咳喘一贴康治疗急性支气管炎所致咳喘735例临床及实验研究

根据中医“内病外治”理论,研制出治疗急性支气管炎的外用膏药咳喘一贴康。经1158例(治疗组735例,对照组423例)临床观察疗效较为满意,两组治愈率进行比较,具有非常显著性差异(P<0.01)。风寒组治愈率明显优于风热组(P<0.01)。实验研究表明,本品具有止咳平喘作用,对皮肤无刺激,无明显毒副反应。本品使用方便,疗效显著,价格低廉。值得临床进一步推广使用。

Observation on clinical effects of tuina plus montelukast sodium tablets for children with cough variant asthma

Objective： To observe the clinical effects of tuina plus oral administration of montelukast sodium tablets for children with cough variant asthma （CVA）. Methods： A hundred and six children with CVA were randomly divided into a treatment group and a control group, 53 cases in each group. The treatment group was treated with Tuina therapy plus oral administration of montelukast sodium tablets, and the control group was treated only by oral administration of montelukast sodium tablets. Tuina treatment was given three times per week. 5 mg of montelukast sodium tablets was given orally before bedtime every night. The therapeutic effects were assessed after the treatment of four weeks in both groups. Results： The total effective rates were 92.5% in the treatment group and 77.4% in the control group. The difference in the total effective rate between the two groups was statistically significant （P〈0.05）. Conclusion： The therapeutic effect of tuina plus montelukast sodium tablets for children with CVA is better than that of oral administration of montelukast sodium tablets alone.

Clinical Observation on Acupoint Application in the Hottest Summer Days for Asthmatic Diseases

Objective： To observe the clinical effects of acupoint application therapy for asthmatic diseases in the hottest of summer days. Methods： 500 cases of patients with asthmatic diseases were treated by applying a herbal drug on the acupoints in the hottest summer days, namely herbal cake stuck on the acupoint with a piece of plaster, for 6 h every time, once respectively in the first, second and third period of the hottest summer days. Six months after the last session, the clinical effects were assessed by questionnaire. Results： In 500 cases of the patients, the results showed a remarkable effect in 267 cases, improvement in 182 cases, failure in 51 cases and the effective rate was 89.9%. Conclusion： The therapeutic effects are positive in the application of a herbal drug on an acupoint for asthmatic diseases. This method is convenient and needs to be popularized clinically.

Manipulation parameter optimization in Liu's back tuina therapy for kids'cough variant asthma in remission stage

Objective:To determine the optimal manipulation parameters in Liu's back tuina therapy for remission-stage cough variant asthma(CVA)in kids.Methods:A 5-factor 3-level L18(37)orthogonal design was adopted.The experimental factors and levels were selected:A,the number of times of Rou-kneading Feishu(BL 13);B,the frequency of Rou-kneading Feishu(BL 13);C,the number of times of Tui-pushing in a'介'-like pattern;D,the frequency of Tui-pushing in a'介'-like pattern;E,the intensity of red color after Ca-scrubbing Feishu(BL 13)with salt.A1,A2 and A3 stood for 10 times,20 times and 30 times,respectively;B1,B2 and B3 stood for 200 times/min,240 times/min and 280 times/min,respectively;C1,C2 and C3 stood for 50 times,75 times and 100 times,respectively;D1,D2 and D3 stood for 150 times/min,175 times/min and 200 times/min,respectively;E1,E2 and E3 stood for pinkish,bright red and dark red,respectively.A total of 108 kids with CVA in remission stage were divided into 18 groups using the random number table method,with 6 cases in each group.Changes in the cough score and fractional exhaled nitric oxide(FENO)level were observed after 15-day treatment.Results:The cough score and FENO level changed significantly in every group after treatment(all P<0.01).By the effect in improving cough score,the factors were listed as D,B,A,C and E in descending order;the most optimal manipulation parameter combination was group 17(A3B2C1D3E1);the second optimal parameter combinations were group 7(A3B1C2D1E3),group 13(A2B1C2D3E1)and group 14(A2B2C3D1E2).Regarding the effect in down-regulating the level of FENO,the factors were listed as C,A,E,B and D in descending order;the most optimal manipulation parameter combination was group 13(A2B1C2D3E1);the second optimal parameter combinations were group 18(A3B3C2D1E2),group 16(A3B1C3D2E3)and group 14(A2B2C3D1E2).Conclusion:Two most effective manipulation parameter combinations were selected out of 18 different parameter combinations in Liu's back tuina therapy for remission-stage CVA in kids.Doctors can choose an appropriate manipulation based on the symptom features of the disease.

Effect and mechanism of application in canicular days plus enteral nutrition for cough variant asthma in kids

Objective： To observe the clinical efficacy of application in canicular days plus enteral nutrition in treating cough variant asthma （CVA） in kids, and to explore its action mechanism. Methods： Following a randomized controlled single-blind parallel-group design, 138 eligible kids with CVA were randomized into an observation group, a canicular-day application group, and an enteral nutrition group, 46 kids in each group. The canicular-day application group was intervened by application in canicular days, the enteral nutrition group was by enteral feeding, and the observation group was by both canicular-day application and enteral feeding. The therapeutic efficacies were evaluated after a treatment course. Results： The recovery rate and total effective rate were respectively 50.0% and 98.0% in the observation group, versus 23.9% and 91.3% in the canicular-day application group, and 13.0% and 78.6% in the enteral nutrition group. The observation group was significantly superior to the other two groups （both P〈0.05）. In comparing the global symptom score, peak expiratory flow （PEF）, forced expiratory volume in one second （FEVl）, CD3^＋, CD4^＋, CD4^＋/CD8^＋, CD8^＋, hemoglobin （Hb）, total protein （TP）, albumin （ALB）, eosinophil cationic protein （ECP）, lipid peroxide （LPO）, leukotriene （LT）, body weight （BW）, triceps skin-fold （TSF）, and arm muscle circumference （AMC）, the observation group was significantly better than the other two groups （both P〈0.05）. Conclusion： Application in canicular days plus enteral nutrition can significantly improve the pulmonary function and symptoms in children＇s CVA, and the effect is possibly produced by regulating cellular immune system, enhancing Hb, TP, ALB, BW, TSF, AMC, and inhibiting the production of ECP, LPO, and LT.

Therapeutic efficacy and safety rating of Tui-Pushing chest-back manipulation for children with cough variant asthma Therapeutic efficacy and safety rating of Tui-Pushing chest-back manipulation for children with cough variant asthma

Objective:To observe and evaluate the clinical efficacy and safety of using pediatric Tuina(Chinese therapeutic massage),Tui-Pushing chest-back manipulation,in treating children with cough variant asthma(CVA).Methods:Seventy-two kids with CVA were divided into two groups using the random number table method,with 36 cases in each group.The control group received the conventional Tuina treatment,and the observation group received additional Tui-Pushing chest-back manipulation.The clinical efficacy and adverse reactions were observed and recorded for the two groups.Results:After three treatment courses,compared with the control group,the observation group showed advantages in the total effective rate,reducing the number and intensity of cough and improving the nature of cough(P<0.05).However,at the one-month follow-up,there were no significant differences between the two groups in these parameters(P>0.05).Regarding the adverse reaction rate,there was no significant between-group difference(P>0.05).Conclusion:It is effective and safe to use pediatric Tuina,Tui-Pushing chest-back manipulation,plus the conventional treatment protocol to treat CVA in children.