 2009 to October 2010, radiotherapy alone （28 cases） and radiation plus chemotherapy （TP） group. There was no difference of radiotherapy between the two groups, the RT ＋ C cases who accepted TP regimen during the radiation, and DDP once weekly injection of vain, according to 20 mg/m2 and taxotere once weekly i.v. according to 35 mg/m2. These regimen were given for 4-5 weeks, and some medicine for vomit- ing was given to the RT ＋ C cases. Two groups were received an oral medicine MA 160 mg every day during the treatment. Results： The early outcome： the complete remission rate was 64.3% and partial remission rate was 35.7% in RT ＋ C. The complete remission rate was 32.1% and partial remission rate was 39.3% in RT. The total response rate and complete remis- sion of RT ＋ C group was higher than that of the RT group. There was significant difference between the two groups. In RT ＋ C group, 1-year survive rate was 100.00% （28/28）; in RT group, 1-year survive rate was 85.71% （24/28）. There was significant difference between the two groups （X2 = 4.31 〉 3.84, P 〈 0.05）. Conclusion： The taxotere and cisplatin chemoradiotherapy can improve the early outcome of the advanced cervical cancer, and the adverse effect are raised, but that can be endured.
基金Project(U1134207)jointly supported by the National Natural Science Foundation and High Speed Railway Key Program of ChinaProject(NCET-12-0843)supported by the Program for New Century Excellent Talents in University of China+1 种基金Projects(51378177,51420105013)supported by the National Natural Science Foundation of ChinaProjects(2015B05014,2014B02814)supported by the Fundamental Research Funds for the Central Universities,China
文摘Considering the transverse inertia effect of pile, the vertical soil layer is studied. The wave propagations in the outer and inner soil dynamic response of a large diameter pipe pile in viscoelastic are simulated by three-dimensional elastodynamic theory and those in the pile are simulated by Rayleigh-Love rod theory. The vertical and radial displacements of the outer and inner soil are obtained by utilizing Laplace transform technique and differentiation on the governing equations of soils. Then, based on the continuous conditions between the pile and soils, the displacements of the pile are derived. The frequency domain velocity admittance and time domain velocity response of the pile top are also presented. The solution is compared to a classical rod model solution to verify the validity. The influences of the radii and Poisson ratio of pile on the transverse inertia effect of pile are analyzed. The parametric study shows that Poisson ratio and outer radius of pile have significant influence on the transverse inertia effect of large diameter pipe piles, while the inner radius has little effect.
